Benzodiazepine augmented γ-amino-butyric acid signaling increases mortality from pneumonia in mice

Critical Care Medicine

Volumn 41, Issue 7, 2013, Pages 1627-1636

  Sanders, Robert D ^a,b   Godlee, Alexandra ^a   Fujimori, Toshifumi ^a   Goulding, John ^a   Xin, Gang ^a   Salek Ardakani, Samira ^a   Snelgrove, Robert J ^a   Ma, Daqing ^a   Maze, Mervyn ^a,c   Hussell, Tracy ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

amino butyric acid type A receptor; benzodiazepine; pneumonia

Indexed keywords

4 AMINOBUTYRIC ACID; BICUCULLINE METHIODIDE; DIAZEPAM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PH; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; DRUG POTENTIATION; IMMUNE RESPONSE; MACROPHAGE; MACROPHAGE FUNCTION; MORTALITY; MOUSE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION;

ANIMALS; BENZODIAZEPINES; BICUCULLINE; CYTOKINES; FEMALE; GABA-A RECEPTOR ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; HYDROGEN-ION CONCENTRATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PNEUMONIA, BACTERIAL; RANDOM ALLOCATION; RECEPTORS, GABA-A; SIGNAL TRANSDUCTION;

EID: 84880572893     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31827c0c8d     Document Type: Article

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