Vitamin D supplementation in older adults: Searching for specific guidelines in nursing homes

Journal of Nutrition, Health and Aging

Volumn 17, Issue 4, 2013, Pages 402-412

  Rolland, Yves ^a,b   De Souto Barreto, P ^a   Van Kan, G Abellan ^a   Annweiler, C ^c   Beauchet, O ^c   Bischoff Ferrari, H ^d   Berrut, G ^e   Blain, H ^f   Bonnefoy, M ^g   Cesari, M ^a,b   Duque, G ^h   Ferry, M ^b   Guerin, O ⁱ   Hanon, O ^j   Lesourd, B ^k   Morley, J ^l   Raynaud Simon, A ^m   Ruault, G ⁿ   Souberbielle, J C ^o   Vellas, B ^a,b  

^a TOULOUSE UNIVERSITY HOSPITAL   (France)

^b INSERM   (France)

^c ANGERS UNIVERSITY HOSPITAL   (France)

^d UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^e NANTES UNIVERSITY HOSPITAL   (France)

^f MONTPELLIER UNIVERSITY HOSPITAL   (France)

^g HOSPICES CIVILS DE LYON   (France)

^h UNIVERSITY OF SYDNEY   (Australia)

ⁱ UNIVERSITY HOSPITAL OF NICE   (France)

^j Paris Descartes University   (France)

^k UNIVERSITÉ CLERMONT AUVERGNE   (France)

^l SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^m BICHAT HOSPITAL   (France)

ⁿ French Society of Geriatrics and Gerontology (SFGG)   (France)

^o HÔPITAL NECKER ENFANTS MALADES   (France)

more..

Author keywords

institution; nursing home; recommendation; resident; Vitamin D

Indexed keywords

CALCIUM; VITAMIN D;

ARTICLE; CALCIUM INTAKE; COST EFFECTIVENESS ANALYSIS; DRUG SAFETY; DRUG TOLERABILITY; FEASIBILITY STUDY; GERIATRIC CARE; HUMAN; INTERVENTION STUDY; NURSING HOME; PRACTICE GUIDELINE; PRIORITY JOURNAL; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; VITAMIN D SUPPLEMENTATION; VITAMIN SUPPLEMENTATION;

EID: 84880696919     PISSN: 12797707     EISSN: 17604788     Source Type: Journal    
DOI: 10.1007/s12603-013-0007-x     Document Type: Article

References (166)

1. Thomas D, Rolland Y, Morley J: Nursing home care. In: John Wiley & Sons L, (eds A. J. Sinclair, J. E. Morley and B. Vellas), ed. Pathy's Principles and Practice of Geriatric Medicine, Volume 1 & 2, Fifth Edition. Chichester, UK, 2012.
2. Rolland Y, Abellan van Kan G, Hermabessiere S, Gerard S, Guyonnet Gillette S, Vellas B:Descriptive study of nursing home residents from the REHPA network. J Nutr Health Aging 2009; 13(8): 679-683.
3. Rolland Y, Andrieu S, Crochard A, Goni S, Hein C, Vellas B: Psychotropic drug consumption at admission and discharge of nursing home residents. J Am Med Dir Assoc 2012; 13(4): 407 e7-12.
4. Duque G, Mallet L, Roberts A, et al.: To treat or not to treat, that is the question: proceedings of the Quebec symposium for the treatment of osteoporosis in long-term care institutions, Saint-Hyacinthe, Quebec, November 5, 2004. J Am Med Dir Assoc 2007; 8(3 Suppl 2): e67-73.
5. Parikh S, Mogun H, Avorn J, Solomon DH: Osteoporosis medication use in nursing home patients with fractures in 1 US state. Arch Intern Med 2008; 168(10): 1111-1115.
6. Cali CM, Kiel DP: An epidemiologic study of fall-related fractures among institutionalized older people. J Am Geriatr Soc 1995; 43(12): 1336-1340.
7. Ooms ME, Vlasman P, Lips P, Nauta J, Bouter LM, Valkenburg HA: The incidence of hip fractures in independent and institutionalized elderly people. Osteoporos Int 1994; 4(1): 6-10.
8. Rudman IW, Rudman D: High rate of fractures for men in nursing homes. Am J Phys Med Rehabil 1989; 68(1): 2-5.
9. Brennannee Saunders J, Johansen A, Butler J, et al.: Place of residence and risk of fracture in older people: a population-based study of over 65-year-olds in Cardiff. Osteoporos Int 2003; 14(6): 515-519.
10. Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, Dawson-Hughes B: Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. Jama 2005; 293(18): 2257-2264.
11. Bischoff-Ferrari HA, Willett WC, Wong JB, et al.: Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Arch Intern Med 2009; 169(6): 551-561.
12. Bischoff-Ferrari HA, Willett WC, Orav EJ, et al.: A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med 2012; 367(1): 40-49.
13. Sawka AM, Ismaila N, Cranney A, et al.: A scoping review of strategies for the prevention of hip fracture in elderly nursing home residents. PLoS One 2010; 5(3): e9515.
14. Tang BM, Eslick GD, Nowson C, Smith C, Bensoussan A: Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet 2007; 370(9588): 657-666.
15. Avenell A, Gillespie WJ, Gillespie LD, O'Connell D: Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis. Cochrane Database Syst Rev 2009 (2): CD000227.
16. Chapuy MC, Arlot ME, Duboeuf F, et al.: Vitamin D3 and calcium to prevent hip fractures in the elderly women. N Engl J Med 1992; 327(23): 1637-1642.
17. Dawson-Hughes B: Impact of vitamin D and calcium on bone and mineral metabolism in older adults.; In: ed. HM, ed. Biologic Effects of Light. Boston, MA: Kluwer Academic Publishers, 2002; 175-183.
18. Lips P: Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev 2001; 22(4): 477-501.
19. Terabe Y, Harada A, Tokuda H, Okuizumi H, Nagaya M, Shimokata H: Vitamin D deficiency in elderly women in nursing homes: investigation with consideration of decreased activation function from the kidneys. J Am Geriatr Soc 2012; 60(2): 251-255.
20. Malik R: Vitamin D and secondary hyperparathyroidism in the institutionalized elderly: a literature review. J Nutr Elder 2007; 26(3-4): 119-138.
21. Lips P, Wiersinga A, van Ginkel FC, et al.: The effect of vitamin D supplementation on vitamin D status and parathyroid function in elderly subjects. J Clin Endocrinol Metab 1988; 67(4): 644-650.
22. Ley SJ, Horwath CC, Stewart JM: Attention is needed to the high prevalence of vitamin D deficiency in our older population. N Z Med J 1999; 112(1101): 471-472.
23. Haller J, Weggemans RM, Lammi-Keefe CJ, Ferry M: Changes in the vitamin status of elderly Europeans: plasma vitamins A, E, B-6, B-12, folic acid and carotenoids. SENECA Investigators. Eur J Clin Nutr 1996; 50Suppl 2: S32-S46.
24. Liu BA, Gordon M, Labranche JM, Murray TM, Vieth R, Shear NH: Seasonal prevalence of vitamin D deficiency in institutionalized older adults. J Am Geriatr Soc 1997; 45(5): 598-603.
25. Lips P, Duong T, Oleksik A, et al.: A global study of vitamin D status and parathyroid function in postmenopausal women with osteoporosis: baseline data from the multiple outcomes of raloxifene evaluation clinical trial. J Clin Endocrinol Metab 2001; 86(3): 1212-1221.
26. Papapetrou PD, Triantafyllopoulou M, Korakovouni A: Severe vitamin D deficiency in the institutionalized elderly. J Endocrinol Invest 2008; 31(9): 784-787.
27. Chel V, Wijnhoven HA, Smit JH, Ooms M, Lips P: Efficacy of different doses and time intervals of oral vitamin D supplementation with or without calcium in elderly nursing home residents. Osteoporos Int 2008; 19(5): 663-671.
28. McKenna MJ: Differences in vitamin D status between countries in young adults and the elderly. Am J Med 1992; 93(1): 69-77.
29. van der Wielen RP, Lowik MR, van den Berg H, et al.: Serum vitamin D concentrations among elderly people in Europe. Lancet 1995; 346(8969): 207-210.
30. Lips P, van Ginkel FC, Jongen MJ, Rubertus F, van der Vijgh WJ, Netelenbos JC: Determinants of vitamin D status in patients with hip fracture and in elderly control subjects. Am J Clin Nutr 1987; 46(6): 1005-1010.
31. McMurtry CT, Young SE, Downs RW, Adler RA: Mild vitamin D deficiency and secondary hyperparathyroidism in nursing home patients receiving adequate dietary vitamin D. J Am Geriatr Soc 1992; 40(4): 343-347.
32. Flicker L, Mead K, MacInnis RJ, et al.: Serum vitamin D and falls in older women in residential care in Australia. J Am Geriatr Soc 2003; 51(11): 1533-1538.
33. O'Dowd KJ, Clemens TL, Kelsey JL, Lindsay R: Exogenous calciferol (vitamin D) and vitamin D endocrine status among elderly nursing home residents in the New York City area. J Am Geriatr Soc 1993; 41(4): 414-421.
34. Wigg AE, Prest C, Slobodian P, Need AG, Cleland LG: A system for improving vitamin D nutrition in residential care. Med J Aust 2006; 185(4): 195-198.
35. Hamid Z, Riggs A, Spencer T, Redman C, Bodenner D: Vitamin D deficiency in residents of academic long-term care facilities despite having been prescribed vitamin D. J Am Med Dir Assoc 2007; 8(2): 71-75.
36. Heaney RP: Barriers to optimizing vitamin D3 intake for the elderly. J Nutr 2006; 136(4): 1123-1125.
37. Gloth FM, 3rd, Gundberg CM, Hollis BW, Haddad JG, Jr.; Tobin JD: Vitamin D deficiency in homebound elderly persons. Jama 1995; 274(21): 1683-1686.
38. Elliott ME, Binkley NC, Carnes M, et al.: Fracture risks for women in long-term care: high prevalence of calcaneal osteoporosis and hypovitaminosis D. Pharmacotherapy 2003; 23(6): 702-710.
39. Broe KE, Chen TC, Weinberg J, Bischoff-Ferrari HA, Holick MF, Kiel DP: A higher dose of vitamin d reduces the risk of falls in nursing home residents: a randomized, multipledose study. J Am Geriatr Soc 2007; 55(2): 234-239.
40. Pilz S, Dobnig H, Tomaschitz A, et al.: Low 25-hydroxyvitamin D is associated with increased mortality in female nursing home residents. J Clin Endocrinol Metab 2012; 97(4): E653-E657.
41. Flicker L, MacInnis RJ, Stein MS, et al.: Should older people in residential care receive vitamin D to prevent falls? Results of a randomized trial. J Am Geriatr Soc 2005; 53(11): 1881-1888.
42. Stein MS, Wark JD, Scherer SC, et al.: Falls relate to vitamin D and parathyroid hormone in an Australian nursing home and hostel. J Am Geriatr Soc 1999; 47(10): 1195-1201.
43. Duque G, Mallet L, Roberts A, et al.: To treat or not to treat, that is the question: proceedings of the Quebec Symposium for the Treatment of Osteoporosis in Long-term Care Institutions, Saint-Hyacinthe, Quebec, November 5, 2004. J Am Med Dir Assoc 2006; 7(7): 435-441.
44. Zochling J, Chen JS, Seibel M, et al.: Calcium metabolism in the frail elderly. Clin Rheumatol 2005; 24(6): 576-582.
45. Pietschmann P, Azizi-Semrad U, Pils K, Fahrleitner-Pammer A, Resch H, Dobnig H: Pharmacologic undertreatment of osteoporosis in Austrian nursing homes and senior's residences. Wien Klin Wochenschr 2010; 122(17-18): 532-537.
46. Perez-Llamas F, Lopez-Contreras MJ, Blanco MJ, Lopez-Azorin F, Zamora S, Moreiras O: Seemingly paradoxical seasonal influences on vitamin D status in nursing-home elderly people from a Mediterranean area. Nutrition 2008; 24(5): 414-420.
47. Rolland Y: Vitamin D deficiency and its impact on functionality in nursing homes. In: meeting IAGG, ed. Paris, 2009; personal communication.
48. Gupta G, Aronow WS: Underuse of procedures for diagnosing osteoporosis and of therapies for osteoporosis in older nursing home residents. J Am Med Dir Assoc 2003; 4(4): 200-202.
49. Kamel HK: Underutilization of calcium and vitamin D supplements in an academic longterm care facility. J Am Med Dir Assoc 2004; 5(2): 98-100.
50. Chandler JM, Zimmerman SI, Girman CJ, et al.: Low bone mineral density and risk of fracture in white female nursing home residents. Jama 2000; 284(8): 972-977.
51. Wright RM: Use of osteoporosis medications in older nursing facility residents. J Am Med Dir Assoc 2007; 8(7): 453-457.
52. Suominen MH, Hosia-Randell HM, Muurinen S, et al.: Vitamin D and calcium supplementation among aged residents in nursing homes. J Nutr Health Aging 2007; 11(5): 433-437.
53. Colon-Emeric C, Lyles KW, Levine DA, et al.: Prevalence and predictors of osteoporosis treatment in nursing home residents with known osteoporosis or recent fracture. Osteoporos Int 2007; 18(4): 553-559.
54. Ross AC, Manson JE, Abrams SA, et al.: The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab 2011; 96(1): 53-58.
55. Dawson-Hughes B, Mithal A, Bonjour JP, et al.: IOF position statement: vitamin D recommendations for older adults. Osteoporos Int 2010; 21(7): 1151-1154.
56. Souberbielle JC, Body JJ, Lappe JM, et al.: Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practice. Autoimmun Rev 2010; 9(11): 709-715.
57. Mosekilde L: Vitamin D requirement and setting recommendation levels: long-term perspectives. Nutr Rev 2008; 66(10 Suppl 2): S170-S177.
58. Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ, Vieth R: Estimates of optimal vitamin D status. Osteoporos Int 2005; 16(7): 713-716.
59. Tangpricha V, Pearce EN, Chen TC, Holick MF: Vitamin D insufficiency among free-living healthy young adults. Am J Med 2002; 112(8): 659-662.
60. Barger-Lux MJ, Heaney RP, Dowell S, Chen TC, Holick MF: Vitamin D and its major metabolites: serum levels after graded oral dosing in healthy men. Osteoporos Int 1998; 8(3): 222-230.
61. Bischoff Ferrari HA: Validated treatments and therapeutic perspectives regarding nutritherapy. J Nutr Health Aging 2009; 13(8): 737-741.
62. Gallagher JC, Sai A, Templin T, 2nd, Smith L: Dose response to vitamin D supplementation in postmenopausal women: a randomized trial. Ann Intern Med 2012; 156(6): 425-437.
63. Zittermann A, Iodice S, Pilz S, Grant WB, Bagnardi V, Gandini S: Vitamin D deficiency and mortality risk in the general population: a meta-analysis of prospective cohort studies. Am J Clin Nutr 2012; 95(1): 91-100.
64. Naesgaard PA, Leon De La Fuente RA, Nilsen ST, et al.: Serum 25(OH)D Is a 2-Year Predictor of All-Cause Mortality, Cardiac Death and Sudden Cardiac Death in Chest Pain Patients from Northern Argentina. PLoS One 2012; 7(9): e43228.
65. Sun Q, Shi L, Rimm EB, et al.: Vitamin D intake and risk of cardiovascular disease in US men and women. Am J Clin Nutr 2012; 94(2): 534-542.
66. Michaelsson K, Baron JA, Snellman G, et al.: Plasma vitamin D and mortality in older men: a community-based prospective cohort study. Am J Clin Nutr 2010; 92(4): 841-848.
67. Szulc P, Duboeuf F, Marchand F, Delmas PD: Hormonal and lifestyle determinants of appendicular skeletal muscle mass in men: the MINOS study. Am J Clin Nutr 2004; 80(2): 496-503.
68. Sato Y, Iwamoto J, Kanoko T, Satoh K: Low-dose vitamin D prevents muscular atrophy and reduces falls and hip fractures in women after stroke: a randomized controlled trial. Cerebrovasc Dis 2005; 20(3): 187-192.
69. Visser M, Deeg DJ, Lips P: Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): the Longitudinal Aging Study Amsterdam. J Clin Endocrinol Metab 2003; 88(12): 5766-5772.
70. Bonjour JP, Benoit V, Pourchaire O, Ferry M, Rousseau B, Souberbielle JC: Inhibition of markers of bone resorption by consumption of vitamin D and calcium-fortified soft plain cheese by institutionalised elderly women. Br J Nutr 2009; 102(7): 962-966.
71. Reid IR, Bolland MJ, Grey A: Effect of calcium supplementation on hip fractures. Osteoporos Int 2008; 19(8): 1119-1123.
72. Cranney A, Weiler HA, O'Donnell S, Puil L: Summary of evidence-based review on vitamin D efficacy and safety in relation to bone health. Am J Clin Nutr 2008; 88(2): 513S-519S.
73. Sanders KM, Stuart AL, Williamson EJ, et al.: Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. JAMA 2010; 303(18): 1815-1822.
74. Cranney A, Horsley T, O'Donnell S, et al.: Effectiveness and safety of vitamin D in relation to bone health. Evid Rep Technol Assess (Full Rep) 2007 (158): 1-235.
75. Boonen S, Lips P, Bouillon R, Bischoff-Ferrari HA, Vanderschueren D, Haentjens P: Need for additional calcium to reduce the risk of hip fracture with vitamin d supplementation: evidence from a comparative metaanalysis of randomized controlled trials. J Clin Endocrinol Metab 2007; 92(4): 1415-1423.
76. Group DIPART G: Patient level pooled analysis of 68 500 patients from seven major vitamin D fracture trials in US and Europe. Bmj 2010; 340: b5463.
77. Lyons RA, Johansen A, Brophy S, et al.: Preventing fractures among older people living in institutional care: a pragmatic randomised double blind placebo controlled trial of vitamin D supplementation. Osteoporos Int 2007; 18(6): 811-818.
78. Law M, Withers H, Morris J, Anderson F: Vitamin D supplementation and the prevention of fractures and falls: results of a randomised trial in elderly people in residential accommodation. Age Ageing 2006; 35(5): 482-486.
79. Rizzoli R, Bruyere O, Cannata-Andia JB, et al.: Management of osteoporosis in the elderly. Curr Med Res Opin 2009; 25(10): 2373-2387.
80. Porthouse J, Cockayne S, King C, et al.: Randomised controlled trial of calcium and supplementation with cholecalciferol (vitamin D3) for prevention of fractures in primary care. Bmj 2005; 330(7498): 1003.
81. Parfitt AM, Gallagher JC, Heaney RP, Johnston CC, Neer R, Whedon GD: Vitamin D and bone health in the elderly. Am J Clin Nutr 1982; 36(5 Suppl): 1014-1031.
82. Verhaar HJ, Samson MM, Jansen PA, de Vreede PL, Manten JW, Duursma SA: Muscle strength, functional mobility and vitamin D in older women. Aging (Milano) 2000; 12(6): 455-460.
83. Latham NK, Anderson CS, Reid IR: Effects of vitamin D supplementation on strength, physical performance, and falls in older persons: a systematic review. J Am Geriatr Soc 2003; 51(9): 1219-1226.
84. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al.: Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011; 96(7): 1911-1930.
85. Reid IR, Bolland MJ: Role of vitamin D deficiency in cardiovascular disease. Heart 2012; 98(8): 609-614.
86. Norman PE, Powell JT: Vitamin D, shedding light on the development of disease in peripheral arteries. Arterioscler Thromb Vasc Biol 2005; 25(1): 39-46.
87. Annweiler C, Schott AM, Rolland Y, Blain H, Herrmann FR, Beauchet O: Dietary intake of vitamin D and cognition in older women: a large population-based study. Neurology 2010; 75(20): 1810-1816.
88. Mora JR, Iwata M, von Andrian UH: Vitamin effects on the immune system: vitamins A and D take centre stage. Nat Rev Immunol 2008; 8(9): 685-698.
89. Yao SG, Fine JB: A review of vitamin D as it relates to periodontal disease. Compend Contin Educ Dent 2012; 33(3): 166-171; quiz 172, 182.
90. Shao T, Klein P, Grossbard ML: Vitamin D and breast cancer. Oncologist 2012; 17(1): 36-45.
91. Barreto PS LMM, Mathieu C, C, Piau C, Bouget C, Vellas B, Rolland Y: A multicentric individually-tailored controlled trial of education and professional support to nursing home staff: research protocol and baseline data of the IQUARE study. J Nutr Health Aging 2013;17(2):173-178.
92. Autier P, Gandini S: Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials. Arch Intern Med 2007; 167(16): 1730-1737.
93. Schaller F, Sidelnikov E, Theiler R, et al.: Mild to moderate cognitive impairment is a major risk factor for mortality and nursing home admission in the first year after hip fracture. Bone 2012; 51(3): 347-352.
94. Rossini M, Bianchi G, Di Munno O, et al.: Determinants of adherence to osteoporosis treatment in clinical practice. Osteoporos Int 2006; 17(6): 914-921.
95. Heaney RP, Davies KM, Chen TC, Holick MF, Barger-Lux MJ: Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr 2003; 77(1): 204-210.
96. Chapuy MC, Pamphile R, Paris E, et al.: Combined calcium and vitamin D3 supplementation in elderly women: confirmation of reversal of secondary hyperparathyroidism and hip fracture risk: the Decalyos II study. Osteoporos Int 2002; 13(3): 257-264.
97. Przybelski R, Agrawal S, Krueger D, Engelke JA, Walbrun F, Binkley N: Rapid correction of low vitamin D status in nursing home residents. Osteoporos Int 2008; 19(11): 1621-1628.
98. Schwalfenberg GK, Genuis SJ: Vitamin D supplementation in a nursing home population. Mol Nutr Food Res 2010; 54(8): 1072-1076.
99. Hathcock JN, Shao A, Vieth R, Heaney R: Risk assessment for vitamin D. Am J Clin Nutr 2007; 85(1): 6-18.
100. Board FaN: DRI Dietary Reference Intake for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, 1997.
101. Chung M, Lee J, Terasawa T, Lau J, Trikalinos TA: Vitamin D with or without calcium supplementation for prevention of cancer and fractures: an updated meta-analysis for the U.S. Preventive Services Task Force. Ann Intern Med 2011; 155(12): 827-838.
102. Dawson-Hughes B, Harris SS: High-dose vitamin D supplementation: too much of a good thing? JAMA 2010; 303(18): 1861-1862.
103. Beckman MJ, Johnson JA, Goff JP, Reinhardt TA, Beitz DC, Horst RL: The role of dietary calcium in the physiology of vitamin D toxicity: excess dietary vitamin D3 blunts parathyroid hormone induction of kidney 1-hydroxylase. Arch Biochem Biophys 1995; 319(2): 535-539.
104. Bischoff-Ferrari HA, Dietrich T, Orav EJ, et al.: Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged > or =60 y. Am J Clin Nutr 2004; 80(3): 752-758.
105. Bischoff-Ferrari HA, Dawson-Hughes B, Platz A, et al.: Effect of high-dosage cholecalciferol and extended physiotherapy on complications after hip fracture: a randomized controlled trial. Arch Intern Med 2010; 170(9): 813-820.
106. Wallace RB, Wactawski-Wende J, O'Sullivan MJ, et al.: Urinary tract stone occurrence in the Women's Health Initiative (WHI) randomized clinical trial of calcium and vitamin D supplements. Am J Clin Nutr 2011; 94(1): 270-277.
107. Bolland MJ, Grey A, Avenell A, Gamble GD, Reid IR: Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis. Bmj 2011; 342: d2040.
108. Reid IR, Bolland MJ, Avenell A, Grey A: Cardiovascular effects of calcium supplementation. Osteoporos Int 2012; 22(6): 1649-1658.
109. Bischoff HA, Stahelin HB, Dick W, et al.: Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. J Bone Miner Res 2003; 18(2): 343-351.
110. de Paula FJ, Rosen CJ: Vitamin D safety and requirements. Arch Biochem Biophys 2011; 523(1): 64-72.
111. Kinder BK, Stewart AF: Hypercalcemia. Curr Probl Surg 2002; 39(4): 349-448.
112. Cardus A, Panizo S, Parisi E, Fernandez E, Valdivielso JM: Differential effects of vitamin D analogs on vascular calcification. J Bone Miner Res 2007; 22(6): 860-866.
113. Qunibi WY, Nolan CA, Ayus JC: Cardiovascular calcification in patients with end-stage renal disease: a century-old phenomenon. Kidney Int Suppl 2002 (82): S73-S80.
114. Steingrimsdottir L, Gunnarsson O, Indridason OS, Franzson L, Sigurdsson G: Relationship between serum parathyroid hormone levels, vitamin D sufficiency, and calcium intake. Jama 2005; 294(18): 2336-2341.
115. Bischoff-Ferrari HA, Kiel DP, Dawson-Hughes B, et al.: Dietary calcium and serum 25-hydroxyvitamin D status in relation to BMD among U.S. adults. J Bone Miner Res 2009; 24(5): 935-942.
116. Duque G, Close JJ, de Jager JP, et al. Treatment for osteoporosis in Australian residential aged care facilities: consensus recommendations for fracture prevention. Med J Aust 2010; 193(3): 173-179.
117. Souberbielle JC, Prie D, Courbebaisse M, et al. Update on vitamin D and evaluation of vitamin D status. Ann Endocrinol (Paris) 2008; 69(6): 501-510.
118. Souberbielle JC, Courbebaisse M, Cormier C, et al.: When should we measure vitamin D concentration in clinical practice? Scand J Clin Lab Invest Suppl 2012; 243: 129-135.
119. AGS expert panel. Recommendations for Vitamin D to Reduce Falls and Injuries in Older Adults. AGS meeting, Seattle, Oral communication. 5 May 2012, 2012.
120. Snellman G, Melhus H, Gedeborg R, et al.: Determining vitamin D status: a comparison between commercially available assays. PLoS One; 5(7): e11555.
121. Doupe M, Brownell M, St John P, Strang DG, Chateau D, Dik N: Nursing home adverse events: further insight into highest risk periods. J Am Med Dir Assoc 2011; 12(6): 467-474.
122. Tolson D, Rolland Y, Andrieu S, et al. International Association of Gerontology and Geriatrics: a global agenda for clinical research and quality of care in nursing homes. J Am Med Dir Assoc 2011; 12(3): 184-189.
123. Nowson CA, Margerison C. Vitamin D intake and vitamin D status of Australians. Med J Aust 2002; 177(3): 149-152.
124. Holick MF, Biancuzzo RM, Chen TC, et al. Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. J Clin Endocrinol Metab 2008; 93(3): 677-681.
125. Mistretta VI, Delanaye P, Chapelle JP, Souberbielle JC, Cavalier E. Vitamin D2 or vitamin D3?. Rev Med Interne 2008; 29(10): 815-820.
126. Armas LA, Hollis BW, Heaney RP: Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab 2004; 89(11): 5387-5391.
127. Romagnoli E, Mascia ML, Cipriani C, et al.: Short and long-term variations in serum calciotropic hormones after a single very large dose of ergocalciferol (vitamin D2) or cholecalciferol (vitamin D3) in the elderly. J Clin Endocrinol Metab 2008; 93(8): 3015-3020.
128. Mocanu V, Stitt PA, Costan AR, et al.: Long-term effects of giving nursing home residents bread fortified with 125 microg (5000 IU) vitamin D(3) per daily serving. Am J Clin Nutr 2009; 89(4): 1132-1137.
129. Chel VG, Ooms ME, Pavel S, de Gruijl F, Brand A, Lips P: Prevention and treatment of vitamin D deficiency in Dutch psychogeriatric nursing home residents by weekly half-body UVB exposure after showering: a pilot study. Age Ageing 2011; 40(2): 211-214.
130. Reid IR, Gallagher DJ, Bosworth J: Prophylaxis against vitamin D deficiency in the elderly by regular sunlight exposure. Age Ageing 1986; 15(1): 35-40.
131. Young V GC: Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutritional Board. Institute of Medicine. Intakes SCotSEoDR. National Academy Press. Washington, DC, 1997.
132. Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B: Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr 2006; 84(1): 18-28.
133. Holick MF: Vitamin D deficiency. N Engl J Med 2007; 357(3): 266-281.
134. Demontiero O, Herrmann M, Duque G: Supplementation with vitamin D and calcium in long-term care residents. J Am Med Dir Assoc 2011; 12(3): 190-194.
135. Egsmose C, Lund B, McNair P, Lund B, Storm T, Sorensen OH: Low serum levels of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in institutionalized old people: influence of solar exposure and vitamin D supplementation. Age Ageing 1987; 16(1): 35-40.
136. Sem SW, Sjoen RJ, Trygg K, Pedersen JI: Vitamin D status of two groups of elderly in Oslo: living in old people's homes and living in own homes. Compr Gerontol A 1987; 1(3): 126-130.
137. Webb AR, Pilbeam C, Hanafin N, Holick MF: An evaluation of the relative contributions of exposure to sunlight and of diet to the circulating concentrations of 25-hydroxyvitamin D in an elderly nursing home population in Boston. Am J Clin Nutr 1990; 51(6): 1075-1081.
138. Himmelstein S, Clemens TL, Rubin A, Lindsay R: Vitamin D supplementation in elderly nursing home residents increases 25(OH)D but not 1,25(OH)2D. Am J Clin Nutr 1990; 52(4): 701-706.
139. Lowik MR, van den Berg H, Schrijver J, Odink J, Wedel M, van Houten P: Marginal nutritional status among institutionalized elderly women as compared to those living more independently (Dutch Nutrition Surveillance System). J Am Coll Nutr 1992; 11(6): 673-681.
140. Komar L, Nieves J, Cosman F, Rubin A, Shen V, Lindsay R: Calcium homeostasis of an elderly population upon admission to a nursing home. J Am Geriatr Soc 1993; 41(10): 1057-1064.
141. Stein MS, Scherer SC, Walton SL, et al.: Risk factors for secondary hyperparathyroidism in a nursing home population. Clin Endocrinol (Oxf) 1996; 44(4): 375-383.
142. Plantalech L, Knoblovits P, Cambiazzo E, et al.: [Hypervitaminosis D in institutionalized elderly in Buenos Aires]. Medicina (B Aires) 1997; 57(1): 29-35.
143. Kinyamu HK, Gallagher JC, Balhorn KE, Petranick KM, Rafferty KA: Serum vitamin D metabolites and calcium absorption in normal young and elderly free-living women and in women living in nursing homes. Am J Clin Nutr 1997; 65(3): 790-797.
144. Krieg MA, Jacquet AF, Bremgartner M, Cuttelod S, Thiebaud D, Burckhardt P: Effect of supplementation with vitamin D3 and calcium on quantitative ultrasound of bone in elderly institutionalized women: a longitudinal study. Osteoporos Int 1999; 9(6): 483-488.
145. Nashimoto M, Nakamura K, Matsuyama S, Hatakeyama M, Yamamoto M: Hypovitaminosis D and hyperparathyroidism in physically inactive elderly Japanese living in nursing homes: relationship with age, sunlight exposure and activities of daily living. Aging Clin Exp Res 2002; 14(1): 5-12.
146. Sambrook PN, Chen JS, March LM, et al.: Serum parathyroid hormone predicts time to fall independent of vitamin D status in a frail elderly population. J Clin Endocrinol Metab 2004; 89(4): 1572-1576.
147. Drinka PJ, Krause PF, Nest LJ, Goodman BM: Determinants of vitamin D levels in nursing home residents. J Am Med Dir Assoc 2007; 8(2): 76-79.
148. Rinaldi I, Setiati S, Oemardi M, Aries W, Tamin TZ: Correlation between serum vitamin D (25(OH)D) concentration and quadriceps femoris muscle strength in Indonesian elderly women living in three nursing homes. Acta Med Indones 2007; 39(3): 107-111.
149. Braddy KK, Imam SN, Palla KR, Lee TA: Vitamin d deficiency/insufficiency
150. Verhoeven V, Vanpuyenbroeck K, Lopez-Hartmann M, Wens J, Remmen R: Walk on the sunny side of life - epidemiology of hypovitaminosis D and mental health in elderly nursing home residents. J Nutr Health Aging 2012; 16(4): 417-420.
151. Kruavit A, Chailurkit LO, Thakkinstian A, Sriphrapradang C, Rajatanavin R: Prevalence of Vitamin D insufficiency and low bone mineral density in elderly Thai nursing home residents. BMC Geriatr 2012; 12(1): 49.
152. Salle B, Duhamel J, Souberbielle J et al. Statut vitaminique, role extra osseux et besoins quotidiens en vitamine D. Rapport, conclusions et recommandations. Académie Nationale de Médecine, 2012; 40.
153. Papaioannou A, Morin S, Cheung AM, et al.: 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summary. Cmaj 2010; 182(17): 1864-1873.
154. Michael YL, Whitlock EP, Lin JS, Fu R, O'Connor EA, Gold R: Primary care-relevant interventions to prevent falling in older adults: a systematic evidence review for the U.S. Preventive Services Task Force. Ann Intern Med 2010; 153(12): 815-825.
155. Morley JE, Argiles JM, Evans WJ, et al.: Nutritional recommendations for the management of sarcopenia. J Am Med Dir Assoc 2010; 11(6): 391-396.
156. Norman AW, Bouillon R, Whiting SJ, Vieth R, Lips P: 13th Workshop consensus for vitamin D nutritional guidelines. J Steroid Biochem Mol Biol 2007; 103(3-5): 204-205.
157. Himeno M, Tsugawa N, Kuwabara A, et al.: Effect of vitamin D supplementation in the institutionalized elderly. J Bone Miner Metab 2009; 27(6): 733-737.
158. Becker W, Alexander J, Andersen S, et al.: [Nordic nutrition recommendations]. Ugeskr Laeger 2006; 168(1): 76-77; author reply 77.
159. American M, Directors, Associations, (AMDA). Osteoporosis in assisted living. In: Stefanacci RG, ed. Assisted living consul, vol September/October Vol. 1, Number 5. Philadelphia, 2005; 30-34.
160. Kasiske BL CB, Rosenberg M, Foley R, Swan S, eds.: K/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease. Am J Kidney Dis 2003; 42(4 Suppl 3): S1-S201.
161. Close JC, McMurdo ME: Falls and bone health services for older people. Age Ageing 2003; 32(5): 494-496.
162. Cumming C GC, Hallberg L, et al. Rome: Food and Nutrition, Division F: Human Vitamin and Mineral Requirements. Report of a Joint FAO/WHO Expert Consultation, Bangkok. Thailand. In: Rome FaNDF, ed. FAO Rome, 2001; 303.
163. Prentice A: What are the dietary requirements for calcium and vitamin D? Calcif Tissue Int 2002; 70(2): 83-88.
164. Erbersdobler H EI, Keller U, Walter P.: Referenzwerte für die Nährstoffzufuhr. Deutsche Gesellschaft für Ernährung, Österreichische Gesellschaft für Ernährung, Schweizerische Gesellschaft für Ernährungsforschung, Schweizerchen Vereinigung für Ernährung. Frankfurt am Main: Umschau/Braus, 2000.
165. Finnish Endocrinological Society FMS: Osteoporosis. Current Care Guidelines. 2000.
166. Printice AAP, Bolton-Smith C, et al.; Working Group on the Nutritional Status of the Population of the Committee on Medical Aspects of Food and Nutrition Policy.: Nutrition and Bone Health: with Particular Reference to Calcium and Vitamin D. Report of the Subgroup on Bone Health. London: The Stationery Office, 1998.