Post-junctional α-adrenoceptors and basal limb vascular tone in healthy men

Journal of Physiology

Volumn 540, Issue 3, 2002, Pages 1103-1110

  Dinenno, Frank A ^a   Eisenach, John H ^a   Dietz, Niki M ^a   Joyner, Michael J ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; NORADRENALIN; PHENTOLAMINE; PRAZOSIN; PROPRANOLOL; TYRAMINE; YOHIMBINE; ALPHA ADRENERGIC RECEPTOR;

ADULT; ALPHA ADRENERGIC RECEPTOR BLOCKING; ARM BLOOD FLOW; ARTICLE; BLOOD VESSEL TONE; BRACHIAL ARTERY; CONTROLLED STUDY; FOREARM; HUMAN; HUMAN EXPERIMENT; MALE; NORADRENALIN RELEASE; NORMAL HUMAN; PRIORITY JOURNAL; SYMPATHECTOMY; SYMPATHETIC TONE; VASOCONSTRICTION; VASODILATATION; VEIN OCCLUSION PLETHYSMOGRAPHY; FOREARM BLOOD FLOW;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ADULT; BLOOD FLOW VELOCITY; DOSE-RESPONSE RELATIONSHIP, DRUG; FOREARM; HUMANS; MALE; MUSCLE TONUS; MUSCLE, SMOOTH, VASCULAR; PHENTOLAMINE; PHENYLEPHRINE; PRAZOSIN; RECEPTORS, ADRENERGIC, ALPHA; REFERENCE VALUES; REGIONAL BLOOD FLOW; VASODILATION; YOHIMBINE;

EID: 0036588267     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2001.015297     Document Type: Article

References (30)

1. 2-adrenoceptor constriction to metabolic inhibition during rat skeletal muscle contraction. Circulation Research 69, 178-184.
2. ANGUS, J. A., COCKS, T. M. & SATOH, K. (1986). The α adrenoceptors on endothelial cells. Federation Proceedings 45, 2355-2359.
3. BOLLI, P. E., KIOWSKI, W., JI, B. H., AMANN, F. W. & BUHLER, F. R. (1983). Important contribution of post-junctional a, adrenoceptor-mediated vasoconstriction to arteriolar tone in man. Journal of Hypertension 1, 257-259.
4. BUCKWALTER, J. B., NAIK, J. S., VALIC, Z. & CLIFFORD, P. S. (2001). Exercise attenuates α-adrenergic-receptor responsiveness in skeletal muscle vasculature. Journal of Applied Physiology 90, 172-178.
5. BYLUND, D. B., REGAN, J. A., FABER, J. E., HIEBLE, J. P., TRIGGLE, C. R. & RUFFOLO, R. R. (1995). Vascular α-adrenoceptors: from the gene to the human. Canadian Journal of Physiology and Pharmacology 73, 533-543.
6. CAMBRIDGE, D., DAVEY, M. J. & MASSINGHAM, R. (1977). Prazosin, a selective antagonist of post-synaptic α-adrenoceptors. British Journal of Pharmacology 59, 514-515.
7. DIETZ, N. M., RIVERA, J. M., EGGENER, E. S., FIX, R. J., WARNER, D. O. & JOYNER, M. J. (1994). Nitric oxide contributes to the rise in forearm blood flow during mental stress in humans. Journal of Physiology 480, 361-368.
8. DOXEY, J. C., SMITH, G. F. C. & WALKER, J. M. (1977). Selectivity for blocking agents for pre- and postsynaptic α-adrenoceptors. British Journal of Pharmacology 60, 91-96.
9. DUFF, R. S. (1951). Circulatory changes in the forearm following sympathectomy. Clinical Science 10, 529-540.
10. EGAN, B., PANIS, R., HINDERLITER, A., SCHORK, N. & JULIUS, S. (1987). Mechanism of increased α adrenergic vasoconstriction in human essential hypertension. Journal of Clinical Investigation 80, 812-817.
11. FREWIN, D. B. & WHELAN, R. F. (1968). The mechanism of action of tyramine on the blood vessels of the forearm in man. British Journal of Pharmacology 22, 105-116.
12. GREENFIELD, A. D. M., WHITNEY, R. J. & MOWBRAY, J. F. (1963). Methods for the investigation of peripheral blood flow. British Medical Bulletin 19, 101-109.
13. 2-adrenoceptors on vascular sympathetic nerve endings in the human forearm. Circulation Research 69, 887-897.
14. HANSEN, J., SANDER, M., HALD, C. F., VICTOR, R. G. & THOMAS, G. D. (2000). Metabolic modulation of sympathetic vasoconstriction in human skeletal muscle: role of tissue hypoxia. Journal of Physiology 527, 387-396.
15. JIE, K., VAN BRUMMELEN, P., VERMEY, P., TIMMERMANS, P. & VAN ZWIETEN, P. A. (1984) Identification of vascular postsynaptic α-1 and α-2 adrenoceptors in man. Circulation Research 54, 447-452.
16. JIE, K., VAN BRUMMELEN, P., VERMEY, P., TIMMERMANS, P. & VAN ZWIETEN, P. A. (1987a). Modulation of noradrenaline release by peripheral presynaptic α2-adrenoceptors in humans. Journal of Cardiovascular Pharmacology 9, 407-413.
17. JIE, K., VAN BRUMMELEN, P., VERMEY, P., TIMMERMANS, P. & VAN ZWIETEN, P. A. (1987b). Postsynaptic α and α2-adrenoceptors in human blood vessels: interactions with exogenous and endogenous catecholamines. European Journal of Clinical Investigation 17, 174-181.
18. JOHNSSON, G. (1967). The effects of intra-arterially administered propranolol and H 56-28 on blood flow in the forearm - a comparative study of two β-adrenergic receptor antagonists. Acta Pharmacologica Toxicologica 25, 63-74.
19. 2 uptake in rhythmically contracting human forearm muscles. American Journal of Physiology 263, H1078-1083.
20. 2-Adrenoceptor-mediated vasoconstriction of arteries. Clinical Pharmacology and Therapeutics 34, 565-569.
21. 2-Receptor-mediated vasoconstriction in patients with congestive heart failure. Circulation 80, 1660-1667.
22. MINSON, C. T., HALLIWILL, J. R., YOUNG, T. M. & JOYNER, M. J. (2000). Influence of the menstrual cycle on sympathetic activity, baroreflex sensitivity, and vascular transduction in young women. Circulation 101, 862-868.
23. NIIMI, Y., MATSUKAWA, T., SUGIYAMA, S., SHAMSUZZAMAN, A. S. & MANO, T. (1999). Comparison of sympathetic nerve response to head-up tilt in summer and winter. Journal of Gravitational Physiology 6, 43-44.
24. 2-adrenoceptors on microvascular smooth muscle during sympathetic nerve stimulation. Circulation Research 68, 232-244.
25. PIASCIK, M. T., SOLTIS, E. E., PIASCIK, M. M. & MACMILLAN, L. B. (1996). α-Adrenoceptors and vascular regulation: molecular, pharmacologic and clinical correlates. Pharmacology and Therapeutics 72, 215-241.
26. RUFFOLO, R. R., NICHOLS, A. J., STADEL, J. M. & HIEBLE, J. P. (1991). Structure and function of α-adrenoceptors. Pharmacological Reviews 43, 475-505.
27. SAFED, M., SOMMER, O., HOLTZ, J.& BASSENGE, E. (1982). α-Adrenoceptor blockade by phentolamine causes β-adrenergic vasodilation by increased catecholamine release due to presynaptic α-blockade. Journal of Cardiovascular Pharmacology 4, 44-52.
28. 2-mediated adrenergic vasoconstriction in human vessels. European Journal of Clinical Pharmacology 34, 407-410.
29. 2-adrenergic vasoconstriction during contraction of glycolytic, not oxidative, rat hindlimb muscle. American Journal of Physiology 266, H920-929.
30. TORP, K. D., TSCHAKOVSKY, M. E., HALLIWILL, J. R., MINSON, C. T. & JOYNER, M. J. (2001). β-receptor agonist activity of phenylephrine in the human forearm. Journal of Applied Physiology 90, 1855-1859.