Cleavage site specificity of cathepsin K toward cartilage proteoglycans and protease complex formation

Biological Chemistry

Volumn 384, Issue 6, 2003, Pages 891-897

  Hou, Wu Shiun ^a   Li, Zhenqiang ^a   Büttner, Frank H ^b   Bartnik, Eckart ^b   Brömme, Dieter ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

Cathepsin; Chondroitin sulfate; Collagenase; Link protein; Proteolysis

Indexed keywords

AGGRECAN; CATHEPSIN K; GLYCOSAMINOGLYCAN; PROTEINASE; PROTEOGLYCAN;

ANIMAL TISSUE; ARTICLE; CARTILAGE; COLLAGEN DEGRADATION; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SPECIFICITY; HYDROLYSIS; LYSOSOME; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION;

AGGRECANS; AMINO ACID SEQUENCE; ANIMALS; CARTILAGE; CATHEPSINS; CATTLE; EXTRACELLULAR MATRIX PROTEINS; GLYCOSAMINOGLYCANS; HUMANS; LECTINS, C-TYPE; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; PROTEINS; PROTEOGLYCANS; SUBSTRATE SPECIFICITY;

ANIMALIA; BOVINAE;

EID: 0038486755     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2003.100     Document Type: Article

References (35)

1. Arner, E. C. (2002). Aggrecanase-mediated cartilage degradation. Curr. Opin. Pharmacol. 2, 322-329.
2. Barrett, A. J., Kembhavi, A. A., Brown, M. A., Kirschke, H., Knight, C. G., Tamai, M., and Hanada, K. (1982). L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L. Biochem. J. 201, 189-198.
3. Bogyo, M., Verhelst, S., Bellingard-Dubouchaud, V., Toba, S., and Greenbaum, D. (2000). Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs. Chem. Biol. 7, 27-38.
4. Brömme, D., and Okamoto, K. (1995). Human cathepsin O2, a novel cysteine protease highly expressed in osteoclastomas and ovary molecular cloning, sequencing and tissue distribution. Biol. Chem. Hoppe-Seyler 376, 379-384.
5. Brömme, D., and McGrath, M. E. (1996). High level expression and crystallization of recombinant human cathepsin S. Protein Sci. 5, 787-791.
6. Brömme, D., Okamoto, K., Wang, B. B., and Biroc, S. (1996). Human cathepsin O2, a matrix protein-degrading cysteine protease expressed in osteoclasts. Functional expression of human cathepsin O2 in Spodoptera frugiperda and characterization of the enzyme. J. Biol. Chem. 271, 2126-2132.
7. Dodds, R. A., Connor, J. R., Drake, F. H., and Gowen, M. (1999). Expression of cathepsin K messenger RNA in giant cells and their precursors in human osteoarthritic synovial tissues. Arthritis Rheum. 42, 1588-1593.
8. Drake, F. H., Dodds, R. A., James, I. E., Connor, J. R., Debouck, C., Richardson, S., Lee-Rykaczewski, E., Coleman, L., Rieman, D., Barthlow, R. et al. (1996). Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts. J. Biol. Chem. 271, 12511-12516.
9. Everts, V., Aronson, D. C., and Beertsen, W. (1985). Phagocytosis of bone collagen by osteoclasts in two cases of pycnodysostosis. Calcif. Tissue Int. 37, 25-31.
10. Firschein, H. E., and Shill, J. P. (1966). The determination of total hydroxyproline in urine and bone extracts. Anal. Biochem. 14, 296-304.
11. Fosang, A. J., Neame, P. J., Hardingham, T. E., Murphy, G., and Hamilton, J. A. (1991). Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins. J. Biol. Chem. 266, 15579-15582.
12. Garnero, P., Borel, O., Byrjalsen, I., Ferreras, M., Drake, F. H., McQueney, M. S., Foged, N. T., Delmas, P. D., and Delaisse, J. M. (1998). The collagenolytic activity of cathepsin K is unique among mammalian proteinases. J. Biol. Chem. 273, 32347-32352.
13. Gelb, B. D., Shi, G. P., Chapman, H. A., and Desnick, R. J. (1996). Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency. Science 273, 1236-1238.
14. Gravallese, E. M., Harada, Y., Wang, J. T., Gorn, A. H., Thornhill, T. S., and Goldring, S. R. (1998). Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis. Am. J. Pathol. 152, 943-951.
15. Greenbaum, D., Medzihradszky, K. F., Burlingame, A., and Bogyo, M. (2000). Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools. Chem. Biol. 7, 569-581.
16. Hardingham, T. E. (1979). The role of link-protein in the structure of cartilage proteoglycan aggregates. Biochem. J. 177, 237-247.
17. Heinegard, D. (1972). Extraction, fractionation and characterization of proteoglycans from bovine tracheal cartilage. Biochim. Biophys. Acta 285, 181-192.
18. Hou, W. S., Li, Z., Gordon, R. E., Chan, K., Klein, M. J., Levy, R., Keysser, M., Keyszer, G., and Brömme, D. (2001). Cathepsin K is a critical protease in synovial fibroblast-mediated collagen degradation. Am. J. Pathol. 159, 2167-2177.
19. Hou, W.-S., Li, W., Keyszer, G., Weber, E., Levy, R., Klein, M. J., Gravallese, E. M., Goldring, S. R., and Brömme, D. (2002). Comparison of cathepsins K and S expression within the rheumatoid and osteoarthritic synovium. Arthritis Rheum. 46, 663-674.
20. Hummel, K. M., Petrow, P. K., Franz, J. K., Müller-Ladner, U., Aicher, W. K., Gay, R. E., Brömme, D., and Gay, S. (1998). Cysteine proteinase cathepsin K mRNA is expressed in synovium of patients with rheumatoid arthritis and is detected at sites of synovial bone destruction. J. Rheumatol. 25, 1887-1894.
21. Kafienah, W., Brömme, D., Buttle, D. J., Croucher, L. J., and Hollander, A. P. (1998). Human cathepsin K cleaves native type I and II collagens at the N-terminal end of the triple helix. Biochem. J. 331, 727-732.
22. Konttinen, Y. T., Mandelin, J., Li, T. F., Salo, J., Lassus, J., Liljestrom, M., Hukkanen, M., Takagi, M., Virtanen, I., and Santavirta, S. (2002). Acidic cysteine endoproteinase cathepsin K in the degeneration of the superficial articular hyaline cartilage in osteoarthritis. Arthritis Rheum. 46, 953-960.
23. Lecaille, F., Choe, Y., Brandt, W., Li, Z., Craik, C. S., and Brömme, D. (2002). Selective inhibition of the collagenolytic activity of human cathepsin K by altering its S2 subsite specificity. Biochemistry 41, 8447-8454.
24. Li, Z., Hou, W. S., and Bromme, D. (2000). Collagenolytic activity of cathepsin K is specifically modulated by cartilage-resident chondroitin sulfates. Biochemistry 39, 529-536.
25. Li, Z., Hou, W. S., Escalante-Torres, C. R., Gelb, B. D., and Brömme, D. (2002). Collagenase activity of cathepsin K depends on complex formation with chondroitin sulfate. J. Biol. Chem. 277, 28669-28676.
26. Linnevers, C. J., McGrath, M. E., Armstrong, R., Mistry, F. R., Barnes, M., Klaus, J. L., Palmer, J. T., Katz, B. A., and Brömme, D. (1997). Expression of human cathepsin K in Pichia pastoris and preliminary crystallographic studies of an inhibitor complex. Protein Sci. 6, 919-921.
27. Loulakis, P., Shrikhande, A., Davis, G., and Maniglia, C. A. (1992). N-terminal sequence of proteoglycan fragments isolated from medium of interleukin-1-treated articular-cartilage cultures. Putative site(s) of enzymic cleavage. Biochem. J. 284, 589-593.
28. Morgelin, M., Paulsson, M., Hardingham, T. E., Heinegard, D., and Engel, J. (1988). Cartilage proteoglycans. Assembly with hyaluronate and link protein as studied by electron microscopy. Biochem. J. 253, 175-185.
29. Mort, J. S., Magny, M. C., and Lee, E. R. (1998). Cathepsin B: an alternative protease for the generation of an aggrecan 'metalloproteinase' cleavage neoepitope. Biochem. J. 335, 491-494.
30. Nguyen, Q., Mort, J. S., and Roughley, P, J. (1990). Cartilage proteoglycan aggregate is degraded more extensively by cathepsin L than by cathepsin B. Biochem. J. 266, 569-573.
31. Nguyen, Q., Liu, J., Roughley, P. J., and Mort, J. S. (1991). Link protein as a monitor in situ of endogenous proteolysis in adult human articular cartilage. Blochem. J. 278, 143-147.
32. Sandy, J. D., Neame, P. J., Boynton, R. E., and Flannery, C. R. (1991). Catabolism of aggrecan in cartilage explants. Identification of a major cleavage site within the interglobular domain. J. Biol. Chem. 266, 8683-8685.
33. Schechter, I. and Berger, A. (1967). On the size of the active site in proteases. I. Papain. Biochem. Biophys. Res. Commun. 27, 157-162.
34. Stroup, G. B., Lark, M. W., Veber, D. F., Bhattacharyya, A., Blake, S., Dare, L. C., Erhard, K. F., Hoffman, S. J., James, I. E., Marquis, R. W. et al. (2001). Potent and selective inhibition of human cathepsin K leads to inhibition of bone resorption in vivo in a nonhuman primate. J. Bone Miner. Res. 16, 1739-1746.
35. Xia, L., Kilb, J., Wex, H., Lipyansky, A., Breuil, V., Stein, L., Palmer, J. T., Dempster, D. W., and Brömme, D. (1999). Localization of rat cathepsin K in osteoclasts and resorption pits: inhibition of bone resorption cathepsin K-activity by peptidyl vinyl sulfones. Biol. Chem. 380, 679-687.