Lithium Induces ER Stress and N-Glycan Modification in Galactose-Grown Jurkat Cells

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Nagy, Tamás ^a   Frank, Dorottya ^a   Kátai, Emese ^a   Yahiro, Rikki K K ^a   Poór, Viktor S ^a   Montskó, Gergely ^a   Zrínyi, Zita ^a   Kovács, Gábor L ^a   Miseta, Attila ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

GALACTOSE; GLUCOSE; GLYCAN; GLYCOGEN; HEXOSE; LITHIUM; MESSENGER RNA; N ACETYLGLUCOSAMINE; URIDINE DIPHOSPHATE; X BOX BINDING PROTEIN 1;

ARTICLE; CARBOHYDRATE METABOLISM; CELL SURVIVAL; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; HYPOGLYCEMIA; LEUKEMIA CELL LINE; PROTEIN PROCESSING; UNFOLDED PROTEIN RESPONSE;

CALCIUM; CELL PROLIFERATION; ENDOPLASMIC RETICULUM STRESS; GALACTOSE; HOMEOSTASIS; HUMANS; JURKAT CELLS; LITHIUM; PHOSPHOGLUCOMUTASE; POLYSACCHARIDES; UNFOLDED PROTEIN RESPONSE;

EID: 84880694317     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0070410     Document Type: Article

References (50)

1. Acosta PB, Gross KC (1995) Hidden sources of galactose in the environment. Eur J Pediatr 154:: S87-92. Available:http://www.ncbi.nlm.nih.gov/pubmed/7671974. Accessed 21 March 2012.
2. Vannucci SJ, Maher F, Simpson I a (1997) Glucose transporter proteins in brain: delivery of glucose to neurons and glia. Glia 21:: 2-21. Available:http://www.ncbi.nlm.nih.gov/pubmed/9298843. Accessed 1 August 2011.
3. Berry GT, Nissim I, Lin Z, Mazur AT, Gibson JB, et al. (1995) Endogenous synthesis of galactose in normal men and patients with hereditary galactosaemia. Lancet 346:: 1073-1074. Available:http://www.ncbi.nlm.nih.gov/pubmed/7564790. Accessed 21 March 2012.
4. Lorenzi M (2007) The polyol pathway as a mechanism for diabetic retinopathy: attractive, elusive, and resilient. Exp Diabetes Res 2007: 61038. Available:http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1950230&tool=pmcentrez&rendertype=abstract. Accessed 6 March 2012.
5. Masuda CA, Xavier MA, Mattos KA, Galina A, Montero-Lomeli M (2001) Phosphoglucomutase is an in vivo lithium target in yeast. J Biol Chem 276:: 37794-37801. Available:http://www.ncbi.nlm.nih.gov/pubmed/11500487. Accessed 21 March 2012.
6. Csutora P, Strassz A, Boldizsár F, Németh P, Sipos K, et al. (2005) Inhibition of phosphoglucomutase activity by lithium alters cellular calcium homeostasis and signaling in Saccharomyces cerevisiae. Am J Physiol Cell Physiol 289:: C58-67. Available:http://www.ncbi.nlm.nih.gov/pubmed/15703203.
7. Bro C, Regenberg B, Lagniel G, Labarre J, Montero-Lomelí M, et al. (2003) Transcriptional, proteomic, and metabolic responses to lithium in galactose-grown yeast cells. J Biol Chem 278:: 32141-32149. Available:http://www.ncbi.nlm.nih.gov/pubmed/12791685.
8. Schou M (2001) Lithium treatment at 52. J Affect Disord 67:: 21-32. Available:http://www.ncbi.nlm.nih.gov/pubmed/11869750. Accessed 22 March 2011.
9. Pasquali L, Busceti CL, Fulceri F, Paparelli A, Fornai F (2010) Intracellular pathways underlying the effects of lithium. Behav Pharmacol 21:: 473-492. Available:http://www.ncbi.nlm.nih.gov/pubmed/20700048. Accessed 13 April 2011.
10. Gould TD, Quiroz J a, Singh J, Zarate C a, Manji HK (2004) Emerging experimental therapeutics for bipolar disorder: insights from the molecular and cellular actions of current mood stabilizers. Molecular psychiatry 9:: 734-755. Available:http://www.ncbi.nlm.nih.gov/pubmed/15136794. Accessed 7 March 2012.
11. Aiello DP, Fu L, Miseta A, Sipos K, Bedwell DM (2004) The Ca2+ homeostasis defects in a pgm2Delta strain of Saccharomyces cerevisiae are caused by excessive vacuolar Ca2+ uptake mediated by the Ca2+-ATPase Pmc1p. J Biol Chem 279:: 38495-38502. Available:http://www.ncbi.nlm.nih.gov/pubmed/15252028.
12. Slepak TI, Tang M, Slepak VZ, Lai K (2007) Involvement of endoplasmic reticulum stress in a novel Classic Galactosemia model. Mol Genet Metab 92:: 78-87. Available:http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2141683&tool=pmcentrez&rendertype=abstract. Accessed 27 September 2011.
13. Lu J, Wu D, Zheng Y, Hu B, Zhang Z, et al. (2010) Ursolic acid attenuates D-galactose-induced inflammatory response in mouse prefrontal cortex through inhibiting AGEs/RAGE/NF-κB pathway activation. Cereb Cortex 20:: 2540-2548. Available:http://www.ncbi.nlm.nih.gov/pubmed/20133359. Accessed 13 December 2011.
14. Hartl FU, Bracher A, Hayer-Hartl M (2011) Molecular chaperones in protein folding and proteostasis. Nature 475:: 324-332. Available:http://www.ncbi.nlm.nih.gov/pubmed/21776078. Accessed 30 March 2012.
15. Cai B, Tomida A, Mikami K, Nagata K, Tsuruo T (1998) Down-regulation of epidermal growth factor receptor-signaling pathway by binding of GRP78/BiP to the receptor under glucose-starved stress conditions. J Cell Physiol 177:: 282-288. Available:http://www.ncbi.nlm.nih.gov/pubmed/9766525. Accessed 19 January 2012.
16. Sturiale L, Barone R, Fiumara A, Perez M, Zaffanello M, et al. (2005) Hypoglycosylation with increased fucosylation and branching of serum transferrin N-glycans in untreated galactosemia. Glycobiology 15:: 1268-1276. Available:http://www.ncbi.nlm.nih.gov/pubmed/16037488. Accessed 13 January 2012.
17. Miseta A, Tökés-Füzesi M, Aiello DP, Bedwell DM (2003) A Saccharomyces cerevisiae mutant unable to convert glucose to glucose-6-phosphate accumulates excessive glucose in the endoplasmic reticulum due to core oligosaccharide trimming. Eukaryot cell 2:: 534-541. Available:http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=161446&tool=pmcentrez&rendertype=abstract. Accessed 16 April 2011.
18. Isono T (2011) O-GlcNAc-specific antibody CTD110.6 cross-reacts with N-GlcNAc2-modified proteins induced under glucose deprivation. PloS one 6:: e18959. Available:http://dx.plos.org/10.1371/journal.pone.0018959. Accessed 5 August 2011.
19. Comer FI, Vosseller K, Wells L, Accavitti MA, Hart GW (2001) Characterization of a mouse monoclonal antibody specific for O-linked N-acetylglucosamine. Anal Biochem 293:: 169-177. Available:http://www.ncbi.nlm.nih.gov/pubmed/11399029.
20. Kiernan JA (1999) Histological and Histochemical Methods: Theory and Practice. 3rd ed. Oxford, UK, Butterworth-Heinemann.
21. Nagy T, Champattanachai V, Marchase RB, Chatham JC (2006) Glucosamine inhibits angiotensin II-induced cytoplasmic Ca2+ elevation in neonatal cardiomyocytes via protein-associated O-linked N-acetylglucosamine. Am J Physiol Cell Physiol 290:: C57-65. Available:http://www.ncbi.nlm.nih.gov/pubmed/16107505. Accessed 16 March 2011.
22. Schulz JM, Ross KL, Malmstrom K, Krieger M, Fridovich-Keil JL (2005) Mediators of galactose sensitivity in UDP-galactose 4′-epimerase-impaired mammalian cells. J Biol Chem 280:: 13493-13502. Available:http://www.ncbi.nlm.nih.gov/pubmed/15701638. Accessed 18 January 2012.
23. Hayhoe FGJG (1984) Cytochemistry of the acute leukaemias. Histochem J 16:: 1051-1059. Available:http://www.ncbi.nlm.nih.gov/pubmed/6209245. Accessed 16 March 2011.
24. Nagy T, Balasa A, Frank D, Rab A, Rideg O, et al. (2010) O-GlcNAc modification of proteins affects volume regulation in Jurkat cells. Eur Biophys J 39:: 1207-1217. Available:http://www.ncbi.nlm.nih.gov/pubmed/20043149. Accessed 7 September 2011.
25. Marroquin LD, Hynes J, Dykens J a, Jamieson JD, Will Y (2007) Circumventing the Crabtree effect: replacing media glucose with galactose increases susceptibility of HepG2 cells to mitochondrial toxicants. Toxicol Sci 97:: 539-547. Available:http://www.ncbi.nlm.nih.gov/pubmed/17361016. Accessed 1 April 2012.
26. Thomsen K, Shirley DG (2006) A hypothesis linking sodium and lithium reabsorption in the distal nephron. Nephrol Dial Transplant 21:: 869-880. Available:http://www.ncbi.nlm.nih.gov/pubmed/16410274. Accessed 15 May 2013.
27. Weinberg JM, Davis J a, Venkatachalam M a (1997) Cytosolic-free calcium increases to greater than 100 micromolar in ATP-depleted proximal tubules. J Clin Invest 100:: 713-722. Available:http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=508241&tool=pmcentrez&rendertype=abstract. Accessed 17 March 2011.
28. Wang C, Nguyen HN, Maguire JL, Perry DC (2002) Role of Intracellular Calcium Stores in Cell Death From Oxygen-Glucose Deprivation in a Neuronal Cell Line. J Cereb Blood Flow Metab 22:: 206-214. Available:http://www.nature.com/doifinder/10.1097/00004647-200202000-00008. Accessed 4 May 2012.
29. Chen X, Kintner DB, Luo J, Baba A, Matsuda T, et al. (2008) Endoplasmic reticulum Ca2+ dysregulation and endoplasmic reticulum stress following in vitro neuronal ischemia: role of Na+-K+-Cl- cotransporter. J Neurochem 106: 1563-1576. Available:http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2834254&tool=pmcentrez&rendertype=abstract. Accessed 17 March 2011.
30. Roderick HL, Lechleiter JD, Camacho P (2000) Cytosolic phosphorylation of calnexin controls intracellular Ca(2+) oscillations via an interaction with SERCA2b. J Cell Biol 149:: 1235-1248. Available:http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2175122&tool=pmcentrez&rendertype=abstract. Accessed 26 April 2012.
31. Lee D, Singaravelu G, Park B-J, Ahnn J (2007) Differential requirement of unfolded protein response pathway for calreticulin expression in Caenorhabditis elegans. J Mol Biol 372:: 331-340. Available:http://www.ncbi.nlm.nih.gov/pubmed/17651753. Accessed 26 April 2012.
32. Corbett EF, Oikawa K, Francois P, Tessier DC, Kay C, et al. (1999) Ca2+ regulation of interactions between endoplasmic reticulum chaperones. J Biol Chem 274:: 6203-6211. Available:http://www.ncbi.nlm.nih.gov/pubmed/10037706. Accessed 26 April 2012.
33. Brostrom MA, Brostrom CO (2003) Calcium dynamics and endoplasmic reticular function in the regulation of protein synthesis: implications for cell growth and adaptability. Cell Calcium 34:: 345-363. Available:http://linkinghub.elsevier.com/retrieve/pii/S0143416003001271. Accessed 7 May 2012.
34. Lee A (2001) The glucose-regulated proteins: stress induction and clinical applications. Trends Biochem Sci 26:: 504-510. Available:http://www.ncbi.nlm.nih.gov/pubmed/11504627. Accessed 19 January 2012.
35. Shao L, Sun X, Xu L, Young LT, Wang J-F (2006) Mood stabilizing drug lithium increases expression of endoplasmic reticulum stress proteins in primary cultured rat cerebral cortical cells. Life Sci 78:: 1317-1323. Available:http://www.ncbi.nlm.nih.gov/pubmed/16236328.
36. Hiroi T, Wei H, Hough C, Leeds P, Chuang D-M (2005) Protracted lithium treatment protects against the ER stress elicited by thapsigargin in rat PC12 cells: roles of intracellular calcium, GRP78 and Bcl-2. Pharmacogenomics J 5:: 102-111. Available:http://www.ncbi.nlm.nih.gov/pubmed/15668729. Accessed 7 March 2012.
37. Baumann H, Jahreis GP (1983) Glucose starvation leads in rat hepatoma cells to partially N-glycosylated glycoproteins including alpha 1-acid glycoproteins. Identification by endoglycolytic digestions in polyacrylamide gels. J Biol Chem 258:: 3942-3949. Available:http://www.ncbi.nlm.nih.gov/pubmed/6403521. Accessed 18 January 2012.
38. Gershman H, Robbins PW (1981) Transitory effects of glucose starvation on the synthesis of dolichol-linked oligosaccharides in mammalian cells. J Biol Chem 256:: 7774-7780. Available:http://www.ncbi.nlm.nih.gov/pubmed/6267025. Accessed 19 January 2012.
39. Coss KP, Byrne JC, Coman DJ, Adamczyk B, Abrahams JL, et al. (2011) IgG N-glycans as potential biomarkers for determining galactose tolerance in Classical Galactosaemia. Mol Genet Metab: 1-9. Available:http://www.ncbi.nlm.nih.gov/pubmed/22133299. Accessed 19 January 2012.
40. Charlwood J, Clayton P, Keir G, Mian N, Winchester B (1998) Defective galactosylation of serum transferrin in galactosemia. Glycobiology 8:: 351-357. Available:http://www.ncbi.nlm.nih.gov/pubmed/9499382. Accessed 19 January 2012.
41. Bhat PJ (2003) Galactose-1-phosphate is a regulator of inositol monophosphatase: a fact or a fiction? Med Hypotheses 60:: 123-128. Available:http://linkinghub.elsevier.com/retrieve/pii/S030698770200347X. Accessed 9 May 2012.
42. Cannon DM, Ichise M, Rollis D, Klaver JM, Gandhi SK, et al. (2007) Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and [11C]DASB; comparison with bipolar disorder. Biol Psychiatry 62:: 870-877. Available:http://www.ncbi.nlm.nih.gov/pubmed/17678634. Accessed 6 March 2012.
43. Blakely RD, De Felice LJ, Hartzell HC (1994) Molecular physiology of norepinephrine and serotonin transporters. J Exp Biol 196:: 263-281. Available:http://www.ncbi.nlm.nih.gov/pubmed/7823027. Accessed 6 January 2012.
44. Akasaka-Manya K, Manya H, Sakurai Y, Wojczyk BS, Kozutsumi Y, et al. (2010) Protective effect of N-glycan bisecting GlcNAc residues on beta-amyloid production in Alzheimer's disease. Glycobiology 20:: 99-106. Available:http://www.ncbi.nlm.nih.gov/pubmed/19776078. Accessed 19 January 2012.
45. Sato Y, Naito Y, Grundke-Iqbal I, Iqbal K, Endo T (2001) Analysis of N-glycans of pathological tau: possible occurrence of aberrant processing of tau in Alzheimer's disease. FEBS letters 496: 152-160. Available:http://www.ncbi.nlm.nih.gov/pubmed/11356201. Accessed 19 January 2012.
46. Nunes P V, Forlenza O V, Gattaz WF (2007) Lithium and risk for Alzheimer's disease in elderly patients with bipolar disorder. Br J Psychiatry 190:: 359-360. Available:http://www.ncbi.nlm.nih.gov/pubmed/17401045.
47. Grigorian A, Lee S-U, Tian W, Chen I-J, Gao G, et al. (2007) Control of T Cell-mediated autoimmunity by metabolite flux to N-glycan biosynthesis. J Biol Chem 282:: 20027-20035. Available:http://www.ncbi.nlm.nih.gov/pubmed/17488719. Accessed 12 December 2011.
48. Liu K-J, Lee Y-L, Yang Y-Y, Shih N-Y, Ho C-C, et al. (2011) Modulation of the development of human monocyte-derived dendritic cells by lithium chloride. J Cell Physiol 226:: 424-433. Available:http://www.ncbi.nlm.nih.gov/pubmed/20672290. Accessed 10 May 2012.
49. Lazarus JH (2009) Lithium and thyroid. Best Pract Res Clin Endocrinol Metab 23:: 723-733. Available:http://www.ncbi.nlm.nih.gov/pubmed/19942149. Accessed 10 May 2012.
50. De Sarno P, Axtell RC, Raman C, Roth KA, Alessi DR, et al. (2008) Lithium prevents and ameliorates experimental autoimmune encephalomyelitis. J Immunol 181:: 338-345. Available:http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2704026&tool=pmcentrez&rendertype=abstract. Accessed 10 May 2012.