Albumin overload induces expression of hypoxia-inducible factor 1α and its target genes in HK-2 human renal proximal tubular cell line

Biochemical and Biophysical Research Communications

Volumn 434, Issue 3, 2013, Pages 670-675

  Nagai, Junya ^a   Yamamoto, Ayaka ^a   Yumoto, Ryoko ^a   Takano, Mikihisa ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Albumin; HIF 1 ; HK 2 cells; Proteinuria; Renal proximal tubular cells

Indexed keywords

BETA ACTIN; GLUCOSE TRANSPORTER 1; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HUMAN SERUM ALBUMIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LACTATE DEHYDROGENASE; MESSENGER RNA; HIF1A PROTEIN, HUMAN; SERUM ALBUMIN;

ARTICLE; CELL NUCLEUS; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; HUMAN; HUMAN CELL; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; WESTERN BLOTTING; CELL LINE; CYTOLOGY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; METABOLISM; REAL TIME POLYMERASE CHAIN REACTION;

BLOTTING, WESTERN; CELL LINE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KIDNEY TUBULES, PROXIMAL; MICROSCOPY, CONFOCAL; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; SERUM ALBUMIN;

MLCS; MLOWN;

EID: 84880486011     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.03.140     Document Type: Article

References (37)

1. M. Abbate, C. Zoja, G. Remuzzi, How does proteinuria cause progressive renal damage?, J Am. Soc. Nephrol. 17 (2006) 2974-2984.
2. E.I. Christensen, J. Gburek, Protein reabsorption in renal proximal tubule-function and dysfunction in kidney pathophysiology, Pediatr. Nephrol. 19 (2004) 714-721.
3. A.A. Eddy, Proteinuria and interstitial injury, Nephrol. Dial. Transplant. 19 (2004) 277-281.
4. H. Birn, E.I. Christensen, Renal albumin absorption in physiology and pathology, Kidney Int. 69 (2006) 440-449.
5. R. Nielsen, E.I. Christensen, Proteinuria and events beyond the slit, Pediatr. Nephrol. 25 (2010) 813-822.
6. R.J. Baines, N.J. Brunskill, Tubular toxicity of proteinuria, Nat. Rev. Nephrol. 7 (2011) 177-180.
7. H. Nakajima, M. Takenaka, J.Y. Kaimori, et al., Gene expression profile of renal proximal tubules regulated by proteinuria, Kidney Int. 61 (2002) 1577-1587.
8. C. Zoja, R. Donadelli, S. Colleoni, et al., Protein overload stimulates RANTES production by proximal tubular cells depending on NF-kappa B activation, Kidney Int. 53 (1998) 1608-1615.
9. C. Guijarro, J. Egido, Transcription factor-κB (NF-κB) and renal disease, Kidney Int. 59 (2001) 415-424.
10. 2 through a PKC-dependent pathway, J. Am. Soc. Nephrol. 13 (2002) 1179-1189.
11. J.E. Baek, W.S. Yang, J.W. Chang, et al., Fatty acid-bearing albumin induces VCAM-1 expression through c-Src kinase-AP-1/NF-κB pathways: effect of L-carnitine, Kidney Blood Press Res. 33 (2010) 72-84.
12. G.L. Semenza, Oxygen sensing, homeostasis, and disease, N. Engl. J. Med. 365 (2011) 537-547.
13. Q. Ke, M. Costa, Hypoxia-inducible factor-1 (HIF-1), Mol. Pharmacol. 70 (2006) 1469-1480.
14. V.H. Haase, Hypoxia-inducible factors in the kidney, Am. J. Physiol. Renal Physiol. 291 (2006) F271-F281.
15. A. Weidemann, W.M. Bernhardt, B. Klanke, et al., HIF activation protects from acute kidney injury, J. Am. Soc. Nephrol. 19 (2008) 486-494.
16. S. Ohtomo, M. Nangaku, Y. Izuhara, et al., Cobalt ameliorates renal injury in an obese, hypertensive type 2 diabetes rat model, Nephrol. Dial. Transplant. 23 (2008) 1166-1172.
17. P. Hill, D. Shukla, M.G. Tran, et al., Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury, J. Am. Soc. Nephrol. 19 (2008) 39-46.
18. Y.R. Song, S.J. You, Y.M. Lee, et al., Activation of hypoxia-inducible factor attenuates renal injury in rat remnant kidney, Nephrol. Dial. Transplant. 25 (2010) 77-85.
19. A. Deng, M.A. Arndt, J. Satriano, et al., Renal protection in chronic kidney disease: hypoxia-inducible factor activation vs. angiotensin II blockade, Am. J. Physiol. Renal Physiol. 299 (2010) F1365-F1373.
20. H. Oka, H. Goto, K. Koizumi, et al., Effect of hachimijiogan against renal dysfunction and involvement of hypoxia-inducible factor-1α in the remnant kidney model, Evid. Based Complement. Alternat. Med. 2011 (2011) 348686.
21. J.M. Ahn, S.J. You, Y.M. Lee, et al., Hypoxia-inducible factor activation protects the kidney from gentamicin-induced acute injury, PLoS One 7 (2012) e48952.
22. D.F. Higgins, M.P. Biju, Y. Akai, et al., Hypoxic induction of Ctgf is directly mediated by Hif-1, Am. J. Physiol. Renal Physiol. 287 (2004) F1223-F1232.
23. K. Kimura, M. Iwano, D.F. Higgins, et al., Stable expression of HIF-1alpha in tubular epithelial cells promotes interstitial fibrosis, Am. J. Physiol. Renal Physiol. 295 (2008) F1023-F1029.
24. P. Katavetin, R. Inagi, T. Miyata, et al., Albumin suppresses vascular endothelial growth factor via alteration of hypoxia-inducible factor/hypoxia-responsive element pathway, Biochem. Biophys. Res. Commun. 367 (2008) 305-310.
25. T. Sawada, J. Nagai, Y. Okada, et al., Gadolinium modulates gentamicin uptake via an endocytosis-independent pathway in HK-2 human renal proximal tubular cell line, Eur. J. Pharmacol. 684 (2012) 146-153.
26. S. Bonello, C. Zähringer, R.S. BelAiba, et al., Reactive oxygen species activate the HIF-1α promoter via a functional NFκB site, Arterioscler. Thromb. Vasc. Biol. 27 (2007) 755-761.
27. L. Shalamanova, F. McArdle, A.B. Amara, et al., Albumin overload induces adaptive responses in human proximal tubular cells through oxidative stress but not via angiotensin II type 1 receptor, Am. J. Physiol. Renal Physiol. 292 (2007) F1846-F1857.
28. 1 cells, Am. J. Physiol. Renal Physiol. 280 (2001) F1107-F1114.
29. E. Zelzer, Y. Levy, C. Kahana, et al., Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT, EMBO J. 17 (1998) 5085-5094.
30. D.E. Richard, E. Berra, J. Pouyssegur, Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells, J. Biol. Chem. 275 (2000) 26765-26771.
31. R. Largo, D. Gómez-Garre, K. Soto, et al., Angiotensin-converting enzyme is upregulated in the proximal tubules of rats with intense proteinuria, Hypertension 33 (1999) 732-739.
32. B.C. Liu, J. Gao, Q. Li, et al., Albumin caused the increasing production of angiotensin II due to the dysregulation of ACE/ACE2 expression in HK2 cells, Clin. Chim. Acta 403 (2009) 23-30.
33. A.V. Bryksin, P.P. Laktionov, Role of glyceraldehyde-3-phosphate dehydrogenase in vesicular transport from golgi apparatus to endoplasmic reticulum, Biochemistry (Moscow) 73 (2008) 619-625.
34. M.A. Sirover, On the functional diversity of glyceraldehyde-3-phosphate dehydrogenase: biochemical mechanisms and regulatory control, Biochim. Biophys. Acta 2011 (1810) 741-751.
35. R.S. Belaiba, S. Bonello, C. Zähringer, et al., Hypoxia up-regulates hypoxia-inducible factor-1α transcription by involving phosphatidylinositol 3-kinase and nuclear factor κB in pulmonary artery smooth muscle cells, Mol. Biol. Cell. 18 (2007) 4691-4697.
36. S. Tang, J.C. Leung, K. Abe, et al., Albumin stimulates interleukin-8 expression in proximal tubular epithelial cells in vitro and in vivo, J. Clin. Invest. 111 (2003) 515-527.
37. H. Nakajima, M. Takenaka, J.Y. Kaimori, et al., Activation of the signal transducer and activator of transcription signaling pathway in renal proximal tubular cells by albumin, J. Am. Soc. Nephrol. 15 (2004) 276-285.