Plasmid pUDK-HGF encoding human hepatocyte growth factor gene attenuates gentamicin-induced kidney injury in rats

Experimental and Toxicologic Pathology

Volumn 65, Issue 5, 2013, Pages 541-547

  Chen, Xing ^a,b   Chen, Zhi ^b   Wang, Hanbin ^b   Xiong, Xishan ^b   Liu, Xiaoling ^b   Hu, Chunsheng ^c   Han, Yuan ^c   Lu, Yuxin ^c   Wu, Zuze ^c   Zhang, Qinglin ^c  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^c BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

Author keywords

Gene therapy; Hepatocyte growth factor; Kidney injury; Renal fibrosis

Indexed keywords

CREATININE; GENTAMICIN; PLASMID VECTOR; SCATTER FACTOR; URIDINE TRIPHOSPHATE;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; GENE THERAPY; KIDNEY CELL; KIDNEY DISEASE; KIDNEY FIBROSIS; KIDNEY FUNCTION; KIDNEY INJURY; MALE; NEPHROTOXICITY; NONHUMAN; RAT; SCORING SYSTEM; UREA NITROGEN BLOOD LEVEL;

ACUTE KIDNEY INJURY; ANIMALS; ANTI-BACTERIAL AGENTS; APOPTOSIS; FIBROSIS; GENE TRANSFER TECHNIQUES; GENETIC THERAPY; GENTAMICINS; HEPATOCYTE GROWTH FACTOR; HUMANS; IN SITU NICK-END LABELING; KIDNEY FUNCTION TESTS; MALE; MICROINJECTIONS; PLASMIDS; RATS; RATS, WISTAR;

RATTUS;

EID: 84878351081     PISSN: 09402993     EISSN: 16181433     Source Type: Journal    
DOI: 10.1016/j.etp.2012.03.003     Document Type: Article

References (22)

1. Cai M.S., Yu Z.Y., Wang Y.Z., Tian S., Li Y.H., Zhu J. Renal intracapsular injection of methylprednisolone in treating primary glomerulonephritis. Chinese Journal of Practical Internal Medicine 2001, 21:280-281.
2. Dai C., Yang J., Bastacky S., Xia J., Li Y., Liu Y. Intravenous administration of hepatocyte growth factor gene ameliorates diabetic nephropathy in mice. Journal of the American Society of Nephrology 2004, 15:2637-2647.
3. Eddy A.A. Progression in chronic kidney disease. Advances in Chronic Kidney Disease 2005, 12:353-365.
4. Gao X., Mae H., Ayabe N., Takai T., Oshima K., Hattori M., et al. Hepatocyte growth factor gene therapy retards the progression of chronic obstructive nephropathy. Kidney International 2002, 62:1238-1248.
5. Ha X.Q., Li Y.M., Bi J.J., Zhang Q.L., Wu Z.Z. Plasmid pUDKH gene therapy of rat acute hindlimb ischemia: an experimental study. Zhonghua Yi Xue Za Zhi 2003, 83:1521-1524.
6. Ha X.Q., Ren J.P., Bi J.J., Zhang J.H., Zhang Q.L., Wu Z.Z. Therapeutic angiogenesis induced by human hepatocyte growth factor gene in hindlimb ischemia of dogs. Chinese Science Bulletin 2003, 48:676-680.
7. Ha X.Q., Wang X.G., Wu Z.Z. Study on construction of a plasmid vector carrying human hepatocyte growth factor gene and activity of its expression product. Zhongguo Ying Yong Sheng Li Xue Za Zhi 2002, 18:278-282.
8. Hewitson T.D. Renal tubulointerstitial fibrosis: common but never simple. American Journal of Physiology. Renal Physiology 2009, 296:F1239-F1244.
9. Isaka Y., Takahara S., Imai E. Chronic deteriorating renal function and renal fibrosis. Contributions to Nephrology 2008, 159:109-121.
10. Isaka Y., Yamada K., Takabatake Y., Mizui M., Miura-Tsujie M., Ichimaru N., et al. Electroporation-mediated HGF gene transfection protected the kidney against graft injury. Gene Therapy 2005, 12:815-820.
11. Kobayashi N., Nishikawa M., Takakura Y. The hydrodynamics-based procedure for controlling the pharmacokinetics of gene medicines at whole body, organ and cellular levels. Advanced Drug Delivery Reviews 2005, 57:713-731.
12. Kolgazi M., Arbak S., Alican I. The effect of alpha-melanocyte stimulating hormone on gentamicin-induced acute nephrotoxicity in rats. Journal of Applied Toxicology 2007, 27:183-188.
13. Liu Y. Renal fibrosis: new insights into the pathogenesis and therapeutics. Kidney International 2006, 69:213-217.
14. Liu Y., Yang J. Hepatocyte growth factor: new arsenal in the fights against renal fibrosis?. Kidney International 2006, 70:238-240.
15. Mizui M., Isaka Y., Takabatake Y., Mizuno S., Nakamura T., Ito T., et al. Electroporation-mediated HGF gene transfer ameliorated cyclosporine nephrotoxicity. Kidney International 2004, 65:2041-2053.
16. Newman C.M., Bettinger T. Gene therapy progress and prospects: ultrasound for gene transfer. Gene Therapy 2007, 14:465-475.
17. Radford M.G., Donadio J.V., Bergstralh E.J., Grande J.P. Predicting renal outcome in IgA nephropathy. Journal of the American Society of Nephrology 1997, 8:199-207.
18. Schievenbusch S., Strack I., Scheffler M., Wennhold K., Maurer J., Nischt R., et al. Profiling of anti-fibrotic signaling by hepatocyte growth factor in renal fibroblasts. Biochemical and Biophysical Research Communications 2009, 385:55-61.
19. Tanaka T., Ichimaru N., Takahara S., Yazawa K., Hatori M., Suzuki K., et al. In vivo gene transfer of hepatocyte growth factor to skeletal muscle prevents changes in rat kidneys after 5/6 nephrectomy. American Journal of Transplantation 2002, 2:828-836.
20. Teissie J. In vivo gene expression: combining hydrodynamics-based transfection and electrotransfer. Trends in Biotechnology 2002, 20:487-488.
21. Volpini R.A., Balbi A.P., Costa R.S., Coimbra T.M. Increased expression of p38 mitogen-activated protein kinase is related to the acute renal lesions induced by gentamicin. Brazilian Journal of Medical and Biological Research 2006, 39:817-823.
22. Yazawa K., Isaka Y., Takahara S., Imai E., Ichimaru N., Shi Y., et al. Direct transfer of hepatocyte growth factor gene into kidney suppresses cyclosporin A nephrotoxicity in rats. Nephrology, Dialysis, Transplantation 2004, 19:812-816.