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Volumn 9, Issue 3, 2009, Pages 254-262

Anti-vascular endothelial growth factor therapy for malignant glioma

Author keywords

[No Author keywords available]

Indexed keywords

6 [4 (4 ETHYL 1 PIPERAZINYLMETHYL)PHENYL] 4 (ALPHA METHYLBENZYLAMINO) 7H PYRROLO[2,3 D]PYRIMIDINE; AFLIBERCEPT; BEVACIZUMAB; CEDIRANIB; ERLOTINIB; ETOPOSIDE; EVEROLIMUS; HYDROXYUREA; IRINOTECAN; LOMUSTINE; SORAFENIB; SUNITINIB; TEMOZOLOMIDE; TEMSIROLIMUS; VANDETANIB; VASCULOTROPIN; VASCULOTROPIN INHIBITOR; VATALANIB;

EID: 64649097553     PISSN: 15284042     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11910-009-0037-2     Document Type: Review
Times cited : (16)

References (52)
  • 1
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • Stupp R, Mason WP, van den Bent MJ, et al.: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005, 352:987-996.
    • (2005) N Engl J Med , vol.352 , pp. 987-996
    • Stupp, R.1    Mason, W.P.2    van den Bent, M.J.3
  • 3
    • 33745767945 scopus 로고    scopus 로고
    • Inhibition of hypoxia inducible factor-1alpha (HIF-1alpha) decreases vascular endothelial growth factor (VEGF) secretion and tumor growth in malignant gliomas
    • Jensen RL, Ragel BT, Whang K, Gillespie D: Inhibition of hypoxia inducible factor-1alpha (HIF-1alpha) decreases vascular endothelial growth factor (VEGF) secretion and tumor growth in malignant gliomas. J Neurooncol 2006, 78:233-247.
    • (2006) J Neurooncol , vol.78 , pp. 233-247
    • Jensen, R.L.1    Ragel, B.T.2    Whang, K.3    Gillespie, D.4
  • 4
    • 0029761644 scopus 로고    scopus 로고
    • Activation of vascular endothelial growth factor gene transcription by hypoxiainducible factor 1
    • Forsythe JA, Jiang BH, Iyer NV, et al.: Activation of vascular endothelial growth factor gene transcription by hypoxiainducible factor 1. Mol Cell Biol 1996, 16:4604-4613.
    • (1996) Mol Cell Biol , vol.16 , pp. 4604-4613
    • Forsythe, J.A.1    Jiang, B.H.2    Iyer, N.V.3
  • 5
    • 0026446102 scopus 로고
    • Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo
    • Plate KH, Breier G, Weich HA, Risau W: Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 1992, 359:845-848.
    • (1992) Nature , vol.359 , pp. 845-848
    • Plate, K.H.1    Breier, G.2    Weich, H.A.3    Risau, W.4
  • 6
    • 0037234235 scopus 로고    scopus 로고
    • Mechanisms underlying PTEN regulation of vascular endothelial growth factor and angiogenesis
    • Gomez-Manzano C, Fueyo J, Jiang H, et al.: Mechanisms underlying PTEN regulation of vascular endothelial growth factor and angiogenesis. Ann Neurol 2003, 53:109-117.
    • (2003) Ann Neurol , vol.53 , pp. 109-117
    • Gomez-Manzano, C.1    Fueyo, J.2    Jiang, H.3
  • 7
    • 34547673869 scopus 로고    scopus 로고
    • Activation of p38 MAPK and/or JNK contributes to increased levels of VEGF secretion in human malignant glioma cells
    • Yoshino Y, Aoyagi M, Tamaki M, et al.: Activation of p38 MAPK and/or JNK contributes to increased levels of VEGF secretion in human malignant glioma cells. Int J Oncol 2006, 29:981-987.
    • (2006) Int J Oncol , vol.29 , pp. 981-987
    • Yoshino, Y.1    Aoyagi, M.2    Tamaki, M.3
  • 8
    • 21644482527 scopus 로고    scopus 로고
    • Inhibition of angiogenesis in human glioma cell lines by antisense RNA from the soluble guanylate cyclase genes, GUCY1A3 and GUCY1B3
    • Saino M, Maruyama T, Sekiya T, et al.: Inhibition of angiogenesis in human glioma cell lines by antisense RNA from the soluble guanylate cyclase genes, GUCY1A3 and GUCY1B3. Oncol Rep 2004, 12:47-52.
    • (2004) Oncol Rep , vol.12 , pp. 47-52
    • Saino, M.1    Maruyama, T.2    Sekiya, T.3
  • 9
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • Kerbel RS: Tumor angiogenesis. N Engl J Med 2008, 358:2039-2049.
    • (2008) N Engl J Med , vol.358 , pp. 2039-2049
    • Kerbel, R.S.1
  • 10
    • 37049012486 scopus 로고    scopus 로고
    • Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo
    • Li JL, Sainson RC, Shi W, et al.: Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo. Cancer Res 2007, 67:11244-11253.
    • (2007) Cancer Res , vol.67 , pp. 11244-11253
    • Li, J.L.1    Sainson, R.C.2    Shi, W.3
  • 11
    • 0028941001 scopus 로고
    • Vascular endothelial growth factor in human glioma cell lines: Induced secretion by EGF, PDGF-BB, and bFGF
    • Tsai JC, Goldman CK, Gillespie GY: Vascular endothelial growth factor in human glioma cell lines: Induced secretion by EGF, PDGF-BB, and bFGF. J Neurosurg 1995, 82:864-873.
    • (1995) J Neurosurg , vol.82 , pp. 864-873
    • Tsai, J.C.1    Goldman, C.K.2    Gillespie, G.Y.3
  • 12
    • 0027412319 scopus 로고
    • Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: A model of glioblastoma multiforme pathophysiology
    • Goldman CK, Kim J, Wong WL, et al.: Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: A model of glioblastoma multiforme pathophysiology. Mol Biol Cell 1993, 4:121-133.
    • (1993) Mol Biol Cell , vol.4 , pp. 121-133
    • Goldman, C.K.1    Kim, J.2    Wong, W.L.3
  • 13
    • 0029953517 scopus 로고    scopus 로고
    • Induction of vascular endothelial growth factor by tumor necrosis factor alpha in human glioma cells. Possible roles of SP-1
    • Ryuto M, Ono M, Izumi H, et al.: Induction of vascular endothelial growth factor by tumor necrosis factor alpha in human glioma cells. Possible roles of SP-1. J Biol Chem 1996, 271:28220-28228.
    • (1996) J Biol Chem , vol.271 , pp. 28220-28228
    • Ryuto, M.1    Ono, M.2    Izumi, H.3
  • 14
    • 0025214980 scopus 로고
    • Basic fibroblast growth factor-like activity and receptors are expressed in a human glioma cell line
    • Morrison RS, Gross JL, Herblin WF, et al.: Basic fibroblast growth factor-like activity and receptors are expressed in a human glioma cell line. Cancer Res 1990, 50:2524-2529.
    • (1990) Cancer Res , vol.50 , pp. 2524-2529
    • Morrison, R.S.1    Gross, J.L.2    Herblin, W.F.3
  • 15
    • 27944446867 scopus 로고    scopus 로고
    • The role of angiopoietins during angiogenesis in gliomas
    • Reiss Y, Machein MR, Plate KH: The role of angiopoietins during angiogenesis in gliomas. Brain Pathol 2005, 15:311-317.
    • (2005) Brain Pathol , vol.15 , pp. 311-317
    • Reiss, Y.1    Machein, M.R.2    Plate, K.H.3
  • 16
    • 33947732977 scopus 로고    scopus 로고
    • Angiogenesis: An organizing principle for drug discovery?
    • Folkman A: Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov 2007, 6:273-286.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 273-286
    • Folkman, J.1
  • 17
    • 30944446883 scopus 로고    scopus 로고
    • Lessons from phase III clinical trials on anti-VEGF therapy for cancer
    • Jain RK, Duda DG, Clark JW, Loeffler JS: Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Nat Clin Pract Oncol 2006, 3:24-40.
    • (2006) Nat Clin Pract Oncol , vol.3 , pp. 24-40
    • Jain, R.K.1    Duda, D.G.2    Clark, J.W.3    Loeffler, J.S.4
  • 18
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • Jain RK: Normalization of tumoA vasculature: an emerging concept in antiangiogenic therapy. Science 2005, 307:58-62.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 19
    • 33846029123 scopus 로고    scopus 로고
    • A perivascular niche for brain tumor stem cells
    • Calabrese C, Poppleton H, Kocak M, et al.: A perivascular niche for brain tumor stem cells. Cancer Cell 2007, 11:69-82.
    • (2007) Cancer Cell , vol.11 , pp. 69-82
    • Calabrese, C.1    Poppleton, H.2    Kocak, M.3
  • 20
    • 33748051406 scopus 로고    scopus 로고
    • Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor
    • Bao S, Wu Q, Sathornsumetee S, et al.: Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res 2006, 66:7843-7848.
    • (2006) Cancer Res , vol.66 , pp. 7843-7848
    • Bao, S.1    Wu, Q.2    Sathornsumetee, S.3
  • 21
    • 36049037819 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan in recurrent glioblastoma multiforme
    • Vredenburgh JJ, Desjardins A, Herndon JE 2nd, et al.: Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. J Clin Oncol 2007, 25:4722-4729.
    • (2007) J Clin Oncol , vol.25 , pp. 4722-4729
    • Vredenburgh, J.J.1    Desjardins, A.2    Herndon II, J.E.3
  • 22
    • 0032767387 scopus 로고    scopus 로고
    • Outcomes and prognostic factors in recurrent glioma patients enrolled onto phase II clinical trials
    • Wong ET, Hess KR, Gleason MJ, et al.: Outcomes and prognostic factors in recurrent glioma patients enrolled onto phase II clinical trials. J Clin Oncol 1999, 17:2572-2578.
    • (1999) J Clin Oncol , vol.17 , pp. 2572-2578
    • Wong, E.T.1    Hess, K.R.2    Gleason, M.J.3
  • 23
    • 38349155463 scopus 로고    scopus 로고
    • Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan
    • Sathornsumetee S, Cao Y, Marcello JE, et al.: Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan. J Clin Oncol 2008, 26:271-278.
    • (2008) J Clin Oncol , vol.26 , pp. 271-278
    • Sathornsumetee, S.1    Cao, Y.2    Marcello, J.E.3
  • 24
    • 54949106715 scopus 로고    scopus 로고
    • A phase II, randomized, non-comparative clinical trial of the effect of bevacizumab (BV) alone or in combination with irinotecan (CPT) on 6-month progression free survival (PFS6) in recurrent, treatment-refractory glioblastoma (GBM)
    • [abstract 2010b]
    • Cloughesy TF, Prados MD, Wen PY, et al.: A phase II, randomized, non-comparative clinical trial of the effect of bevacizumab (BV) alone or in combination with irinotecan (CPT) on 6-month progression free survival (PFS6) in recurrent, treatment-refractory glioblastoma (GBM) [abstract 2010b]. J Clin Oncol 2008, 26(Suppl).
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Cloughesy, T.F.1    Prados, M.D.2    Wen, P.Y.3
  • 25
    • 59949083263 scopus 로고    scopus 로고
    • Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma
    • Kreisl TN, Kim L, Moore K, et al.: Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma. J Clin Oncol 2009, 27:740-745.
    • (2009) J Clin Oncol , vol.27 , pp. 740-745
    • Kreisl, T.N.1    Kim, L.2    Moore, K.3
  • 26
    • 60749117109 scopus 로고    scopus 로고
    • Phase II study of bevacizumab and erlotinib in patients with recurrent glioblastoma multiforme
    • [abstract 13008]
    • Sathornsumetee S, Vredenburgh J, Rich J, et al.: Phase II study of bevacizumab and erlotinib in patients with recurrent glioblastoma multiforme [abstract 13008]. J Clin Oncol 2008, 26(Suppl).
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Sathornsumetee, S.1    Vredenburgh, J.2    Rich, J.3
  • 27
    • 60749106240 scopus 로고    scopus 로고
    • Phase II study of bevacizumab and etoposide in patients with recurrent malignant glioma
    • [abstract 2022]
    • Rich J, Desjardins A, Sathornsumetee S, et al.: Phase II study of bevacizumab and etoposide in patients with recurrent malignant glioma [abstract 2022]. J Clin Oncol 2008, 26(Suppl).
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Rich, J.1    Desjardins, A.2    Sathornsumetee, S.3
  • 28
    • 45249097586 scopus 로고    scopus 로고
    • Phase II pilot study of bevacizumab in combination with temozolomide and regional radiation therapy for up-front treatment of patients with newly diagnosed glioblastoma multiforme: Interim analysis of safety and tolerability
    • Lai A, Filka E, McGibbon B, et al.: Phase II pilot study of bevacizumab in combination with temozolomide and regional radiation therapy for up-front treatment of patients with newly diagnosed glioblastoma multiforme: Interim analysis of safety and tolerability. Int J Radiat Oncol Biol Phys 2008, 71:1372-1380.
    • (2008) Int J Radiat Oncol Biol Phys , vol.71 , pp. 1372-1380
    • Lai, A.1    Filka, E.2    McGibbon, B.3
  • 29
    • 0037143764 scopus 로고    scopus 로고
    • VEGF-Trap: A VEGF blocker with potent antitumor effects
    • HolasA J, Davis S, Papadopoulos N, et al.: VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc Natl Acad Sci U S A 2002, 99:11393-11398.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 11393-11398
    • Holash, J.1    Davis, S.2    Papadopoulos, N.3
  • 30
    • 55749102152 scopus 로고    scopus 로고
    • Phase II single arm trial of aflibercept in patients with recurrent temozolomideresistant glioblastoma: NABTC 0601
    • [abstract 2020]
    • De Groot J, Wen P, Lamborn K, et al.: Phase II single arm trial of aflibercept in patients with recurrent temozolomideresistant glioblastoma: NABTC 0601 [abstract 2020]. J Clin Oncol 2008, 26(Suppl).
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • De Groot, J.1    Wen, P.2    Lamborn, K.3
  • 31
    • 33947531672 scopus 로고    scopus 로고
    • VEGF trap in combination with radiotherapy improves tumor control in u87 glioblastoma
    • Wachsberger PR, Burd R, Cardi C, et al.: VEGF trap in combination with radiotherapy improves tumor control in u87 glioblastoma. Int J Radiat Oncol Biol Phys 2007, 67:1526-1537.
    • (2007) Int J Radiat Oncol Biol Phys , vol.67 , pp. 1526-1537
    • Wachsberger, P.R.1    Burd, R.2    Cardi, C.3
  • 32
    • 33846149645 scopus 로고    scopus 로고
    • AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
    • Batchelor TT, Sorensen AG, di Tomaso E, et al.: AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 2007, 11:83-95.
    • (2007) Cancer Cell , vol.11 , pp. 83-95
    • Batchelor, T.T.1    Sorensen, A.G.2    di Tomaso, E.3
  • 33
    • 0034655182 scopus 로고    scopus 로고
    • PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration
    • Wood JM, Bold G, Buchdunger E, et al.: PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res 2000, 60:2178-2189.
    • (2000) Cancer Res , vol.60 , pp. 2178-2189
    • Wood, J.M.1    Bold, G.2    Buchdunger, E.3
  • 34
    • 0034491197 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-driven glioma growth and vascularization in an orthotopic rat model monitored by magnetic resonance imaging
    • discussion 929-930
    • Goldbrunner RH, Bendszus M, Sasaki M, et al.: Vascular endothelial growth factor-driven glioma growth and vascularization in an orthotopic rat model monitored by magnetic resonance imaging. Neurosurgery 2000, 47:921-929; discussion 929-930.
    • (2000) Neurosurgery , vol.47 , pp. 921-929
    • Goldbrunner, R.H.1    Bendszus, M.2    Sasaki, M.3
  • 35
    • 16844382092 scopus 로고    scopus 로고
    • A phase I/II trial of single-agent PTK 787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in patients with recurrent glioblastoma multiforme (GBM)
    • [abstract 1512]
    • Conrad C, Friedman H, Reardon D, et al.: A phase I/II trial of single-agent PTK 787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in patients with recurrent glioblastoma multiforme (GBM) [abstract 1512]. ASCO Annu Meeting Proc (Post-Meeting Edition) 2004, 22(Suppl):1512.
    • (2004) ASCO Annu Meeting Proc (Post-Meeting Edition) , vol.22 , Issue.SUPPL. , pp. 1512
    • Conrad, C.1    Friedman, H.2    Reardon, D.3
  • 36
    • 16844371774 scopus 로고    scopus 로고
    • A phase I/II trial of PTK787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in combination with either temozolomide or lomustine for patients with recurrent glioblastoma multiforme (GBM)
    • [abstract 1513]
    • Reardon D, Friedman H, Yung WKA, et al.: A phase I/II trial of PTK787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in combination with either temozolomide or lomustine for patients with recurrent glioblastoma multiforme (GBM) [abstract 1513]. ASCO Annu Meeting Proc (Post-Meeting Edition) 2004, 22(Suppl):1513.
    • (2004) ASCO Annu Meeting Proc (Post-Meeting Edition) , vol.22 , Issue.SUPPL. , pp. 1513
    • Reardon, D.1    Friedman, H.2    Yung, W.K.A.3
  • 37
    • 55749091026 scopus 로고    scopus 로고
    • Final report: Phase I trial of imatinib mesylate, hydroxyurea, and vatalanib for patients with recurrent malignant glioma (MG)
    • [abstract 2057]
    • KirkpatrPck J, Rich J, Vredenburgh J, et al.: Final report: phase I trial of imatinib mesylate, hydroxyurea, and vatalanib for patients with recurrent malignant glioma (MG) [abstract 2057]. J Clin Oncol 2008, 26(Suppl).
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Kirkpatrick, J.1    Rich, J.2    Vredenburgh, J.3
  • 38
    • 36849058341 scopus 로고    scopus 로고
    • A phase I trial of sorafenib (BAY 43-9006) for patients with recurrent or progressive malignant glioma (NABTT 0401)
    • Nabors L, Rosenfeld M, Chamberlain M, et al.: A phase I trial of sorafenib (BAY 43-9006) for patients with recurrent or progressive malignant glioma (NABTT 0401). ASCO Annu Meeting Proc 2007, 25(Suppl):2058.
    • (2007) ASCO Annu Meeting Proc , vol.25 , Issue.SUPPL. , pp. 2058
    • Nabors, L.1    Rosenfeld, M.2    Chamberlain, M.3
  • 39
    • 28144450936 scopus 로고    scopus 로고
    • ZD6474, a novel tyrosine kinase inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor, inhibits tumor growth of multiple nervous system tumors
    • Rich JN, Sathornsumetee S, Keir ST, et al.: ZD6474, a novel tyrosine kinase inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor, inhibits tumor growth of multiple nervous system tumors. Clin Cancer Res 2005, 11:8145-8157.
    • (2005) Clin Cancer Res , vol.11 , pp. 8145-8157
    • Rich, J.N.1    Sathornsumetee, S.2    Keir, S.T.3
  • 40
    • 38349085651 scopus 로고    scopus 로고
    • Effects of the VEGFR inhibitor ZD6474 in combination with radiotherapy and temozolomide in an orthotopic glioma model
    • Sandstrom M, Johansson M, Bergstrom P, et al.: Effects of the VEGFR inhibitor ZD6474 in combination with radiotherapy and temozolomide in an orthotopic glioma model. J Neurooncol 2008, 88:1-9.
    • (2008) J Neurooncol , vol.88 , pp. 1-9
    • Sandstrom, M.1    Johansson, M.2    Bergstrom, P.3
  • 41
    • 3142774878 scopus 로고    scopus 로고
    • AEE788: A dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity
    • TrAxler P, Allegrini PR, Brandt R, et al.: AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res 2004, 64:4931-4941.
    • (2004) Cancer Res , vol.64 , pp. 4931-4941
    • Traxler, P.1    Allegrini, P.R.2    Brandt, R.3
  • 42
    • 13944269599 scopus 로고    scopus 로고
    • Combination therapy of inhibitors of epidermal growth factor receptor/ vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition
    • Goudar RK, Shi Q, Hjelmeland MD, et al.: Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition. Mol Cancer Ther 2005, 4:101-112.
    • (2005) Mol Cancer Ther , vol.4 , pp. 101-112
    • Goudar, R.K.1    Shi, Q.2    Hjelmeland, M.D.3
  • 43
    • 28044436878 scopus 로고    scopus 로고
    • A phase I study of AEE788, a novel multitargeted inhibitor of ErbB and VEGF receptor family tyrosine kinases, in recurrent GBM patients
    • [abstract 3063]
    • Reardon D, Cloughesy T, Conrad C, et al.: A phase I study of AEE788, a novel multitargeted inhibitor of ErbB and VEGF receptor family tyrosine kinases, in recurrent GBM patients [abstract 3063]. ASCO Annu Meeting Proc 2005, 23(Suppl):3063.
    • (2005) ASCO Annu Meeting Proc , vol.23 , Issue.SUPPL. , pp. 3063
    • Reardon, D.1    Cloughesy, T.2    Conrad, C.3
  • 44
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers G, Hanahan D: Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 2008, 8:592-603.
    • (2008) Nat Rev Cancer , vol.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 45
    • 34249294557 scopus 로고    scopus 로고
    • Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition
    • Verheul HM, Pinedo HM: Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition. Nat Rev Cancer 2007, 7:475-485.
    • (2007) Nat Rev Cancer , vol.7 , pp. 475-485
    • Verheul, H.M.1    Pinedo, H.M.2
  • 46
    • 0037099598 scopus 로고    scopus 로고
    • PTK787/ZK 222584, a specific vascular endothelial growth factor-receptor tyrosine kinase inhibitor, affects the anatomy of the tumor vascular bed and the functional vascular properties as detected by dynamic enhanced magnetic resonance imaging
    • Drevs J, Muller-Driver R, Wittig C, et al.: PTK787/ZK 222584, a specific vascular endothelial growth factor-receptor tyrosine kinase inhibitor, affects the anatomy of the tumor vascular bed and the functional vascular properties as detected by dynamic enhanced magnetic resonance imaging. Cancer Res 2002, 62:4015-4022.
    • (2002) Cancer Res , vol.62 , pp. 4015-4022
    • Drevs, J.1    Muller-Driver, R.2    Wittig, C.3
  • 47
    • 33646675851 scopus 로고    scopus 로고
    • MRI in patients with high-grade gliomas treated with bevacizumab and chemotherapy
    • Pope WB, Lai A, Nghiemphu P, et al.: MRI in patients with high-grade gliomas treated with bevacizumab and chemotherapy. Neurology 2006, 66:1258-1260.
    • (2006) Neurology , vol.66 , pp. 1258-1260
    • Pope, W.B.1    Lai, A.2    Nghiemphu, P.3
  • 49
    • 12144277278 scopus 로고    scopus 로고
    • Upregulation of VEGF and FGF2 in normal rat brain after experimental intraoperative radiation therapy
    • Kim JH, Chung YG, Kim CY, et al.: Upregulation of VEGF and FGF2 in normal rat brain after experimental intraoperative radiation therapy. J Korean Med Sci 2004, 19:879-886.
    • (2004) J Korean Med Sci , vol.19 , pp. 879-886
    • Kim, J.H.1    Chung, Y.G.2    Kim, C.Y.3
  • 50
    • 0033822622 scopus 로고    scopus 로고
    • Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption
    • Rubenstein JL, Kim J, Ozawa T, et al.: Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption. Neoplasia 2000, 2:306-314.
    • (2000) Neoplasia , vol.2 , pp. 306-314
    • Rubenstein, J.L.1    Kim, J.2    Ozawa, T.3
  • 51
    • 0035884609 scopus 로고    scopus 로고
    • Inhibition of glioma angiogenesis and growth in vivo by systemic treatment with a monoclonal antibody against vascular endothelial growth factor receptor-2
    • Kunkel P, Ulbricht U, Bohlen P, et al.: Inhibition of glioma angiogenesis and growth in vivo by systemic treatment with a monoclonal antibody against vascular endothelial growth factor receptor-2. Cancer Res 2001, 61:6624-6628.
    • (2001) Cancer Res , vol.61 , pp. 6624-6628
    • Kunkel, P.1    Ulbricht, U.2    Bohlen, P.3
  • 52
    • 60549106878 scopus 로고    scopus 로고
    • VEGF Trap induces antiglioma effect at different stages of disease
    • Gomez-Manzano C, Holash J, Fueyo J, et al.: VEGF Trap induces antiglioma effect at different stages of disease. Neuro Oncol 2008, 10:940-945.
    • (2008) Neuro Oncol , vol.10 , pp. 940-945
    • Gomez-Manzano, C.1    Holash, J.2    Fueyo, J.3


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