Reducing signs of aging and increasing lifespan by drug synergy

Aging Cell

Volumn 12, Issue 4, 2013, Pages 652-660

  Huang, Xinhe ^a   Liu, Jun ^a,c   Withers, Bradley R ^a   Samide, Aaron J ^a   Leggas, Markos ^b   Dickson, Robert C ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b University of Kentucky   (United States)

^c SICHUAN UNIVERSITY   (China)

Author keywords

Aging; Autophagy; Genomic stability; Longevity; S6 Kinase; TORC1

Indexed keywords

ADENYLATE KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PROTEIN SERINE THREONINE KINASE; RAPAMYCIN; SPHINGOLIPID; TARGET OF RAPAMYCIN PROTEIN KINASE COMPLEX 1; THERMOZYMOCIDIN; UNCLASSIFIED DRUG; MONOUNSATURATED FATTY ACID; REACTIVE OXYGEN METABOLITE; SACCHAROMYCES CEREVISIAE PROTEIN; SNF1-RELATED PROTEIN KINASES; TORC1 PROTEIN COMPLEX, S CEREVISIAE; TRANSCRIPTION FACTOR;

AGING; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENOMIC INSTABILITY; LIFESPAN; LIPOGENESIS; LOW DRUG DOSE; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; STRESS; DRUG EFFECTS; ENZYMOLOGY; GENETICS; METABOLISM; MICROBIAL VIABILITY; PHYSIOLOGICAL STRESS; PHYSIOLOGY; TIME;

SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

AUTOPHAGY; DRUG SYNERGISM; ENZYME ACTIVATION; FATTY ACIDS, MONOUNSATURATED; GENOMIC INSTABILITY; MICROBIAL VIABILITY; MITOCHONDRIA; PROTEIN-SERINE-THREONINE KINASES; REACTIVE OXYGEN SPECIES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; SIROLIMUS; STRESS, PHYSIOLOGICAL; TIME FACTORS; TRANSCRIPTION FACTORS;

EID: 84880511561     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12090     Document Type: Article

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