-
1
-
-
79960561552
-
Glioblastoma-derived leptin induces tube formation and growth of endothelial cells: Comparison with VEGF effects
-
21771332 10.1186/1471-2407-11-303 1:CAS:528:DC%2BC3MXhtVGht7rP
-
Ferla R, Bonomi M, Otvos L Jr, Surmacz E (2011) Glioblastoma-derived leptin induces tube formation and growth of endothelial cells: comparison with VEGF effects. BMC Cancer 11:303
-
(2011)
BMC Cancer
, vol.11
, pp. 303
-
-
Ferla, R.1
Bonomi, M.2
Otvos, Jr.L.3
Surmacz, E.4
-
2
-
-
64649097553
-
Anti-vascular endothelial growth factor therapy for malignant glioma
-
19348715 10.1007/s11910-009-0037-2 1:CAS:528:DC%2BC3cXhtFeku7fI
-
Gerstner ER, Sorensen AG, Jain RK, Batchelor TT (2009) Anti-vascular endothelial growth factor therapy for malignant glioma. Curr Neurol Neurosci Rep 9:254-262
-
(2009)
Curr Neurol Neurosci Rep
, vol.9
, pp. 254-262
-
-
Gerstner, E.R.1
Sorensen, A.G.2
Jain, R.K.3
Batchelor, T.T.4
-
3
-
-
34447632643
-
Angiogenesis in brain tumours
-
17643088 10.1038/nrn2175 1:CAS:528:DC%2BD2sXnvFKntbk%3D
-
Jain RK, di Tomaso E, Duda DG, Loeffler JS, Sorensen AG, Batchelor TT (2007) Angiogenesis in brain tumours. Nat Rev Neurosci 8:610-622
-
(2007)
Nat Rev Neurosci
, vol.8
, pp. 610-622
-
-
Jain, R.K.1
Di Tomaso, E.2
Duda, D.G.3
Loeffler, J.S.4
Sorensen, A.G.5
Batchelor, T.T.6
-
4
-
-
0030044984
-
Vascular endothelial growth factor, a potent and selective angiogenic agent
-
8557658 10.1074/jbc.271.2.603 1:CAS:528:DyaK28XksFKrtg%3D%3D
-
Thomas KA (1996) Vascular endothelial growth factor, a potent and selective angiogenic agent. J Biol Chem 271:603-606
-
(1996)
J Biol Chem
, vol.271
, pp. 603-606
-
-
Thomas, K.A.1
-
5
-
-
0026446102
-
Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo
-
1279432 10.1038/359845a0 1:CAS:528:DyaK38XmsV2gsb8%3D
-
Plate KH, Breier G, Weich HA, Risau W (1992) Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 359:845-848
-
(1992)
Nature
, vol.359
, pp. 845-848
-
-
Plate, K.H.1
Breier, G.2
Weich, H.A.3
Risau, W.4
-
6
-
-
33846149645
-
AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
-
17222792 10.1016/j.ccr.2006.11.021 1:CAS:528:DC%2BD2sXhtFClsLc%3D
-
Batchelor TT, Sorensen AG, di Tomaso E, Zhang WT, Duda DG, Cohen KS, Kozak KR, Cahill DP, Chen PJ, Zhu M, Ancukiewicz M, Mrugala MM, Plotkin S, Drappatz J, Louis DN, Ivy P, Scadden DT, Benner T, Loeffler JS, Wen PY, Jain RK (2007) AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 11:83-95
-
(2007)
Cancer Cell
, vol.11
, pp. 83-95
-
-
Batchelor, T.T.1
Sorensen, A.G.2
Di Tomaso, E.3
Zhang, W.T.4
Duda, D.G.5
Cohen, K.S.6
Kozak, K.R.7
Cahill, D.P.8
Chen, P.J.9
Zhu, M.10
Ancukiewicz, M.11
Mrugala, M.M.12
Plotkin, S.13
Drappatz, J.14
Louis, D.N.15
Ivy, P.16
Scadden, D.T.17
Benner, T.18
Loeffler, J.S.19
Wen, P.Y.20
Jain, R.K.21
more..
-
7
-
-
0037967272
-
Tumorigenesis and the angiogenic switch
-
12778130 10.1038/nrc1093 1:CAS:528:DC%2BD3sXktFOnsb8%3D
-
Bergers G, Benjamin LE (2003) Tumorigenesis and the angiogenic switch. Nat Rev Cancer 3:401-410
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 401-410
-
-
Bergers, G.1
Benjamin, L.E.2
-
8
-
-
67649120009
-
Biology of angiogenesis and invasion in glioma
-
19560735 10.1016/j.nurt.2009.04.001 1:CAS:528:DC%2BD1MXhsFent7bN
-
Tate MC, Aghi MK (2009) Biology of angiogenesis and invasion in glioma. Neurotherapeutics 6:447-457
-
(2009)
Neurotherapeutics
, vol.6
, pp. 447-457
-
-
Tate, M.C.1
Aghi, M.K.2
-
9
-
-
33947191055
-
Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma
-
17317837 10.1158/1078-0432.CCR-06-2309 1:CAS:528:DC%2BD2sXhvF2htr8%3D
-
Vredenburgh JJ, Desjardins A, Herndon JE 2nd, Dowell JM, Reardon DA, Quinn JA, Rich JN, Sathornsumetee S, Gururangan S, Wagner M, Bigner DD, Friedman AH, Friedman HS (2007) Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma. Clin Cancer Res 13:1253-1259
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1253-1259
-
-
Vredenburgh, J.J.1
Desjardins, A.2
Herndon II, J.E.3
Dowell, J.M.4
Reardon, D.A.5
Quinn, J.A.6
Rich, J.N.7
Sathornsumetee, S.8
Gururangan, S.9
Wagner, M.10
Bigner, D.D.11
Friedman, A.H.12
Friedman, H.S.13
-
10
-
-
36049037819
-
Bevacizumab plus irinotecan in recurrent glioblastoma multiforme
-
17947719 10.1200/JCO.2007.12.2440 1:CAS:528:DC%2BD2sXhtlCgsLjF
-
Vredenburgh JJ, Desjardins A, Herndon JE 2nd, Marcello J, Reardon DA, Quinn JA, Rich JN, Sathornsumetee S, Gururangan S, Sampson J, Wagner M, Bailey L, Bigner DD, Friedman AH, Friedman HS (2007) Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. J Clin Oncol 25:4722-4729
-
(2007)
J Clin Oncol
, vol.25
, pp. 4722-4729
-
-
Vredenburgh, J.J.1
Desjardins, A.2
Herndon II, J.E.3
Marcello, J.4
Reardon, D.A.5
Quinn, J.A.6
Rich, J.N.7
Sathornsumetee, S.8
Gururangan, S.9
Sampson, J.10
Wagner, M.11
Bailey, L.12
Bigner, D.D.13
Friedman, A.H.14
Friedman, H.S.15
-
11
-
-
84856806386
-
A clinical trial of bevacizumab, temozolomide, and radiation for newly diagnosed glioblastoma
-
22035272 10.3171/2011.9.JNS11656 1:CAS:528:DC%2BC38XjtFGlsLY%3D
-
Narayana A, Gruber D, Kunnakkat S, Golfinos JG, Parker E, Raza S, Zagzag D, Eagan P, Gruber ML (2012) A clinical trial of bevacizumab, temozolomide, and radiation for newly diagnosed glioblastoma. J Neurosurg 116:341-345
-
(2012)
J Neurosurg
, vol.116
, pp. 341-345
-
-
Narayana, A.1
Gruber, D.2
Kunnakkat, S.3
Golfinos, J.G.4
Parker, E.5
Raza, S.6
Zagzag, D.7
Eagan, P.8
Gruber, M.L.9
-
12
-
-
84863754907
-
VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex
-
22789536 10.1016/j.ccr.2012.05.037 1:CAS:528:DC%2BC38XhtVSltLbO
-
Lu KV, Chang JP, Parachoniak CA, Pandika MM, Aghi MK, Meyronet D, Isachenko N, Fouse SD, Phillips JJ, Cheresh DA, Park M, Bergers G (2012) VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex. Cancer Cell 22:21-35
-
(2012)
Cancer Cell
, vol.22
, pp. 21-35
-
-
Lu, K.V.1
Chang, J.P.2
Parachoniak, C.A.3
Pandika, M.M.4
Aghi, M.K.5
Meyronet, D.6
Isachenko, N.7
Fouse, S.D.8
Phillips, J.J.9
Cheresh, D.A.10
Park, M.11
Bergers, G.12
-
13
-
-
0035313701
-
The Stat family in cytokine signaling
-
11248555 10.1016/S0955-0674(00)00199-X 1:CAS:528:DC%2BD3MXisVCnsro%3D
-
Ihle JN (2001) The Stat family in cytokine signaling. Curr Opin Cell Biol 13:211-217
-
(2001)
Curr Opin Cell Biol
, vol.13
, pp. 211-217
-
-
Ihle, J.N.1
-
14
-
-
51049123447
-
Signal transducer and activator of transcription-3: A molecular hub for signaling pathways in gliomas
-
18505913 10.1158/1541-7786.MCR-07-2180 1:CAS:528:DC%2BD1cXmt1Ojs7s%3D
-
Brantley EC, Benveniste EN (2008) Signal transducer and activator of transcription-3: a molecular hub for signaling pathways in gliomas. Mol Cancer Res 6:675-684
-
(2008)
Mol Cancer Res
, vol.6
, pp. 675-684
-
-
Brantley, E.C.1
Benveniste, E.N.2
-
15
-
-
75149195336
-
The transcriptional network for mesenchymal transformation of brain tumours
-
20032975 10.1038/nature08712 1:CAS:528:DC%2BD1MXhs1SktbzP
-
Carro MS, Lim WK, Alvarez MJ, Bollo RJ, Zhao X, Snyder EY, Sulman EP, Anne SL, Doetsch F, Colman H, Lasorella A, Aldape K, Califano A, Iavarone A (2010) The transcriptional network for mesenchymal transformation of brain tumours. Nature 463:318-325
-
(2010)
Nature
, vol.463
, pp. 318-325
-
-
Carro, M.S.1
Lim, W.K.2
Alvarez, M.J.3
Bollo, R.J.4
Zhao, X.5
Snyder, E.Y.6
Sulman, E.P.7
Anne, S.L.8
Doetsch, F.9
Colman, H.10
Lasorella, A.11
Aldape, K.12
Califano, A.13
Iavarone, A.14
-
16
-
-
79953757100
-
Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3
-
21481791 10.1016/j.ccr.2011.03.004 1:CAS:528:DC%2BC3MXks1Wqsbw%3D
-
Guryanova OA, Wu Q, Cheng L, Lathia JD, Huang Z, Yang J, MacSwords J, Eyler CE, McLendon RE, Heddleston JM, Shou W, Hambardzumyan D, Lee J, Hjelmeland AB, Sloan AE, Bredel M, Stark GR, Rich JN, Bao S (2011) Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3. Cancer Cell 19:498-511
-
(2011)
Cancer Cell
, vol.19
, pp. 498-511
-
-
Guryanova, O.A.1
Wu, Q.2
Cheng, L.3
Lathia, J.D.4
Huang, Z.5
Yang, J.6
Macswords, J.7
Eyler, C.E.8
McLendon, R.E.9
Heddleston, J.M.10
Shou, W.11
Hambardzumyan, D.12
Lee, J.13
Hjelmeland, A.B.14
Sloan, A.E.15
Bredel, M.16
Stark, G.R.17
Rich, J.N.18
Bao, S.19
-
17
-
-
0033975850
-
Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: Control of hypoxia-inducible factor-1 activity by nitric oxide
-
10607702 1:CAS:528:DC%2BD3cXhslKhtg%3D%3D
-
Kimura H, Weisz A, Kurashima Y, Hashimoto K, Ogura T, D'Acquisto F, Addeo R, Makuuchi M, Esumi H (2000) Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide. Blood 95:189-197
-
(2000)
Blood
, vol.95
, pp. 189-197
-
-
Kimura, H.1
Weisz, A.2
Kurashima, Y.3
Hashimoto, K.4
Ogura, T.5
D'Acquisto, F.6
Addeo, R.7
Makuuchi, M.8
Esumi, H.9
-
18
-
-
0028105848
-
Hypoxia regulatory elements of the human vascular endothelial growth factor gene
-
7528597 1:CAS:528:DyaK2cXmslart7s%3D
-
Minchenko A, Salceda S, Bauer T, Caro J (1994) Hypoxia regulatory elements of the human vascular endothelial growth factor gene. Cell Mol Biol Res 40:35-39
-
(1994)
Cell Mol Biol Res
, vol.40
, pp. 35-39
-
-
Minchenko, A.1
Salceda, S.2
Bauer, T.3
Caro, J.4
-
19
-
-
0031893214
-
Stat3 activation is required for cellular transformation by v-src
-
9566875 1:CAS:528:DyaK1cXis1Gntb4%3D
-
Bromberg JF, Horvath CM, Besser D, Lathem WW, Darnell JE Jr (1998) Stat3 activation is required for cellular transformation by v-src. Mol Cell Biol 18:2553-2558
-
(1998)
Mol Cell Biol
, vol.18
, pp. 2553-2558
-
-
Bromberg, J.F.1
Horvath, C.M.2
Besser, D.3
Lathem, W.W.4
Darnell, Jr.J.E.5
-
20
-
-
0345492424
-
SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer
-
14617776 10.1073/pnas.2232790100 1:CAS:528:DC%2BD3sXpsFGitLk%3D
-
He B, You L, Uematsu K, Zang K, Xu Z, Lee AY, Costello JF, McCormick F, Jablons DM (2003) SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer. Proc Natl Acad Sci USA 100:14133-14138
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 14133-14138
-
-
He, B.1
You, L.2
Uematsu, K.3
Zang, K.4
Xu, Z.5
Lee, A.Y.6
Costello, J.F.7
McCormick, F.8
Jablons, D.M.9
-
21
-
-
0032570637
-
Comparative analysis of expression of hepatocyte growth factor and its receptor, c-met, in gliomas, meningiomas and schwannomas in humans
-
9500204 10.1016/S0304-3835(97)00469-2 1:CAS:528:DyaK1cXht1Ortbk%3D
-
Moriyama T, Kataoka H, Kawano H, Yokogami K, Nakano S, Goya T, Uchino H, Koono M, Wakisaka S (1998) Comparative analysis of expression of hepatocyte growth factor and its receptor, c-met, in gliomas, meningiomas and schwannomas in humans. Cancer Lett 124:149-155
-
(1998)
Cancer Lett
, vol.124
, pp. 149-155
-
-
Moriyama, T.1
Kataoka, H.2
Kawano, H.3
Yokogami, K.4
Nakano, S.5
Goya, T.6
Uchino, H.7
Koono, M.8
Wakisaka, S.9
-
22
-
-
16544373271
-
Constitutive activation of Stat3 correlates with increased expression of the c-Met/HGF receptor in oral squamous cell carcinoma
-
15254691 1:CAS:528:DC%2BD2cXms1Kisbg%3D
-
Klosek SK, Nakashiro K, Hara S, Li C, Shintani S, Hamakawa H (2004) Constitutive activation of Stat3 correlates with increased expression of the c-Met/HGF receptor in oral squamous cell carcinoma. Oncol Rep 12:293-296
-
(2004)
Oncol Rep
, vol.12
, pp. 293-296
-
-
Klosek, S.K.1
Nakashiro, K.2
Hara, S.3
Li, C.4
Shintani, S.5
Hamakawa, H.6
-
23
-
-
0029761644
-
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
-
8756616 1:CAS:528:DyaK28XltFKjsrc%3D
-
Forsythe JA, Jiang BH, Iyer NV, Agani F, Leung SW, Koos RD, Semenza GL (1996) Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 16:4604-4613
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4604-4613
-
-
Forsythe, J.A.1
Jiang, B.H.2
Iyer, N.V.3
Agani, F.4
Leung, S.W.5
Koos, R.D.6
Semenza, G.L.7
-
24
-
-
0029103274
-
Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5′ enhancer
-
7641334 10.1161/01.RES.77.3.638 1:CAS:528:DyaK2MXns1altLs%3D
-
Liu Y, Cox SR, Morita T, Kourembanas S (1995) Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5′ enhancer. Circ Res 77:638-643
-
(1995)
Circ Res
, vol.77
, pp. 638-643
-
-
Liu, Y.1
Cox, S.R.2
Morita, T.3
Kourembanas, S.4
-
25
-
-
85047695527
-
Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
-
11960372 10.1038/sj.onc.1205260 1:CAS:528:DC%2BD38XivVelur4%3D
-
Niu G, Wright KL, Huang M, Song L, Haura E, Turkson J, Zhang S, Wang T, Sinibaldi D, Coppola D, Heller R, Ellis LM, Karras J, Bromberg J, Pardoll D, Jove R, Yu H (2002) Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene 21:2000-2008
-
(2002)
Oncogene
, vol.21
, pp. 2000-2008
-
-
Niu, G.1
Wright, K.L.2
Huang, M.3
Song, L.4
Haura, E.5
Turkson, J.6
Zhang, S.7
Wang, T.8
Sinibaldi, D.9
Coppola, D.10
Heller, R.11
Ellis, L.M.12
Karras, J.13
Bromberg, J.14
Pardoll, D.15
Jove, R.16
Yu, H.17
-
26
-
-
0035910753
-
CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation
-
11181699 10.1084/jem.193.4.471 1:CAS:528:DC%2BD3MXhtlGmtb0%3D
-
Suzuki A, Hanada T, Mitsuyama K, Yoshida T, Kamizono S, Hoshino T, Kubo M, Yamashita A, Okabe M, Takeda K, Akira S, Matsumoto S, Toyonaga A, Sata M, Yoshimura A (2001) CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J Exp Med 193:471-481
-
(2001)
J Exp Med
, vol.193
, pp. 471-481
-
-
Suzuki, A.1
Hanada, T.2
Mitsuyama, K.3
Yoshida, T.4
Kamizono, S.5
Hoshino, T.6
Kubo, M.7
Yamashita, A.8
Okabe, M.9
Takeda, K.10
Akira, S.11
Matsumoto, S.12
Toyonaga, A.13
Sata, M.14
Yoshimura, A.15
-
27
-
-
0035188432
-
Suppressor of cytokine signaling-3 is a biomechanical stress-inducible gene that suppresses gp130-mediated cardiac myocyte hypertrophy and survival pathways
-
11714737 1:CAS:528:DC%2BD3MXosVyrur0%3D
-
Yasukawa H, Hoshijima M, Gu Y, Nakamura T, Pradervand S, Hanada T, Hanakawa Y, Yoshimura A, Ross J Jr, Chien KR (2001) Suppressor of cytokine signaling-3 is a biomechanical stress-inducible gene that suppresses gp130-mediated cardiac myocyte hypertrophy and survival pathways. J Clin Investig 108:1459-1467
-
(2001)
J Clin Investig
, vol.108
, pp. 1459-1467
-
-
Yasukawa, H.1
Hoshijima, M.2
Gu, Y.3
Nakamura, T.4
Pradervand, S.5
Hanada, T.6
Hanakawa, Y.7
Yoshimura, A.8
Ross, Jr.J.9
Chien, K.R.10
-
28
-
-
0034082217
-
Negative regulation of cytokine signaling pathways
-
10837055 10.1146/annurev.immunol.18.1.143 1:CAS:528:DC%2BD3cXjs1GmsLY%3D
-
Yasukawa H, Sasaki A, Yoshimura A (2000) Negative regulation of cytokine signaling pathways. Annu Rev Immunol 18:143-164
-
(2000)
Annu Rev Immunol
, vol.18
, pp. 143-164
-
-
Yasukawa, H.1
Sasaki, A.2
Yoshimura, A.3
-
29
-
-
57349117925
-
Prognostic relevance of SOCS3 hypermethylation in patients with glioblastoma multiforme
-
18770864 10.1002/ijc.23805 1:CAS:528:DC%2BD1cXhsVKgt7%2FJ
-
Martini M, Pallini R, Luongo G, Cenci T, Lucantoni C, Larocca LM (2008) Prognostic relevance of SOCS3 hypermethylation in patients with glioblastoma multiforme. Int J Cancer 123:2955-2960
-
(2008)
Int J Cancer
, vol.123
, pp. 2955-2960
-
-
Martini, M.1
Pallini, R.2
Luongo, G.3
Cenci, T.4
Lucantoni, C.5
Larocca, L.M.6
-
30
-
-
79961131128
-
Hypoxia-induced epigenetic regulation and silencing of the BRCA1 promoter
-
21670155 10.1128/MCB.01121-10 1:CAS:528:DC%2BC3MXhtVemtL3L
-
Lu Y, Chu A, Turker MS, Glazer PM (2011) Hypoxia-induced epigenetic regulation and silencing of the BRCA1 promoter. Mol Cell Biol 31:3339-3350
-
(2011)
Mol Cell Biol
, vol.31
, pp. 3339-3350
-
-
Lu, Y.1
Chu, A.2
Turker, M.S.3
Glazer, P.M.4
-
31
-
-
0035793584
-
Molecular mechanism of hypoxia-inducible factor 1alpha -p300 interaction. A leucine-rich interface regulated by a single cysteine
-
11063749 10.1074/jbc.M009522200 1:CAS:528:DC%2BD3MXhtFWisLs%3D
-
Gu J, Milligan J, Huang LE (2001) Molecular mechanism of hypoxia-inducible factor 1alpha -p300 interaction. A leucine-rich interface regulated by a single cysteine. J Biol Chem 276:3550-3554
-
(2001)
J Biol Chem
, vol.276
, pp. 3550-3554
-
-
Gu, J.1
Milligan, J.2
Huang, L.E.3
-
32
-
-
0033574767
-
Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300
-
10205054 10.1126/science.284.5413.479 1:CAS:528:DyaK1MXisFOkt74%3D
-
Nakashima K, Yanagisawa M, Arakawa H, Kimura N, Hisatsune T, Kawabata M, Miyazono K, Taga T (1999) Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300. Science 284:479-482
-
(1999)
Science
, vol.284
, pp. 479-482
-
-
Nakashima, K.1
Yanagisawa, M.2
Arakawa, H.3
Kimura, N.4
Hisatsune, T.5
Kawabata, M.6
Miyazono, K.7
Taga, T.8
|