Supplementation With Vitamin D and Calcium in Long-Term Care Residents

Journal of the American Medical Directors Association

Volumn 12, Issue 3, 2011, Pages 190-194

  Demontiero, Oddom ^a   Herrmann, Markus ^a   Duque, Gustavo ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Calcium; Falls; Fractures; Nursing homes; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; CALCIUM; COLECALCIFEROL; VITAMIN D;

BONE DENSITY; CALCIUM ABSORPTION; CALCIUM BLOOD LEVEL; CALCIUM INTAKE; CALCIUM TRANSPORT; DIET SUPPLEMENTATION; FALLING; GERIATRIC NUTRITION; HUMAN; HYPERCALCEMIA; HYPERCALCIURIA; MUSCLE FUNCTION; NURSING HOME PATIENT; OUTCOME ASSESSMENT; REVIEW; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION;

EID: 79951683546     PISSN: 15258610     EISSN: 15389375     Source Type: Journal    
DOI: 10.1016/j.jamda.2010.09.013     Document Type: Review

References (59)

1. Bischoff-Ferrari H.A., Dawson-Hughes B. Where do we stand on vitamin D?. Bone 2007, 41:S13-S19.
2. Bischoff-Ferrari H.A., Giovannucci E., Willett W.C., et al. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr 2006, 84:18-28.
3. Adams J.S., Hewison M. Update in vitamin D. J Clin Endocrinol Metab 2010, 95:471-478.
4. Montero-Odasso M., Duque G. Vitamin D in the aging musculoskeletal system: An authentic strength preserving hormone. Mol Aspects Med 2005, 26:203-219.
5. Braddy K.K., Imam S.N., Palla K.R., Lee T.A. Vitamin D deficiency/insufficiency practice patterns in a Veterans Health Administration long-term care population: A retrospective analysis. J Am Med Dir Assoc 2009, 10:653-657.
6. Papapetrou P.D., Triantafyllopoulou M., Korakovouni A. Severe vitamin D deficiency in the institutionalized elderly. J Endocrinol Invest 2008, 31:784-787.
7. Visser M., Deeg D.J., Puts M.T., et al. Low serum concentrations of 25-hydroxyvitamin D in older persons and the risk of nursing home admission. Am J Clin Nutr 2006, 84:616-622.
8. Stein M., Wark J.D., Scherer S.C., et al. Falls relate to vitamin D and parathyroid hormone in an Australian nursing home and hostel. J Am Ger Soc 1999, 47:1195-1201.
9. Hamid Z., Riggs A., Spencer T., et al. Vitamin D deficiency in residents of academic long-term care facilities despite having been prescribed vitamin D. J Am Med Dir Assoc 2007, 8:71-75.
10. Brennan J., Johansen A., Butler J., et al. Place of residence and risk of fracture in older people: A population-based study of over 65-year-olds in Cardiff. Osteoporosis Int 2003, 14:515-519.
11. Aspray T.J., Stevenson P., Abdy S.E., et al. Low bone mineral density measurements in care home residents-a treatable cause of fractures. Age Ageing 2006, 35:37-41.
12. Ballard C.G., Shaw F., Lowery K., et al. The prevalence, assessment and associations of falls in dementia with Lewy bodies and Alzheimer's disease. Dement Geriatr Cogn Disord 1999, 10:97-103.
13. DeLuca H.F. Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr 2004, 80:1689S-1696S.
14. Heaney R.P. Quantifying human calcium absorption using pharmacokinetic methods. J Nutr 2003, 133:1224-1226.
15. Heaney R.P., Dowell M.S., Hale C.A., Bendich A. Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D. J Am Coll Nutr 2003, 22:142-146.
16. Holick M.F. Vitamin D deficiency. N Engl J Med 2007, 357:266-281.
17. Duque G., Macoritto M., Dion N., et al. 1,25(OH)2D3 acts as a bone forming agent in the hormone-independent senescence-accelerated mouse (SAM-P/6). Am J Physiol Endocrinol Metab 2005, 288:E723-E730.
18. Duque G., Macoritto M., Kremer R. 1,25(OH)2D3 inhibits bone marrow adipogenesis in senescence accelerated mice (SAM-P/6) by decreasing the expression of peroxisome proliferator-activated receptor gamma 2 (PPARgamma2). Exp Gerontol 2004, 39:333-338.
19. Duque G., Troen B.R. Understanding the mechanisms of senile osteoporosis: New facts for a major geriatric syndrome. J Am Geriatr Soc 2008, 56:935-941.
20. Boland R. Role of vitamin D in skeletal muscle function. Endocr Rev 1986, 7:434-438.
21. de Boland A.R., Boland R.L. 1,25-Dihydroxyvitamin D-3 induces arachidonate mobilization in embryonic chick myoblasts. Biochem Biophys Acta 1993, 1179:98-104.
22. Morelli S., de Boland A.R., Boland R.L. Generation of inositol phosphates, diacylglycerol and calcium fluxes in myoblasts treated with 1,25-dihydroxyvitamin D3. Biochem J 1993, 289:675-679.
23. Morley J.E. Sarcopenia revisited. J Gerontol Med Sci A 2003, 58:M909-M910.
24. Selles J., Boland R. Rapid stimulation of calcium uptake and protein phosphorylation in isolated cardiac muscle by 1,25-dihydroxyvitamin D3. Mol Cell Endocrinol 1991, 77:67-73.
25. Bischoff-Ferrari H.A., Staehelin H.B. Importance of vitamin D and calcium at older age. Int J Vitam Nutr Res 2008, 78:286-289.
26. Dawson-Hughes B., Heaney R.P., Holick M.F., et al. Estimates of optimal vitamin D status. Osteoporos Int 2005, 16:713-716.
27. Woitge H.W., Knothe A., Witte K., et al. Circaannual rhythms and interactions of vitamin D metabolites, parathyroid hormone, and biochemical markers of skeletal homeostasis: A prospective study. J Bone Miner Res 2000, 15:2443-2450.
28. Chen J.S., Sambrook P.N., March L., et al. Hypovitaminosis D and parathyroid hormone response in the elderly: Effects on bone turnover and mortality. Clin Endocrinol (Oxf) 2008, 68:290-298.
29. Khaw K.T., Sneyd M.J., Compston J. Bone density parathyroid hormone and 25-hydroxyvitamin D concentrations in middle aged women. BMJ 1992, 305:273-277.
30. McAuley K.A., Jones S., Lewis-Barned N.J., et al. Low vitamin D status is common among elderly Dunedin women. N Z Med J 1997, 110:275-277.
31. Cummings S.R., Browner W.S., Bauer D., et al. Endogenous hormones and the risk of hip and vertebral fractures among older women. Study of Osteoporotic Fractures Research Group. N Engl J Med 1998, 339:733-738.
32. Looker A.C., Mussolino M.E. Serum 25-hydroxyvitamin D and hip fracture risk in older US white adults. J Bone Miner Res 2008, 23:143-150.
33. Cauley J.A., LaCroix A.Z., Wu L., et al. Serum 25-hydroxyvitamin D concentrations and risk for hip fractures. Ann Intern Med 2008, 19(149):242-250.
34. Gerdhem P., Ringsberg K.A., Obrant K.J., Akesson K. Association between 25-hydroxy vitamin D levels, physical activity, muscle strength and fractures in the prospective population-based OPRA Study of Elderly Women. Osteoporos Int 2005, 16:1425-1431.
35. Woo J., Lau E., Swaminathan R., et al. Biochemical predictors for osteoporotic fractures in elderly Chinese-a longitudinal study. Gerontology 1990, 36:55-58.
36. Dobnig H., Piswanger-Sölkner J.C., Obermayer-Pietsch B., et al. Hip and nonvertebral fracture prediction in nursing home patients: Role of bone ultrasound and bone marker measurements. J Clin Endocrinol Metab 2007, 92:1678-1686.
37. Lyles K.W., Colón-Emeric C. Treating vitamin D deficiency in long-term care: It should be done yesterday, but how?. J Am Med Dir Assoc 2004, 5:416-417.
38. Chen J.S., Sambrook P.N., Simpson J.M., et al. Risk factors for hip fracture among institutionalised older people. Age Ageing 2009, 38:429-434.
39. Bischoff-Ferrari H.A., Dietrich T., Orav E.J., et al. Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged > or =60 y. Am J Clin Nutr 2004, 80:752-758.
40. Visser M., Deeg D.J., Lips P. Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): The Longitudinal Aging Study Amsterdam. J Clin Endocrinol Metab 2003, 88:5766-5772.
41. Flicker L., Mead K., MacInnis R.J., et al. Serum vitamin D and falls in older women in residential care in Australia. J Am Geriatr Soc 2003, 51:1533-1538.
42. Elliott M.E., Binkley N.C., Carnes M., et al. Fracture risks for women in long-term care: High prevalence of calcaneal osteoporosis and hypovitaminosis D. Pharmacotherapy 2003, 23:702-711.
43. Lyles K.W., Schenck A.P., Colón-Emeric C.S. Hip and other osteoporotic fractures increase the risk of subsequent fractures in nursing home residents. Osteoporos Int 2008, 19:1225-1233.
44. Przybelski R., Agrawal S., Krueger D., et al. Rapid correction of low vitamin D status in nursing home residents. Osteoporos Int 2008, 19:1621-1628.
45. Sambrook P.N., Chen J.S., March L.M., et al. Serum parathyroid hormone predicts time to fall independent of vitamin D status in a frail elderly population. J Clin Endocrinol Metab 2004, 89:1572-1576.
46. Zochling J., Chen J.S., Seibel M., et al. Calcium metabolism in the frail elderly. Clin Rheumatol 2005, 24:576-582.
47. Parikh S., Avorn J., Solomon D.H. Pharmacological management of osteoporosis in nursing home populations: A systematic review. J Am Geriatr Soc 2009, 57:327-334.
48. Bischoff-Ferrari H.A., Willett W.C., Wong J.B., et al. Fracture prevention with vitamin D supplementation: A meta-analysis of randomized controlled trials. JAMA 2005, 293:2257-2264.
49. Sawka A.M., Ismaila N., Cranney A., et al. A scoping review of strategies for the prevention of hip fracture in elderly nursing home residents. PLoS One 2010, 5:e9515.
50. Reid I.R., Gallagher D.J.A., Bosworth J. Prophylaxis against vitamin D deficiency in the elderly by regular sunlight exposure. Age Ageing 1986, 15:35-40.
51. Romagnoli E., Mascia M.L., Cipriani C., et al. Short and long-term variations in serum calciotropic hormones after a single very large dose of ergocalciferol (vitamin D2) or cholecalciferol (vitamin D3) in the elderly. J Clin Endocrinol Metab 2008, 93:3015-3022.
52. Sanders K.M., Stuart A.L., Williamson E.J., et al. Annual high-dose oral vitamin D and falls and fractures in older women: A randomized controlled trial. JAMA 2010, 303:1815-1822.
53. Tang B.M., Eslick G.D., Nowson C., et al. Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: A meta-analysis. Lancet 2007, 370:657-666.
54. Sanders K.M., Nowson C.A., Kotowicz M.A., et al. Calcium and bone health: Position statement for the Australian and New Zealand Bone and Mineral Society, Osteoporosis Australia and the Endocrine Society of Australia. Med J Aust 2009, 190:316-320.
55. Cranney A.H., Horsley T., O'Donnell S., et al. Effectiveness and Safety of Vitamin D in Relation to Bone Health. Evidence Report/Technology Assessment No. 158 (Prepared by the University of Ottawa Evidence-based Practice Center (UO-EPC) under Contract No. 290-02-0021 2007, Agency for Healthcare Research and Quality, Rockville, MD, AHRQ Publication No.: 07-E013.
56. Diamond T.H., Ho K.W., Rohl P.G., Meerkin M. Annual intramuscular injection of a megadose of cholecalciferol for treatment of vitamin D deficiency: Efficacy and safety data. Med J Aust 2005, 183:10-12.
57. Heaney R.P. Vitamin D: Criteria for safety and efficacy. Nutr Rev 2008, 66:S178-S188.
58. Sabbagh Z., Vatanparast H. Is calcium supplementation a risk factor for cardiovascular diseases in older women?. Nutr Rev 2009, 67:105-108.
59. Bolland M.J., Avenell A., Baron J.A., et al. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: Meta-analysis. BMJ 2010, 341:c3691.