The ratio of metastatic/resected lymph nodes is an independent prognostic factor in patients with node-positive pancreatic head cancer

Pancreas

Volumn 33, Issue 3, 2006, Pages 240-245

  Sierzega, Marek ^a   Popiela, Tadeusz ^a   Kulig, Jan ^a   Nowak, Krystyna ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

Lymph nodes; Metastatic lymph node ratio; Pancreatic cancer; Prognosis

Indexed keywords

HEMATOXYLIN;

ADULT; ARTICLE; CANCER SURVIVAL; CONFIDENCE INTERVAL; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MODERATE TUMOR DIFFERENTIATION; PANCREAS ADENOCARCINOMA; PANCREATICODUODENECTOMY; POOR TUMOR DIFFERENTIATION; PRIORITY JOURNAL; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; SURVIVAL RATE; TUMOR DIFFERENTIATION;

FEMALE; HUMANS; LYMPH NODE EXCISION; LYMPH NODES; MALE; MIDDLE AGED; NEOPLASM METASTASIS; PANCREAS; PANCREATECTOMY; PANCREATIC NEOPLASMS; PROGNOSIS; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS;

EID: 33749121597     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mpa.0000235306.96486.2a     Document Type: Article

References (41)

1. Sahmoun AE, D'Agostino RA Jr, Bell RA, et al. International variation in pancreatic cancer mortality for the period 1955-1998. Eur J Epidemiol. 2003;18:801-816.
2. Mulder I, Hoogenveen RT, van Genugten ML, et al. Smoking cessation would substantially reduce the future incidence of pancreatic cancer in the European Union. Eur J Gastroenterol Hepatol. 2002;14:1343-1353.
3. Simon B, Printz H. Epidemiological trends in pancreatic neoplasias. Dig Dis. 2001;19:614.
4. Levi F, Lucchini F, Negri E, et al. Pancreatic cancer mortality in Europe: the leveling of an epidemic. Pancreas. 2003;27:139-142.
5. Wray CJ, Ahmad SA, Matthews JB, et al. Surgery for pancreatic cancer: recent controversies and current practice. Gastroenterology. 2005;128:1626-1641.
6. Stojadinovic A, Brooks A, Hoos A, et al. An evidence-based approach to the surgical management of resectable pancreatic adenocarcinoma. J Am Coll Surg. 2003;196:954-964.
7. DiMagno EP, Reber HA, Tempero MA. AGA technical review on the epidemiology, diagnosis, and treatment of pancreatic ductal adenocarcinoma. American Gastroenterological Association. Gastroenterology. 1999;117:1464-1484.
8. Garcea G, Neal CP, Pattenden CJ, et al. Molecular prognostic markers in pancreatic cancer: a systematic review. Eur J Cancer. 2005;41:2213-2236.
9. Eskelinen MJ, Haglund UH. Prognosis of human pancreatic adenocarcinoma: review of clinical and histopathological variables and possible uses of new molecular methods. Eur J Surg. 1999;165:292-306.
10. Yeo CJ, Cameron JL. Prognostic factors in ductal pancreatic cancer. Langenbecks Arch Surg. 1998;383:129-133.
11. Sohn TA, Yeo CJ, Cameron JL, et al. Resected adenocarcinoma of the pancreas-616 patients: results, outcomes, and prognostic indicators. J Gastrointest Surg. 2000;4:567-579.
12. Braat AE, Oosterhuis JW, de Vries JE, et al. Lymphatic staging in colorectal cancer: pathologic, molecular, and sentinel node techniques. Dis Colon Rectum. 2005;48:371-383.
13. Compton CC, Greene FL. The staging of colorectal cancer: 2004 and beyond. CA Cancer J Clin. 2004;54:295-308.
14. Hayashi H, Ochiai T, Suzuki T, et al. Superiority of a new UICC - TNM staging system for gastric carcinoma. Surgery. 2000;127:129-135.
15. Yoo CH, Noh SH, Kim YI, et al. Comparison of prognostic significance of nodal staging between old (4th edition) and new (5th edition) UICC TNM classification for gastric carcinoma. International Union Against Cancer. World J Surg. 1999;23:492-497.
16. Kunisaki C, Shimada H, Nomura M, et al. Comparative evaluation of gastric carcinoma staging: Japanese classification versus new American Joint Committee on Cancer/International Union Against Cancer classification. Ann Surg Oncol. 2004;11:203-206.
17. van der Wal BC, Butzelaar RM, van der Meij S, et al. Axillary lymph node ratio and total number of removed lymph nodes: predictors of survival in stage I and II breast cancer. Eur J Surg Oncol. 2002;28:481-489.
18. Megale Costa LJ, Soares HP, Gaspar HA, et al. Ratio between positive lymph nodes and total dissected axillaries lymph nodes as an independent prognostic factor for disease-free survival in patients with breast cancer. Am J Clin Oncol. 2004;27:304-306.
19. Nitti D, Marchet A, Olivieri M, et al. Ratio between metastatic and examined lymph nodes is an independent prognostic factor after D2 resection for gastric cancer: analysis of a large European mono institutional experience. Ann Surg Oncol. 2003;10:1077-1085.
20. Uittges J, Zamboni G, Klöppel G. Recommendation for the examination of pancreaticoduodenectomy specimens removed from patients with carcinoma of the exocrine pancreas. A proposal for a standardized pathological staging of pancreaticoduodenectomy specimens including a checklist. Dig Surg. 1999;16:291-296.
21. ADASP. The Association of Directors of Anatomic and Surgical Pathology. Recommendations for reporting resected pancreatic neoplasms. Mod Pathol. 1998;11:500-504.
22. Sobin LH, Wittekind C. TNM Classification of Malignant Tumours (DICC). 6th ed. New York: John Wiley & Sons; 2002.
23. Pedrazzoli S, Beger HG, Obertop H, et al. A surgical and pathological based classification of resective treatment of pancreatic cancer. Summary of an international workshop on surgical procedures in pancreatic cancer. Dig Surg. 1999;16:337-345.
24. Japan Pancreas Society. Classification of Pancreatic Carcinoma. 2nd English ed. Tokyo: Kanehara; 2003.
25. Sarli L, Bader G, Iusco D, et al. Number of lymph nodes examined and prognosis of TNM stage II colorectal cancer. Eur J Cancer. 2005;41:272-279.
26. Hermanek P. Staging of exocrine pancreatic carcinoma. Eur J Surg Oncol. 1991;17:167-172.
27. Ishikawa O, Ohigashi H, Sasaki Y, et al. Practical grouping of positive lymph nodes in pancreatic head cancer treated by an extended pancreatectomy. Surgery. 1997;121:244-249.
28. Sobin LH, Wittekind C. TNM Classification of Malignant Tumours (DICC). 5th ed. New York: John Wiley & Sons; 1997.
29. Gospodarowicz MK, Henson DE, Hutter RVP, et al. Prognostic Factors in Cancer. 2nd ed. Wiley-Liss; 2001.
30. Nakao A, Takeda S, Sakai M, et al. Extended radical resection versus standard resection for pancreatic cancer: the rationale for extended radical resection. Pancreas. 2004;28:289-292.
31. Lim JE, Chien MW, Earle CC. Prognostic factors following curative resection for pancreatic adenocarcinoma: a population-based, linked database analysis of 396 patients. Ann Surg. 2003;237:74-85.
32. Ozaki H, Hiraoka T, Mizumoto R, et al. The prognostic significance of lymph node metastasis and intrapancreatic perineural invasion in pancreatic cancer after curative resection. Surg Today. 1999;29:16-22.
33. Berger AC, Watson JC, Ross EA, et al. The metastatic/examined lymph node ratio is an important prognostic factor after pancreaticoduodenectomy for pancreatic adenocarcinoma. Am Surg. 2004;70:235-240.
34. Kobari M, Matsuno S. Staging systems for pancreatic cancer: differences between the Japanese and UICC systems. J Hepatobiliary Pancreat Surg. 1998;5:121-127.
35. Kobari M, Sunamura M, Ohashi O, et al. Usefulness of Japanese staging in the prognosis of patients treated operatively for adenocarcinoma of the head of the pancreas. J Am Coll Surg. 1996;182:24-32.
36. Hirata K, Sato T, Mukaiya M, et al. Results of 1001 pancreatic resections for invasive ductal adenocarcinoma of the pancreas. Arch Surg. 1997;132:771-776.
37. Matsuno S, Egawa S, Fukuyama S, et al. Pancreatic cancer registry in Japan: 20 years of experience. Pancreas. 2004;28:219-230.
38. Sakai M, Nakao A, Kaneko T, et al. Para-aortic lymph node metastasis in carcinoma of the head of the pancreas. Surgery. 2005;137:606-611.
39. Kayahara M, Nagakawa T, Ohta T, et al. Analysis of para aortic lymph node involvement in pancreatic carcinoma: a significant indication for surgery? Cancer. 1999;85:583-590.
40. Connor S, Bosonnet L, Ghaneh P, et al. Survival of patients with periampullary carcinoma is predicted by lymph node 8a but not by lymph node 16b 1 status. Br J Surg. 2004;91:1592-1599.
41. Bogoevski D, Yekebas EF, Schurr P, et al. Mode of spread in the early phase of lymphatic metastasis in pancreatic ductal adenocarcinoma: prognostic significance of nodal microinvolvement. Ann Surg. 2004;240:993-1000.