CYP3A5-mediated metabolism of midazolam in recombinant systems is highly sensitive to NADPH-cytochrome P450 reductase activity

Xenobiotica

Volumn 41, Issue 1, 2011, Pages 1-5

  Christensen, Hege ^a   Hestad, Anette L ^a   Molden, Espen ^a   Mathiesen, Liv ^b  

^a UNIVERSITY OF OSLO   (Norway)

^b Norwegian Medicines Agency   (Norway)

Author keywords

Cytochrome P450 reductase; In vitro metabolism; Midazolam; Recombinant CYP3A5

Indexed keywords

CYTOCHROME P450 3A5; MIDAZOLAM; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE FERRIHEMOPROTEIN REDUCTASE;

ANIMAL CELL; ARTICLE; CLINICAL ASSESSMENT; DRUG CLEARANCE; DRUG HYDROXYLATION; DRUG METABOLISM; MICROSOME; NONHUMAN;

ANIMALS; BIOCATALYSIS; CELL LINE; CYTOCHROME P-450 CYP3A; GENETIC ENGINEERING; HUMANS; INSECTS; KINETICS; MICROSOMES, LIVER; MIDAZOLAM; NADPH-FERRIHEMOPROTEIN REDUCTASE; RECOMBINATION, GENETIC;

EID: 78650192860     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2010.523734     Document Type: Article

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