Extended lymphadenectomy in patients with pancreatic cancer is debatable

World Journal of Surgery

Volumn 37, Issue 8, 2013, Pages 1782-1788

  Sergeant, Gregory ^a   Melloul, Emmanuel ^a   Lesurtel, Mickael ^a   Deoliveira, Michelle L ^a   Clavien, Pierre Alain ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CLINICAL TRIAL (TOPIC); HUMAN; LYMPH NODE DISSECTION; LYMPH NODE METASTASIS; PANCREATIC NEOPLASMS; PATHOLOGY; PROCEDURES; TUMOR RECURRENCE; ARTICLE; METHODOLOGY; PANCREAS TUMOR;

CLINICAL TRIALS AS TOPIC; HUMANS; LYMPH NODE EXCISION; LYMPHATIC METASTASIS; NEOPLASM RECURRENCE, LOCAL; PANCREATIC NEOPLASMS;

EID: 84880789931     PISSN: 03642313     EISSN: 14322323     Source Type: Journal    
DOI: 10.1007/s00268-013-2064-z     Document Type: Article

References (34)

1. Ferrone CR, Pieretti-Vanmarcke R, Bloom JP, et al. (2012) Pancreatic ductal adenocarcinoma: long-term survival does not equal cure. Surgery 152:S43-S49
2. Lim JE, Chien MW, Earle CC (2003) Prognostic factors following curative resection for pancreatic adenocarcinoma: a population-based, linked database analysis of 396 patients. Ann Surg 237:74-85
3. Anonymous (2010) Exocrine pancreas. In: AJCC cancer staging manual, 7th edn. Springer, New York, p 285-296
4. Schwarz RE, Smith DD (2006) Extent of lymph node retrieval and pancreatic cancer survival: information from a large US population database. Ann Surg Oncol 13:1189-1200
5. Estrella JS, Rashid A, Fleming JB, et al. (2012) Post-therapy pathologic stage and survival in patients with pancreatic ductal adenocarcinoma treated with neoadjuvant chemoradiation. Cancer 118:268-277
6. House M, Gönen M, Jarnagin W, et al. (2007) Prognostic significance of pathologic nodal status in patients with resected pancreatic cancer. J Gastrointest Surg 11:1549-1555
7. Slidell MB, Chang DC, Cameron JL, et al. (2008) Impact of total lymph node count and lymph node ratio on staging and survival after pancreatectomy for pancreatic adenocarcinoma: a large, population-based analysis. Ann Surg Oncol 15:165-174
8. Sierzega M, Popiela T, Kulig J, et al. (2006) The ratio of metastatic/resected lymph nodes is an independent prognostic factor in patients with node-positive pancreatic head cancer. Pancreas 33:240-245
9. Berger AC, Watson JC, Ross EA, et al. (2004) The metastatic/examined lymph node ratio is an important prognostic factor after pancreaticoduodenectomy for pancreatic adenocarcinoma. Am Surg 70:235-240 discussion 240
10. Pawlik TM, Gleisner AL, Cameron JL, et al. (2007) Prognostic relevance of lymph node ratio following pancreaticoduodenectomy for pancreatic cancer. Surgery 141:610-618
11. Sergeant G, Ectors N, Fieuws S, et al. (2007) Prognostic relevance of extracapsular lymph node involvement in pancreatic ductal adenocarcinoma. Ann Surg Oncol 16:3070-3079
12. Pai RK, Beck AH, Mitchem J, et al. (2011) Pattern of lymph node involvement and prognosis in pancreatic adenocarcinoma: direct lymph node invasion has similar survival to node-negative disease. Am J Surg Pathol 35:228-234
13. Bogoevski D, Yekebas EF, Schurr P, et al. (2004) Mode of spread in the early phase of lymphatic metastasis in pancreatic ductal adenocarcinoma: prognostic significance of nodal microinvolvement. Ann Surg 240:993-1000 discussion 1000-1001
14. Fortner JG (1973) Regional resection of cancer of the pancreas: a new surgical approach. Surgery 73:307-320
15. Anonymous (2009) Japan pancreas society: classification of pancreatic carcinoma. Kanehara, Tokyo
16. Pavlidis TE, Pavlidis ET, Sakantamis AK (2011) Current opinion on lymphadenectomy in pancreatic cancer surgery. Hepatobiliary Pancreat Dis Int 10:21-25
17. Pedrazzoli S, DiCarlo V, Dionigi R, et al. (1998) Standard versus extended lymphadenectomy associated with pancreatoduodenectomy in the surgical treatment of adenocarcinoma of the head of the pancreas: a multicenter, prospective, randomized study - lymphadenectomy study group. Ann Surg 228:508-517
18. Yeo CJ, Cameron JL, Sohn TA, et al. (1999) Pancreaticoduodenectomy with or without extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma: comparison of morbidity and mortality and short-term outcome. Ann Surg 229:613-622 discussion 622-614
19. Yeo CJ, Cameron JL, Lillemoe KD, et al. (2002) Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma. Part 2. Randomized controlled trial evaluating survival, morbidity, and mortality. Ann Surg 236:355-366 discussion 366-358
20. Farnell MB, Pearson RK, Sarr MG, et al. (2005) A prospective randomized trial comparing standard pancreatoduodenectomy with pancreatoduodenectomy with extended lymphadenectomy in resectable pancreatic head adenocarcinoma. Surgery 138:618-628 discussion 628-630
21. Nimura Y, Nagino M, Takao S, et al. (2012) Standard versus extended lymphadenectomy in radical pancreatoduodenectomy for ductal adenocarcinoma of the head of the pancreas: long-term results of a Japanese multicenter randomized controlled trial. J Hepatobiliary Pancreat Sci 19:230-241
22. Michalski CW, Kleeff J, Wente MN, et al. (2007) Systematic review and meta-analysis of standard and extended lymphadenectomy in pancreaticoduodenectomy for pancreatic cancer. Br J Surg 94:265-273
23. Evans DB, Farnell MB, Lillemoe KD, et al. (2009) Surgical treatment of resectable and borderline resectable pancreas cancer: expert consensus statement. Ann Surg Oncol 16:1736-1744
24. Sahin TT, Fujii T, Kanda M, et al. (2011) Prognostic implications of lymph node metastases in carcinoma of the body and tail of the pancreas. Pancreas 40:1029-1033
25. Valsangkar NP, Bush DM, Michaelson JS, et al. (2013) N0/N1, PNL, or LNR? The effect of lymph node number on accurate survival prediction in pancreatic ductal adenocarcinoma. J Gastrointest Surg 17:257-266
26. Peparini N, Chirletti P (2012) Extended lymphadenectomy does not improve prognosis in pancreatic carcinoma: is that really so? J Hepatobiliary Pancreat Sci 19:297-298 author reply 299
27. Van den Broeck A, Sergeant G, Ectors N, et al. (2009) Patterns of recurrence after curative resection of pancreatic ductal adenocarcinoma. Eur J Surg Oncol 35:600-604
28. Asiyanbola B, Gleisner A, Herman JM, et al. (2009) Determining pattern of recurrence following pancreaticoduodenectomy and adjuvant 5-flurouracil-based chemoradiation therapy: effect of number of metastatic lymph nodes and lymph node ratio. J Gastrointest Surg 13:752-759
29. Cubilla AL, Fortner J, Fitzgerald PJ (1978) Lymph node involvement in carcinoma of the head of the pancreas area. Cancer 41:880-887
30. Kayahara M, Nagakawa T, Ueno K, et al. (1995) Surgical strategy for carcinoma of the pancreas head area based on clinicopathologic analysis of nodal involvement and plexus invasion. Surgery 117:616-623
31. Ishikawa O, Ohigashi H, Sasaki Y, et al. (1997) Practical grouping of positive lymph nodes in pancreatic head cancer treated by an extended pancreatectomy. Surgery 121:244-249
32. Yamada S, Nakao A, Fujii T, et al. (2009) Pancreatic cancer with paraaortic lymph node metastasis: a contraindication for radical surgery? Pancreas 38:e13-e17
33. Russ AJ, Weber SM, Rettammel RJ, et al. (2010) Impact of selection bias on the utilization of adjuvant therapy for pancreas adenocarcinoma. Ann Surg Oncol 17:371-376
34. Strasberg SM, Drebin JA, Linehan D (2003) Radical antegrade modular pancreatosplenectomy. Surgery 133:521-527