Sex and ageing differences in resting arterial pressure regulation: The role of the β-adrenergic receptors

Journal of Physiology

Volumn 589, Issue 21, 2011, Pages 5285-5297

  Hart, Emma C ^a   Charkoudian, Nisha ^b   Wallin, B Gunnar ^c   Curry, Timothy B ^a   Eisenach, John ^a   Joyner, Michael J ^a  

^a MAYO CLINIC   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; NORADRENALIN; PROPRANOLOL;

ADRENERGIC ACTIVITY; ADULT; AGING; ARTERIAL PRESSURE; ARTERY BLOOD FLOW; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; BLOOD PRESSURE REGULATION; BLOOD VESSEL TONE; BRACHIAL ARTERY; CONTROLLED STUDY; FEMALE; HEART OUTPUT; HUMAN; HUMAN EXPERIMENT; MALE; MEAN ARTERIAL PRESSURE; MUSCLE FIBER MEMBRANE CONDUCTANCE; MUSCLE INNERVATION; NEUROGRAPHY; NORMAL HUMAN; POSTMENOPAUSE; PRIORITY JOURNAL; SEX DIFFERENCE; SIGNAL TRANSDUCTION; VASCULAR RESISTANCE; VASOCONSTRICTION;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC BETA-ANTAGONISTS; ADULT; AGE FACTORS; BLOOD PRESSURE; CARDIAC OUTPUT; FEMALE; HEART RATE; HUMANS; MALE; MIDDLE AGED; NOREPINEPHRINE; POSTMENOPAUSE; PROPRANOLOL; RECEPTORS, ADRENERGIC, ALPHA; RECEPTORS, ADRENERGIC, BETA; SEX FACTORS; STROKE VOLUME; VASCULAR RESISTANCE;

EID: 80054997492     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2011.212753     Document Type: Article

References (36)

1. Bell C, Seals DR, Monroe MB, Day DS, Shapiro LF, Johnson DG & Jones PP (2001). Tonic sympathetic support of metabolic rate is attenuated with age, sedentary lifestyle, and female sex in healthy adults. J Clin Endocrinol Metab 86, 4440-4444.
2. Burt VL, Whelton P, Roccella EJ, Brown C, Cutler JA, Higgins M, Horan MJ & Labarthe D (1995). Prevalence of hypertension in the US adult population. Results from the Third National Health and Nutrition Examination Survey, 1988-1991. Hypertension 25, 305-313.
3. Cardillo C, Kilcoyne CM, Quyyumi AA, Cannon RO 3rd & Panza JA (1997). Decreased vasodilator response to isoproterenol during nitric oxide inhibition in humans. Hypertension 30, 918-921.
4. Carter JR & Ray CA (2009). Sympathetic neural responses to mental stress: responders, nonresponders and sex differences. Am J Physiol Heart Circ Physiol 296, H847-H853.
5. Charkoudian N, Joyner MJ, Johnson CP, Eisenach JH, Dietz NM & Wallin BG (2005). Balance between cardiac output and sympathetic nerve activity in resting humans: role in arterial pressure regulation. J Physiol 568, 315-321.
6. Dinenno FA, Dietz NM & Joyner MJ (2002). Aging and forearm postjunctional α-adrenergic vasoconstriction in healthy men. Circulation 106, 1349-1354.
7. Dinenno FA, Tanaka H, Stauffer BL & Seals DR (2001). Reductions in basal limb blood flow and vascular conductance with human ageing: role for augmented α-adrenergic vasoconstriction. J Physiol 536, 977-983.
8. Eisenach JH, Clark ES, Charkoudian N, Dinenno FA, Atkinson JL, Fealey RD, Dietz NM & Joyner MJ (2002). Effects of chronic sympathectomy on vascular function in the human forearm. J Appl Physiol 92, 2019-2025.
9. Ferrer M, Meyer M & Osol G (1996). Estrogen replacement increases β-adrenoceptor-mediated relaxation of rat mesenteric arteries. J Vasc Res 33, 124-131.
10. Ferro A, Queen LR, Priest RM, Xu B, Ritter JM, Poston L & Ward JP (1999). Activation of nitric oxide synthase by β2-adrenoceptors in human umbilical vein endothelium in vitro. Br J Pharmacol 126, 1872-1880.
11. Freedman RR, Sabharwal SC & Desai N (1987). Sex differences in peripheral vascular adrenergic receptors. Circ Res 61, 581-585.
12. Gracia CR, Sammel MD, Freeman EW, Lin H, Langan E, Kapoor S & Nelson DB (2005). Defining menopause status: creation of a new definition to identify the early changes of the menopausal transition. Menopause 12, 128-135.
13. Hart EC, Charkoudian N, Wallin BG, Curry TB, Eisenach JH & Joyner MJ (2009a). Sex differences in sympathetic neural-hemodynamic balance: implications for human blood pressure regulation. Hypertension 53, 571-576.
14. Hart EC, Joyner MJ, Wallin BG, Johnson CP, Curry TB, Eisenach JH & Charkoudian N (2009b). Age-related differences in the sympathetic-hemodynamic balance in men. Hypertension 54, 127-133.
15. Jordan J, Tank J, Stoffels M, Franke G, Christensen NJ, Luft FC & Boschmann M (2001). Interaction between β-adrenergic receptor stimulation and nitric oxide release on tissue perfusion and metabolism. J Clin Endocrinol Metab 86, 2803-2810.
16. Joyner MJ, Dietz NM & Shepherd JT (2001). From Belfast to Mayo and beyond: the use and future of plethysmography to study blood flow in human limbs. J Appl Physiol 91, 2431-2441.
17. Kienbaum P, Karlssonn T, Sverrisdottir YB, Elam M & Wallin BG (2001). Two sites for modulation of human sympathetic activity by arterial baroreceptors? J Physiol 531, 861-869.
18. Kneale BJ, Chowienczyk PJ, Brett SE, Coltart DJ & Ritter JM (2000). Gender differences in sensitivity to adrenergic agonists of forearm resistance vasculature. J Am Coll Cardiol 36, 1233-1238.
19. Matsukawa T, Sugiyama Y, Watanabe T, Kobayashi F & Mano T (1998). Gender difference in age-related changes in muscle sympathetic nerve activity in healthy subjects. Am J Physiol Regul Integr Comp Physiol 275, R1600-R1604.
20. Meyer MR, Haas E & Barton M (2008). Need for research on estrogen receptor function: importance for postmenopausal hormone therapy and atherosclerosis. Gend Med 5, S19-S33.
21. Miller VM & Duckles SP (2008). Vascular actions of estrogens: functional implications. Pharmacol Rev 60, 210-241.
22. Minson CT, Halliwill JR, Young TM & Joyner MJ (2000). Influence of the menstrual cycle on sympathetic activity, baroreflex sensitivity, and vascular transduction in young women. Circulation 101, 862-868.
23. Narkiewicz K, Phillips BG, Kato M, Hering D, Bieniaszewski L & Somers VK (2005). Gender-selective interaction between aging, blood pressure, and sympathetic nerve activity. Hypertension 45, 522-525.
24. Roger VL, Go AS, Lloyd-Jones DM, Adams RJ, Berry JD, Brown TM et al (2011). Heart disease and stroke statistics - 2011 update: a report from the American Heart Association. Circulation 123, e18-e209.
25. Rothwell PM, Coull AJ, Silver LE, Fairhead JF, Giles MF, Lovelock CE et al (2005). Population-based study of event-rate, incidence, case fatality, and mortality for all acute vascular events in all arterial territories (Oxford Vascular Study). Lancet 366, 1773-1783.
26. Sherwood A, Park SB, Hughes JW, Blumenthal JA, Hinderliter A, Trivedi R & McFetridge-Durdle J (2010). Cardiovascular hemodynamics during stress in premenopausal versus postmenopausal women. Menopause 17, 403-409.
27. Shibasaki M, Wilson TE, Bundgaard-Nielsen M, Seifert T, Secher NH & Crandall CG (2011). Modelflow underestimates cardiac output in heat-stressed individuals. Am J Physiol Regul Integr Comp Physiol 300, R486-R491.
28. Shoemaker JK, Hogeman CS, Khan M, Kimmerly DS & Sinoway LI (2001). Gender affects sympathetic and hemodynamic response to postural stress. Am J Physiol Heart Circ Physiol 281, H2028-H2035.
29. Sudhir K, Jennings GL, Funder JW & Komesaroff PA (1996). Estrogen enhances basal nitric oxide release in the forearm vasculature in perimenopausal women. Hypertension 28, 330-334.
30. Sundlof G & Wallin BG (1977). The variability of muscle nerve sympathetic activity in resting recumbent man. J Physiol 272, 383-397.
31. Sundlof G & Wallin BG (1978a). Human muscle nerve sympathetic activity at rest. Relationship to blood pressure and age. J Physiol 274, 621-637.
32. Sundlof G & Wallin BG (1978b). Muscle-nerve sympathetic activity in man. Relationship to blood pressure in resting normo- and hyper-tensive subjects. Clin Sci Mol Med Suppl 4, 387s-389s.
33. Vivat V, Cohen-Tannoudji J, Revelli JP, Muzzin P, Giacobino JP, Maltier JP & Legrand C (1992). Progesterone transcriptionally regulates the beta 2-adrenergic receptor gene in pregnant rat myometrium. J Biol Chem 267, 7975-7978.
34. Wesseling KH, Jansen JR, Settels JJ & Schreuder JJ (1993). Computation of aortic flow from pressure in humans using a nonlinear, three-element model. J Appl Physiol 74, 2566-2573.
35. Wiinberg N, Hoegholm A, Christensen HR, Bang LE, Mikkelsen KL, Nielsen PE et al (1995). 24-h ambulatory blood pressure in 352 normal Danish subjects, related to age and gender. Am J Hypertens 8, 978-986.
36. Wuest JH Jr, Dry TJ & Edwards JE (1953). The degree of coronary atherosclerosis in bilaterally oophorectomized women. Circulation 7, 801-809.