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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 16, 2013, Pages 4685-4691

1,1-Dioxo-5,6-dihydro-[4,1,2]oxathiazines, a novel class of 11ß-HSD1 inhibitors for the treatment of diabetes

(7) Böhme, Thomas a Engel, Christian K a Farjot, Géraldine b Güssregen, Stefan a Haack, Torsten a Tschank, Georg a Ritter, Kurt a

a Sanofi Deutschland GmbH (Germany)

b SANOFI (France)

Author keywords

1,1 Dioxo 5,6 dihydro 4,1,2 oxathiazine; 11 HSD1 inhibitors; 11 Hydroxysteroid dehydrogenase type 1; Diabetes

Indexed keywords

1,1 DIOXO 5,6 DIHYDRO [4,1,2]OXATHIAZINE; 11BETA HYDROXYSTEROID DEHYDROGENASE 1; ANTIDIABETIC AGENT; THIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHIRAL CHROMATOGRAPHY; DIABETES MELLITUS; DIASTEREOISOMER; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG POTENCY; DRUG STABILITY; DRUG STRUCTURE; ENANTIOMER; ENZYME INHIBITION; HUMAN; NONHUMAN; PHARMACODYNAMICS; PROTEIN CONFORMATION; STEROID BINDING;

1,1-DIOXO-5,6-DIHYDRO-[4,1,2]OXATHIAZINE; 11Β-HSD1 INHIBITORS; 11Β-HYDROXYSTEROID DEHYDROGENASE TYPE 1; DIABETES;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ANIMALS; BINDING SITES; DIABETES MELLITUS; ENZYME ACTIVATION; ENZYME INHIBITORS; ENZYME STABILITY; HUMANS; HYPOGLYCEMIC AGENTS; INHIBITORY CONCENTRATION 50; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZINES;

MURINAE;

EID: 84880627776 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.05.102 Document Type: Article

Times cited : (22)

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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.