Acute glutathione depletion induces hepatic methylglyoxal accumulation by impairing its detoxification to d-lactate

Experimental Biology and Medicine

Volumn 238, Issue 4, 2013, Pages 360-369

  Masterjohn, Christopher ^a   Mah, Eunice ^b   Park, Youngki ^a   Pei, Ruisong ^a   Lee, Jiyoung ^a   Manautou, Jose E ^a   Bruno, Richard S ^b  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Buthionine sulfoximine; Glutathione experimental; Glyoxalase I; Glyoxalase II; Pyruvaldehyde; S D lactoylglutathione

Indexed keywords

DEXTRO LACTIC ACID; GLUTATHIONE; GLYOXALASE; HYDROXYACYLGLUTATHIONE HYDROLASE; LACTIC ACID; LACTOYLGLUTATHIONE LYASE; MESSENGER RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DETOXIFICATION; ENZYMATIC ASSAY; MALE; METABOLISM; METHYLGLYOXAL ACCUMULATION; NONHUMAN; OXIDATIVE STRESS; RAT; REAL TIME POLYMERASE CHAIN REACTION; SPECTROPHOTOMETRY;

EID: 84880459672     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1177/1535370213477987     Document Type: Article

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