Prognostic relevance of extracapsular lymph node involvement in pancreatic ductal adenocarcinoma

Annals of Surgical Oncology

Volumn 16, Issue 11, 2009, Pages 3070-3079

  Sergeant, Gregory ^a   Ectors, Nadine ^a   Fieuws, Steffen ^b   Aerts, Raymond ^a   Topal, Baki ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b KU LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT;

ADULT; AGED; ARTICLE; CANCER ADJUVANT THERAPY; CANCER RADIOTHERAPY; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PANCREAS ADENOCARCINOMA; PANCREAS RESECTION; PANCREATICODUODENECTOMY; PROGNOSIS; SPLENECTOMY;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, PANCREATIC DUCTAL; FEMALE; HUMANS; LIVER NEOPLASMS; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM STAGING; PANCREATIC NEOPLASMS; PROGNOSIS; RETROSPECTIVE STUDIES; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 70350391631     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-009-0627-x     Document Type: Article

References (49)

1. A Jemal R Siegel E Ward Y Hao J Xu T Murray, et al. 2008 Cancer statistics, 2008 CA Cancer J Clin. 58 71 96 10.3322/CA.2007.0010 18287387
2. J Luttges S Schemm I Vogel J Hedderich B Kremer G Klöppel 2000 The grade of pancreatic ductal carcinoma is an independent prognostic factor and is superior to the immunohistochemical assessment of proliferation J Pathol. 191 154 161 10.1002/(SICI)1096-9896(200006)191:2<154::AID-PATH603>3.0.CO;2-C 1:STN:280:DC%2BD3czitV2luw%3D%3D 10861575 (Pubitemid 30394893)
3. SP Cleary R Gryfe M Guindi P Greig L Smith R Mackenzie, et al. 2004 Prognostic factors in resected pancreatic adenocarcinoma: analysis of actual 5-year survivors J Am Coll Surg. 198 722 731 10.1016/j.jamcollsurg.2004.01.008 15110805 (Pubitemid 38542900)
4. JE Lim MW Chien CC Earle 2003 Prognostic factors following curative resection for pancreatic adenocarcinoma: a population-based, linked database analysis of 396 patients Ann Surg. 237 74 85 10.1097/00000658-200301000-00011 12496533 (Pubitemid 36622320)
5. TA Sohn CJ Yeo JL Cameron L Koniaris S Kaushal RA Abrams, et al. 2000 Resected adenocarcinoma of the pancreas-616 patients: results, outcomes, and prognostic indicators J Gastrointest Surg. 4 567 579 10.1016/S1091-255X(00) 80105-5 1:STN:280:DC%2BD3Mzlt1yqtA%3D%3D 11307091
6. M House M Gönen W Jarnagin M D'Angelica RP DeMatteo Y Fong, et al. 2007 Prognostic significance of pathologic nodal status in patients with resected pancreatic cancer J Gastrointest Surg. 11 1549 1555 10.1007/s11605-007-0243-7 17786531
7. MB Slidell DC Chang JL Cameron C Wolfgang JM Herman RD Schulick, et al. 2008 Impact of total lymph node count and lymph node ratio on staging and survival after pancreatectomy for pancreatic adenocarcinoma: A large, population-based analysis Ann Surg Oncol. 15 165 174 10.1245/s10434-007-9587-1 17896141
8. M Sierzega T Popiela J Kulig K Nowak 2006 The ratio of metastatic/resected lymph nodes is an independent prognostic factor in patients with node-positive pancreatic head cancer Pancreas. 33 240 245 10.1097/01.mpa.0000235306.96486.2a 17003644 (Pubitemid 44470138)
9. AC Berger JC Watson EA Ross JP Hoffman 2004 The metastatic/examined lymph node ratio is an important prognostic factor after pancreaticoduodenectomy for pancreatic adenocarcinoma Am Surg. 70 235 240 15055847 discussion 240
10. TM Pawlik AL Gleisner JL Cameron JM Winter L Assumpcao KD Lillemoe, et al. 2007 Prognostic relevance of lymph node ratio following pancreaticoduodenectomy for pancreatic cancer Surgery. 141 610 618 10.1016/j.surg.2006.12.013 17462460 (Pubitemid 46616937)
11. J Wind SM Lagarde FJ Ten Kate DT Ubbink WA Bemelman JJ van Lanschot 2007 A systematic review on the significance of extracapsular lymph node involvement in gastrointestinal malignancies Eur J Surg Oncol. 33 401 408 10.1016/j.ejso.2006.11.001 1:STN:280:DC%2BD2s3jvVansQ%3D%3D 17175130 (Pubitemid 46613468)
12. Cubila A, Fitzgerald P. Tumors of the exocrine pancreas. In: Atlas of tumor pathology. 2nd ed. Washington: Armed Forces Institute of Pathology; 1984.
13. Solcia E, Capella C, Klöppel G. Tumors of the pancreas. In: Atlas of tumor pathology. 3rd ed. Washington: Armed Forces Institute of Pathology; 1997.
14. K Peters G Klöppel 2005 Undifferenzierte Pankreaskarzinome. Der Sprung ins Chaos Pathologe. 26 18 21 10.1007/s00292-004-0731-4 1:STN:280:DC%2BD2M%2FovVygsw%3D%3D 15592673 (Pubitemid 40385377)
15. Exocrine pancreas. In: American joint committee on cancer: AJCC cancer staging manual. 6th ed. New York: Springer, 2002. p. 157-64.
16. SM Lagarde FJ ten Kate DJ de Boer OR Busch H Obertop JJ van Lanschot 2006 Extracapsular lymph node involvement in node-positive patients with adenocarcinoma of the distal esophagus or gastroesophageal junction Am J Surg Pathol. 30 171 176 10.1097/01.pas.0000189182.92815.12 16434890 (Pubitemid 43740185)
17. JMAD Bland 1998 Survival probabilities. The Kaplan-Meier method BMJ. 317 1572 1:STN:280:DyaK1M%2FlsFaitQ%3D%3D 9836663
18. Klein J, Moeschberger M. Survival analysis: techniques for censored and truncated data. New York: Springer, 1992. p. 187-228.
19. Klein J, Moeschberger M. Survival analysis: techniques for censored and truncated data. New York: Springer, 1992. p. 229-68.
20. PC Austin JV Tu 2004 Automated variable selection methods for logistic regression produced unstable models for predicting acute myocardial infarction mortality J Clin Epidemiol. 57 1138 1146 10.1016/j.jclinepi.2004.04.003 15567629 (Pubitemid 39573020)
21. PJ Heagerty Y Zheng 2005 Survival model predictive accuracy and ROC curves Biometrics. 61 92 105 10.1111/j.0006-341X.2005.030814.x 15737082 (Pubitemid 40380968)
22. MJ Pencina RB D'Agostino Sr RB D'Agostino Jr RS Vasan 2008 Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond Stat Med. 27 157 172 10.1002/sim.2929 17569110 discussion 207-12 (Pubitemid 351193639)
23. NA van der Gaag FJ ten Kate SM Lagarde OR Busch TM van Gulik DJ Gouma 2008 Prognostic significance of extracapsular lymph node involvement in patients with adenocarcinoma of the ampulla of Vater Br J Surg. 95 735 743 10.1002/bjs.6076 18300268
24. T Lerut W Coosemans G Decker P De Leyn N Ectors S Fieuws, et al. 2003 Extracapsular lymph node involvement is a negative prognostic factor in T3 adenocarcinoma of the distal esophagus and gastroesophageal junction J Thorac Cardiovasc Surg. 126 1121 1128 10.1016/S0022-5223(03)00941-3 1:STN:280:DC%2BD3svovFaluw%3D%3D 14566257 (Pubitemid 37305700)
25. G Garcea AR Dennison SL Ong CJ Pattenden CP Neal CD Sutton, et al. 2007 Tumour characteristics predictive of survival following resection for ductal adenocarcinoma of the head of pancreas Eur J Surg Oncol. 33 892 897 1:STN:280:DC%2BD2svpvVertw%3D%3D 17398060
26. X Zhou S Temam M Oh N Pungpravat BL Huang L Mao, et al. 2006 Global expression-based classification of lymph node metastasis and extracapsular spread of oral tongue squamous cell carcinoma Neoplasia. 8 925 932 10.1593/neo.06430 1:CAS:528:DC%2BD28Xht1eitrfK 17132224 (Pubitemid 44706242)
27. K Yamagata K Kumagai 2000 Experimental study of lymphogenous peritoneal cancer dissemination: migration of fluorescent-labelled tumor cells in a rat model of mesenteric lymph vessel obstruction J Exp Clin Cancer Res. 19 211 217 1:STN:280:DC%2BD3M%2FmtVCrtw%3D%3D 10965821
28. A Goyal AG Douglas-Jones RG Newcombe RE Mansel 2005 Effect of lymphatic tumor burden on sentinel lymph node biopsy in breast cancer Breast J. 11 188 194 10.1111/j.1075-122X.2005.21591.x 15871704 (Pubitemid 40664062)
29. JS Tomlinson S Jain DJ Bentrem EG Sekeris MA Maggard OJ Hines, et al. 2007 Accuracy of staging node-negative pancreas cancer: a potential quality measure Arch Surg. 142 767 773 10.1001/archsurg.142.8.767 17709731 discussion 773-74 (Pubitemid 47295740)
30. RE Schwarz DD Smith 2006 Extent of lymph node retrieval and pancreatic cancer survival: information from a large US population database Ann Surg Oncol. 13 1189 1200 10.1245/s10434-006-9016-x 16955385 (Pubitemid 44440420)
31. JC Gutierrez D Franceschi LG Koniaris 2008 How many lymph nodes properly stage a periampullary malignancy? J Gastrointest Surg. 12 77 85 10.1007/s11605-007-0251-7 17701264
32. G Cserni 2008 Axillary sentinel lymph node micrometastases with extracapsular extension: a distinct pattern of breast cancer metastasis? J Clin Pathol. 61 115 118 10.1136/jcp.2007.047357 1:STN:280:DC%2BD2sjlvFKqug%3D%3D 17468292 (Pubitemid 351158236)
33. LC Horn B Hentschel D Galle K Bilek 2008 Extracapsular extension of pelvic lymph node metastases is of prognostic value in carcinoma of the cervix uteri Gynecol Oncol. 108 63 67 10.1016/j.ygyno.2007.08.086 17920109 (Pubitemid 350299422)
34. RL Carter LC Barr CJ O'Brien KC Soo HJ Shaw 1985 Transcapsular spread of metastatic squamous cell carcinoma from cervical lymph nodes Am J Surg. 150 495 499 10.1016/0002-9610(85)90162-X 1:STN:280:DyaL28%2Fitleqsg%3D%3D 4051115
35. HG Smeenk J Erdmann H van Dekken R van Marion WC Hop J Jeekel, et al. 2007 Long-term survival after radical resection for pancreatic head and ampullary cancer: a potential role for the EGF-R Dig Surg. 24 38 45 10.1159/000100917 1:CAS:528:DC%2BD2sXktlSltr0%3D 17369680 (Pubitemid 46625213)
36. A Van den Broeck G Sergeant N Ectors W Van Steenbergen R Aerts B Topal 2009 Patterns of recurrence after curative resection of pancreatic ductal adenocarcinoma Eur J Surg Oncol. 35 600 604 19131205
37. K Shimada Y Sakamoto T Sano T Kosuge 2006 The role of paraarotic lymph node involvement on early recurrence and survival after macroscopic curative resection with extended lymphadenectomy for pancreatic carcinoma J Am Coll Surg. 203 345 352 10.1016/j.jamcollsurg.2006.05.289 16931307 (Pubitemid 44247756)
38. H Ozaki T Hiraoka R Mizumoto S Matsuno Y Matsumoto T Nakayama, et al. 1999 The prognostic significance of lymph node metastasis and intrapancreatic perineural invasion in pancreatic cancer after curative resection Surg Today. 29 16 22 10.1007/BF02482964 1:STN:280:DyaK1M7jtFGhtw%3D%3D 9934826
39. S Mitsunaga T Hasebe T Kinoshita M Konishi S Takahashi N Gotohda, et al. 2007 Detail histologic analysis of nerve plexus invasion in invasive ductal carcinoma of the pancreas and its prognostic impact Am J Surg Pathol. 31 1636 1644 10.1097/PAS.0b013e318065bfe6 18059219 (Pubitemid 350287561)
40. M Wagner C Redaelli M Lietz CA Seiler H Friess MW Büchler 2004 Curative resection is the single most important factor determining outcome in patients with pancreatic adenocarcinoma Br J Surg. 91 586 594 10.1002/bjs.4484 1:STN:280:DC%2BD2c3it1ansA%3D%3D 15122610 (Pubitemid 38624667)
41. MH van Roest AS Gouw PM Peeters RJ Porte MJ Slooff V Fidler, et al. 2008 Results of pancreaticoduodenectomy in patients with periampullary adenocarcinoma: perineural growth more important prognostic factor than tumor localization Ann Surg. 248 97 103 10.1097/SLA.0b013e31817b6609 18580212
42. H Oettle S Post P Neuhaus K Gellert J Langrehr K Ridwelski, et al. 2007 Adjuvant chemotherapy with gemcitabine vs. observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial JAMA. 297 267 277 10.1001/jama.297.3.267 1:CAS:528:DC%2BD2sXotVCmug%3D%3D 17227978 (Pubitemid 46143304)
43. M Sakai A Nakao T Kaneko S Takeda S Inoue Y Kodera, et al. 2005 Para-aortic lymph node metastasis in carcinoma of the head of the pancreas Surgery. 137 606 611 10.1016/j.surg.2005.02.009 15933626 (Pubitemid 40755416)
44. M Kayahara T Nagakawa T Ohta H Kitagawa K Ueno H Tajima, et al. 1999 Analysis of paraaortic lymph node involvement in pancreatic carcinoma: a significant indication for surgery? Cancer. 85 583 590 10.1002/(SICI)1097- 0142(19990201)85:3<583::AID-CNCR8>3.0.CO;2-J 1:STN:280: DyaK1M7ptVWmsA%3D%3D 10091731 (Pubitemid 29075279)
45. CR Ferrone DM Finkelstein SP Thayer A Muzikansky C Fernandez-delCastillo AL Warshaw 2006 Perioperative CA19-9 levels can predict stage and survival in patients with resectable pancreatic adenocarcinoma J Clin Oncol. 24 2897 2902 10.1200/JCO.2005.05.3934 1:CAS:528:DC%2BD28XntV2gs7o%3D 16782929 (Pubitemid 46630592)
46. F Safi W Schlosser S Falkenreck HG Beger 1998 Prognostic value of CA 19-9 serum course in pancreatic cancer Hepatogastroenterology. 45 253 259 1:STN:280:DyaK1c7lslKjug%3D%3D 9496523
47. I Dominguez S Crippa SP Thayer YP Hung CR Ferrone AL Warshaw, et al. 2008 Preoperative platelet count and survival prognosis in resected pancreatic ductal adenocarcinoma World J Surg. 32 1051 1056 10.1007/s00268-007-9423-6 18224462
48. CM Kang JY Kim GH Choi KS Kim JS Choi WJ Lee, et al. 2007 The use of adjusted preoperative CA 19-9 to predict the recurrence of resectable pancreatic cancer J Surg Res. 140 31 35 10.1016/j.jss.2006.10.007 1:CAS:528: DC%2BD2sXkvFOqsrs%3D 17418869 (Pubitemid 46669540)
49. G Sergeant N Ectors B Topal 2008 Prognostic significance of extracapsular lymph node involvement in patients with adenocarcinoma of the ampulla of Vater (Br J Surg 2008; 95: 735-743) Br J Surg. 95 1188 10.1002/bjs.6368 1:STN:280:DC%2BD1crhs12nsQ%3D%3D 18690628 author reply 1188-9