Chrysin promotes osteogenic differentiation via ERK/MAPK activation

Protein and Cell

Volumn 4, Issue 7, 2013, Pages 539-547

  Zeng, Wenfeng ^a,b   Yan, Yan ^c   Zhang, Fayun ^a   Zhang, Chunling ^a   Liang, Wei ^a  

^a INSTITUTE OF BIOPHYSICS   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

chrysin; ERK1 2; estrogen receptor; osteogenesis

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CHRYSIN; COLLAGEN TYPE 1; FULVESTRANT; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; OSTEOCALCIN; OSTEOPONTIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2;

ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; BONE MINERALIZATION; CELL DIFFERENTIATION; COL1A1 GENE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; MARKER GENE; MOUSE; NONHUMAN; OCN GENE; OPN GENE; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; ENZYME ACTIVATION; FLAVONOIDS; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; OSTEOBLASTS; OSTEOGENESIS; OSTEOPOROSIS; PHOSPHORYLATION; RECEPTORS, ESTROGEN;

EID: 84880814305     PISSN: 1674800X     EISSN: 16748018     Source Type: Journal    
DOI: 10.1007/s13238-013-3003-3     Document Type: Article

References (33)

1. Becker, D. J., Kilgore, M. L., and Morrisey, M. A. (2010). The societal burden of osteoporosis. Curr Rheumatol Rep 12, 186-191.
2. Celil, A. B., and Campbell, P. G. (2005). BMP-2 and insulin-like growth factor-I mediate Osterix (Osx) expression in human mesenchymal stem cells via the MAPK and protein kinase D signaling pathways. J Biol Chem 280, 31353-31359.
3. Chang, L., and Karin, M. (2001). Mammalian MAP kinase signalling cascades. Nature 410, 37-40.
4. Franceschi, R. T., Ge, C., Xiao, G., Roca, H., and Jiang, D. (2007). Transcriptional regulation of osteoblasts. Ann N Y Acad Sci 1116, 196-207.
5. Ge, C., Xiao, G., Jiang, D., and Franceschi, R. T. (2007). Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development. J Cell Biol 176, 709-718.
6. Ha, S. K., Moon, E., and Kim, S. Y. (2010). Chrysin suppresses LPSstimulated proinflammatory responses by blocking NF-kappaB and JNK activations in microglia cells. Neurosci Lett 485, 143-147.
7. Higuchi, C., Myoui, A., Hashimoto, N., Kuriyama, K., Yoshioka, K., Yoshikawa, H., and Itoh, K. (2002). Continuous inhibition of MAPK signaling promotes the early osteoblastic differentiation and mineralization of the extracellular matrix. J Bone Miner Res 17, 1785-1794.
8. Hsieh, T. P., Sheu, S. Y., Sun, J. S., and Chen, M. H. (2011). Icariin inhibits osteoclast differentiation and bone resorption by suppression of MAPKs/NF-kappaB regulated HIF-1alpha and PGE(2) synthesis. Phytomedicine 18, 176-185.
9. Hsu, Y. L., and Kuo, P. L. (2008). Diosmetin induces human osteoblastic differentiation through the protein kinase C/p38 and extracellular signal-regulated kinase 1/2 pathway. J Bone Miner Res 23, 949-960.
10. Jia, T. L., Wang, H. Z., Xie, L. P., Wang, X. Y., and Zhang, R. Q. (2003). Daidzein enhances osteoblast growth that may be mediated by increased bone morphogenetic protein (BMP) production. Biochem Pharmacol 65, 709-715.
11. Jungbauer, A., and Medjakovic, S. (2013). Phytoestrogens and the metabolic syndrome. J Steroid Biochem Mol Biol. (In Press).
12. Kawai, M., Modder, U. I., Khosla, S., and Rosen, C. J. (2011). Emerging therapeutic opportunities for skeletal restoration. Nat Rev Drug Discov 10, 141-156.
13. Khosla, S., Melton, L. J., 3rd, and Riggs, B. L. (2011). The unitary model for estrogen deficiency and the pathogenesis of osteoporosis: is a revision needed? J Bone Miner Res 26, 441-451.
14. Komori, T., Yagi, H., Nomura, S., Yamaguchi, A., Sasaki, K., Deguchi, K., Shimizu, Y., Bronson, R. T., Gao, Y. H., Inada, M., et al. (1997). Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89, 755-764.
15. Kousteni, S., Bellido, T., Plotkin, L. I., O'Brien, C. A., Bodenner, D. L., Han, L., Han, K., DiGregorio, G. B., Katzenellenbogen, J. A., Katzenellenbogen, B. S., et al. (2001). Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity. Cell 104, 719-730.
16. Kozawa, O., Hatakeyama, D., and Uematsu, T. (2002). Divergent regulation by p44/p42 MAP kinase and p38 MAP kinase of bone morphogenetic protein-4-stimulated osteocalcin synthesis in osteoblasts. J Cell Biochem 84, 583-589.
17. Kunath, T., Saba-El-Leil, M. K., Almousailleakh, M., Wray, J., Meloche, S., and Smith, A. (2007). FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment. Development 134, 2895-2902.
18. Lai, C. F., Chaudhary, L., Fausto, A., Halstead, L. R., Ory, D. S., Avioli, L. V., and Cheng, S. L. (2001). Erk is essential for growth, differentiation, integrin expression, and cell function in human osteoblastic cells. J Biol Chem 276, 14443-14450.
19. Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J. M., Behringer, R. R., and de Crombrugghe, B. (2002). The novel zinc fingercontaining transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108, 17-29.
20. Nakayama, K., Tamura, Y., Suzawa, M., Harada, S., Fukumoto, S., Kato, M., Miyazono, K., Rodan, G. A., Takeuchi, Y., and Fujita, T. (2003). Receptor tyrosine kinases inhibit bone morphogenetic protein-Smad responsive promoter activity and differentiation of murine MC3T3-E1 osteoblast-like cells. J Bone Miner Res 18, 827-835.
21. Penckofer, S. M., Hackbarth, D., and Schwertz, D. W. (2003). Estrogen plus progestin therapy: the cardiovascular risks exceed the benefits. J Cardiovasc Nurs 18, 347-355.
22. Pileggi, R., Antony, K., Johnson, K., Zuo, J., and Shannon Holliday, L. (2009). Propolis inhibits osteoclast maturation. Dent Traumatol 25, 584-588.
23. Rossouw, J. E., Anderson, G. L., Prentice, R. L., LaCroix, A. Z., Kooperberg, C., Stefanick, M. L., Jackson, R. D., Beresford, S. A., Howard, B. V., Johnson, K. C., et al. (2002). Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA 288, 321-333.
24. Schindeler, A., and Little, D. G. (2006). Ras-MAPK signaling in osteogenic differentiation: friend or foe? J Bone Miner Res 21, 1331-1338.
25. Shin, E. K., Kwon, H. S., Kim, Y. H., Shin, H. K., and Kim, J. K. (2009). Chrysin, a natural flavone, improves murine inflammatory bowel diseases. Biochem Biophys Res Commun 381, 502-507.
26. Suzawa, M., Takeuchi, Y., Fukumoto, S., Kato, S., Ueno, N., Miyazono, K., Matsumoto, T., and Fujita, T. (1999). Extracellular matrix-associated bone morphogenetic proteins are essential for differentiation of murine osteoblastic cells in vitro. Endocrinology 140, 2125-2133.
27. Swarnkar, G., Sharan, K., Siddiqui, J. A., Mishra, J. S., Khan, K., Khan, M. P., Gupta, V., Rawat, P., Maurya, R., Dwivedi, A. K., et al. (2012). A naturally occurring naringenin derivative exerts potent bone anabolic effects by mimicking oestrogen action on osteoblasts. Br J Pharmacol 165, 1526-1542.
28. Trzeciakiewicz, A., Habauzit, V., Mercier, S., Lebecque, P., Davicco, M. J., Coxam, V., Demigne, C., and Horcajada, M. N. (2010). Hesperetin stimulates differentiation of primary rat osteoblasts involving the BMP signalling pathway. J Nutr Biochem 21, 424-431.
29. Weng, M. S., Ho, Y. S., and Lin, J. K. (2005). Chrysin induces G1 phase cell cycle arrest in C6 glioma cells through inducing p21Waf1/Cip1 expression: involvement of p38 mitogen-activated protein kinase. Biochem Pharmacol 69, 1815-1827.
30. Woo, K. J., Jeong, Y. J., Park, J. W., and Kwon, T. K. (2004). Chrysin induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells. Biochem Biophys Res Commun 325, 1215-1222.
31. Xiao, G., Gopalakrishnan, R., Jiang, D., Reith, E., Benson, M. D., and Franceschi, R. T. (2002). Bone morphogenetic proteins, extracellular matrix, and mitogen-activated protein kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells. J Bone Miner Res 17, 101-110.
32. Xiao, G., Jiang, D., Thomas, P., Benson, M. D., Guan, K., Karsenty, G., and Franceschi, R. T. (2000). MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1. J Biol Chem 275, 4453-4459.
33. Zhao, J., Ohba, S., Shinkai, M., Chung, U. I., and Nagamune, T. (2008). Icariin induces osteogenic differentiation in vitro in a BMP- and Runx2-dependent manner. Biochem Biophys Res Commun 369, 444-448.