Low 25-hydroxyvitamin D is associated with increased mortality in female nursing home residents

Journal of Clinical Endocrinology and Metabolism

Volumn 97, Issue 4, 2012, Pages

  Pilz, Stefan ^a,b   Dobnig, Harald ^a   Tomaschitz, Andreas ^a   Kienreich, Katharina ^a   Meinitzer, Andreas ^a   Friedl, Claudia ^a   Wagner, Doris ^a   Piswanger Sol̈kner, Claudia ^a   Mar̈z, Winfried ^a,c,d   Fahrleitner Pammer, Astrid ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c SYNLAB ACADEMY   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D;

AGED; ARTICLE; AUSTRIA; COHORT ANALYSIS; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; GERIATRIC PATIENT; HAZARD RATIO; HUMAN; MAJOR CLINICAL STUDY; MORTALITY; NURSING HOME; NURSING HOME PATIENT; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK FACTOR; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; WINTER;

25-HYDROXYVITAMIN D 2; AGED; AGED, 80 AND OVER; AGING; AUSTRIA; CALCIFEDIOL; COHORT STUDIES; FEMALE; FOLLOW-UP STUDIES; FRAIL ELDERLY; HOMES FOR THE AGED; HUMANS; MORTALITY; MULTIVARIATE ANALYSIS; NURSING HOMES; PREVALENCE; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; SEASONS; VITAMIN D DEFICIENCY;

EID: 84859548233     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2011-3043     Document Type: Article

References (22)

1. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Jones G, Kovacs CS, Mayne ST, Rosen CJ, Shapses SA 2011 The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab 96:53-58
2. Lips P 2001 Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev 22:477-501 (Pubitemid 32762324)
3. Malik R 2007 Vitamin D and secondary hyperparathyroidism in the institutionalized elderly: a literature review. J Nutr Elder 26:119-138 (Pubitemid 351664742)
4. Dawson-Hughes B, Mithal A, Bonjour JP, Boonen S, Burckhardt P, Fuleihan GE, Josse RG, Lips P, Morales-Torres J, Yoshimura N 2010 IOF position statement: vitamin D recommendations for older adults. Osteoporos Int 21:1151-1154
5. Souberbielle JC, Body JJ, Lappe JM, Plebani M, Shoenfeld Y, Wang TJ, Bischoff-Ferrari HA, Cavalier E, Ebeling PR, Fardellone P, Gandini S, Gruson D, Guérin AP, Heickendorff L, Hollis BW, Ish-Shalom S, Jean G, von Landenberg P, Largura A, Olsson T, Pierrot-Deseilligny C, Pilz S, Tincani A, Valcour A, Zittermann A 2010 Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: recommendations for clinical practice. Autoimmun Rev 9:709-715
6. Bjelakovic G, Gluud LL, Nikolova D, Whitfield K, Wetterslev J, Simonetti RG, Bjelakovic M, Gluud C 2011 Vitamin D supplementation for prevention of mortality in adults. Cochrane Database Syst Rev 7:CD007470
7. Pilz S, Iodice S, Zittermann A, Grant WB, Gandini S 2011 Vitamin D status and mortality risk in CKD: a meta-analysis of prospective studies. Am J Kidney Dis 58:374-382
8. Zittermann A, Iodice S, Pilz S, Grant WB, Bagnardi V, Gandini S 2012 Vitamin D deficiency and mortality risk in the general population: a meta-analysis of prospective cohort studies. Am J Clin Nutr 95:91-100
9. Sambrook PN, Chen JS, March LM, Cameron ID, Cumming RG, Lord SR, Schwarz J, Seibel MJ 2004 Serum parathyroid hormone is associated with increased mortality independent of 25-hydroxy vitamin d status, bone mass, and renal function in the frail and very old: a cohort study. J Clin Endocrinol Metab 89:5477-5481 (Pubitemid 39518428)
10. Dobnig H, Piswanger-Sölkner JC, Roth M, Obermayer-Pietsch B, Tiran A, Strele A, Maier E, Maritschnegg P, Sieberer C, Fahrleitner-Pammer A 2006 Type 2 diabetes mellitus in nursing home patients: effects on bone turnover, bone mass, and fracture risk. J Clin Endocrinol Metab 91:3355-3363 (Pubitemid 44402104)
11. Dobnig H, Piswanger-Sölkner JC, Obermayer-Pietsch B, Tiran A, Strele A, Maier E, Maritschnegg P, Riedmüller G, Brueck C, Fahrleitner-Pammer A 2007 Hip and nonvertebral fracture prediction in nursing home patients: role of bone ultrasound and bone marker measurements. J Clin Endocrinol Metab 92:1678-1686 (Pubitemid 46997171)
12. Papapetrou PD, Triantafyllopoulou M, Korakovouni A 2008 Severe vitamin D deficiency in the institutionalized elderly. J Endocrinol Invest 31:784-787
13. Lips P, Wiersinga A, van Ginkel FC, Jongen MJ, Netelenbos JC, Hackeng WH, Delmas PD, van der Vijgh WJ 1988 The effect of vitamin D supplementation on vitamin D status and parathyroid function in elderly subjects. J Clin Endocrinol Metab 67:644-650
14. Chel V, Wijnhoven HA, Smit JH, Ooms M, Lips P 2008 Efficacy of different doses and time intervals of oral vitamin D supplementation with or without calcium in elderly nursing home residents. Osteoporos Int 19:663-671 (Pubitemid 351642168)
15. McKenna MJ 1992 Differences in vitamin D status between countries in young adults and the elderly. Am J Med 93:69-77
16. Cawthon PM, Parimi N, Barrett-Connor E, Laughlin GA, Ensrud KE, Hoffman AR, Shikany JM, Cauley JA, Lane NE, Bauer DC, Orwoll ES, Cummings SR; Osteoporotic Fractures in Men (MrOS) Research Group 2010 Serum 25-hydroxyvitamin D, parathyroid hormone, and mortality in older men. J Clin Endocrinol Metab 95:4625-4634
17. Bouillon R, Carmeliet G, Verlinden L, van Etten E, Verstuyf A, Luderer HF, Lieben L, Mathieu C, Demay M 2008 Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev 29:726-776
18. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM; Endocrine Society 2011 Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96:1911-1930
19. Stockton KA, Mengersen K, Paratz JD, Kandiah D, Bennell KL 2011 Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis. Osteoporos Int 22:859-871
20. Zittermann A, Grant WB 2009 25-Hydroxyvitamin D levels and all-cause mortality. Arch Intern Med 169:1075-1076
21. Pilz S, Tomaschitz A, März W, Drechsler C, Ritz E, Zittermann A, Cavalier E, Pieber TR, Lappe JM, Grant WB, Holick MF, Dekker JM 2011 Vitamin D, cardiovascular disease and mortality. Clin Endocrinol (Oxf) 75:575-584
22. Pilz S, Tomaschitz A, Obermayer-Pietsch B, Dobnig H, Pieber TR 2009 Epidemiology of vitamin D insufficiency and cancer mortality. Anticancer Res 29:3699-3704