CXCR4-transfected human umbilical cord blood-derived mesenchymal stem cells exhibit enhanced migratory capacity toward gliomas

International Journal of Oncology

Volumn 38, Issue 1, 2011, Pages 97-103

  Park, Soon A ^a   Ryu, Chung Heon ^a   Kim, Seong Muk ^a   Lim, Jung Yeon ^a   Park, Sang In ^a   Jeong, Chang Hyun ^a   Jun, Jin Ae ^a   Oh, Ji Hyeon ^a   Park, Sun Hwa ^a   Oh, Wonil ^c   Jeun, Sin Soo ^a,b  

^a The Catholic University of Korea   (South Korea)

^b The Catholic University of Korea   (South Korea)

^c MEDIPOST Co Ltd   (South Korea)

Author keywords

CXCR4; Glioma; Migration; Sdf 1 ; Umbilical cord blood derived mesenchymal stem cell

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; PLERIXAFOR; STROMAL CELL DERIVED FACTOR 1ALPHA;

ARTICLE; CARCINOGENESIS; CELL MIGRATION; CONTROLLED STUDY; FEMALE; GLIOMA; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR XENOGRAFT; UMBILICAL CORD BLOOD;

ANIMALS; BRAIN NEOPLASMS; CELL MOVEMENT; CELLS, CULTURED; FETAL BLOOD; GLIOMA; HUMANS; MESENCHYMAL STEM CELLS; MICE; MICE, NUDE; RECEPTORS, CXCR4; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 78650836835     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo-00000828     Document Type: Article

References (37)

1. Davis FG, McCarthy BJ and Berger MS: Centralized databases available for describing primary brain tumor incidence, survival, and treatment: Central Brain Tumor Registry of the United States; Surveillance, Epidemiology, and End Results; and National Cancer Data Base. J Neurooncol 1: 205-211, 1999.
2. De Angelis LM: Brain tumors. N Engl J Med 344: 114-123, 2001.
3. Aboody KS, Brown A, Rainov NG, et al: Neural stem cells display extensive tropism for pathology in adult br ain: evidence from intracranial gliomas. Proc Natl Acad Sci USA 97:12846-12851, 2000.
4. Ehtesham M, Kabos P, Kabosova A, Neuman T, Black KL and Yu JS: The use of interleukin 12-secreting neural stem cells for the treatment of intracranial glioma. Cancer Res 62: 5657-5663, 2002. (Pubitemid 35204717)
5. Yipa S, Sabetrasekh R, Sidmand RL and Snyder EY: Neural stem cells as novel cancer therapeutic vehicles. Eur J Cancer 42: 1298-1308, 2006.
6. Ehtesham M, Stevenson CB and Thompson RC: Stem cell therapies for malignant glioma. Neurosurg Focus 19: E5, 2005.
7. Nakamizo A, Marini F, Amano T, et al: Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas. Cancer Res 65: 3307-3318, 2005.
8. Tokalov SV, Grüner S, Schindler S, Iagunov AS, Baumann M and Abolmaali ND: A number of bone marrow mesenchymal stem cells but neither phenotype nor differentiation capacities changes with age of rats. Mol Cells 24: 255-260, 2007.
9. Yang SE, Ha CW, Jung MH, et al: Mesenchymal stem/progenitor cells developed in cultures from UC blood. Cytotherapy 6: 476-486, 2004.
10. Qiao C, Xu W, Zhu W, et al: Human mesenchymal stem cells isolated from the umbilical cord. Cell Biol Int 32: 8-15, 2008. (Pubitemid 351255581)
11. Kim DS, Kim JH, Lee JK, et al: Overexpression of CXC chemokine receptors is required for the superior glioma-tracking property of umbilical cord blood-derived mesenchymal stem cells. Stem Cells Dev 18: 511-519, 2009.
12. Kim SM, Lim JY, Park SI, et al: Gene therapy using TRAILsecreting human umbilical cord blood-derived mesenchymal stem cells against intracranial glioma. Cancer Res 68: 9614-9623, 2008.
13. Yamanaka R, Tanaka R, Saitoh T and Okoshi S: Cytokine gene expression on glioma cell lines and specimens. J Neurooncol 21: 243-247, 1994.
14. Kielian T, Rooijen NV and Hickey WF: MCP-1 expression in CNS-1 astrocytoma cells: implications for macrophage infiltration into tumors in vivo. J Neurooncol 56: 1-12, 2002.
15. Chamberlain G, Wright K, Rot A, Ashton B and Middleton J: Murine mesenchymal stem cells exhibit a restricted repertoire of functional chemokine receptors: comparison with human. Plos One 3: e2934, 2008.
16. Ponte AL, Marais E, Gallay N, et al: The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities. Stem Cells 25: 1737-1745, 2007.
17. Van der Meulen AA, Biber K, Lukovac S, Balasubramaniyan V, den Dunnen WF, Boddeke HW and Mooij JJ: The role of CXCL12-CXCR4 signalling in the migration of neural stem cells towards a brain tumour. Neuropathol Appl Neurobiol 35: 579-591, 2009.
18. Xu Q, Yuan X, Xu M, et al: Chemokine CXC receptor 4- mediated glioma tumor tracking by bone marrow-derived neural progenitor/stem cells. Mol Cancer Ther 9: 2746-2753, 2009.
19. Schmidt NO, Przylecki W, Yang W, et al: Brain tumor tropism of transplanted human neural stem cells is induced by vascular endothelial growth factor. Neoplasia 7: 623-629, 2005.
20. Gutova M, Najbauer J, Frank RT, et al: uPA and uPAR mediate human stem cell tropism to malignant solid tumors. Stem Cells 26: 1406-1413, 2008.
21. Sato H, Kuwashima N, Sakaida T, et al: Epidermal growth factor receptor-transfected bone marrow stromal cells exhibit enhanced migratory response and therapeutic potential against murine brain tumors. Cancer Gene Ther 12: 757-768, 2005.
22. Jurvansuu J, Zhao Y, Leung DSY, Boulaire J, Yu YH, Ahmed S and Wang S: Transmembrane protein 18 enhances the tropism of neural stem cells for glioma cells. Cancer Res 68: 4614-4622, 2008.
23. Miller RJ, Banisadr G and Bhattacharyya BJ: CXCR4 signaling in the regulation of stem cell migration and development. J Neuroimmunol 198: 31-38, 2008.
24. Kahn J, Byk T, Jansson-Sjostrand L, et al: Overexpression of CXCR4 on human CD34+ progenitors increases their proliferation, migration, and NOD/SCID repopulation. Blood 103: 2942-2949, 2004.
25. Xu F and Zhu J-H: Stem cells tropism for malignant gliomas. Neurosci Bull 23: 363-369, 2007.
26. Ehtesham M, Yuan X, Kabos P, et al: Glioma tropic neural stem cells consist of astrocytic precursors and their migratory capacity is mediated by CXCR4. Neoplasia 6: 287-293, 2004. (Pubitemid 38657085)
27. Son BR, Marquez-Curtis LA, Kucia M, et al: Migration of bone marrow and cord blood mesenchymal stem cells in vitro is regulated by stromal-derived factor-1-CXCR4 and hepatocyte growth factor-c-met axes and involves matrix metalloproteinases. Stem Cells 24: 1254-1264, 2006.
28. Kramm CM, Sena-Esteves M, Barnett FH, et al: Gene therapy for brain tumors. Brain Pathol 5: 345-381, 1995.
29. Johnson TV, Bull ND and Martin KR: Identification of barriers to retinal engraftment of transplanted stem cells. Invest Ophthalmol Vis Sci 51: 960-970, 2010.
30. Spaeth E, Klopp A, Dembinski J, Andreeff M and Marini F: Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells. Gene Ther 15:730-738, 2008.
31. Magge SN, Malik SJ, Royo NC, et al: Role of monocyte chemoattractant protein-1 (MCP-1/CCL2) in migration of neural progenitor cells toward glial tumors. J Neurosci Res 87: 1547-1555, 2009.
32. Brat DJ, Bellail AC and van Meir EG: The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis. Neurooncology 7: 122-133, 2005.
33. Dunn IF, Heese O and Black PM: Growth factors in glioma angiogenesis: FGFs, PDGF, EGF, and TGFs. J Neurooncol 50: 121-137, 2000.
34. Schichor C, Birnbaum T, Etminan N, et al: Vascular endothelial growth factor A contributes to glioma-induced migration of human marrow stromal cells (hMSC). Exp Neurol 199: 301-310, 2006
35. Imitola J, Raddassi K, Park KI, et al: Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor1α/CXC chemokine receptor 4 pathway. Proc Natl Acad Sci USA 101: 18117-18122, 2004. (Pubitemid 40054083)
36. Rempel SA, Dudas S, Ge S and Gutiérrez JA: Identification and localization of the cytokine SDF1 and its receptor, CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma. Clin Cancer Res 6: 102-111, 2000.
37. Wang YH, Ho ML, Chang JK, Chu HC, Lai SC and Wang GJ: Microporation is a valuable transfection method for gene expression in human adipose tissue-derived stem cells. Mol Ther 17: 302-308, 2009.