Anti-arthritic effect of eugenol on collagen-induced arthritis experimental model

Biological and Pharmaceutical Bulletin

Volumn 35, Issue 10, 2012, Pages 1818-1820

  Grespan, Renata ^a   Paludo, Marcia ^a   De Paula Lemos, Henrique ^b   Barbosa, Carmem Patrícia ^a   Bersani Amado, Ciomar Aparecida ^a   De Oliveira Dalalio, Marcia Machado ^a   Cuman, Roberto Kenji Nakamura ^a  

^a STATE UNIVERSITY OF MARINGÁ   (Brazil)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Collagen induced arthritis; Cytokine; Eugenol; Inflammation; Mononuclear cell

Indexed keywords

COLLAGEN TYPE 2; EUGENOL; GAMMA INTERFERON; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL INFILTRATION; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFICACY; ERYTHEMA; IN VITRO STUDY; MONONUCLEAR CELL; MOUSE; NONHUMAN; PAW EDEMA; RHEUMATOID ARTHRITIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRITIS, EXPERIMENTAL; CELL SURVIVAL; CELLS, CULTURED; CYTOKINES; EUGENOL; MALE; MICE; MICE, INBRED DBA; NEUTROPHILS;

EID: 84867251825     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b12-00128     Document Type: Article

References (11)

1. Park SH, Sim YB, Lee JK, Kim SM, Kang YJ, Jung JS, Suh HW. The analgesic effects and mechanisms of orally administered eugenol. Arch. Pharm. Res., 34, 501-507 (2011).
2. Yogalakshmi B, Viswanathan P, Anuradha CV. Investigation of antioxidant, anti-inflammatory and DNA-protective properties of eugenol in thioacetamide-induced liver injury in rats. Toxicology, 268, 204-212 (2010).
3. Murakami Y, Shoji M, Hirata A, Tanaka S, Yokoe I, Fujisawa S. Dehydrodiisoeugenol, an isoeugenol dimer, inhibits lipopolysaccharide-stimulated nuclear factor kappa B activation and cyclooxy genase-2 expression in macrophages. Arch. Biochem. Biophys., 434, 326-332 (2005).
4. Raghavenra H, Diwakr BT, Lokesh BR, Naidu KA. Eugenol - the active principle from cloves inhibits 5-lipoxygenase activity and leukotriene-C4 in human PMNL cells. Prostaglandins Leukot. Essent. Fatty Acids, 74, 23-27 (2006).
5. Sharma JN, Srivastava KC, Gan EK. Suppressive effects of eugenol and ginger oil on arthritic rats. Pharmacology, 49, 314-318 (1994).
6. Brand DD, Latham KA, Rosloniec EF. Collagen-induced arthritis. Nat. Protoc., 2, 1269-1275 (2007).
7. Carrasco FR, Schmidt G, Romero AL, Sartoretto JL, Caparroz-Assef SM, Bersani-Amado CA, Cuman RK. Immunomodulatory activity of Zingiber officinale ROSCOE, Salvia officinalis L. and Syzygium aromaticum L. essential oils: evidence for humor- and cell-mediated responses. J. Pharm. Pharmacol., 61, 961-967 (2009).
8. Chen M, Lam BK, Kanaoka Y, Nigrovic PA, Audoly LP, Austen KF, Lee DM. Neutrophil-derived leukotriene B4 is required for inflammatory arthritis. J. Exp. Med., 203, 837-842 (2006).
9. Dong J, Gao Y, Liu Y, Shi J, Feng J, Li Z, Pan H, Xue Y, Liu C, Shen B, Shao N, Yang G. The protective antibodies induced by a novel epitope of human TNF-alpha could suppress the development of collagen-induced arthritis. PLoS ONE, 5, e8920 (2010).
10. Carregaro V, Sá-Nunes A, Cunha TM, Grespan R, Oliveira CJ, Lima-Junior DS, Costa DL, Verri WA Jr, Milanezi CM, Pham VM, Brand DD, Valenzuela JG, Silva JS, Ribeiro JM, Cunha FQ. Nucleosides from Phlebotomus papatasi salivary gland ameliorate murine collagen-induced arthritis by impairing dendritic cell functions. J. Immunol., 187, 4347-4359 (2011).
11. Kochetkova I, Golden S, Holderness K, Callis G, Pascual DW. IL-35 stimulation of CD39+ regulatory T cells confers protection against collagen II-induced arthritis via the production of IL-10. J. Immunol., 184, 7144-7153 (2010).