Gene therapy of gastric cancer using LIGHT-secreting human umbilical cord blood-derived mesenchymal stem cells

Gastric Cancer

Volumn 16, Issue 2, 2013, Pages 155-166

  Zhu, Xinhong ^a   Su, Dongming ^b   Xuan, Shiying ^a   Ma, Guiliang ^a   Dai, Zhenbo ^c   Liu, Tongyun ^a   Tang, Dongqi ^d   Mao, Weizheng ^a   Dong, Chenfang ^e  

^a QINGDAO MUNICIPAL HOSPITAL   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

^c TIANJIN MEDICAL UNIVERSITY   (China)

^d UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^e UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Gastric cancer; Lentiviral vector; LIGHT (TNFSF14); Umbilical cord blood mesenchymal stem cells (UCB MSCs)

Indexed keywords

HERPESVIRUS ENTRY MEDIATOR LIGAND; LENTIVIRUS VECTOR; SODIUM CHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GENE THERAPY; CANCER INHIBITION; CONTROLLED STUDY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL GENE THERAPY; STOMACH CANCER; TUMOR NECROSIS; TUMOR VOLUME; UMBILICAL CORD BLOOD; VIRUS PARTICLE;

ANIMALS; BASE SEQUENCE; DISEASE MODELS, ANIMAL; FETAL BLOOD; GENE EXPRESSION REGULATION; GENETIC THERAPY; HUMANS; LENTIVIRUS; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MICE; MICE, NUDE; MOLECULAR SEQUENCE DATA; STOMACH NEOPLASMS; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 14;

EID: 84880697108     PISSN: 14363291     EISSN: 14363305     Source Type: Journal    
DOI: 10.1007/s10120-012-0166-1     Document Type: Article

References (32)

1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55:74-108.
2. Macdonald JS. Gastric cancer - new therapeutic options. N Engl J Med. 2006;355:76-7.
3. Pereboeva L, Komarova S, Mikheeva G, Krasnykh V, Curiel DT. Approaches to utilize mesenchymal progenitor cells as cellular vehicles. Stem Cells. 2003;21:389-404.
4. Aboody KS, Brown A, Rainov NG, Bower KA, Liu S, et al. Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas. Proc Natl Acad Sci USA. 2000;97:12846-51.
5. Studeny M, Marini FC, Champlin RE, Zompetta C, Fidler IJ, et al. Bone marrow-derived mesenchymal stem cells as vehicles for interferon-β delivery into tumors. Cancer Res. 2002;62:3603-8.
6. Miletic H, Fischer Y, Litwak S, Giroglou T, Waerzeggers Y, et al. Bystander killing of malignant glioma by bone marrow-derived tumor-infiltrating progenitor cells expressing a suicide gene. Mol Ther. 2007;15:1373-81.
7. Nakamizo A, Marini F, Amano T, Khan A, Studeny M, et al. Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas. Cancer Res. 2005;65:3307-18.
8. Van Damme A, Vanden Driessche T, Collen D, Chuah MK. Bone marrow stromal cells as targets for gene therapy. Curr Gene Ther. 2002;2:195-209.
9. Kern S, Eichler H, Stoeve J, Klüter H, Bieback K. Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells. 2006;24:1294-301.
10. Kim SM, Lim JY, Park SI, Jeong CH, Oh JH, Jeong M, Oh W, Park SH, Sung YC, Jeun SS. Gene therapy using TRAIL-secreting human umbilical cord blood-derived mesenchymal stem cells against intracranial glioma. Cancer Res. 2008;23:9614-23.
11. Bhoopathi P, Chetty C, Gogineni VR, Gujrati M, Dinh DH, Rao JS, Lakka SS. MMP-2 mediates mesenchymal stem cell tropism towards medulloblastoma tumors. Gene Ther. 2011;7:692-701.
12. Kim SM, Kim DS, Jeong CH, Kim DH, Kim JH, Jeon HB, Kwon SJ, Jeun SS, Yang YS, Oh W, Chang JW. CXC chemokine receptor 1 enhances the ability of human umbilical cord blood-derived mesenchymal stem cells to migrate toward gliomas. Biochem Biophys Res Commun. 2011;4:741-6.
13. Park SA, Ryu CH, Kim SM, Lim JY, Park SI, Jeong CH, Jun JA, Oh JH, Park SH, Oh W, Jeun SS. CXCR4-transfected human umbilical cord blood-derived mesenchymal stem cells exhibit enhanced migratory capacity toward gliomas. Int J Oncol. 2011;1:97-103.
14. Mauri DN, Ebner R, Montgomery RI, Kochel KD, Cheung TC, et al. LIGHT, a new member of the LIGHT superfamily, and lymphotoxin are ligands for herpesvirus entry mediator. Immunity. 1998;8:21-30.
15. Zhai Y, Guo R, Hsu TL, Yu GL, Ni J, et al. LIGHT, a novel ligand for lymphotoxin beta receptor and TR2/HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer. J Clin Invest. 1998;102:1142-51.
16. Tamada K, Shimozaki K, Chapoval AI, Zhai Y, Su J, et al. LIGHT, a LIGHT-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response. J Immunol. 2000;164:4105-10.
17. Shi G, Luo H, Wan X, Salcedo TW, Zhang J, et al. Mouse T cells receive costimulatory signals from LIGHT, a TNF family member. Blood. 2002;100:3279-86.
18. Wan X, Zhang J, Luo H, Shi G, Kapnik E, et al. A LIGHT family member LIGHT transduces costimulatory signals into human T cells. J Immunol. 2002;169:6813-21.
19. Shi G, Mao J, Yu G, Zhang J, Wu J. Tumor vaccine based on cell surface expression of DcR3/TR6. J Immunol. 2005;174:4727-35.
20. Harrop JA, Reddy M, Dede K, Brigham-Burke M, Lyn S, et al. Antibodies to TR2 (herpesvirus entry mediator), a new member of the LIGHT receptor superfamily, block T cell proliferation, expression of activation markers, and production of cytokines. J Immunol. 1998;161:1786-94.
21. Tamada K, Shimozaki K, Chapoval AI, Zhu G, Sica G, et al. Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway. Nat Med. 2000;6:283-9.
22. Lu FZ, Fujino M, Kitazawa Y, Uyama T, Hara Y, Funeshima N, Jiang JY, Umezawa A, Li XK. Characterization and gene transfer in mesenchymal stem cells derived from human umbilical-cord blood. J Lab Clin Med. 2005;146:271-8.
23. Yu KY, Kwon B, Ni J, Zhai Y, Ebner R, et al. A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis. J Biol Chem. 1999;274:13733-6.
24. Morishige T, Yoshioka Y, Tanabe A, Yao X, Miuguchi H, et al. Comparison of the anti-tumor activity of native, secreted, and membrane-bound LIGHT in mouse tumor models. Int Immunopharmacol. 2010;10:26-33.
25. Hu G, Liu Y, Li H, Zhao D, Yang L, et al. Adenovirus-mediated LIGHT gene modification in murine B-cell lymphoma elicits a potent antitumor effect. Cell Mol Immunol. 2010;7:296-305.
26. Loeffler M, Le'Negrate G, Krajewska M, Reed JC. Attenuated Salmonella engineered to produce human cytokine LIGHT inhibit tumor growth. Proc Natl Acad Sci USA. 2007;104:12879-83.
27. Yu P, Fu YX. Targeting tumors with LIGHT to generate metastasis-clearing immunity. Cytokine Growth Factor Rev. 2008;19:285-94.
28. Fan Z, Yu P, Wang Y, Wang Y, Fu ML, et al. NK-cell activation by LIGHT triggers tumor-specific CD8+ T-cell immunity to reject established tumors. Blood. 2006;107:1342-51.
29. Rubinstein P, Rosenfeld RE, Adamson JW, Stevens CE. Stored placental blood for unrelated bone marrow reconstitution. Blood. 1993;81:679-1690.
30. Nakamura K, Ito Y, Kawano Y, Kurozumi K, Kobune Tsudal M, et al. Antitumor effect of genetically engineered mesenchymal stem cells in a rat glioma model. Gene Ther. 2004;11:1155-64.
31. Wolf D, Rumpold H, Koeck R, Gunsilius E. Mesenchymal stem cells: potential precursors for tumor stroma and targeted-delivery vehicles for anticancer agents. J Natl Cancer Inst. 2005;97:540-1.
32. Zhao BC, Wang ZJ, Ma HC, Han JG, Zhao B, et al. CXCR4/SDF-1 axis is involved in the lymph node metastasis of gastric carcinoma. World J Gastroenterol. 2011;19:2389-96.