An inhibitor of cathepsin K, icariin suppresses cartilage and bone degradation in mice of collagen-induced arthritis

Phytomedicine

Volumn 20, Issue 11, 2013, Pages 975-979

  Sun, Peijiao ^a,b,d   Liu, Yonggang ^b   Deng, Xiaoxia ^a   Yu, Chunmei ^c   Dai, Nasang ^a   Yuan, Xianglian ^a,b   Chen, Liping ^b   Yu, Shenye ^b   Si, Wei ^b   Wang, Xiumei ^b   Wu, Defeng ^d   Liu, Siguo ^b   Pang, Hai ^a  

^a Tsinghua University   (China)

^b INSTITUTE OF PLANT PROTECTION   (China)

^c BEIJING CHUIYANGLIU HOSPITAL   (China)

^d FUJIAN AGRICULTURE AND FORESTRY UNIVERSITY   (China)

Author keywords

Arthritis; Bone; Cartilage; Cathepsin K; Icariin; Inhibitor; Mice

Indexed keywords

CARBOXY TERMINAL TELOPEPTIDE; CARTILAGE OLIGOMERIC MATRIX PROTEIN; CATHEPSIN K; DEOXYPYRIDINOLINE; ICARIIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; BONE DEFECT; CARTILAGE DEGENERATION; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; IMMUNIZATION; KIDNEY CONCENTRATING CAPACITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

ARTHRITIS; BONE; CARTILAGE; CATHEPSIN K; ICARIIN; INHIBITOR; MICE;

AMINO ACIDS; ANIMALS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; BONE AND BONES; CARTILAGE; CARTILAGE OLIGOMERIC MATRIX PROTEIN; CATHEPSIN K; COLLAGEN TYPE I; COLLAGEN TYPE II; DRUGS, CHINESE HERBAL; EPIMEDIUM; FEMALE; FLAVONOIDS; MICE; MICE, INBRED BALB C; PEPTIDES; PHYTOTHERAPY;

MURINAE; MUS;

EID: 84880772839     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2013.04.019     Document Type: Article

References (30)

1. M.C. Boissier, X.Z. Feng, A. Carlioz, R. Roudier, and C. Fournier Experimental autoimmune arthritis in mice. I. Homologous type II collagen is responsible for self-perpetuating chronic polyarthritis Annals of the Rheumatic Diseases 46 9 1987 691 700 (Pubitemid 17123503)
2. M.J. Bossard, T.A. Tomaszek, S.K. Thompson, B.Y. Amegadzie, C.R. Hanning, and C. Jones Proteolytic activity of human osteoclast cathepsin K. Expression, purification, activation, and substrate identification Journal of Biological Chemistry 271 21 1996 12517 12524 (Pubitemid 26160924)
3. D.D. Brand, K.A. Latham, and E.F. Rosloniec Collagen-induced arthritis Nature Protocols 2 5 2007 1269 1275 (Pubitemid 46901304)
4. S. Bugatti, V. Codullo, R. Caporali, and C. Montecucco B cells in rheumatoid arthritis Autoimmunity Reviews 7 2007 137 142 (Pubitemid 350116726)
5. K.M. Chen, B.F. Ge, X.Y. Liu, P.H. Ma, M.B. Lu, M.H. Bai, and Y. Wang Icariin inhibits the osteoclast formation induced by RANKL and macrophage-colony stimulating factor in mouse bone marrow culture Pharmazie 62 5 2007 388 391 (Pubitemid 46847945)
6. Y.G. Cho, M.L. Cho, S.Y. Min, and H.Y. Kim Type II collagen autoimmunity in a mouse model of human rheumatoid arthritis Autoimmunity Reviews 7 2007 65 70
7. R. Grespan, M. Paludo, H. de Paula Lemos, C.P. Barbosa, C.A. Bersani-Amado, M.M. de Oliveira Dalalio, and R.K.N. Cuman Anti-arthritic effect of eugenol on collagen-induced arthritis experimental model Biological & Pharmaceutical Bulletin 35 10 2012 1818 1820
8. W.S. Hou, Z. Li, F.H. Buttner, E. Bartnik, and D. Bromme Cleavage site specificity of cathepsin K toward cartilage proteoglycans and protease complex formation Journal of Biological Chemistry 384 6 2003 891 897 (Pubitemid 36874503)
9. 2 synthesis Phytomedicine 18 2-3 2011 176 185
10. C. Jerome, M. Missbach, and R. Gamse Balicatib, a cathepsin K inhibitor, stimulates periosteal bone formation in monkeys Osteoporosis International 23 2012 339 349
11. K. Kassahun, W.C. Black, D. Nicoll-Griffith, I. McIntosh, N. Cauret, and S. Day Pharmacokinetics and metabolism in rats, dogs, and monkeys of the cathepsin K inhibitor odanacatib: demethylation of a methylsulfonyl moiety as a major metabolic pathway Drug Metabolism and Disposition 39 6 2011 1079 1087
12. E. Larsson, H. Erlandsson Harris, A. Larsson, B. Mansson, T. Saxne, and L. Klareskog Corticosteroid treatment of experimental arthritis retards cartilage destruction as determined by histology and serum COMP Rheumatology 43 4 2004 428 434 (Pubitemid 38489358)
13. P. Leung, M. Pickarski, Y. Zhuo, P.J. Masarachia, and L.T. Duong The effects of the cathepsin K inhibitor odanacatib on osteoclastic bone resorption and vesicular trafficking Bone 49 2011 623 635
14. A. Maetzel, A. Wong, V. Strand, P. Tugwell, G. Wells, and C. Bombardier Meta-analysis of treatment termination rates among rheumatoid arthritis patients receiving diseasemodifying anti-rheumatic drugs Rheumatology 39 2000 975 981
15. P. Maffia, J.M. Brewer, J.A. Gracie, A. Ianaro, B.P. Leung, and P.J. Mitchell Inducing experimental arthritis and breaking self-tolerance to joint-specific antigens with trackable, ovalbumin-specific T cells Journal of Immunology 173 1 2004 151 156 (Pubitemid 38797336)
16. E.O. Michelle, S.M. Katherine, M. Stephen, S. Dean, and B. Alex Systematic review and network meta-analysis of combination and monotherapy treatments in disease-modifying antirheumatic drug-experienced patients with rheumatoid arthritis: analysis of American College of Rheumatology criteria scores 20, 50, and 70 Biologics: Targets and Therapy 6 2012 429 464
17. J. Morko, R. Kiviranta, K. Joronen, A.M. Saamanen, E. Vuorio, and H. Salminen-Mankonen Spontaneous development of synovitis and cartilage degeneration in transgenic mice overexpressing cathepsin K Arthritis and Rheumatism 52 2005 3713 3717 (Pubitemid 41798207)
18. M. Nagashima, H. Takahashi, K. Shimane, Y. Nagase, and K. Wauke Osteogenesis and osteoclast inhibition in rheumatoid arthritis patients treated with bisphosphonates alone or in combination with pitavastatin over an 18-month follow-up after more than 4 years of treatment with bisphosphonates Arthritis Research & Therapy 14 2012 R224
19. S. Peng, G. Zhang, Y. He, X. Wang, P. Leung, K. Leung, and L. Qin Epimedium-derived flavonoids promote osteoblastogenesis and suppress adipogenesis in bone marrow stromal cells while exerting an anabolic effect on osteoporotic bone Bone 45 3 2009 534 544
20. R. Prasad, and V. Koul Transdermal delivery of methotrexate: past, present and future prospects Therapeutic Delivery 3 3 2012 315 325
21. H.J. Salminen-Mankonen, J. Morko, and E. Vuorio Role of cathepsin K in normal joints and in the development of arthritis Current Drug Targets 8 2 2007 315 323
22. M. Skoumal, G. Haberhauer, G. Kolarz, G. Hawa, W. Woloszczuk, and A. Klingler Serum cathepsin K levels of patients with longstanding rheumatoid arthritis: correlation with radiological destruction Arthritis Research & Therapy 7 2005 65 70
23. H.S. Smith, A.R. Smith, and P. Seidner Painful rheumatoid arthritis Pain Physician 14 5 2011 427 458
24. L. Svelander, H. Erlandsson-Harris, L. Astner, U. Grabowska, L. Klareskog, and E. Lindstrom Inhibition of cathepsin K reduces bone erosion, cartilage degradation and inflammation evoked by collagen-induced arthritis in mice European Journal of Pharmacology 613 2009 155 162
25. S.C. Sze, Y. Tong, T.B. Ng, C.L. Cheng, and H.P. Cheung Herba Epimedii: anti-oxidative properties and its medical implications Molecules 15 11 2010 7861 7870
26. C. Thwaites, and A. Finney Rheumatoid arthritis. 2. Exploring treatment options to achieve early control and remission Nursing Times 106 10 2010 18 20
27. D.E. Trentham, A.S. Townes, and A.H. Kang Autoimmunity to type II collagen: an experimental model of arthritis Journal of Experimental Medicine 146 3 1977 857 868 (Pubitemid 8175993)
28. C.R. Vasco, C. Helena, and E.F. João Old drugs, old problems: where do we stand in prediction of rheumatoid arthritis responsiveness to methotrexate and other synthetic DMARDs? BMC Medicine 11 1 2013 17
29. F. Wang, Z.F. Liu, S.S. Lin, H.X. Lu, and J. Xu Icariin enhances the healing of rapid palatal expansion induced root resorption in Rats Phytomedicine 19 2012 1035 1041
30. M.E. Weinblatt, H. Kaplan, B.F. Germain, S. Block, S.D. Solomon, and R.C. Merriman Methotrexate in rheumatoid arthritis. A five-year prospective multicenter study Arthritis and Rheumatism 37 1994 1492 1498 Biotechnology