메뉴 건너뛰기




Volumn 13, Issue 4, 2013, Pages 351-359

Clinical efficacy and management of temsirolimus in patients with relapsed or refractory mantle cell lymphoma

Author keywords

mTOR; Non Hodgkin lymphoma

Indexed keywords

ALEMTUZUMAB; AMIODARONE; ANTIBIOTIC AGENT; BENDAMUSTINE; BORTEZOMIB; CHLORAMBUCIL; CLADRIBINE; CORTICOSTEROID; CYCLOPHOSPHAMIDE; CYTARABINE; DEXAMETHASONE; DIPHENHYDRAMINE; DOXORUBICIN; ETOPOSIDE; GEMCITABINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LENALIDOMIDE; METHOTREXATE; MITOXANTRONE; PENTAMIDINE; PREDNISOLONE; PREDNISONE; RITUXIMAB; TEMSIROLIMUS; THALIDOMIDE; VINBLASTINE; VINCRISTINE;

EID: 84880760560     PISSN: 21522650     EISSN: 21522669     Source Type: Journal    
DOI: 10.1016/j.clml.2013.04.003     Document Type: Review
Times cited : (11)

References (62)
  • 2
    • 84879533106 scopus 로고    scopus 로고
    • Update on the molecular pathogenesis and clinical treatment of mantle cell lymphoma: Report of the 11th annual conference of the European Mantle Cell Lymphoma Network
    • M. Dreyling, H.C. Kluin-Nelemans, and S. Bea Update on the molecular pathogenesis and clinical treatment of mantle cell lymphoma: report of the 11th annual conference of the European Mantle Cell Lymphoma Network Leuk Lymphoma 54 2013 699 707
    • (2013) Leuk Lymphoma , vol.54 , pp. 699-707
    • Dreyling, M.1    Kluin-Nelemans, H.C.2    Bea, S.3
  • 3
    • 79955401258 scopus 로고    scopus 로고
    • Patterns and outcome of relapse after autologous stem cell transplantation for mantle cell lymphoma
    • S. Dietrich, B. Tielesch, and M. Rieger Patterns and outcome of relapse after autologous stem cell transplantation for mantle cell lymphoma Cancer 117 2011 1901 1910
    • (2011) Cancer , vol.117 , pp. 1901-1910
    • Dietrich, S.1    Tielesch, B.2    Rieger, M.3
  • 4
    • 59149105528 scopus 로고    scopus 로고
    • Improvement of overall survival in advanced stage mantle cell lymphoma
    • A. Herrmann, E. Hoster, and T. Zwingers Improvement of overall survival in advanced stage mantle cell lymphoma J Clin Oncol 27 2009 511 518
    • (2009) J Clin Oncol , vol.27 , pp. 511-518
    • Herrmann, A.1    Hoster, E.2    Zwingers, T.3
  • 5
    • 27244434474 scopus 로고    scopus 로고
    • Current treatment approaches for mantle-cell lymphoma
    • DOI 10.1200/JCO.2005.55.017
    • T.E. Witzig Current treatment approaches for mantle-cell lymphoma J Clin Oncol 23 2005 6409 6414 (Pubitemid 46222241)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.26 , pp. 6409-6414
    • Witzig, T.E.1
  • 7
    • 84872054301 scopus 로고    scopus 로고
    • CHOP and DHAP plus rituximab followed by autologous stem cell transplantation in mantle cell lymphoma: A phase 2 study from the Groupe d'Etude des Lymphomes de l'Adulte
    • R. Delarue, C. Haioun, and V. Ribrag CHOP and DHAP plus rituximab followed by autologous stem cell transplantation in mantle cell lymphoma: a phase 2 study from the Groupe d'Etude des Lymphomes de l'Adulte Blood 121 2013 48 53
    • (2013) Blood , vol.121 , pp. 48-53
    • Delarue, R.1    Haioun, C.2    Ribrag, V.3
  • 8
    • 78951495411 scopus 로고    scopus 로고
    • Alternating courses of 3x CHOP and 3x DHAP plus rituximab followed by a high dose ARA-C containing myeloablative regimen and autologous stem cell transplantation (ASCT is superior to 6 courses CHOP plus rituximab followed by myeloablative radiochemotherapy and ASCT in mantle cell lymphoma: Results of the MCL younger trial of the European Mantle Cell Lymphoma Network (MCL net)
    • (ASH Annual Meeting Abstracts) (abstract 110)
    • O. Hermine, E. Hoster, and J. Walewski Alternating courses of 3x CHOP and 3x DHAP plus rituximab followed by a high dose ARA-C containing myeloablative regimen and autologous stem cell transplantation (ASCT is superior to 6 courses CHOP plus rituximab followed by myeloablative radiochemotherapy and ASCT in mantle cell lymphoma: results of the MCL younger trial of the European Mantle Cell Lymphoma Network (MCL net) Blood 116 2010 (ASH Annual Meeting Abstracts) (abstract 110)
    • (2010) Blood , vol.116
    • Hermine, O.1    Hoster, E.2    Walewski, J.3
  • 9
    • 79960490364 scopus 로고    scopus 로고
    • Treatment of younger patients with mantle cell lymphoma
    • S. Harel, R. Delarue, and V. Ribrag Treatment of younger patients with mantle cell lymphoma Semin Hematol 48 2011 194 207
    • (2011) Semin Hematol , vol.48 , pp. 194-207
    • Harel, S.1    Delarue, R.2    Ribrag, V.3
  • 10
    • 84864715966 scopus 로고    scopus 로고
    • Treatment of older patients with mantle-cell lymphoma
    • H.C. Kluin-Nelemans, E. Hoster, and O. Hermine Treatment of older patients with mantle-cell lymphoma N Engl J Med 367 2012 520 531
    • (2012) N Engl J Med , vol.367 , pp. 520-531
    • Kluin-Nelemans, H.C.1    Hoster, E.2    Hermine, O.3
  • 11
    • 77953426741 scopus 로고    scopus 로고
    • Temsirolimus for the treatment of mantle cell lymphoma
    • G. Hess Temsirolimus for the treatment of mantle cell lymphoma Expert Rev Hematol 2 2009 631 640
    • (2009) Expert Rev Hematol , vol.2 , pp. 631-640
    • Hess, G.1
  • 12
    • 68949102180 scopus 로고    scopus 로고
    • Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma
    • G. Hess, R. Herbrecht, and J. Romaguera Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma J Clin Oncol 27 2009 3822 3829
    • (2009) J Clin Oncol , vol.27 , pp. 3822-3829
    • Hess, G.1    Herbrecht, R.2    Romaguera, J.3
  • 14
    • 79952154013 scopus 로고    scopus 로고
    • Bortezomib plus CHOP-rituximab for previously untreated diffuse large B-cell lymphoma and mantle cell lymphoma
    • J. Ruan, P. Martin, and R.R. Furman Bortezomib plus CHOP-rituximab for previously untreated diffuse large B-cell lymphoma and mantle cell lymphoma J Clin Oncol 29 2011 690 697
    • (2011) J Clin Oncol , vol.29 , pp. 690-697
    • Ruan, J.1    Martin, P.2    Furman, R.R.3
  • 15
    • 64149112784 scopus 로고    scopus 로고
    • Lenalidomide oral monotherapy produces a high response rate in patients with relapsed or refractory mantle cell lymphoma
    • T.M. Habermann, I.S. Lossos, and G. Justice Lenalidomide oral monotherapy produces a high response rate in patients with relapsed or refractory mantle cell lymphoma Br J Haematol 145 2009 344 349
    • (2009) Br J Haematol , vol.145 , pp. 344-349
    • Habermann, T.M.1    Lossos, I.S.2    Justice, G.3
  • 16
    • 54449095901 scopus 로고    scopus 로고
    • Lenalidomide monotherapy in relapsed or refractory aggressive non-Hodgkin's lymphoma
    • P.H. Wiernik, I.S. Lossos, and J.M. Tuscano Lenalidomide monotherapy in relapsed or refractory aggressive non-Hodgkin's lymphoma J Clin Oncol 26 2008 4952 4957
    • (2008) J Clin Oncol , vol.26 , pp. 4952-4957
    • Wiernik, P.H.1    Lossos, I.S.2    Tuscano, J.M.3
  • 17
    • 84863107308 scopus 로고    scopus 로고
    • Lenalidomide in combination with rituximab for patients with relapsed or refractory mantle-cell lymphoma: A phase 1/2 clinical trial
    • M. Wang, L. Fayad, and N. Wagner-Bartak Lenalidomide in combination with rituximab for patients with relapsed or refractory mantle-cell lymphoma: a phase 1/2 clinical trial Lancet Oncol 13 2012 716 723
    • (2012) Lancet Oncol , vol.13 , pp. 716-723
    • Wang, M.1    Fayad, L.2    Wagner-Bartak, N.3
  • 18
    • 80052774270 scopus 로고    scopus 로고
    • The role of mTOR inhibitors for the treatment of B-cell lymphomas
    • P. Argyriou, P. Economopoulou, and S. Papageorgiou The role of mTOR inhibitors for the treatment of B-cell lymphomas Adv Hematol 2012 2012 435342
    • (2012) Adv Hematol , vol.2012 , pp. 435342
    • Argyriou, P.1    Economopoulou, P.2    Papageorgiou, S.3
  • 19
    • 72049083386 scopus 로고    scopus 로고
    • Exploring mammalian target of rapamycin (mTOR) inhibition for treatment of mantle cell lymphoma and other hematologic malignancies
    • B. Coiffier, and V. Ribrag Exploring mammalian target of rapamycin (mTOR) inhibition for treatment of mantle cell lymphoma and other hematologic malignancies Leuk Lymphoma 50 2009 1916 1930
    • (2009) Leuk Lymphoma , vol.50 , pp. 1916-1930
    • Coiffier, B.1    Ribrag, V.2
  • 20
    • 79959610128 scopus 로고    scopus 로고
    • Utility of mTOR inhibition in hematologic malignancies
    • A. Younes, and N. Samad Utility of mTOR inhibition in hematologic malignancies Oncologist 16 2011 730 741
    • (2011) Oncologist , vol.16 , pp. 730-741
    • Younes, A.1    Samad, N.2
  • 21
    • 34250619165 scopus 로고    scopus 로고
    • The mammalian target of rapamycin signaling pathway: Twists and turns in the road to cancer therapy
    • DOI 10.1158/1078-0432.CCR-06-2798
    • R.T. Abraham, and J.J. Gibbons The mammalian target of rapamycin signaling pathway: twists and turns in the road to cancer therapy Clin Cancer Res 13 2007 3109 3114 (Pubitemid 46944891)
    • (2007) Clinical Cancer Research , vol.13 , Issue.11 , pp. 3109-3114
    • Abraham, R.T.1    Gibbons, J.J.2
  • 22
    • 42349113247 scopus 로고    scopus 로고
    • A new pharmacologic action of CCI-779 involves FKBP12-independent inhibition of mTOR kinase activity and profound repression of global protein synthesis
    • DOI 10.1158/0008-5472.CAN-07-6487
    • B. Shor, W.G. Zhang, and L. Toral-Barza A new pharmacologic action of CCI-779 involves FKBP12-independent inhibition of mTOR kinase activity and profound repression of global protein synthesis Cancer Res 68 2008 2934 2943 (Pubitemid 351556294)
    • (2008) Cancer Research , vol.68 , Issue.8 , pp. 2934-2943
    • Shor, B.1    Zhang, W.-G.2    Toral-Barza, L.3    Lucas, J.4    Abraham, R.T.5    Gibbons, J.J.6    Yu, K.7
  • 24
    • 78650985963 scopus 로고    scopus 로고
    • Mantle cell lymphoma: Biology, pathogenesis, and the molecular basis of treatment in the genomic era
    • P. Perez-Galan, M. Dreyling, and A. Wiestner Mantle cell lymphoma: biology, pathogenesis, and the molecular basis of treatment in the genomic era Blood 117 2011 26 38
    • (2011) Blood , vol.117 , pp. 26-38
    • Perez-Galan, P.1    Dreyling, M.2    Wiestner, A.3
  • 25
    • 46749155539 scopus 로고    scopus 로고
    • Distinct functional significance of Akt and mTOR constitutive activation in mantle cell lymphoma
    • J. Dal Col, P. Zancai, and L. Terrin Distinct functional significance of Akt and mTOR constitutive activation in mantle cell lymphoma Blood 111 2008 5142 5151
    • (2008) Blood , vol.111 , pp. 5142-5151
    • Dal Col, J.1    Zancai, P.2    Terrin, L.3
  • 26
    • 34248647440 scopus 로고    scopus 로고
    • Activation of mammalian target of rapamycin signaling promotes cell cycle progression and protects cells from apoptosis in mantle cell lymphoma
    • DOI 10.2353/ajpath.2006.051078
    • E. Peponi, E. Drakos, and G. Reyes Activation of mammalian target of rapamycin signaling promotes cell cycle progression and protects cells from apoptosis in mantle cell lymphoma Am J Pathol 169 2006 2171 2180 (Pubitemid 351181976)
    • (2006) American Journal of Pathology , vol.169 , Issue.6 , pp. 2171-2180
    • Peponi, E.1    Drakos, E.2    Reyes, G.3    Leventaki, V.4    Rassidakis, G.Z.5    Medeiros, L.J.6
  • 27
    • 77956483087 scopus 로고    scopus 로고
    • Cytostatic and anti-angiogenic effects of temsirolimus in refractory mantle cell lymphoma
    • L. Wang, W.Y. Shi, and Z.Y. Wu Cytostatic and anti-angiogenic effects of temsirolimus in refractory mantle cell lymphoma J Hematol Oncol 3 2010 30
    • (2010) J Hematol Oncol , vol.3 , pp. 30
    • Wang, L.1    Shi, W.Y.2    Wu, Z.Y.3
  • 28
    • 40749094917 scopus 로고    scopus 로고
    • Temsirolimus downregulates p21 without altering cyclin D1 expression and induces autophagy and synergizes with vorinostat in mantle cell lymphoma
    • DOI 10.1016/j.exphem.2007.12.008, PII S0301472X07007059
    • V.Y. Yazbeck, D. Buglio, and G.V. Georgakis Temsirolimus downregulates p21 without altering cyclin D1 expression and induces autophagy and synergizes with vorinostat in mantle cell lymphoma Exp Hematol 36 2008 443 450 (Pubitemid 351384743)
    • (2008) Experimental Hematology , vol.36 , Issue.4 , pp. 443-450
    • Yazbeck, V.Y.1    Buglio, D.2    Georgakis, G.V.3    Li, Y.4    Iwado, E.5    Romaguera, J.E.6    Kondo, S.7    Younes, A.8
  • 29
    • 49049087320 scopus 로고    scopus 로고
    • Low-dose, single-agent temsirolimus for relapsed mantle cell lymphoma: A phase 2 trial in the North Central Cancer Treatment Group
    • S.M. Ansell, D.J. Inwards, and K.M. Rowland Jr. Low-dose, single-agent temsirolimus for relapsed mantle cell lymphoma: a phase 2 trial in the North Central Cancer Treatment Group Cancer 113 2008 508 514
    • (2008) Cancer , vol.113 , pp. 508-514
    • Ansell, S.M.1    Inwards, D.J.2    Rowland, Jr.K.M.3
  • 34
    • 79953182631 scopus 로고    scopus 로고
    • Temsirolimus and rituximab in patients with relapsed or refractory mantle cell lymphoma: A phase 2 study
    • S.M. Ansell, H. Tang, and P.J. Kurtin Temsirolimus and rituximab in patients with relapsed or refractory mantle cell lymphoma: a phase 2 study Lancet Oncol 12 2011 361 368
    • (2011) Lancet Oncol , vol.12 , pp. 361-368
    • Ansell, S.M.1    Tang, H.2    Kurtin, P.J.3
  • 35
    • 84880731755 scopus 로고    scopus 로고
    • Temsirolimus in combination with bendamustine and rituximab for the treatment of relapsed mantle cell and follicular lymphoma: Report on an ongoing phase I/II trial
    • December 10-13, 2011; San Diego, CA. Abstract 2697
    • Hess G, Keller U, Atta J, et al. Temsirolimus in combination with bendamustine and rituximab for the treatment of relapsed mantle cell and follicular lymphoma: report on an ongoing phase I/II trial. Presented at: Annual Meeting of the American Society of Hematology; December 10-13, 2011; San Diego, CA. Abstract 2697.
    • Annual Meeting of the American Society of Hematology
    • Hess, G.1    Keller, U.2    Atta, J.3
  • 36
    • 77952118055 scopus 로고    scopus 로고
    • European Medicines Agency. Available at:. Accessed October 18, 2011
    • Torisel [annex 1 summary of product characteristics]. European Medicines Agency. Available at: www.emea.europa.eu/docs/en-GB/document-library/EPAR--- Product-Information/human/000799/WC500039912.pdf. Accessed October 18, 2011.
    • Torisel [Annex 1 Summary of Product Characteristics]
  • 37
    • 84880738464 scopus 로고    scopus 로고
    • Temsirolimus in patients with relapsed/refractory mantle cell lymphoma: Does prognostic risk affect outcomes?
    • Amsterdam, The Netherlands; June 14-17, 2012. Abstract 0250
    • Hess G, Kang L, Moran PJ. Temsirolimus in patients with relapsed/refractory mantle cell lymphoma: does prognostic risk affect outcomes? Presented at: 17th Congress of the European Hematology Association; Amsterdam, The Netherlands; June 14-17, 2012. Abstract 0250.
    • 17th Congress of the European Hematology Association
    • Hess, G.1    Kang, L.2    Moran, P.J.3
  • 38
    • 77949890943 scopus 로고    scopus 로고
    • The Mantle Cell Lymphoma International Prognostic Index (MIPI) is superior to the International Prognostic Index (IPI) in predicting survival following intensive first-line immunochemotherapy and autologous stem cell transplantation (ASCT)
    • C.H. Geisler, A. Kolstad, and A. Laurell The Mantle Cell Lymphoma International Prognostic Index (MIPI) is superior to the International Prognostic Index (IPI) in predicting survival following intensive first-line immunochemotherapy and autologous stem cell transplantation (ASCT) Blood 115 2010 1530 1533
    • (2010) Blood , vol.115 , pp. 1530-1533
    • Geisler, C.H.1    Kolstad, A.2    Laurell, A.3
  • 39
    • 38349104577 scopus 로고    scopus 로고
    • A new prognostic index (MIPI) for patients with advanced-stage mantle cell lymphoma
    • E. Hoster, M. Dreyling, and W. Klapper A new prognostic index (MIPI) for patients with advanced-stage mantle cell lymphoma Blood 111 2008 558 565
    • (2008) Blood , vol.111 , pp. 558-565
    • Hoster, E.1    Dreyling, M.2    Klapper, W.3
  • 40
    • 84880738941 scopus 로고    scopus 로고
    • Randomized phase IV trial comparing efficacy and tolerability of temsirolimus with and without an elevated starting dose in patients with relapsed, refractory mantle cell lymphoma
    • abstract TPS222
    • A. Bair, G. Hess, and J. Boni Randomized phase IV trial comparing efficacy and tolerability of temsirolimus with and without an elevated starting dose in patients with relapsed, refractory mantle cell lymphoma J Clin Oncol 29 2011 abstract TPS222
    • (2011) J Clin Oncol , vol.29
    • Bair, A.1    Hess, G.2    Boni, J.3
  • 41
    • 34548076410 scopus 로고    scopus 로고
    • In vitro metabolic study of temsirolimus: Preparation, isolation, and identification of the metabolites
    • DOI 10.1124/dmd.107.014746
    • P. Cai, R. Tsao, and M.E. Ruppen In vitro metabolic study of temsirolimus: preparation, isolation, and identification of the metabolites Drug Metab Dispos 35 2007 1554 1563 (Pubitemid 47296048)
    • (2007) Drug Metabolism and Disposition , vol.35 , Issue.9 , pp. 1554-1563
    • Cai, P.1    Tsao, R.2    Ruppen, M.E.3
  • 42
    • 35448978367 scopus 로고    scopus 로고
    • Pharmacokinetic profile of temsirolimus with concomitant administration of cytochrome P450-inducing medications
    • DOI 10.1177/0091270007306957
    • J. Boni, C. Leister, and J. Burns Pharmacokinetic profile of temsirolimus with concomitant administration of cytochrome P450-inducing medications J Clin Pharmacol 47 2007 1430 1439 (Pubitemid 47624594)
    • (2007) Journal of Clinical Pharmacology , vol.47 , Issue.11 , pp. 1430-1439
    • Boni, J.1    Leister, C.2    Burns, J.3    Cincotta, M.4    Hug, B.5    Moore, L.6
  • 43
    • 44349099754 scopus 로고    scopus 로고
    • Differential effects of ketoconazole on exposure to temsirolimus following intravenous infusion of temsirolimus
    • DOI 10.1038/sj.bjc.6604376, PII 6604376
    • J.P. Boni, C. Leister, and J. Burns Differential effects of ketoconazole on exposure to temsirolimus following intravenous infusion of temsirolimus Br J Cancer 98 2008 1797 1802 (Pubitemid 351748841)
    • (2008) British Journal of Cancer , vol.98 , Issue.11 , pp. 1797-1802
    • Boni, J.P.1    Leister, C.2    Burns, J.3    Hug, B.4
  • 44
    • 72049114956 scopus 로고    scopus 로고
    • Intravenous temsirolimus in cancer patients: Clinical pharmacology and dosing considerations
    • J.P. Boni, B. Hug, and C. Leister Intravenous temsirolimus in cancer patients: clinical pharmacology and dosing considerations Semin Oncol 36 2009 S18 S25
    • (2009) Semin Oncol , vol.36
    • Boni, J.P.1    Hug, B.2    Leister, C.3
  • 45
    • 67349176688 scopus 로고    scopus 로고
    • Disposition of desipramine, a sensitive cytochrome P450 2D6 substrate, when coadministered with intravenous temsirolimus
    • J. Boni, R. Abbas, and C. Leister Disposition of desipramine, a sensitive cytochrome P450 2D6 substrate, when coadministered with intravenous temsirolimus Cancer Chemother Pharmacol 64 2009 263 270
    • (2009) Cancer Chemother Pharmacol , vol.64 , pp. 263-270
    • Boni, J.1    Abbas, R.2    Leister, C.3
  • 46
    • 80052783465 scopus 로고    scopus 로고
    • Sirolimus-induced pneumonitis complicated by pentamidine-induced phospholipidosis in a renal transplant recipient: A case report
    • E.J. Filippone, J.M. Carson, and R.A. Beckford Sirolimus-induced pneumonitis complicated by pentamidine-induced phospholipidosis in a renal transplant recipient: a case report Transplant Proc 43 2011 2792 2797
    • (2011) Transplant Proc , vol.43 , pp. 2792-2797
    • Filippone, E.J.1    Carson, J.M.2    Beckford, R.A.3
  • 48
    • 79952806004 scopus 로고    scopus 로고
    • Drug-related pneumonitis in patients with advanced renal cell carcinoma treated with temsirolimus
    • J.P. Maroto, G. Hudes, and J.P. Dutcher Drug-related pneumonitis in patients with advanced renal cell carcinoma treated with temsirolimus J Clin Oncol 29 2011 1750 1756
    • (2011) J Clin Oncol , vol.29 , pp. 1750-1756
    • Maroto, J.P.1    Hudes, G.2    Dutcher, J.P.3
  • 49
    • 84863303079 scopus 로고    scopus 로고
    • New strategies in the treatment of mantle cell lymphoma
    • C. Deng, S. Lee, and O.A. O'Connor New strategies in the treatment of mantle cell lymphoma Clin Cancer Res 18 2012 3499 3508
    • (2012) Clin Cancer Res , vol.18 , pp. 3499-3508
    • Deng, C.1    Lee, S.2    O'Connor, O.A.3
  • 51
    • 82555187990 scopus 로고    scopus 로고
    • New molecular targets in mantle cell lymphoma
    • S. Parekh, M.A. Weniger, and A. Wiestner New molecular targets in mantle cell lymphoma Semin Cancer Biol 21 2011 335 346
    • (2011) Semin Cancer Biol , vol.21 , pp. 335-346
    • Parekh, S.1    Weniger, M.A.2    Wiestner, A.3
  • 52
    • 84862200758 scopus 로고    scopus 로고
    • Targeting mTOR in mantle cell lymphoma: Current and future directions
    • S.M. Smith Targeting mTOR in mantle cell lymphoma: current and future directions Best Pract Res Clin Haematol 25 2012 175 183
    • (2012) Best Pract Res Clin Haematol , vol.25 , pp. 175-183
    • Smith, S.M.1
  • 54
    • 84863971730 scopus 로고    scopus 로고
    • A multicenter phase II trial (SAKK 36/06) of single-agent everolimus (RAD001) in patients with relapsed or refractory mantle cell lymphoma
    • C. Renner, P.L. Zinzani, and R. Gressin A multicenter phase II trial (SAKK 36/06) of single-agent everolimus (RAD001) in patients with relapsed or refractory mantle cell lymphoma Haematologica 97 2012 1085 1091
    • (2012) Haematologica , vol.97 , pp. 1085-1091
    • Renner, C.1    Zinzani, P.L.2    Gressin, R.3
  • 55
    • 77951002653 scopus 로고    scopus 로고
    • Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia
    • J.W. Friedberg, J. Sharman, and J. Sweetenham Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia Blood 115 2010 2578 2585
    • (2010) Blood , vol.115 , pp. 2578-2585
    • Friedberg, J.W.1    Sharman, J.2    Sweetenham, J.3
  • 56
    • 78751553221 scopus 로고    scopus 로고
    • CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability
    • B.J. Lannutti, S.A. Meadows, and S.E. Herman CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability Blood 117 2011 591 594
    • (2011) Blood , vol.117 , pp. 591-594
    • Lannutti, B.J.1    Meadows, S.A.2    Herman, S.E.3
  • 57
    • 84880734744 scopus 로고    scopus 로고
    • A phase i dose expansion cohort study of the safety, pharmacokinetics and pharmacodynamics of SAR245409 (S09), an orally administered PI3K/mTOR inhibitor, in patients with lymphoma
    • December 10-13, 2011. San Diego, CA. Abstract 1608
    • Papadopoulis KP, Abrisqueta P, Chambers G, et al. A phase I dose expansion cohort study of the safety, pharmacokinetics and pharmacodynamics of SAR245409 (S09), an orally administered PI3K/mTOR inhibitor, in patients with lymphoma. Presented at: 53rd American Society of Hematology Annual Meeting; December 10-13, 2011. San Diego, CA. Abstract 1608.
    • 53rd American Society of Hematology Annual Meeting
    • Papadopoulis, K.P.1    Abrisqueta, P.2    Chambers, G.3
  • 58
    • 84871806385 scopus 로고    scopus 로고
    • Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies
    • R.H. Advani, J.J. Buggy, and J.P. Sharman Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies J Clin Oncol 31 2013 88 94
    • (2013) J Clin Oncol , vol.31 , pp. 88-94
    • Advani, R.H.1    Buggy, J.J.2    Sharman, J.P.3
  • 59
    • 84880708619 scopus 로고    scopus 로고
    • The Bruton's tyrosine kinase inhibitor PCI-32765 is highly active as single-agent therapy in previously-treated mantle cell lymphoma (MCL): Preliminary results of a phase II trial
    • December 10-13, 2011; San Diego, CA. Abstract 442
    • Wang L, Martin P, Blum KA, et al. The Bruton's tyrosine kinase inhibitor PCI-32765 is highly active as single-agent therapy in previously-treated mantle cell lymphoma (MCL): preliminary results of a phase II trial. Presented at: 53rd American Society of Hematology Annual Meeting; December 10-13, 2011; San Diego, CA. Abstract 442.
    • 53rd American Society of Hematology Annual Meeting
    • Wang, L.1    Martin, P.2    Blum, K.A.3
  • 60
    • 84862325029 scopus 로고    scopus 로고
    • The dual PI3K and mTOR inhibitor NVP-BEZ235 exhibits anti-proliferative activity and overcomes bortezomib resistance in mantle cell lymphoma cells
    • A. Kim, S. Park, and J.E. Lee The dual PI3K and mTOR inhibitor NVP-BEZ235 exhibits anti-proliferative activity and overcomes bortezomib resistance in mantle cell lymphoma cells Leuk Res 36 2012 912 920
    • (2012) Leuk Res , vol.36 , pp. 912-920
    • Kim, A.1    Park, S.2    Lee, J.E.3
  • 61
    • 84866898723 scopus 로고    scopus 로고
    • Counteracting autophagy overcomes resistance to everolimus in mantle cell lymphoma
    • L. Rosich, S. Xargay-Torrent, and M. Lopez-Guerra Counteracting autophagy overcomes resistance to everolimus in mantle cell lymphoma Clin Cancer Res 18 2012 5278 5289
    • (2012) Clin Cancer Res , vol.18 , pp. 5278-5289
    • Rosich, L.1    Xargay-Torrent, S.2    Lopez-Guerra, M.3
  • 62
    • 84859709788 scopus 로고    scopus 로고
    • Relapsed and/or refractory mantle cell lymphoma: What role for temsirolimus?
    • S. Kirschey, S. Wagner, and G. Hess Relapsed and/or refractory mantle cell lymphoma: what role for temsirolimus? Clin Med Insights Oncol 6 2012 153 164
    • (2012) Clin Med Insights Oncol , vol.6 , pp. 153-164
    • Kirschey, S.1    Wagner, S.2    Hess, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.