Discovery of novel benzo[b][1,4]oxazin-3(4H)-ones as poly(ADP-ribose) polymerase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 16, 2013, Pages 4501-4505

  Gangloff, Anthony R ^a   Brown, Jason ^a   De Jong, Ron ^a   Dougan, Douglas R ^a   Grimshaw, Charles E ^a   Hixon, Mark ^a   Jennings, Andy ^a   Kamran, Ruhi ^a   Kiryanov, Andre ^a   O'Connell, Shawn ^b   Taylor, Ewan ^a   Vu, Phong ^a  

^a Takeda San Diego Inc   (United States)

^b Quanticel Pharmaceuticals Inc   (United States)

Author keywords

1,4 Benzoxazin 3 one; Chemopotentiation; PARP 1; Poly(ADP ribose)polymerase inhibitors; Structure based drug design

Indexed keywords

BENZO[B][1,4]OXAZIN 3(4H) ONE DERIVATIVE; BENZOXAZINE DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ARTICLE; CANCER INHIBITION; CELL VIABILITY; DRUG DESIGN; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HYDROGEN BOND; LEUKEMIA CELL LINE;

1,4-BENZOXAZIN-3-ONE; CHEMOPOTENTIATION; PARP-1; POLY(ADP-RIBOSE)POLYMERASE INHIBITORS; STRUCTURE-BASED DRUG DESIGN;

ANIMALS; BENZOXAZINES; CELL LINE, TUMOR; DRUG DESIGN; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; MICE; MICE, NUDE; MOLECULAR STRUCTURE; POLY(ADP-RIBOSE) POLYMERASES;

MUS MUSCULUS;

EID: 84880586264     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.06.055     Document Type: Article

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