IL-23 Receptor expression on γδ T cells correlates with their enhancing or suppressive effects on autoreactive t cells in experimental autoimmune uveitis

Journal of Immunology

Volumn 191, Issue 3, 2013, Pages 1118-1125

  Liang, Dongchun ^a   Zuo, Aijun ^a   Shao, Hui ^b   Born, Willi K ^c   O'Brien, Rebecca L ^c   Kaplan, Henry J ^b   Sun, Deming ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b University of Louisville School of Medicine   (United States)

^c DEPARTMENT OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 23 RECEPTOR;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE UVEITIS; CONTROLLED STUDY; FEMALE; GAMMA DELTA T LYMPHOCYTE; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TH17 CELL;

ANIMALS; ANTIBODIES; AUTOIMMUNE DISEASES; AUTOIMMUNITY; INTERLEUKIN-17; INTERLEUKIN-23; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; RECEPTORS, INTERLEUKIN; T-LYMPHOCYTES; UVEITIS;

EID: 84880684533     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1300626     Document Type: Article

References (39)

1. Petermann, F., V. Rothhammer, M. C. Claussen, J. D. Haas, L. R. Blanco, S. Heink, I. Prinz, B. Hemmer, V. K. Kuchroo, M. Oukka, and T. Korn. 2010. gd T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism. Immunity 33: 351-363.
2. Born, W., C. Cady, J. Jones-Carson, A. Mukasa, M. Lahn, and R. O'Brien. 1999. Immunoregulatory functions of g d T cells. Adv. Immunol. 71: 77-144.
3. Dodd, J., S. Riffault, J. S. Kodituwakku, A. C. Hayday, and P. J. M. Openshaw. 2009. Pulmonary V g 4+ g d T cells have proinflammatory and antiviral effects in viral lung disease. J. Immunol. 182: 1174-1181.
4. Hayday, A., and L. Geng. 1997. g d cells regulate autoimmunity. Curr. Opin. Immunol. 9: 884-889.
5. Nian, H., H. Shao, G. Zhang, W. K. Born, R. L. O'Brien, H. J. Kaplan, and D. Sun. 2010. Regulatory effect of gammadelta T cells on IL-17+ uveitogenic T cells. Invest. Ophthalmol. Vis. Sci. 51: 4661-4667.
6. Peng, G., H. Y.Wang,W. Peng, Y. Kiniwa, K. H. Seo, and R. F.Wang. 2007. Tumorinfiltrating gammadelta T cells suppress T and dendritic cell function via mechanisms controlled by a unique toll-like receptor signaling pathway. Immunity 27: 334-348.
7. Rajan, A. J., V. C. Asensio, I. L. Campbell, and C. F. Brosnan. 2000. Experimental autoimmune encephalomyelitis on the SJL mouse: effect of g d T cell depletion on chemokine and chemokine receptor expression in the central nervous system. J. Immunol. 164: 2120-2130.
8. Spahn, T. W., S. Issazadah, A. J. Salvin, and H. L. Weiner. 1999. Decreased severity of myelin oligodendrocyte glycoprotein peptide 33 -35-induced experimental autoimmune encephalomyelitis in mice with a disrupted TCR d chain gene. Eur. J. Immunol. 29: 4060-4071.
9. Tagawa, T., H. Nishimura, T. Yajima, H. Hara, K. Kishihara, G. Matsuzaki, I. Yoshino, Y. Maehara, and Y. Yoshikai. 2004. Vdelta1+ gammadelta T cells producing CC chemokines may bridge a gap between neutrophils and macrophages in innate immunity during Escherichia coli infection in mice. J. Immunol. 173: 5156-5164.
10. D'Souza, C. D., A. M. Cooper, A. A. Frank, R. J. Mazzaccaro, B. R. Bloom, and I. M. Orme. 1997. An anti-inflammatory role for g d T lymphocytes in acquired immunity to Mycobacterium tuberculosis. J. Immunol. 158: 1217-1221.
11. Tsuchiya, T., S. Fukuda, H. Hamada, A. Nakamura, Y. Kohama, H. Ishikawa, K. Tsujikawa, and H. Yamamoto. 2003. Role of g d T cells in the inflammatory response of experimental colitis mice. J. Immunol. 171: 5507-5513.
12. Uezu, K., K. Kawakami, K. Miyagi, Y. Kinjo, T. Kinjo, H. Ishikawa and A. Saito. 2004. Accumulation of gammadelta T cells in the lungs and their regulatory roles in Th1 response and host defense against pulmonary infection with Cryptococcus neoformans. J. Immunol. 172: 7629-7634.
13. Dalton,J.E.,J.Pearson,P.Scott,andS.R.Carding.2003. TheinteractionofgdTcellswith activatedmacrophagesisapropertyoftheVg1subset.J. Immunol.171:6488-6494.
14. Hahn, Y. S., C. Taube, N. Jin, L. Sharp, J. M. Wands, M. K. Aydintug, M. Lahn, S. A. Huber, R. L. O'Brien, E. W. Gelfand, and W. K. Born. 2004. Different potentials of g delta T cell subsets in regulating airway responsiveness: V g 1+ cells, but not V g 4+ cells, promote airway hyperreactivity, Th2 cytokines, and airway inflammation. J. Immunol. 172: 2894-2902.
15. Huber, S. A., D. Graveline, M. K. Newell, W. K. Born, and R. L. O'Brien. 2000. V g 1+ T cells suppress and V g 4+ T cells promote susceptibility to coxsackievirus B3-induced myocarditis in mice. J. Immunol. 165: 4174-4181.
16. O'Brien, R. L., X. Yin, S. A. Huber, K. Ikuta, and W. K. Born. 2000. Depletion of a g d T cell subset can increase host resistance to a bacterial infection. J. Immunol. 165: 6472-6479.
17. Nian, H., H. Shao, R. L. O'Brien, W. K. Born, H. J. Kaplan, and D. Sun. 2011. Activated gammadelta T cells promote the activation of uveitogenic T cells and exacerbate EAU development. Invest. Ophthalmol. Vis. Sci. 52: 5920-5927.
18. Nian, H., D. Liang, A. Zuo, R. Wei, H. Shao, W. K. Born, H. J. Kaplan, and D. Sun. 2012. Characterization of autoreactive and bystander IL-17+ T cells induced in immunized C57BL/6 mice. Invest. Ophthalmol. Vis. Sci. 53: 897-905.
19. Cheng, L., Y. Cui, H. Shao, G. Han, L. Zhu, Y. Huang, R. L. O'Brien, W. K. Born, H. J. Kaplan, and D. Sun. 2008. Mouse gammadelta T cells are capable of expressing MHC class II molecules, and of functioning as antigenpresenting cells. J. Neuroimmunol. 203: 3-11.
20. Cui, Y., H. Shao, C. Lan, H. Nian, R. L. O'Brien, W. K. Born, H. J. Kaplan, and D. Sun. 2009. Major role of g d T cells in the generation of IL-17+ uveitogenic T cells. J. Immunol. 183: 560-567.
21. Riol-Blanco, L., V. Lazarevic, A. Awasthi, M. Mitsdoerffer, B. S. Wilson, A. Croxford, A. Waisman, V. K. Kuchroo, L. H. Glimcher, and M. Oukka. 2010. IL-23 receptor regulates unconventional IL-17-producing T cells that control bacterial infections. J. Immunol. 184: 1710-1720.
22. Kabelitz, D., D. Wesch, and W. He. 2007. Perspectives of gammadelta T cells in tumor immunology. Cancer Res. 67: 5-8.
23. Girardi, M. 2006. Immunosurveillance and immunoregulation by gammadelta T cells. J. Invest. Dermatol. 126: 25-31.
24. Poccia, F., C. Agrati, F. Martini, G. Mejia, M. Wallace, and M. Malkovsky. 2005. Vgamma9Vdelta2 T cell-mediated non-cytolytic antiviral mechanisms and their potential for cell-based therapy. Immunol. Lett. 100: 14-20.
25. Liang, D., A. Zuo, H. Shao, W. K. Born, R. L. O'Brien, H. J. Kaplan, and D. Sun. 2012. Role of CD25+ dendritic cells in the generation of Th17 autoreactive T cells in autoimmune experimental uveitis. J. Immunol. 188: 5785-5791.
26. Doisne, J.M.,V. Soulard, C. Bécourt, L. Amniai, P. Henrot, C. Havenar-Daughton, C.Blanchet,L.Zitvogel,B.Ryffel,J.M.Cavaillon,etal.2011. Cuttingedge:crucialroleofIL-1 and IL-23 in the innate IL-17 response of peripheral lymph nodeNK1.12invariant NKTcellstobacteria.J.Immunol.186:662-666.
27. Ghoreschi, K., A. Laurence, X. P. Yang, C. M. Tato, M. J. McGeachy, J. E. Konkel, H. L. Ramos, L. Wei, T. S. Davidson, N. Bouladoux, et al. 2010. Generation of pathogenic T(H)17 cells in the absence of TGF-b signalling. Nature 467: 967-971.
28. Korn, T., E. Bettelli, M. Oukka, and V. K. Kuchroo. 2009. IL-17 and Th17 cells. Annu. Rev. Immunol. 27: 485-517.
29. Gerosa, F., B. Baldani-Guerra, L. A. Lyakh, G. Batoni, S. Esin, R. T. Winkler-Pickett, M. R. Consolaro, M. De Marchi, D. Giachino, A. Robbiano, et al. 2008. Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells. J. Exp. Med. 205: 1447-1461.
30. Roses, R. E., S. Xu, M. Xu, U. Koldovsky, G. Koski, and B. J. Czerniecki. 2008. Differential production of IL-23 and IL-12 by myeloid-derived dendritic cells in response to TLR agonists. J. Immunol. 181: 5120-5127.
31. Aydintug, M. K., C. L. Roark, J. L. Chain, W. K. Born, and R. L. O'Brien. 2008. Macrophages express multiple ligands for gammadelta TCRs. Mol. Immunol. 45: 3253-3263.
32. Havlir, D. V., J. J. Ellner, K. A. Chervenak, and W. H. Boom. 1991. Selective expansion of human g d T cells by monocytes infected with live Mycobacterium tuberculosis. J. Clin. Invest. 87: 729-733.
33. Rincon-Orozco, B., V. Kunzmann, P. Wrobel, D. Kabelitz, A. Steinle, and T. Herrmann. 2005. Activation of V g 9V d 2 T cells by NKG2D. J. Immunol. 175: 2144-2151.
34. Wesch, D., S. Beetz, H. H. Oberg, M. Marget, K. Krengel, and D. Kabelitz. 2006. Direct costimulatory effect of TLR3 ligand poly(I:C) on human gamma delta T lymphocytes. J. Immunol. 176: 1348-1354.
35. Sutton, C. E., S. J. Lalor, C. M. Sweeney, C. F. Brereton, E. C. Lavelle, and K. H. G. Mills. 2009. Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. Immunity 31: 331-341.
36. Leclercq, G., and J. Plum. 1995. Stimulation of TCR V g 3 cells by gramnegative bacteria. J. Immunol. 154: 5313-5319.
37. Mokuno, Y., T. Matsuguchi, M. Takano, H. Nishimura, J. Washizu, T. Ogawa, O. Takeuchi, S. Akira, Y. Nimura, and Y. Yoshikai. 2000. Expression of toll-like receptor 2 on g d T cells bearing invariant V g 6/V d 1 induced by Escherichia coli infection in mice. J. Immunol. 165: 931-940.
38. Hayday, A., and R. Tigelaar. 2003. Immunoregulation in the tissues by gammadelta T cells. Nat. Rev. Immunol. 3: 233-242.
39. Peng, Y., G. Han, H. Shao, Y. Wang, H. J. Kaplan, and D. Sun. 2007. Characterization of IL-17+ interphotoreceptor retinoid-binding protein-specific T cells in experimental autoimmune uveitis. Invest. Ophthalmol. Vis. Sci. 48: 4153-4161.