Mast cell-restricted, tetramer-forming tryptases induce aggrecanolysis in articular cartilage by activating matrix metalloproteinase-3 and -13 zymogens

Journal of Immunology

Volumn 191, Issue 3, 2013, Pages 1404-1412

  Magarinos, Natalia J ^a,b   Bryant, Katherine J ^a,b   Fosang, Amanda J ^c,d   Adachi, Roberto ^e   Stevens, Richard L ^f   McNeil, H Patrick ^a,b,g  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

^e UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

^g LIVERPOOL HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; ENZYME PRECURSOR; EPITOPE; MATRIX METALLOPROTEINASE; METALLOPROTEINASE 13; RECOMBINANT ENZYME; RECOMBINANT MAST CELL PROTEASE 6; RECOMBINANT TRYPTASE BETA; STROMELYSIN; TETRAMER; TRYPTASE; TRYPTASE BETA; UNCLASSIFIED DRUG;

AGGRECANOLYSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; CARBOXY TERMINAL SEQUENCE; CELL LYSATE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; EX VIVO STUDY; FEMUR HEAD; IN VITRO STUDY; MAST CELL; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DOMAIN;

AGGRECANS; ANIMALS; ARTHRITIS; CARTILAGE, ARTICULAR; CELLS, CULTURED; ENZYME PRECURSORS; EXTRACELLULAR MATRIX; INFLAMMATION; MAST CELLS; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASE INHIBITORS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; TRYPTASES;

EID: 84880655481     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1300856     Document Type: Article

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