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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 16, 2013, Pages 4696-4700

Synthesis and the 5-HT6 receptor antagonistic effect of 3-arylsulfonylamino-5,6-dihydro-6-substituted pyrazolo[3,4]pyridinones for neuropathic pain treatment

(8) Devegowda, Vani Nelamane a Hong, Jin Ri b Cho, Sungjin a Lim, Eun Jeong a Choo, Hyunah a Keum, Gyochang a Rhim, Hyewon a Nam, Ghilsoo a

a Korea Institute of Science and Technology (South Korea)

b University of Science and Technology (UST) (South Korea)

Author keywords

5 HT6 receptor antagonist; Arylsufonylamino 5,6 dihydro pyrazolo 3,4 c pyridine 7 one; Neuropathic pain; Synthesis

Indexed keywords

3 PHENYLSULFONYL 8 (1 PIPERAZINYL)QUINOLINE; 4 AMINO N [2,6 BIS(METHYLAMINO) 4 PYRIDINYL]BENZENESULFONAMIDE; 4 AMINO N [2,6 BIS(METHYLAMINO) 4 PYRIMIDINYL]BENZENESULFONAMIDE; AVN 211; BVT 74316; SAM 532; SB 258585; SB 737050A; SEROTONIN 6 ANTAGONIST; SEROTONIN 6 RECEPTOR; UNCLASSIFIED DRUG; ENZYME INHIBITOR; PYRAZOLE DERIVATIVE; PYRIDONE DERIVATIVE; SEROTONIN RECEPTOR; PROTEIN BINDING;

ALKYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG DESIGN; HUMAN; HUMAN CELL; IN VITRO STUDY; NEUROPATHIC PAIN; NONHUMAN; POLYMERIZATION; RAT; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; 5-HT(6) RECEPTOR ANTAGONIST; ANIMAL; ARYLSUFONYLAMINO-5,6-DIHYDRO-PYRAZOLO[3,4-C]PYRIDINE-7-ONE; CHEMICAL STRUCTURE; CHEMISTRY; DISEASE MODEL; DRUG EFFECT; DRUG STABILITY; IC 50; METABOLISM; NEURALGIA; PROTEIN BINDING; SYNTHESIS; DRUG EFFECTS; IC50;

ANIMALIA; RATTUS;

5-HT(6) RECEPTOR ANTAGONIST; ARYLSUFONYLAMINO-5,6-DIHYDRO-PYRAZOLO[3,4-C]PYRIDINE-7-ONE; NEUROPATHIC PAIN; SYNTHESIS;

ANIMALS; DISEASE MODELS, ANIMAL; DRUG STABILITY; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; NEURALGIA; PROTEIN BINDING; PYRAZOLES; PYRIDONES; RATS; RECEPTORS, SEROTONIN;

EID: 84880601634 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.05.100 Document Type: Article

Times cited : (13)

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