The overexpression of BAMBI and its involvement in the growth and invasion of human osteosarcoma cells

Oncology Reports

Volumn 30, Issue 3, 2013, Pages 1315-1322

  Zhou, Lu ^a   Park, Jin ^d   Jang, Kyu Yun ^b   Park, Ho Sung ^b   Wagle, Sajeev ^a   Yang, Kyu Hyun ^d   Lee, Kwang Bok ^a   Park, Byung Hyun ^c   Kim, Jung Ryul ^a  

^a Chonbuk National University Medical School   (South Korea)

^b Departments of Pathology   (South Korea)

^c Departments of Biochemistry   (South Korea)

^d Yonsei University College of Medicine   (South Korea)

Author keywords

catenin; BAMBI; Cell cycle; Invasion; Osteosarcoma; Proliferation

Indexed keywords

ADENOVIRUS VECTOR; BETA CATENIN; BONE MORPHOGENETIC PROTEIN AND ACTIVIN MEMBRANE BOUND INHIBITOR; GELATINASE A; GELATINASE B; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GROWTH; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME RELEASE; GENE FUNCTION; GENE OVEREXPRESSION; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; NUCLEOTIDE SEQUENCE; OSTEOSARCOMA; OSTEOSARCOMA CELL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RNA INTERFERENCE; TISSUE DISTRIBUTION; UPREGULATION;

APOPTOSIS; BLOTTING, WESTERN; BONE AND BONES; BONE NEOPLASMS; CELL CYCLE; CELL MOVEMENT; CELL PROLIFERATION; COLLAGEN; DRUG COMBINATIONS; HUMANS; IMMUNOENZYME TECHNIQUES; LAMININ; MEMBRANE PROTEINS; NEOPLASM INVASIVENESS; OSTEOSARCOMA; PROTEOGLYCANS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; TUMOR CELLS, CULTURED; WOUND HEALING;

EID: 84880615039     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2569     Document Type: Article

References (27)

1. Bacci G, Longhi A, Versari M, Mercuri M, Briccoli A and Picci P: Prognostic factors for osteosarcoma of the extremity treated with neoadjuvant chemotherapy: 15-year experience in 789 patients treated at a single institution. Cancer 106: 1154-1161, 2006.
2. Ferguson WS and Goorin AM: Current treatment of osteosarcoma. Cancer Invest 19: 292-315, 2001.
3. Bacci G, Briccoli A, Ferrari S, et al: Neoadjuvant chemotherapy for osteosarcoma of the extremities with synchronous lung metastases: treatment with cisplatin, adriamycin and high dose of methotrexate and ifosfamide. Oncol Rep 7: 339-346, 2000.
4. Saeter G, Hoie J, Stenwig AE, Johansson AK, Hannisdal E and Solheim OP: Systemic relapse of patients with osteogenic sarcoma. Prognostic factors for long term survival. Cancer 75: 1084-1093, 1995.
5. Massague J: TGFbeta in cancer. Cell 134: 215-230, 2008.
6. Osuna D and de Alava E: Molecular pathology of sarcomas. Rev Recent Clin Trials 4: 12-26, 2009.
7. Massague J, Blain SW and Lo RS: TGFβ signaling in growth control, cancer, and heritable disorders. Cell 103: 295-309, 2000.
8. Onichtchouk D, Chen YG, Dosch R, et al: Silencing of TGF-β signalling by the pseudoreceptor BAMBI. Nature 401: 480-485, 1999.
9. Fritzmann J, Morkel M, Besser D, et al: A colorectal cancer expression profile that includes transforming growth factor β inhibitor BAMBI predicts metastatic potential. Gastroenterology 137: 165-175, 2009.
10. Yan X, Lin Z, Chen F, et al: Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-β signaling. J Biol Chem 284: 30097-30104, 2009.
11. Seki E, De Minicis S, Osterreicher CH, et al: TLR4 enhances TGF-β signaling and hepatic fibrosis. Nat Med 13: 1324-1332, 2007.
12. van Amerongen R, Mikels A and Nusse R: Alternative Wnt signaling is initiated by distinct receptors. Sci Signal 1: re9, 2008.
13. Nusse R and Varmus HE: Wnt genes. Cell 69: 1073-1087, 1992.
14. Polakis P: Wnt signaling in cancer. Cold Spring Harb Perspect Biol 4: 2012.
15. Lee JH, Song MY, Song EK, et al: Overexpression of SIRT1 protects pancreatic β-cells against cytokine toxicity by suppressing the nuclear factor-κB signaling pathway. Diabetes 58: 344-351, 2009.
16. Aizawa J, Sakayama K, Kamei S, et al: Effect of troglitazone on tumor growth and pulmonary metastasis development of the mouse osteosarcoma cell line LM8. BMC Cancer 10:51, 2010.
17. Tetsu O and McCormick F: β-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398: 422-426, 1999.
18. Khin SS, Kitazawa R, Win N, et al: BAMBI gene is epigenetically silenced in subset of high-grade bladder cancer. Int J Cancer 125: 328-338, 2009.
19. Subramaniam N, Sherman MH, Rao R, et al: Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/β-catenin signaling. Cancer Prev Res 5: 553-561, 2012.
20. Lin Z, Gao C, Ning Y, He X, Wu W and Chen YG: The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/β-catenin signaling. J Biol Chem 283: 33053-33058, 2008.
21. Liu C, Li Y, Semenov M, et al: Control of β-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108: 837-847, 2002.
22. Morin PJ, Sparks AB, Korinek V, et al: Activation of beta-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC. Science 275: 1787-1790, 1997.
23. Willert K and Jones KA: Wnt signaling: is the party in the nucleus? Genes Dev 20: 1394-1404, 2006.
24. Stetler-Stevenson WG, Aznavoorian S and Liotta LA: Tumor cell interactions with the extracellular matrix during invasion and metastasis. Annu Rev Cell Biol 9: 541-573, 1993.
25. Shapiro GI: Cyclin-dependent kinase pathways as targets for cancer treatment. J Clin Oncol 24: 1770-1783, 2006.
26. Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R and Beach D: p21 is a universal inhibitor of cyclin kinases. Nature 366: 701-704, 1993.
27. Zhou L, Park BH, Park JH, et al: Overexpression of the prolyl isomerase PIN1 promotes cell growth in osteosarcoma cells. Oncol Rep 29: 193-198, 2013.