The role of α-adrenergic receptors in mediating beat-by-beat sympathetic vascular transduction in the forearm of resting man

Journal of Physiology

Volumn 591, Issue 14, 2013, Pages 3637-3649

  Fairfax, Seth T ^a   Holwerda, Seth W ^b   Credeur, Daniel P ^b   Zuidema, Mozow Y ^c   Medley, John H ^d   Dyke Ii, Peter C ^e   Wray, D Walter ^g   Davis, Michael J ^b,f   Fadel, Paul J ^b,f  

^a Biomedical Sciences   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

^c Departments of Internal Medicine Hepatology   (United States)

^d Anesthesiology   (United States)

^e Pediatric Cardiology   (United States)

^f UNIVERSITY OF MISSOURI   (United States)

^g UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ADRENERGIC RECEPTOR; ANGIOTENSIN II; PHENTOLAMINE; SODIUM CHLORIDE;

ADRENERGIC TRANSMISSION; ADULT; ARM BLOOD FLOW; ARTERIAL PRESSURE; ARTERY BLOOD FLOW; ARTICLE; BLOOD PRESSURE; BLOOD VESSEL PARAMETERS; BRACHIAL ARTERY; CONTROLLED STUDY; EVOKED RESPONSE; FOREARM; HEART CYCLE; HUMAN; HUMAN EXPERIMENT; MALE; MOLECULAR MECHANICS; MUSCLE SYMPATHETIC NERVE ACTIVITY; NERVE FUNCTION; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RECEPTOR BLOCKING; REST; SIGNAL TRANSDUCTION; SPIKE WAVE; SUPINE POSITION; VASCULAR CONDUCTANCE; VASOCONSTRICTION;

ADRENERGIC ALPHA-ANTAGONISTS; ADULT; ANGIOTENSIN II; FOREARM; HUMANS; MALE; PHENTOLAMINE; RECEPTORS, ADRENERGIC, ALPHA; REGIONAL BLOOD FLOW; REST; VASOCONSTRICTOR AGENTS; YOUNG ADULT;

EID: 84880749927     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2013.250894     Document Type: Article

References (41)

1. Barrett-O'Keefe Z, Witman MA, McDaniel J, Fjeldstad AS, Trinity JD, Ives SJ, Conklin JD, Reese V, Runnels S, Morgan DE, Sander M, Richardson RS & Wray DW (2013). Angiotensin II potentiates α-adrenergic vasoconstriction in the elderly. Clin Sci (Lond) 124, 413-422.
2. Cardillo C, Kilcoyne CM, Waclawiw M, Cannon RO, 3rd & Panza JA (1999). Role of endothelin in the increased vascular tone of patients with essential hypertension. Hypertension 33, 753-758.
3. Casey DP, Padilla J & Joyner MJ (2012). a-adrenergic vasoconstriction contributes to the age-related increase in conduit artery retrograde and oscillatory shear. Hypertension 60, 1016-1022.
4. Davis MJ (2012). Perspective: physiological role(s) of the vascular myogenic response. Microcirculation 19, 99-114.
5. Davy KP, Seals DR & Tanaka H (1998). Augmented cardiopulmonary and integrative sympathetic baroreflexes but attenuated peripheral vasoconstriction with age. Hypertension 32, 298-304.
6. Diedrich A, Crossman AA, Beightol LA, Tahvanainen KU, Kuusela TA, Ertl AC & Eckberg DL (2013). Baroreflex physiology studied in healthy subjects with very infrequent muscle sympathetic bursts. J Appl Physiol 114, 203-210.
7. Dinenno FA, Eisenach JH, Dietz NM & Joyner MJ (2002). Post-junctional alpha-adrenoceptors and basal limb vascular tone in healthy men. J Physiol 540, 1103-1110.
8. Dyson KS, Shoemaker JK, Arbeille P & Hughson RL (2010). Modelflow estimates of cardiac output compared with Doppler ultrasound during acute changes in vascular resistance in women. Exp Physiol 95, 561-568.
9. Esler MD, Hasking GJ, Willett IR, Leonard PW & Jennings GL (1985). Noradrenaline release and sympathetic nervous system activity. J Hypertens 3, 117-129.
10. Fadel PJ (2008). Arterial baroreflex control of the peripheral vasculature in humans: rest and exercise. Med Sci Sports Exerc 40, 2055-2062.
11. Fagius J & Wallin BG (1993). Long-term variability and reproducibility of resting human muscle nerve sympathetic activity at rest, as reassessed after a decade. Clin Auton Res 3, 201-205.
12. Fairfax ST, Padilla J, Vianna LC, Davis MJ & Fadel PJ (2013). Spontaneous bursts of muscle sympathetic nerve activity decrease leg vascular conductance in resting humans. Am J Physiol Heart Circ Physiol 304, H759-H766.
13. Hart EC, Charkoudian N, Wallin BG, Curry TB, Eisenach J & Joyner MJ (2011). Sex and ageing differences in resting arterial pressure regulation: the role of the beta-adrenergic receptors. J Physiol 589, 5285-5297.
14. Johansson K, Eriksson M, Wahlqvist I, von zur Muhlen B & Lind L (2002). Effects of blockade of alpha- and beta-adrenoceptors and neuropeptide Y(1) receptors, as well as brachial plexus blockade, on endothelium-dependent vasodilation in the human forearm. Clin Exp Pharmacol Physiol 29, 603-607.
15. Jones PP, Shapiro LF, Keisling GA, Jordan J, Shannon JR, Quaife RA & Seals DR (2001). Altered autonomic support of arterial blood pressure with age in healthy men. Circulation 104, 2424-2429.
16. Jordan J, Shannon JR, Diedrich A, Black BK & Robertson D (2002). Increased sympathetic activation in idiopathic orthostatic intolerance: role of systemic adrenoreceptor sensitivity. Hypertension 39, 173-178.
17. Joyner MJ, Charkoudian N & Wallin BG (2010). Sympathetic nervous system and blood pressure in humans: individualized patterns of regulation and their implications. Hypertension 56, 10-16.
18. Kahan T, Pernow J, Schwieler J, Wallin BG, Lundberg JM & Hjemdahl P (1988). Noradrenaline release evoked by a physiological irregular sympathetic discharge pattern is modulated by prejunctional alpha- and beta-adrenoceptors in vivo. Br J Pharmacol 95, 1101-1108.
19. Kim A, Deo SH, Vianna LC, Balanos GM, Hartwich D, Fisher JP & Fadel PJ (2012). Sex differences in carotid baroreflex control of arterial blood pressure in humans: relative contribution of cardiac output and total vascular conductance. Am J Physiol Heart Circ Physiol 301, H2454-H2465.
20. Kiviniemi AM, Frances MF, Tiinanen S, Craen R, Rachinsky M, Petrella RJ, Seppanen T, Huikuri HV, Tulppo MP & Shoemaker JK (2011). alpha-Adrenergic effects on low-frequency oscillations in blood pressure and R-R intervals during sympathetic activation. Exp Physiol 96, 718-735.
21. Kurjiaka DT & Segal SS (1995). Interaction between conducted vasodilation and sympathetic nerve activation in arterioles of hamster striated muscle. Circ Res 76, 885-891.
22. Lott ME, Hogeman C, Herr M, Bhagat M, Kunselman A & Sinoway LI (2009). Vasoconstrictor responses in the upper and lower limbs to increases in transmural pressure. J Appl Physiol 106, 302-310.
23. Lundvall J & Edfeldt H (1994). Very large range of baroreflex sympathetic control of vascular resistance in human skeletal muscle and skin. J Appl Physiol 76, 204-211.
24. Minson CT, Halliwill JR, Young TM & Joyner MJ (2000). Influence of the menstrual cycle on sympathetic activity, baroreflex sensitivity, and vascular transduction in young women. Circulation 101, 862-868.
25. Moore PA, Hersh EV, Papas AS, Goodson JM, Yagiela JA, Rutherford B, Rogy S & Navalta L (2008). Pharmacokinetics of lidocaine with epinephrine following local anaesthesia reversal with phentolamine mesylate. Anesth Prog 55, 40-48.
26. Newcomer SC, Leuenberger UA, Hogeman CS, Handly BD & Proctor DN (2004). Different vasodilator responses of human arms and legs. J Physiol 556, 1001-1011.
27. Ninomiya I, Malpas SC, Matsukawa K, Shindo T & Akiyama T (1993). The amplitude of synchronized cardiac sympathetic nerve activity reflects the number of activated pre- and postganglionic fibers in anaesthetized cats. J Auton Nerv Syst 45, 139-147.
28. Ozkor MA, Murrow JR, Rahman AM, Kavtaradze N, Lin J, Manatunga A & Quyyumi AA (2011). Endothelium-derived hyperpolarizing factor determines resting and stimulated forearm vasodilator tone in health and in disease. Circulation 123, 2244-2253.
29. Padilla J, Young CN, Simmons GH, Deo SH, Newcomer SC, Sullivan JP, Laughlin MH & Fadel PJ (2010). Increased muscle sympathetic nerve activity acutely alters conduit artery shear rate patterns. Am J Physiol Heart Circ Physiol 298, H1128-H1135.
30. Padilla J, Simmons GH, Vianna LC, Davis MJ, Laughlin MH & Fadel PJ (2011). Brachial artery vasodilatation during prolonged lower limb exercise: role of shear rate. Exp Physiol 96, 1019-1027.
31. Pawelczyk JA & Levine BD (2002). Heterogeneous responses of human limbs to infused adrenergic agonists: a gravitational effect J Appl Physiol 92, 2105-2113.
32. Ray CA & Monahan KD (2002). Sympathetic vascular transduction is augmented in young normotensive blacks. J Appl Physiol 92, 651-656.
33. Rea RF & Wallin BG (1989). Sympathetic nerve activity in arm and leg muscles during lower body negative pressure in humans. J Appl Physiol 66, 2778-2781.
34. Rosenmeier JB, Fritzlar SJ, Dinenno FA & Joyner MJ (2003). Exogenous NO administration and alpha-adrenergic vasoconstriction in human limbs. J Appl Physiol 95, 2370-2374.
35. Saris JJ, van Dijk MA, Kroon I, Schalekamp MA & Danser AH (2000). Functional importance of angiotensin-converting enzyme-dependent in situ angiotensin II generation in the human forearm. Hypertension 35, 764-768.
36. Simmons GH, Padilla J, Young CN, Wong BJ, Lang JA, Davis MJ, Laughlin MH & Fadel PJ (2011). Increased brachial artery retrograde shear rate at exercise onset is abolished during prolonged cycling: role of thermoregulatory vasodilation. J Appl Physiol 110, 389-397.
37. Sundlof G & Wallin BG (1977). The variability of muscle nerve sympathetic activity in resting recumbent man. J Physiol 272, 383-397.
38. Vallbo AB, Hagbarth KE, Torebjork HE & Wallin BG (1979). Somatosensory, proprioceptive, and sympathetic activity in human peripheral nerves. Physiol Rev 59, 919-957.
39. Vanhoutte PM, Verbeuren TJ & Webb RC (1981). Local modulation of adrenergic neuroeffector interaction in the blood vessel well. Physiol Rev 61, 151-247.
40. Vianna LC, Hart EC, Fairfax ST, Charkoudian N, Joyner MJ & Fadel PJ (2012). Influence of age and sex on the pressor response following a spontaneous burst of muscle sympathetic nerve activity. Am J Physiol Heart Circ Physiol 302, H2419-H2427.
41. Wallin BG, Burke D & Gandevia S (1994). Coupling between variations in strength and baroreflex latency of sympathetic discharges in human muscle nerves. J Physiol 474, 331-338.