-
1
-
-
0038305911
-
Multicenter phase 2 trial of thalidomide in relapsed/refractory multiple myeloma: Adverse prognostic impact of advanced age
-
L. Mileshkin, J.J. Biagi, P. Mitchell, C. Underhil, A. Grigg, R. Bell, et al., Multicenter phase 2 trial of thalidomide in relapsed/refractory multiple myeloma: adverse prognostic impact of advanced age, Blood 102 (2003) 69-77.
-
(2003)
Blood
, vol.102
, pp. 69-77
-
-
Mileshkin, L.1
Biagi, J.J.2
Mitchell, P.3
Underhil, C.4
Grigg, A.5
Bell, R.6
-
2
-
-
0037973279
-
A phase 2 study of bortezomib in relapsed, refractory myeloma
-
P.G. Richardson, B. Barlogie, J. Berenson, S. Singhal, S. Jagannath, D. Irwin, et al., A phase 2 study of bortezomib in relapsed, refractory myeloma, N. Engl. J. Med. 348 (2003) 2609-2617.
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 2609-2617
-
-
Richardson, P.G.1
Barlogie, B.2
Berenson, J.3
Singhal, S.4
Jagannath, S.5
Irwin, D.6
-
3
-
-
0036739745
-
Clinical activity of arsenic trioxide for the treatment of multiple myeloma
-
N.C. Munshi, G. Tricot, R. Desikan, A. Badros, M. Zangari, A. Toor, et al., Clinical activity of arsenic trioxide for the treatment of multiple myeloma, Leukemia 16 (2002) 1835-1837.
-
(2002)
Leukemia
, vol.16
, pp. 1835-1837
-
-
Munshi, N.C.1
Tricot, G.2
Desikan, R.3
Badros, A.4
Zangari, M.5
Toor, A.6
-
4
-
-
0001790293
-
Histone deacetylases and transcriptional therapy with their inhibitors
-
P.P. Pandolfi, Histone deacetylases and transcriptional therapy with their inhibitors, Cancer Chemother. Pharmacol. 48 (2001) 17-19.
-
(2001)
Cancer Chemother. Pharmacol.
, vol.48
, pp. 17-19
-
-
Pandolfi, P.P.1
-
6
-
-
0035755974
-
Histone deacetylases and cancer: Causes and therapies
-
P. Marks, R.A. Rifkind, V.M. Richon, R. Breslow, T. Miller, W.K. Kelly, Histone deacetylases and cancer: causes and therapies, Nat. Rev. Cancer 1 (2001) 194-202.
-
(2001)
Nat. Rev. Cancer
, vol.1
, pp. 194-202
-
-
Marks, P.1
Rifkind, R.A.2
Richon, V.M.3
Breslow, R.4
Miller, T.5
Kelly, W.K.6
-
7
-
-
0036216505
-
Epigenomics and epigenetic therapy of cancer
-
R. Brown, G. Strathdee, Epigenomics and epigenetic therapy of cancer, Trends Mol. Med. 8 (2002) 43-48.
-
(2002)
Trends Mol. Med.
, vol.8
, pp. 43-48
-
-
Brown, R.1
Strathdee, G.2
-
8
-
-
0033523203
-
Chromatin remodeling and transcriptional regulation
-
R.X. Luo, D.C. Dean, Chromatin remodeling and transcriptional regulation, J. Natl. Cancer Inst. 91 (1999) 1288-1294.
-
(1999)
J. Natl. Cancer Inst.
, vol.91
, pp. 1288-1294
-
-
Luo, R.X.1
Dean, D.C.2
-
9
-
-
0035793107
-
Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin
-
R. Furumai, Y. Komatsu, N. Nishino, S. Khochbin, M. Yoshida, S. Horinouchi, Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin, Proc. Natl. Acad. Sci. USA 98 (2001) 87-92.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 87-92
-
-
Furumai, R.1
Komatsu, Y.2
Nishino, N.3
Khochbin, S.4
Yoshida, M.5
Horinouchi, S.6
-
10
-
-
79251566746
-
Physical and functional HAT/HDAC interplay regulates protein acetylation balance
-
A. Peserico, C. Simone, Physical and functional HAT/HDAC interplay regulates protein acetylation balance, J. Biomed. Biotechnol. (2011), http://dx.doi.org/ 10.11155/2011/371832.
-
(2011)
J. Biomed. Biotechnol.
-
-
Peserico, A.1
Simone, C.2
-
11
-
-
33645310174
-
Defining the role of gene regulation in resistance to HDAC inhibitors-mechanisms beyond P-glycoprotein
-
K.B. Glaser, Defining the role of gene regulation in resistance to HDAC inhibitors-mechanisms beyond P-glycoprotein, Leuk. Res. 30 (2006) 651-652.
-
(2006)
Leuk. Res.
, vol.30
, pp. 651-652
-
-
Glaser, K.B.1
-
12
-
-
0842277812
-
Histone deacetylase (HDAC) inhibitor activation of p21WAF1 involves changes in promoter-associated proteins, including HDAC1
-
C.Y. Gui, L. Ngo, W.S. Xu, V.M. Richon, P.A. Marks, Histone deacetylase (HDAC) inhibitor activation of p21WAF1 involves changes in promoter-associated proteins, including HDAC1, Proc. Natl. Acad. Sci. USA 101 (2004) 1241-1246.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 1241-1246
-
-
Gui, C.Y.1
Ngo, L.2
Xu, W.S.3
Richon, V.M.4
Marks, P.A.5
-
13
-
-
0036527775
-
Histone-deacetylase inhibitors: Novel drugs for the treatment of cancer
-
R.W. Johnstone, Histone-deacetylase inhibitors: novel drugs for the treatment of cancer, Nat. Rev. Drug Discov. 1 (2002) 287-299.
-
(2002)
Nat. Rev. Drug Discov.
, vol.1
, pp. 287-299
-
-
Johnstone, R.W.1
-
14
-
-
6344247464
-
Chlamydocinhydroxamic acid analogues as histone deacetylase inhibitors
-
N. Nishino, B. Jose, R. Shinta, T. Kato, Y. Komatsu, M. Yoshida, Chlamydocinhydroxamic acid analogues as histone deacetylase inhibitors, Bioorg. Med. Chem. 12 (2004) 5777-5784.
-
(2004)
Bioorg. Med. Chem.
, vol.12
, pp. 5777-5784
-
-
Nishino, N.1
Jose, B.2
Shinta, R.3
Kato, T.4
Komatsu, Y.5
Yoshida, M.6
-
15
-
-
0033520944
-
Histone deacetylase inhibition selectively alters the activity and expression of cell cycle proteins leading to specific chromatin acetylation and antiproliferative effects
-
L.C. Sambucetti, D.D. Fischer, S. Zabludoff, P.O. Kwon, H. Chamberlin, N. Trogani, et al., Histone deacetylase inhibition selectively alters the activity and expression of cell cycle proteins leading to specific chromatin acetylation and antiproliferative effects, J. Biol. Chem. 274 (1999) 34940-34947.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 34940-34947
-
-
Sambucetti, L.C.1
Fischer, D.D.2
Zabludoff, S.3
Kwon, P.O.4
Chamberlin, H.5
Trogani, N.6
-
16
-
-
0034770423
-
Histone deacetylase inhibitors increase p21 (WAF1) and induce apoptosis of human myeloma cell lines independent of decreased IL-6 receptor expression
-
D. Lavelle, Y.H. Chen, M. Hankewych, J. DeSimone, Histone deacetylase inhibitors increase p21 (WAF1) and induce apoptosis of human myeloma cell lines independent of decreased IL-6 receptor expression, Am. J. Hematol. 68 (2001) 170-178.
-
(2001)
Am. J. Hematol.
, vol.68
, pp. 170-178
-
-
Lavelle, D.1
Chen, Y.H.2
Hankewych, M.3
DeSimone, J.4
-
17
-
-
0028799285
-
Activin A-induced apoptosis is suppressed by BCL-2
-
T. Koseki, K. Yamato, S. Krajewski, J.C. Reed, Y. Tsujimoto, T. Nishihara, Activin A-induced apoptosis is suppressed by BCL-2, FEBS Lett. 376 (1995) 247-250.
-
(1995)
FEBS Lett.
, vol.376
, pp. 247-250
-
-
Koseki, T.1
Yamato, K.2
Krajewski, S.3
Reed, J.C.4
Tsujimoto, Y.5
Nishihara, T.6
-
18
-
-
0029055087
-
Induction of apoptosis in B lineage cells by activin A derived from macrophages
-
T. Nishihara, Y. Ohsaki, N. Ueda, T. Koseki, Y. Eto, Induction of apoptosis in B lineage cells by activin A derived from macrophages, J. Interferon Cytokine Res. 15 (1995) 509-516.
-
(1995)
J. Interferon Cytokine Res.
, vol.15
, pp. 509-516
-
-
Nishihara, T.1
Ohsaki, Y.2
Ueda, N.3
Koseki, T.4
Eto, Y.5
-
19
-
-
1842631408
-
Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer
-
K. Halkidou, L. Gaughan, S. Cook, H.Y. Leung, D.E. Neal, C.N. Robson, Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer, Prostate 59 (2004) 177-189.
-
(2004)
Prostate
, vol.59
, pp. 177-189
-
-
Halkidou, K.1
Gaughan, L.2
Cook, S.3
Leung, H.Y.4
Neal, D.E.5
Robson, C.N.6
-
20
-
-
17144378591
-
Inhibition of histone deacetylase 2 increases apoptosis and p21Cip1/WAF1 expression, independent of histone deacetylase 1
-
B.H. Huang, M. Laban, C.H. Leung, L. Lee, C.K. Lee, M. Salto-Tellez, et al., Inhibition of histone deacetylase 2 increases apoptosis and p21Cip1/WAF1 expression, independent of histone deacetylase 1, Cell Death Differ. 12 (2005) 395-404.
-
(2005)
Cell Death Differ.
, vol.12
, pp. 395-404
-
-
Huang, B.H.1
Laban, M.2
Leung, C.H.3
Lee, L.4
Lee, C.K.5
Salto-Tellez, M.6
-
21
-
-
21044447215
-
Increased expression of histone deacetylase 2 is found in human gastric cancer
-
J. Song, J.H. Noh, J.H. Lee, J.W. Eun, Y.M. Ahn, S.Y. Kim, et al., Increased expression of histone deacetylase 2 is found in human gastric cancer, APMIS 113 (2005) 264-268.
-
(2005)
APMIS
, vol.113
, pp. 264-268
-
-
Song, J.1
Noh, J.H.2
Lee, J.H.3
Eun, J.W.4
Ahn, Y.M.5
Kim, S.Y.6
-
22
-
-
33749572938
-
Valproate inhibition of histone deacetylase 2 affects differentiation and decreases proliferation of endometrial stromal sarcoma cells
-
A. Hrzenjak, F. Moinfar, M.L. Kremser, B. Strohmeier, P.B. Staber, K. Zatloukal, et al., Valproate inhibition of histone deacetylase 2 affects differentiation and decreases proliferation of endometrial stromal sarcoma cells, Mol. Cancer Ther. 5 (2006) 2203-2210.
-
(2006)
Mol. Cancer Ther.
, vol.5
, pp. 2203-2210
-
-
Hrzenjak, A.1
Moinfar, F.2
Kremser, M.L.3
Strohmeier, B.4
Staber, P.B.5
Zatloukal, K.6
-
23
-
-
67349232016
-
Valproic acid exerts anti-tumor as well as anti-angiogenic effects on myeloma
-
K. Kitazoe, M. Abe, M. Hiasa, A. Oda, H. Amou, T. Harada, et al., Valproic acid exerts anti-tumor as well as anti-angiogenic effects on myeloma, Int. J. Hematol. 89 (2009) 45-57.
-
(2009)
Int. J. Hematol.
, vol.89
, pp. 45-57
-
-
Kitazoe, K.1
Abe, M.2
Hiasa, M.3
Oda, A.4
Amou, H.5
Harada, T.6
-
24
-
-
3242765335
-
Histone deacetylase inhibitors-a new tool to treat cancer
-
R. Somech, S. Izraeli, S.J. Simon, Histone deacetylase inhibitors-a new tool to treat cancer, Cancer Treat. Rev. 30 (2004) 461-472.
-
(2004)
Cancer Treat. Rev.
, vol.30
, pp. 461-472
-
-
Somech, R.1
Izraeli, S.2
Simon, S.J.3
-
25
-
-
77955871803
-
Histone deacetylases are critical targets of bortezomib-induced cytotoxicity in multiple myeloma
-
J. Kikuchi, T. Wada, R. Shimizu, T. Izumi, M. Akutsu, K. Mitsunaga, et al., Histone deacetylases are critical targets of bortezomib-induced cytotoxicity in multiple myeloma, Blood 116 (2010) 406-417.
-
(2010)
Blood
, vol.116
, pp. 406-417
-
-
Kikuchi, J.1
Wada, T.2
Shimizu, R.3
Izumi, T.4
Akutsu, M.5
Mitsunaga, K.6
-
26
-
-
0035361402
-
Cyclic hydroxamic-acid-containing peptide 31, a potent synthetic histone deacetylase inhibitor with antitumor activity
-
Y. Komatsu, K.Y. Tomizaki, M. Tsukamoto, T. Kato, N. Nishino, S. Sato, et al., Cyclic hydroxamic-acid-containing peptide 31, a potent synthetic histone deacetylase inhibitor with antitumor activity, Cancer Res. 61 (2001) 4459-4466.
-
(2001)
Cancer Res.
, vol.61
, pp. 4459-4466
-
-
Komatsu, Y.1
Tomizaki, K.Y.2
Tsukamoto, M.3
Kato, T.4
Nishino, N.5
Sato, S.6
-
27
-
-
4143140016
-
Histone deacetylase inhibitors open new doors in cancer therapy
-
F. McLaughlin, N.B. La Thangue, Histone deacetylase inhibitors open new doors in cancer therapy, Biochem. Pharmacol. 68 (2004) 1139-1144.
-
(2004)
Biochem. Pharmacol.
, vol.68
, pp. 1139-1144
-
-
McLaughlin, F.1
La Thangue, N.B.2
-
28
-
-
0029033861
-
The retinoblastoma protein and cell cycle control
-
R.A. Weinberg, The retinoblastoma protein and cell cycle control, Cell 81 (1995) 323-330.
-
(1995)
Cell
, vol.81
, pp. 323-330
-
-
Weinberg, R.A.1
-
29
-
-
0025819962
-
Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle
-
H. Matsushime, M.F. Roussel, R.A. Ashmun, C.J. Sherr, Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle, Cell 65 (1991) 701-713.
-
(1991)
Cell
, vol.65
, pp. 701-713
-
-
Matsushime, H.1
Roussel, M.F.2
Ashmun, R.A.3
Sherr, C.J.4
-
30
-
-
0033822112
-
P21-dependent G1 arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228
-
V. Sandor, A. Senderowicz, S. Mertins, D. Sackett, E. Sausville, M.V. Blagosklonny, et al., P21-dependent G1 arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228, Br. J. Cancer 83 (2000) 817-825.
-
(2000)
Br. J. Cancer
, vol.83
, pp. 817-825
-
-
Sandor, V.1
Senderowicz, A.2
Mertins, S.3
Sackett, D.4
Sausville, E.5
Blagosklonny, M.V.6
-
31
-
-
23244459828
-
Interactive effects of HDAC inhibitors and TRAIL on apoptosis are associated with changes in mitochondrial functions and expressions of cell cycle regulatory genes in multiple myeloma
-
T.E. Fandy, S. Shankar, D.D. Ross, E. Sausville, R.K. Srivastava, Interactive effects of HDAC inhibitors and TRAIL on apoptosis are associated with changes in mitochondrial functions and expressions of cell cycle regulatory genes in multiple myeloma, Neoplasia 7 (2005) 646-657.
-
(2005)
Neoplasia
, vol.7
, pp. 646-657
-
-
Fandy, T.E.1
Shankar, S.2
Ross, D.D.3
Sausville, E.4
Srivastava, R.K.5
-
32
-
-
0033601746
-
Ordering the cytochrome c-initiated caspase cascade: Hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner
-
E.A. Slee, M.T. Harte, R.M. Kluck, B.B. Wolf, C.A. Casiano, D.D. Newmeyer, et al., Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner, J. Cell Biol. 144 (1999) 281-292.
-
(1999)
J. Cell Biol.
, vol.144
, pp. 281-292
-
-
Slee, E.A.1
Harte, M.T.2
Kluck, R.M.3
Wolf, B.B.4
Casiano, C.A.5
Newmeyer, D.D.6
-
33
-
-
0034786019
-
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis
-
E.H. Cheng, M.C. Wei, S. Weiler, R.A. Flavell, T.W. Mak, T. Lindsten, et al., BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis, Mol. Cell 8 (2001) 705-711.
-
(2001)
Mol. Cell
, vol.8
, pp. 705-711
-
-
Cheng, E.H.1
Wei, M.C.2
Weiler, S.3
Flavell, R.A.4
Mak, T.W.5
Lindsten, T.6
-
34
-
-
0033596980
-
An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9
-
H. Zou, Y. Li, X. Liu, X. Wang, An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9, J. Biol. Chem. 274 (1999) 11549-11556.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 11549-11556
-
-
Zou, H.1
Li, Y.2
Liu, X.3
Wang, X.4
-
35
-
-
0031036872
-
Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
-
J. Yang, X. Liu, K. Bhalla, C.N. Kim, A.M. Ibrado, J. Cai, T.I. Peng, D.P. Jones, X. Wang, Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked, Science 275 (1997) 1129-1132.
-
(1997)
Science
, vol.275
, pp. 1129-1132
-
-
Yang, J.1
Liu, X.2
Bhalla, K.3
Kim, C.N.4
Ibrado, A.M.5
Cai, J.6
Peng, T.I.7
Jones, D.P.8
Wang, X.9
|