Fragment screening by weak affinity chromatography: Comparison with established techniques for screening against HSP90

Analytical Chemistry

Volumn 85, Issue 14, 2013, Pages 6756-6766

  Meiby, Elinor ^a   Simmonite, Heather ^b   Le Strat, Loic ^b   Davis, Ben ^b   Matassova, Natalia ^b   Moore, Jonathan D ^b   Mrosek, Michael ^b   Murray, James ^b   Hubbard, Roderick E ^b,c   Ohlson, Sten ^a,d  

^a LINNAEUS UNIVERSITY   (Sweden)

^b Vernalis PLC   (United Kingdom)

^c UNIVERSITY OF YORK   (United Kingdom)

^d NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORESCENCE POLARIZATION; GOOD CORRELATIONS; ISOTHERMAL TITRATION CALORIMETRY; NEW TECHNOLOGIES; NUCLEAR MAGNETIC RESONANCE(NMR); RELIABLE METHODS; REPRODUCIBILITIES; VARIOUS TECHNOLOGIES;

AFFINITY CHROMATOGRAPHY; X RAY CRYSTALLOGRAPHY;

SURFACE PLASMON RESONANCE;

HEAT SHOCK PROTEIN 90; PEPTIDE FRAGMENT;

AFFINITY CHROMATOGRAPHY; AMINO ACID SEQUENCE; ARTICLE; COMPARATIVE STUDY; DRUG SCREENING; GENETICS; METHODOLOGY; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; CHROMATOGRAPHY, AFFINITY; CRYSTALLOGRAPHY, X-RAY; DRUG EVALUATION, PRECLINICAL; HSP90 HEAT-SHOCK PROTEINS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY;

EID: 84880567242     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/ac400715t     Document Type: Article

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