Effects of dietary decosahexaenoic acid (DHA) on eNOS in human coronary artery endothelial cells

Journal of Cardiovascular Pharmacology and Therapeutics

Volumn 13, Issue 4, 2008, Pages 261-268

  Stebbins, Charles L ^a   Stice, James P ^a   Hart, C Michael ^c   Mbai, Fiona N ^a   Knowlton, Anne A ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Northern California Veterans Affairs ^*

^c EMORY UNIVERSITY   (United States)

Author keywords

3 nitrotyrosine; Akt kinase; Cell culture; HSP90; Phospho Akt; Phospho eNOS

Indexed keywords

DOCOSAHEXAENOIC ACID; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HEAT SHOCK PROTEIN 90; NITRIC OXIDE; NITROUS OXIDE; PROTEIN KINASE B; VASCULOTROPIN;

ARTERY ENDOTHELIUM; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANALYSIS OF VARIANCE; BLOTTING, WESTERN; CELLS, CULTURED; CORONARY VESSELS; CYCLIC GMP; DIETARY SUPPLEMENTS; DOCOSAHEXAENOIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; FEMALE; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MALE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; TIME FACTORS; TYROSINE; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 57649240564     PISSN: 10742484     EISSN: None     Source Type: Journal    
DOI: 10.1177/1074248408322470     Document Type: Article

References (40)

1. Drexler H., Hayoz D., Münzel T., et al. Endothelial function and chronic congestive heart failure. Am J Cardiol. 1992 ; 69: 1596-1601.
2. Katz SD, Krum H., Khan T., Knecht M. Exercise-induced vasodilation in forearm circulation of normal subjects and patients with congestive heart failure: role of endothelium-derived nitric oxide. J Am Coll Cardiol. 1996 ; 28: 585-590.
3. Lindsay DC, Holdright DR, Clarke D., Anand IS, Poole-Wilson PA, Collins P. Endothelial control of lower limb blood flow in chronic heart failure. Heart. 1996 ; 75: 469-476.
4. Katz SD, Zheng H. Peripheral limitations of maximal aerobic capacity in patients with chronic heart failure. J Nucl Cardiol. 2002 ; 9: 215-225.
5. Mandinov L., Kaufmann P., Maier W., Hess OM Flow-dependent vasodilation in the coronary circulation: alterations in diseased states. Semin Interv Cardiol. 1998 ; 3: 5-12.
6. Wilcox JN, Subramanian RR, Sundell CL, et al. Expression of multiple isoforms of nitric oxide synthase in normal and atherosclerotic vessels. Aterioscler Thromb Vasc Biol. 1997 ; 17: 2479-2488.
7. Fulton D., Gratton JP, McCabe TJ, et al., Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature. 1999 ; 399: 597-601.
8. Harrison DG Cellular and molecular mechanisms of endothelial dysfunction. J Clin Invest. 1997 ; 100: 2153-2157.
9. Hirafuji M., Machida T., Hamaue N., Minami M. Cardiovascular protective effects of n-3 polyunsaturated fatty acids with special emphasis on docosahexaenoic acid. J Pharmacol Sci. 2003 ; 92: 308-316.
10. Lawson DL, Mehta JL, Saldeen K., Mehta P., Saldeen TG Omega-3 polyunsaturated fatty acids augment endothelium-dependent vasorelaxation by enhanced release of EDRF and vasodilator prostaglandins. Eicosanoids. 1991 ; 4: 217-223.
11. Hirafuji M., Machida T., Tsunoda M., Miyamoto A., Minami M. Docosahexaenoic acid potentiates interleukin-1β induction of nitric oxide synthase through a mechanism involving p44/42 MAPK activation in rat vascular smooth muscle cells. Br J Pharmacol. 2002 ; 136: 613-119.
12. Takahasi S., Mendelsohn ME Synergistic activation of endothelial nitric oxide synthase (eNOS) by HSP90 and Akt. J Biol Chem. 2003 ; 278: 30821-30827.
13. Fisslthaler B., Dimmeler S., Hermann C., Busse R., Fleming I. Phosphorylation and activation of the endothelial nitric oxide synthase by fluid shear stress. Acta Physiol Scand. 2000 ; 68: 81-88.
14. García-Cardeña G., Fan R., Shah V., et al. Dynamic activation of endothelial nitric oxide synthase by Hsp90. Nature. 1998 ; 392: 821-824.
15. Niebauer J., Cooke JP Cardiovascular effects of exercise: role of endothelial shear stress. J Am Coll Cardiol. 1996 ; 28: 1652-1660.
16. Hamilton KL, Mbai FN, Gupta S., Knowlton AA Estrogen, heat shock proteins, and NFkappaB in human vascular endothelium. Aterioscler Thromb Vasc Biol. 2004 ; 24: 1628-1633.
17. De Caterina R., Liao JK, Libby P. Fatty acid modulation of endothelial activation. Am J Clin Nutr. 2000 ; 71 (1 suppl). 213S - 223S.
18. Higdon JV, Liu J., Du S-H., Morrow JD, Ames BN, Wander RC Supplementation of postmenopausal women with fish oil rich in eicosapentaenoic acid and docosahexaenoic acid is not associated with greater in vivo lipid peroxidation compared with oils rich in oleate and linoleate as assessed by plasma malondialdehyde and F2-isoprostanes. Am J Clin Nutr. 2000 ; 72: 714-722.
19. Sun L., Chang J., Kirchhoff SR, Knowlton AA Activation of HSF and selective increase in heat shock proteins by acute dexamethasone treatment. Am J Physiol Heart Circ Physiol. 2000 ; 278: H1091 - H1097.
20. Jia H., Bagherzadeh A., Bicknell R., Duchen MR, Liu D., Zachary I. Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cells. J Biol Chem. 2004 ; 279: 36148-36157.
21. Palmer RM, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature. 1988 ; 333 ; 664-666.
22. Gousset-Dupont A., Robert V., Grynberg A., Lacour B., Tardivel S. The effect of n-3 PUFA on eNOS activity and expression in Ea hy 926 cells. Prostaglandins Leukot Essent Fatty Acids. 2007 ; 76: 131-139.
23. de Lima TM, de Sa Lima L., Scavone C., Curi R. Fatty acid control of nitric oxide production by macrophages. FEBS Lett. 2006 ; 580: 3287-3295.
24. Dimmeler S., Fleming I., Fisslthaler B., Hermann C., Busse R., Zeiher AM Activation of nitric oxide in endothelial cells by Akt-dependent phosphorylation. Nature. 1999 ; 399: 601-605.
25. Zeng G., Quon MJ Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells. J Clin Invest. 1996 ; 98: 894-898.
26. Fleming I., Busse R. Molecular mechanisms involved in the regulation of the endothelial nitric oxide system. Am J Physiol Regul Integr Comp Physiol. 2003 ; 284: R1 - R12.
27. Balligan J-L. Heat shock protein 90 in endothelial nitric oxide synthase signaling: following the lead(er) ? Circ Res. 2002 ; 90: 838-841.
28. Goldstein S., Czapski G. The reaction of NO- with O2-, and HO2-: a pulse radiolysis study. Free Radic Biol Med. 1995 ; 19: 505-510.
29. Ducrocq C., Blanchard B., Pignatelli B., Ohshima H. Peroxynitrite: an endogenous oxidizing and nitrating agent. Cell Mol Life Sci. 1999 ; 55: 1068-1077.
30. Mihm MJ, Jing L., Bauer JA Nitrotyrosine causes selective vascular endothelial dysfunction and DNA damage. J Cardiovasc Pharmacol. 2000 ; 36: 182-187.
31. MacMillan-Crow LA, Crow JP, Thompson JA Peroxynitrite-mediated inactivation of manganese superoxide dismutase involves nitration and oxidation of critical tyrosine residues. Biochemistry. 1998 ; 37: 1613-1622.
32. Bachschmid M., Thurau S., Zou MH, Ullrich V. Endothelial cell activation by endotoxin involves superoxide/NO mediated nitration of prostacyclin synthase and thromboxane receptor stimulation. FASEB J. 2003 ; 17: 914-916.
33. López D., Orta X., Casós K., et al. Upregulation of endothelial nitric oxide synthase in rat aorta after ingestion of fish oil-rich diet. Am J Physiol Heart Circ Physiol. 2004 ; 287: H567 - H572.
34. Gelinas DS, Bernatchez PN, Rollin S., Bazan NG, Sirois MG Immediate and delayed VEGF-mediated NO synthesis in endothelial cells: role of PI3K, PKC and PLC pathways. Br J Pharmacol. 2002 ; 137: 1021-1030.
35. Gooch KJ, Frangos JA Flow- and bradykinin-induced nitric oxide production by endothelial cells is independent of membrane potential. Am J Physiol Cell Physiol. 1996 ; 270: C546 - C551.
36. Ishibashi T., Yoshida J., Nishio M. New methods to evaluate endothelial function: A search for a marker of nitric oxide (NO) in vivo: re-evaluation of NOx in plasma and red blood cells and a trial to detect nitrosothiols. J Pharmacol Sci. 2003 ; 93: 409-416.
37. Ishibashi Y., Duncker DJ, Zhang J., Bache RJ ATP-sensitive K+ channels, adenosine, and nitric oxide-mediated mechanisms account for coronary vasodilation during exercise. Circ Res. 1998 ; 82: 346-359.
38. Lele RD Causation, prevention and reversal of vascular endothelial dysfunction. J Assoc Physicians India. 2007 ; 55: 643-641.
39. Yung LM, Leung FP, Yao X., Chen ZY, Huang Y. Reactive oxygen species in vascular wall. Cardiovasc Hematol Disord Drug Targets. 2006 ; 6: 1-19.
40. Morgan DR, Dixon LJ, Hanratty CG, et al. Effects of dietary omega-3 fatty acid supplementation on endothelium-dependent vasodilation in patients with chronic heart failure. Am J Cardiol. 2006 ; 97: 547-551.