-
1
-
-
73449140168
-
Molecular pathogenesis of liver fibrosis
-
Brenner DA. Molecular pathogenesis of liver fibrosis. Trans Am Clin Climatol Assoc 2009;120:361-8.
-
(2009)
Trans Am Clin Climatol Assoc
, vol.120
, pp. 361-368
-
-
Brenner, D.A.1
-
2
-
-
0037220482
-
Liver fibrosis-from bench to bedside
-
Friedman SL. Liver fibrosis-from bench to bedside. J Hepatol 2003;38 Suppl 1:S38-53.
-
(2003)
J Hepatol
, vol.38
, Issue.SUPPL. 1
-
-
Friedman, S.L.1
-
3
-
-
70350642050
-
Deaths: Final data for 2006
-
Heron M, Hoyert DL, Murphy SL, Xu J, Kochanek KD, Tejada-Vera B. Deaths: final data for 2006. Natl Vital Stat Rep 2009;57:1-134.
-
(2009)
Natl Vital Stat Rep
, vol.57
, pp. 1-134
-
-
Heron, M.1
Hoyert, D.L.2
Murphy, S.L.3
Xu, J.4
Kochanek, K.D.5
Tejada-Vera, B.6
-
5
-
-
79959361853
-
Factors that affect risk for hepatocellular carcinoma and effects of surveillance
-
Yang JD, Harmsen WS, Slettedahl SW, Chaiteerakij R, Enders FT, Therneau TM, et al. Factors that affect risk for hepatocellular carcinoma and effects of surveillance. Clin Gastroenterol Hepatol 2011;9:617-23 e1.
-
(2011)
Clin Gastroenterol Hepatol
, vol.9
-
-
Yang, J.D.1
Harmsen, W.S.2
Slettedahl, S.W.3
Chaiteerakij, R.4
Enders, F.T.5
Therneau, T.M.6
-
6
-
-
77952573691
-
Molecular mechanisms of hepatic fibrosis in non-alcoholic steatohepatitis
-
Rombouts K, Marra F. Molecular mechanisms of hepatic fibrosis in non-alcoholic steatohepatitis. Dig Dis 2010;28:229-35.
-
(2010)
Dig Dis
, vol.28
, pp. 229-235
-
-
Rombouts, K.1
Marra, F.2
-
7
-
-
34249776715
-
Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis
-
DOI 10.1111/j.1440-1746.2006.04658.x
-
Kisseleva T, Brenner DA. Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. J Gastroenterol Hepatol 2007;22 Suppl 1:S73-8. (Pubitemid 46848997)
-
(2007)
Journal of Gastroenterology and Hepatology
, vol.22
, Issue.SUPPL. 1
-
-
Kisseleva, T.1
Brenner, D.A.2
-
8
-
-
0034809804
-
Hepatic stellate cells as a target for the treatment of liver fibrosis
-
DOI 10.1055/s-2001-17558
-
Bataller R, Brenner DA. Hepatic stellate cells as a target for the treatment of liver fibrosis. Semin Liver Dis 2001;21:437-51. (Pubitemid 32923771)
-
(2001)
Seminars in Liver Disease
, vol.21
, Issue.3
, pp. 437-451
-
-
Bataller, R.1
Brenner, D.A.2
-
9
-
-
0032948229
-
Expression and regulation of cell adhesion molecules by hepatic stellate cells (HSC) of rat liver: Involvement of HSC in recruitment of inflammatory cells during hepatic tissue repair
-
Knittel T, Dinter C, Kobold D, Neubauer K, Mehde M, Eichhorst S, et al. Expression and regulation of cell adhesion molecules by hepatic stellate cells (HSC) of rat liver: involvement of HSC in recruitment of inflammatory cells during hepatic tissue repair. Am J Pathol 1999;154:153-67. (Pubitemid 29031623)
-
(1999)
American Journal of Pathology
, vol.154
, Issue.1
, pp. 153-167
-
-
Knittel, T.1
Dinter, C.2
Kobold, D.3
Neubauer, K.4
Mehde, M.5
Eichhorst, S.6
Ramadori, G.7
-
10
-
-
49749145668
-
Senescence of activated stellate cells limits liver fibrosis
-
Krizhanovsky V, Yon M, Dickins RA, Hearn S, Simon J, Miething C, et al. Senescence of activated stellate cells limits liver fibrosis. Cell 2008;134:657-67.
-
(2008)
Cell
, vol.134
, pp. 657-667
-
-
Krizhanovsky, V.1
Yon, M.2
Dickins, R.A.3
Hearn, S.4
Simon, J.5
Miething, C.6
-
11
-
-
33748111665
-
Nonalcoholic Fatty Liver Disease: Cytokine-Adipokine Interplay and Regulation of Insulin Resistance
-
DOI 10.1053/j.gastro.2006.05.054, PII S0016508506012078
-
Tilg H, Hotamisligil GS. Nonalcoholic fatty liver disease: Cytokine-adipokine interplay and regulation of insulin resistance. Gastroenterology 2006;131:934-45. (Pubitemid 44307061)
-
(2006)
Gastroenterology
, vol.131
, Issue.3
, pp. 934-945
-
-
Tilg, H.1
Hotamisligil, G.S.2
-
12
-
-
30544439060
-
Therapy insight: Adipocytokines in metabolic syndrome and related cardiovascular disease
-
DOI 10.1038/ncpcardio0380, PII N0380
-
Matsuzawa Y. Therapy insight: adipocytokines in metabolic syndrome and related cardiovascular disease. Nat Clin Pract Cardiovasc Med 2006;3:35-42. (Pubitemid 43078211)
-
(2006)
Nature Clinical Practice Cardiovascular Medicine
, vol.3
, Issue.1
, pp. 35-42
-
-
Matsuzawa, Y.1
-
13
-
-
0041302377
-
The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
-
DOI 10.1172/JCI200317797
-
Xu A, Wang Y, Keshaw H, Xu LY, Lam KS, Cooper GJ. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest 2003;112:91-100. (Pubitemid 38056380)
-
(2003)
Journal of Clinical Investigation
, vol.112
, Issue.1
, pp. 91-100
-
-
Xu, A.1
Wang, Y.2
Keshaw, H.3
Xu, L.Y.4
Lam, K.S.L.5
Cooper, G.J.S.6
-
14
-
-
10744228583
-
Enhanced Carbon Tetrachloride-Induced Liver Fibrosis in Mice Lacking Adiponectin
-
DOI 10.1053/j.gastro.2003.08.029
-
Kamada Y, Tamura S, Kiso S, Matsumoto H, Saji Y, Yoshida Y, et al. Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin. Gastroenterology 2003;125:1796-807. (Pubitemid 37500444)
-
(2003)
Gastroenterology
, vol.125
, Issue.6
, pp. 1796-1807
-
-
Kamada, Y.1
Tamura, S.2
Kiso, S.3
Matsumoto, H.4
Saji, Y.5
Yoshida, Y.6
Fukui, K.7
Maeda, N.8
Nishizawa, H.9
Nagaretani, H.10
Okamoto, Y.11
Kihara, S.12
Miyagawa, J.-I.13
Shinomura, Y.14
Funahashi, T.15
Matsuzawa, Y.16
-
15
-
-
19544378172
-
The roles of leptin and adiponectin: A novel paradigm in adipocytokine regulation of liver fibrosis and stellate cell biology
-
Ding X, Saxena NK, Lin S, Xu A, Srinivasan S, Anania FA. The roles of leptin and adiponectin: a novel paradigm in adipocytokine regulation of liver fibrosis and stellate cell biology. Am J Pathol 2005;166:1655-69. (Pubitemid 40734389)
-
(2005)
American Journal of Pathology
, vol.166
, Issue.6
, pp. 1655-1669
-
-
Ding, X.1
Saxena, N.K.2
Lin, S.3
Xu, A.4
Srinivasan, S.5
Anania, F.A.6
-
16
-
-
39549118017
-
Adenosine monophosphate-activated protein kinase modulates the activated phenotype of hepatic stellate cells
-
DOI 10.1002/hep.21995
-
Caligiuri A, Bertolani C, Guerra CT, Aleffi S, Galastri S, Trappoliere M, et al. Adenosine monophosphate-activated protein kinase modulates the activated phenotype of hepatic stellate cells. Hepatology 2008;47:668-76. (Pubitemid 351280735)
-
(2008)
Hepatology
, vol.47
, Issue.2
, pp. 668-676
-
-
Caligiuri, A.1
Bertolani, C.2
Guerra, C.T.3
Aleffi, S.4
Galastri, S.5
Trappoliere, M.6
Vizzutti, F.7
Gelmini, S.8
Laffi, G.9
Pinzani, M.10
Marra, F.11
-
17
-
-
39549093795
-
High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase
-
DOI 10.1002/hep.21991
-
Adachi M, Brenner DA. High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase. Hepatology 2008;47:677-85. (Pubitemid 351280736)
-
(2008)
Hepatology
, vol.47
, Issue.2
, pp. 677-685
-
-
Adachi, M.1
Brenner, D.A.2
-
18
-
-
0036851817
-
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
-
DOI 10.1038/nm788
-
Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 2002;8:1288-95. (Pubitemid 35373562)
-
(2002)
Nature Medicine
, vol.8
, Issue.11
, pp. 1288-1295
-
-
Yamauchi, T.1
Kamon, J.2
Minokoshi, Y.3
Ito, Y.4
Waki, H.5
Uchida, S.6
Yamashita, S.7
Noda, M.8
Kita, S.9
Ueki, K.10
Eto, K.11
Akanuma, Y.12
Froguel, P.13
Foufelle, F.14
Ferre, P.15
Carling, D.16
Kimura, S.17
Nagai, R.18
Kahn, B.B.19
Kadowaki, T.20
more..
-
19
-
-
80053035284
-
AMP-activated protein kinase: An energy sensor that regulates all aspects of cell function
-
Hardie DG. AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. Genes Dev 2011;25:1895-908.
-
(2011)
Genes Dev
, vol.25
, pp. 1895-1908
-
-
Hardie, D.G.1
-
20
-
-
80052511813
-
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
-
Mihaylova MM, Shaw RJ. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol 2011;13:1016-23.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 1016-1023
-
-
Mihaylova, M.M.1
Shaw, R.J.2
-
21
-
-
0034773404
-
Role of AMP-activated protein kinase in mechanism of metformin action
-
DOI 10.1172/JCI200113505
-
Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 2001;108:1167-74. (Pubitemid 32995375)
-
(2001)
Journal of Clinical Investigation
, vol.108
, Issue.8
, pp. 1167-1174
-
-
Zhou, G.1
Myers, R.2
Li, Y.3
Chen, Y.4
Shen, X.5
Fenyk-Melody, J.6
Wu, M.7
Ventre, J.8
Doebber, T.9
Fujii, N.10
Musi, N.11
Hirshman, M.F.12
Goodyear, L.J.13
Moller, D.E.14
-
22
-
-
33847072201
-
AMP-activated protein kinase as a drug target
-
Hardie DG. AMP-activated protein kinase as a drug target. Annu Rev Pharmacol Toxicol 2007;47:185-210.
-
(2007)
Annu Rev Pharmacol Toxicol
, vol.47
, pp. 185-210
-
-
Hardie, D.G.1
-
23
-
-
0345167800
-
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
-
DOI 10.1016/S0092-8674(03)00929-2
-
Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003;115:577-90. (Pubitemid 37506046)
-
(2003)
Cell
, vol.115
, Issue.5
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.-L.3
-
24
-
-
77957280791
-
The Necdin-Wnt pathway causes epigenetic peroxisome proliferator- activated receptor gamma repression in hepatic stellate cells
-
Zhu NL, Wang J, Tsukamoto H. The Necdin-Wnt pathway causes epigenetic peroxisome proliferator-activated receptor gamma repression in hepatic stellate cells. J Biol Chem 2010;285:30463-71.
-
(2010)
J Biol Chem
, vol.285
, pp. 30463-30471
-
-
Zhu, N.L.1
Wang, J.2
Tsukamoto, H.3
-
25
-
-
24944475268
-
Isolation and culture of hepatic stellate cells
-
Weiskirchen R, Gressner AM. Isolation and culture of hepatic stellate cells. Methods Mol Med 2005;117:99-113.
-
(2005)
Methods Mol Med
, vol.117
, pp. 99-113
-
-
Weiskirchen, R.1
Gressner, A.M.2
-
26
-
-
42949139481
-
AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
-
DOI 10.1016/j.molcel.2008.03.003, PII S109727650800169X
-
Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 2008;30:214-26. (Pubitemid 351626684)
-
(2008)
Molecular Cell
, vol.30
, Issue.2
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
Vasquez, D.S.6
Turk, B.E.7
Shaw, R.J.8
-
27
-
-
80655127773
-
Vitamin D inhibits proliferation and profibrotic marker expression in hepatic stellate cells and decreases thioacetamide-induced liver fibrosis in rats
-
Abramovitch S, Dahan-Bachar L, Sharvit E, Weisman Y, Ben Tov A, Brazowski E, et al. Vitamin D inhibits proliferation and profibrotic marker expression in hepatic stellate cells and decreases thioacetamide-induced liver fibrosis in rats. Gut 2011;60:1728-37.
-
(2011)
Gut
, vol.60
, pp. 1728-1737
-
-
Abramovitch, S.1
Dahan-Bachar, L.2
Sharvit, E.3
Weisman, Y.4
Ben Tov, A.5
Brazowski, E.6
-
28
-
-
0032586690
-
The role of TGFβ1 in initiating hepatic stellate cell activation in vivo
-
DOI 10.1016/S0168-8278(99)80010-5
-
Hellerbrand C, Stefanovic B, Giordano F, Burchardt ER, Brenner DA. The role of TGFbeta1 in initiating hepatic stellate cell activation in vivo. J Hepatol 1999;30:77-87. (Pubitemid 29023655)
-
(1999)
Journal of Hepatology
, vol.30
, Issue.1
, pp. 77-87
-
-
Hellerbrand, C.1
Stefanovic, B.2
Giordano, F.3
Burchardt, E.R.4
Brenner, D.A.5
-
29
-
-
35948958955
-
TLR4 enhances TGF-β signaling and hepatic fibrosis
-
DOI 10.1038/nm1663, PII NM1663
-
Seki E, De Minicis S, Osterreicher CH, Kluwe J, Osawa Y, Brenner DA, et al. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med 2007;13:1324-32. (Pubitemid 350073596)
-
(2007)
Nature Medicine
, vol.13
, Issue.11
, pp. 1324-1332
-
-
Seki, E.1
De Minicis, S.2
Osterreicher, C.H.3
Kluwe, J.4
Osawa, Y.5
Brenner, D.A.6
Schwabe, R.F.7
-
30
-
-
77954961993
-
Toll-like receptor 4 and hepatic fibrogenesis
-
Pradere JP, Troeger JS, Dapito DH, Mencin AA, Schwabe RF. Toll-like receptor 4 and hepatic fibrogenesis. Semin Liver Dis 2010;30:232-44.
-
(2010)
Semin Liver Dis
, vol.30
, pp. 232-244
-
-
Pradere, J.P.1
Troeger, J.S.2
Dapito, D.H.3
Mencin, A.A.4
Schwabe, R.F.5
-
31
-
-
79955619059
-
Adiponectin induces the transforming growth factor decoy receptor BAMBI in human hepatocytes
-
Wanninger J, Neumeier M, Bauer S, Weiss TS, Eisinger K, Walter R, et al. Adiponectin induces the transforming growth factor decoy receptor BAMBI in human hepatocytes. FEBS Lett 2011;585:1338-44.
-
(2011)
FEBS Lett
, vol.585
, pp. 1338-1344
-
-
Wanninger, J.1
Neumeier, M.2
Bauer, S.3
Weiss, T.S.4
Eisinger, K.5
Walter, R.6
-
33
-
-
64949101091
-
Down-regulation of Wnt signaling during apoptosis of human hepatic stellate cells
-
Shin HW, Park SY, Lee KB, Jang JJ. Down-regulation of Wnt signaling during apoptosis of human hepatic stellate cells. Hepatogastroenterology 2009;56:208-12.
-
(2009)
Hepatogastroenterology
, vol.56
, pp. 208-212
-
-
Shin, H.W.1
Park, S.Y.2
Lee, K.B.3
Jang, J.J.4
-
34
-
-
77958584404
-
BAMBI is expressed in endothelial cells and is regulated by lysosomal/autolysosomal degradation
-
Xavier S, Gilbert V, Rastaldi MP, Krick S, Kollins D, Reddy A, et al. BAMBI is expressed in endothelial cells and is regulated by lysosomal/ autolysosomal degradation. PLoS One 2010;5:e12995.
-
(2010)
PLoS One
, vol.5
-
-
Xavier, S.1
Gilbert, V.2
Rastaldi, M.P.3
Krick, S.4
Kollins, D.5
Reddy, A.6
-
35
-
-
77957349477
-
AMP-activated protein kinase and its downstream transcriptional pathways
-
Canto C, Auwerx J. AMP-activated protein kinase and its downstream transcriptional pathways. Cell Mol Life Sci 2010;67:3407-23.
-
(2010)
Cell Mol Life Sci
, vol.67
, pp. 3407-3423
-
-
Canto, C.1
Auwerx, J.2
-
36
-
-
80052511813
-
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism AMP-activated protein kinase: Nature's energy sensor
-
Mihaylova MM, Shaw RJ, Carling D, Mayer FV, Sanders MJ, Gamblin SJ. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism AMP-activated protein kinase: nature's energy sensor. Nat Cell Biol 2011;13:1016-23.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 1016-1023
-
-
Mihaylova, M.M.1
Shaw, R.J.2
Carling, D.3
Mayer, F.V.4
Sanders, M.J.5
Gamblin, S.J.6
-
37
-
-
74149083791
-
AMPK-independent down-regulation of cFLIP and sensitization to TRAIL-induced apoptosis by AMPK activators
-
Garcia-Garcia C, Fumarola C, Navaratnam N, Carling D, Lopez-Rivas A. AMPK-independent down-regulation of cFLIP and sensitization to TRAIL-induced apoptosis by AMPK activators. Biochem Pharmacol 2010;79:853-63.
-
(2010)
Biochem Pharmacol
, vol.79
, pp. 853-863
-
-
Garcia-Garcia, C.1
Fumarola, C.2
Navaratnam, N.3
Carling, D.4
Lopez-Rivas, A.5
-
38
-
-
35948978063
-
A deer in the headlights: BAMBI meets liver fibrosis
-
DOI 10.1038/nm1107-1281, PII NM11071281
-
Friedman SL. A deer in the headlights: BAMBI meets liver fibrosis. Nat Med 2007;13:1281-2. (Pubitemid 350073583)
-
(2007)
Nature Medicine
, vol.13
, Issue.11
, pp. 1281-1282
-
-
Friedman, S.L.1
-
39
-
-
78649670044
-
The Wnt/beta-catenin signaling pathway in liver biology and disease
-
Behari J. The Wnt/beta-catenin signaling pathway in liver biology and disease. Expert Rev Gastroenterol Hepatol 2010;4:745-56.
-
(2010)
Expert Rev Gastroenterol Hepatol
, vol.4
, pp. 745-756
-
-
Behari, J.1
-
40
-
-
10744228797
-
Identification of BMP and Activin Membrane-bound Inhibitor (BAMBI), an Inhibitor of Transforming Growth Factor-β Signaling, as a Target of the β-Catenin Pathway in Colorectal Tumor Cells
-
DOI 10.1074/jbc.M310876200
-
Sekiya T, Adachi S, Kohu K, Yamada T, Higuchi O, Furukawa Y, et al. Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells. J Biol Chem 2004;279:6840-6. (Pubitemid 38248826)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.8
, pp. 6840-6846
-
-
Sekiya, T.1
Adachi, S.2
Kohu, K.3
Yamada, T.4
Higuchi, O.5
Furukawa, Y.6
Nakamura, Y.7
Nakamura, T.8
Tashiro, K.9
Kuhara, S.10
Ohwada, S.11
Akiyama, T.12
|