Accumulation of γδ T cells in the lungs and their regulatory roles in Th1 response and host defense against pulmonary infection with Cryptococcus neoformans

Journal of Immunology

Volumn 172, Issue 12, 2004, Pages 7629-7634

  Uezu, Kaori ^a   Kawakami, Kazuyoshi ^a   Miyagi, Kazuya ^a   Kinjo, Yuki ^a,c   Kinjo, Takeshi ^a   Ishikawa, Hiromichi ^b   Saito, Atsushi ^a  

^a UNIVERSITY OF THE RYUKYUS   (Japan)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN G; INTERLEUKIN 10; INTERLEUKIN 4; MONOCYTE CHEMOTACTIC PROTEIN 1; T LYMPHOCYTE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; CYTOKINE; LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CRYPTOCOCCOSIS; CRYPTOCOCCUS NEOFORMANS; ENZYME LINKED IMMUNOSORBENT ASSAY; HOST RESISTANCE; IMMUNE RESPONSE; LUNG INFECTION; LUNG MYCOSIS; MOUSE; MYCOSIS; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; ANIMAL; IMMUNITY; IMMUNOLOGY; LUNG; LYMPHOCYTE COUNT; MOUSE MUTANT; PATHOLOGY; TH1 CELL; TIME;

ANIMALS; CRYPTOCOCCOSIS; CRYPTOCOCCUS NEOFORMANS; CYTOKINES; IMMUNITY; LUNG; LUNG DISEASES, FUNGAL; LYMPHOCYTE COUNT; MICE; MICE, KNOCKOUT; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTES; TH1 CELLS; TIME FACTORS;

EID: 2942525398     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.12.7629     Document Type: Article

References (50)

1. Stevens, D. A. 1990. Fungal infections in AIDS patients. Br. J. Clin. Practice 44(Suppl. 1):11.
2. Feldmesser, M., S. Tucker, and A. Casadevall. 2001. Intracellular parasitism of macrophages by Cryptococcus neoformans. Trends Microbiol. 9:273.
3. Lim, T. S., and J. W. Murphy. 1980. Transfer of immunity to cryptococcosis by T-enriched splenic lymphocytes from Cryptococcus neoformans-sensitized mice. Infect. Immun. 30:5.
4. +) lymphocytes in vivo impairs murine host defense to Cryptococcus neoformans. J. Immunol. 144:1472.
5. + T cells. J. Exp. Med. 173:793.
6. + T cells. J. Exp. Med. 173:755.
7. Kawakami, K., M. Tohyama, K. Teruya, N. Kudeken, Q Xie, and A. Saito. 1996. Contribution of interferon-γ in protecting mice during pulmonary and disseminated infection with Cryptococcus neoformans. FEMS Immunol. Med. Microbiol. 13:123.
8. Decken, K., G. Kohler, K. Palmer-Lehmann, A. Wunderlin, F. Mattner, J. Magram, M. K. Gately, and G. Alber. 1998. Interleukin-12 is essential for a protective Th1 response in mice infected with Cryptococcus neoformans. Infect. Immun. 66:4994.
9. Kawakami, K., Y. Koguchi, M. H. Qureshi, A. Miyazato, S. Yara, Y. Kinjo, Y. Iwakura, K. Takeda, S. Akira, M. Kurimoto, and A. Saito. 2000. IL-18 contributes to host resistance against infection with Cryptococcus neoformans in mice with defective IL-12 synthesis through induction of IFN-γ production by NK cells. J. Immunol. 165:941.
10. Blackstock, R., K. L. Buchanan, A. M. Adesina, and J. W. Murphy. 1999. Differential regulation of immune responses by highly and weakly virulent Cryptococcus neoformans isolates. Infect. Immun. 67:601.
11. Gordon, S. 2002. Pattern recognition receptors: doubling up for the innate immune response. Cell 111:927.
12. Linehan, S. A., L. Martinez-Pomares, and S. Gordon. 2000. Macrophage lectins in host defence. Microbes Infect. 2:279.
13. Ehlers, M. R. 2000. CR3: a general purpose adhesion-recognition receptor essential for innate immunity. Microbes Infect. 2:289.
14. Trinchieri, G. 2003. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3:133.
15. Taniguchi, M., M. Harada, S. Kojo, T. Nakayama, and H. Wakao. 2003. The regulatory role of Vα14 NKT cells in innate and acquired immune response. Annu. Rev. Immunol. 21:483.
16. Skeen, M. J., and H. K. Ziegler. 1995. Activation of γδ T cells for production of IFN-γ is mediated by bacteria via macrophage-derived cytokines IL-1 and IL-12, J. Immunol. 154:5832.
17. Lipscomb, M. F., T. Alvarellos, G. B. Toews, R. Tompkins, Z. Evans, G. Koo, and V. Kumar. 1991. Role of natural killer cells in resistance to Cryptococcus neoformans infections in mice. Am. J. Pathol. 128:354.
18. Hidore, M. R., T. W. Mislan, and J. W. Murphy. 1991. Responses of murine natural killer cells to binding of the fungal target Cryptococcus neoformans. Infect. Immun. 59:1489.
19. Hidore, M. R., N. Nabavi, F. Sonleitner, and J. M. Murphy. 1991. Murine natural killer cells are fungicidal to Cryptococcus neoformans. Infect. Immun. 59:1747.
20. Kawakami, K., Y. Koguchi, M. H. Qureshi, S. Yara, Y. Kinjo, K. Uezu, and A. Saito. 2000. NK cells eliminate Cryptococcus neoformans by potentiating the fungicidal activity of macrophages rather than by directly killing them upon stimulation with IL-12 and IL-18. Microbiol. Immunol. 44:1043.
21. Kawakami, K., Y. Kinjo, K. Uezu, S. Yara, K. Miyagi, Y. Koguchi, T. Nakayama, M. Taniguchi, and A. Saito. 2001. Monocyte chemoattractant protein-1-dependent increase of Vα14 NKT cells in lungs and their roles in Th1 response and host defense in cryptococcal infection. J. Immunol. 167:6525.
22. Hayday, A. C. 2000. Gamma δ cells: a right time and a right place for a conserved third way of protection. Annu. Rev. Immunol. 18:975.
23. Moore, T. A., B. B. Moore, M. W. Newstead, and T. J. Standiford. 2000. γδ-T cells are critical for survival and early proinflammatory cytokine gene expression during murine Klebsiella pneumonia. J. Immunol. 165:2643.
24. Takano, M., H. Nishimura, Y. Kimura, Y. Mokuno, J. Washizu, S. Itohara, Y. Nimura, and Y. Yoshikai. 1998. Protective roles of γδ T cells and interleukin-15 in Escherichia coli infection in mice. Infect. Immun. 66:3270.
25. Hiromatsu, K., Y. Yoshikai, G. Matsuzaki, S. Ohga, K. Muramori, K. Matsumoto, J. A. Bluestone, and K. Nomoto. 1992. A protective role of γ/δ T cells in primary infection with Listeria monocytogenes in mice. J. Exp. Med. 175:49.
26. Ladel, C. H., C. Blum, A. Dreher, K. Reifenberg, and S. H. Kaufmann. 1995. Protective role of γ/δ T cells and α/β T cells in tuberculosis. Eur. J. Immunol. 25:2877.
27. King, D. P., D. M. Hyde, K. A. Jackson, D. M. Novosad, T. N. Ellis, L. Putney, M. Y. Stovall, L. S. van Winkle, B. L. Beaman, and D. A. Ferrick. 1999. Cutting edge: protective response to pulmonary injury requires γδ T lymphocytes. J. Immunol. 162:5033.
28. Jones-Carson, J., A. Vazquez-Torres, H. C. van der Heyde, T. Warner, R. D. Wagner, and E. Balish. 1995. γγ T cell-induced nitric oxide production enhances resistance to mucosal candidiasis. Nat. Med. 1:552.
29. + T cells during experimental infection of mice with Leishmania major. J. Immunol. 150:550.
30. Hisaeda, H., H. Nagasawa, K. Maeda, Y. Maekawa, H. Ishikawa, Y. Ito, R. A. Good, and K. Himeno. 1995. γδ T cells play an important role in hsp65 expression and in acquiring protective immune responses against infection with Toxoplasma gondii. J. Immunol. 155:244.
31. O'Brien, R. L., X. Yin, S. A. Huber, K. Ikuta, and W. K. Born. 2000. Depletion of a γδ T cell subset can increase host resistance to a bacterial infection. J. Immunol. 165:6472.
32. Emoto, M., H. Nishimura, T. Sakai, K. Hiromatsu, H. Gomi, S. Itohara, and Y. Yoshikai Y. 1995. Mice deficient in γδ T cells are resistant to lethal infection with Salmonella choleraesuis. Infect. Immun. 63:3736-3738.
33. Wormley, F. L., Jr., C. Steele, K. Wozniak, K. Fujihashi, J. R. McGhee, and P. L. Fidel, Jr. 2001. Resistance of T-cell receptor δ -chain-deficient mice to experimental Candida albicans vaginitis. Infect. Immun. 69:7162.
34. + deficient mice display abnormal but distinct phenotypes toward a natural, widespread infection of the intestinal epithelium. Proc. Natl. Acad. Sci. USA 93:11774.
35. Williams, D. M., B. G. Grubbs, K. Kelly, E. Pack, and R. G. Rank. 1996. Role of γ-δ T cells in murine Chlamydia trachomatis infection. Infect. Immun. 64:3916.
36. Itohara, S., P. Mombaerts, J. Lafaille, J. Iacomini, A. Nelson, A. R. Clarke, M. L. Hooper, A. Farr, and S. Tonegawa S. 1993. T cell receptor δ gene mutant mice: independent generation of αβ T cells and programmed rearrangements of γδ TCR genes. Cell 72:337.
37. Kohyama, M., M. Nanno, M. Kawaguchi-Miyashita, S. Shimada, M. Watanabe, T. Hibi, S. Kaminogawa, and H. Ishikawa. 1999. Cytolytic and IFN-γ-producing activities of γδ T cells in the mouse intestinal epithelium are T cell receptor-γ-chain dependent. Proc. Natl. Acad. Sci. USA 96:7451.
38. Yasuoka, A., S. Kohno, H. Yamada, M. Kaku, and H. Koga. 1994. Influence of molecular sizes of Cryptococcus neoformans capsular polysaccharide on phagocytosis. Microbiol. Immunol. 38:851.
39. Kawakami, K., S. Kohno, N. Morikawa, J. Kadota, A. Saito, and K. Hara. 1994. Activation of macrophages and expansion of specific T lymphocytes in the lungs of mice intratracheally inoculated with Cryptococcus neoformans. Clin. Exp. Immunol. 96:230.
40. Suzuki, H., G. S. Duncan, H. Takimoto, and T. W. Mak. 1997. Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor β chain. J. Exp. Med. 185:499.
41. Lodolce, J. P., D. L. Boone, S. Chai, R. E. Swain, T. Dassopoulos, S. Trettin, and A. Ma. 1998. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 9:669.
42. Glatzel, A., D. Wesch, F. Schiemann, E. Brandt, O. Janssen, and D. Kabelitz. 2002. Patterns of chemokine receptor expression on peripheral blood γδ T lymphocytes: strong expression of CCR5 is a selective feature of Vδ2/γ9γ5 T cells. J. Immunol. 168:4920.
43. Wesch, D., A. Glatzel, and D. Kabelitz. 2001. Differentiation of resting human peripheral blood γ δ T cells toward Th1- or Th2-phenotype. Cell. Immunol. 212:110.
44. Nagaeva, O., L. Jonsson, and L. Mincheva-Nilsson. 2002. Dominant IL-10 and TGF-β mRNA expression in γδ T cells of human early pregnancy decidua suggests immunoregulatory potential. Am. J. Reprod. Immunol. 48:9.
45. Reed, S. G. 1999. TGF-β in infections and infectious diseases. Microbes Infect. 1:1313.
46. Letterio, J. J., and A. B. Roberts. 1998. Regulation of immune responses by TGF-β. Annu. Rev. Immunol. 16:137.
47. Hirsch, C. S., J. J. Ellner, R. Blinkhorn, and Z. Toossi. 1997. In vitro restoration of T cell responses in tuberculosis and augmentation of monocyte effector function against Mycobacterium tuberculosis by natural inhibitors of transforming growth factor β. Proc. Natl. Acad. Sci. USA 94:3926.
48. Li, J., C. A. Hunter, and J. P. Farrell. 1999. Anti-TGF-β treatment promotes rapid healing of Leishmania major infection in mice by enhancing in vivo nitric oxide production. J. Immunol. 162:974.
49. Nakano, Y., H. Hisaeda, T. Sakai, M. Zhang, Y. Maekawa, T. Zhang, and K. Himeno. 2001. Role of innate immune cells in protection against Toxoplasma gondii at inflamed site. J. Med. Invest. 48:73.
50. Nakano, Y., H. Hisaeda, T. Sakai, H. Ishikawa, M. Zhang, Y. Maekawa, T. Zhang, M. Takashima, M. Nishitani, R. A. Good, and K. Himeno. 2002. Roles of NKT cells in resistance against infection with Toxoplasma gondii and in expression of heat shock protein 65 in the host macrophages. Microbes Infect. 4:1.