Marsupial immunology bounding ahead

Australian Journal of Zoology

Volumn 61, Issue 1, 2013, Pages 24-40

  Belov, Katherine ^a   Miller, Robert D ^b   Old, Julie M ^c   Young, Lauren J ^d  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF NEW MEXICO   (United States)

^c UNIVERSITY OF WESTERN SYDNEY   (Australia)

^d CENTRAL QUEENSLAND UNIVERSITY   (Australia)

Author keywords

immunity; immunoglobulin; metatherian; MHC

Indexed keywords

GENOME; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNITY; MARSUPIAL;

EID: 84880453299     PISSN: 0004959X     EISSN: 14465698     Source Type: Journal    
DOI: 10.1071/ZO12111     Document Type: Review

References (192)

1. Ashman, R. B., and Keast, D. (1973). The development of mitogen responses in the quokka, Setonix brachyurus. In 'Phylogeny of Thymus and Bone Marrow - Bursa Cells'. (Eds R. K. Wright and E. L. Cooper.) pp. 257-265. (Elsevier/North Holland Biomedical Press: Amsterdam.)
2. Ashman, R., and Papadimitriou, J. (1975a). Development of the lymphoid tissue in a marsupial, S. brachyurus. Acta Anatomica 91, 594-611. doi:10.1159/000144418
3. Ashman, R., and Papadimitriou, J. (1975b). The effect of thymectomy on the lymphoid tissues of the quokka (Setonix brachyurus). Australian Journal of Wildlife Diseases 53, 129-136.
4. Ashman, R., Keast, D., Stanley, N. F., and Waring, H. (1972). The in vitro response to phytohaemagglutinin (PHA) of leucocytes from intact and thymectomised quokkas. The Australian Journal of Experimental Biology and Medical Science 50, 337-345. doi:10.1038/icb.1972.27
5. Aveskogh, M., and Hellman, L. (1998). Evidence for an early appearance of modern post-switch isotypes in mammalian evolution; cloning of IgE, IgG and IgA from the marsupial Monodelphis domestica. European Journal of Immunology 28, 2738-2750. doi:10.1002/(SICI)1521-4141 (199809)28:09<2738::AID-IMMU2738>3. 0.CO;2-I
6. Azzali, G., and Didio, L. J. A. (1965). The lymphatic system of Didelphys azarae and Didelphys marsupialis. The American Journal of Anatomy 116, 449-469. doi:10.1002/aja.1001160302
7. Baker, M. L., and Miller, R. D. (2007). Evolution of mammalian CD1: Marsupial CD1 is not orthologous to the eutherian isoforms and is a pseudogene in the opossum Monodelphis domestica. Immunology 121, 113-121. doi:10.1111/j.1365-2567.2007.02545.x
8. Baker, M. L., Gemmell, E., and Gemmell, R. T. (1999). Ontogeny of the immune system of the brushtail possum, Trichosurus vulpecula. The Anatomical Record 256, 354-365. doi:10.1002/(SICI)1097-0185 (19991201)256:4<354::AID- AR3>3.0.CO;2-7
9. Baker,M.L., Belov, K., and Miller, R. D. (2005). Unusually similar patterns of antibody V segment diversity in distantly related marsupials. Journal of Immunology 174, 5665-5671.
10. Baker, M. L., Indiviglio, S., Nyberg, A. M., Rosenberg, G. H., Lindblad-Toh, K., Miller, R. D., and Papenfuss, A. T. (2007). Analysis of a set of Australian northern brown bandicoot expressed sequence tags with comparison to the genome sequence of the South American grey short tailed opossum. BMC Genomics 8, 50. doi:10.1186/1471-2164-8-50
11. Baker, M. L., Melman, S. D., Huntley, J., and Miller, R. D. (2009). Evolution of the opossum major histocompatibility complex: Evidence for diverse alternative splice patterns and low polymorphism among Class I genes. Immunology 128, e418-e431. doi:10.1111/j.1365-2567.2008. 02994.x
12. Banks, S. C., Dubach, J., Viggers, K. L., and Lindenmayer, D. B. (2010). Adult survival and microsatellite diversity in possums: Effects of major histocompatibility complex-linked microsatellite diversity but not multilocus inbreeding estimators. Oecologia 162, 359-370. doi:10.1007/s00442-009-1464-0
13. Barnes, T. S., Hinds, L. A., Jenkins, D. J., and Coleman, G. T. (2007). Precocious development of hydatid cysts in a macropodid host. International Journal for Parasitology 37, 1379-1389. doi:10.1016/j. ijpara.2007.04.012
14. Basden, K., Cooper, D. W., and Deane, E. M. (1996). Development of the blood-forming tissues of the tammar wallaby Macropus eugenii. Reproduction, Fertility and Development 8, 989-994. doi:10.1071/RD9960989
15. Basden, K., Cooper, D. W., and Deane, E. M. (1997). Development of the lymphoid tissues of the tammar wallaby Macropuseugenii. Reproduction, Fertility and Development 9, 243-254. doi:10.1071/R96032
16. Belov, K. (2012). Contagious cancer: Lessons from the devil and the dog. BioEssays 34, 285-292. doi:10.1002/bies.201100161
17. Belov, K., Harrison, G. A., and Cooper, D. W. (1998). Molecular cloning of the cDNA encoding the constant region of the immunoglobulin A heavy chain (C alpha) from a marsupial: Trichosurus vulpecula (common brushtail possum). Immunology Letters 60, 165-170. doi:10.1016/S0165-2478(97)00145-4
18. Belov, K., Harrison, G. A., Miller, R. D., and Cooper, D.W.(1999a). Isolation and sequence of a cDNA coding for the heavy chain constant region of IgG from the Australian brushtail possum, Trichosurus vulpecula. Molecular Immunology 36, 535-541. doi:10.1016/S0161-5890(99) 00064-4
19. Belov, K., Harrison, G. A., Miller, R. D., and Cooper, D. W. (1999b). Molecular cloning of the brushtail possum (Trichosurus vulpecula) immunglobulin E heavy chain constant region. Molecular Immunology 36, 1255-1261. doi:10.1016/S0161-5890(99)00097-8
20. Belov, K., Harrison, G. A., Rosenberg, G. H., Miller, R. D., and Cooper, D.W. (1999c). Isolation and comparison of the IgM heavy chain constant regions from Australian (Trichosurus vulpecula) and American (Monodelphis domestica) marsupials. Developmental and Comparative Immunology 23, 649-656. doi:10.1016/S0145-305X(99)00041-5
21. Belov, K., Harrison, G. A., Miller, R. D., and Cooper, D. W. (2001). Characterisation of the kappa light chain of the brushtail possum (Trichosurus vulpecula). Veterinary Immunology and Immunopathology 78, 317-324. doi:10.1016/S0165-2427(01)00239-2
22. Belov, K., Harrison, G. A., Miller, R. D., and Cooper, D. W. (2002a). Molecular cloning of four lambda light chain cDNAs from the Australian brushtail possum Trichosurus vulpecula. European Journal of Immunogenetics 29, 95-99. doi:10.1046/j.1365-2370.2002.00286.x
23. Belov, K., Nguyen, M. A., Zenger, K. R., and Cooper, D. W. (2002b). Ontogeny of immunoglobulin expression in the brushtail possum (Trichosurus vulpecula). Developmental and Comparative Immunology 26, 599-602. doi:10.1016/S0145-305X(02)00015-0
24. Belov, K., Lam, M. K., and Colgan, D. J. (2004). Marsupial MHC Class II DAB and DBB genes are not orthologous to the eutherian b gene families. The Journal of Heredity 95, 338-345. doi:10.1093/jhered/esh049
25. Belov, K., Deakin, J. E., Papenfuss, A. T., Baker, M. L., Melman, S. D. et al. (2006). Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex. PLoS Biology 4(3), e46. doi:10.1371/journal.pbio.0040046
26. Belov, K., Sanderson, C. E., Deakin, J. E., Wong, E. S., Assange, D. et al. (2007). Characterization of the opossum immune genome provides insights into the evolution of the mammalian immune system. Genome Research 17, 982-991. doi:10.1101/gr.6121807
27. Bininda-Emonds, O. R., Cardillo, M., Jones, K. E., MacPhee, R. D., Beck, R. M., Grenyer, R., Price, S. A., Vos, R. A., Gittleman, J. L., and Purvis, A. (2007). The delayed rise of present-day mammals. Nature 446, 507-512. doi:10.1038/nature05634
28. Block, M. (1964). The blood forming tissues of the newborn opossum (Didelphys virginiana). I. Normal development through about the one hundredth day of life Ergebnisse der Anatomie und Entwicklungsgeschichte 37, 1-237.
29. Browning, T. L., Belov, K., Miller, R. D., and Eldridge, M. D. (2004). Molecular cloning and characterization of the polymorphic MHC class II DBB from the tammar wallaby (Macropus eugenii). Immunogenetics 55, 791-795. doi:10.1007/s00251-004-0644-7
30. Brozek, C. M., and Ley, R. D. (1991). Production of interleukin-1 in a South American opossum (Monodelphis domestica). Developmental and Comparative Immunology 15, 401-412. doi:10.1016/0145-305X(91) 90032-T
31. Brozek, C., Kaleta, E., Kusewitt, D., and Ley, R. (1992). Proliferative responses of lymphocytes to mitogens in the grey, short-tailed opossum, Monodelphis domestica. Veterinary Immunology and Immunopathology 31, 11-19. doi:10.1016/0165-2427(92)90083-3
32. Bryant, B. J. (1974). The histo- and morphogenesis of lymph nodes: An interpretation of some mechanisms. Journal of the Reticuloendothelial Society 16, 96-104.
33. Bryant, B. J. (1977). The development of the immunohaematopoietic and lymphatic systems of Marmosa mitis. In 'The Biology of the Marsupials'. (Ed. D. Hunsker.) (Academic Press: New York.)
34. Bryant, B. J., and Shifrine, M. (1974). The immunohaematopoietic and lymphatic systems of Marmosa mitis: A developmental survey. Journal of the Reticuloendothelial Society 16, 105-113.
35. Buddle, B. M., and Young, L. J. (2000). Immunobiology of mycobacterial infections in marsupials. Developmental and Comparative Immunology 24, 517-529. doi:10.1016/S0145-305X(00)00014-8
36. Buddle, B. M., Skinner, M. A., and Chambers, M. A. (2000). Immunological approaches to the control of tuberculosis in wildlife reservoirs. Veterinary Immunology and Immunopathology 74, 1-16. doi:10.1016/S0165-2427 (00)00163-X
37. Canfield, P. J., and Hemsley, S. (2000). The roles of histology and immunohistology in the investigation of marsupial disease and normal lymphoid tissue. Developmental and Comparative Immunology 24, 455-471. doi:10.1016/S0145-305X(00)00009-4
38. Canfield, P., Hemsley, S., and Connolly, J. (1996). Histological and immunological study of the developing and involuting superficial cervical thymus in the koala (Phascolarctos cinereus). Journal of Anatomy 189, 159-169.
39. Carman, R, Simonian, M. R., Old, J. M., Jacques, N. A., and Deane, E. M. (2008). Immunohistochemistry using antibodies to the Cathelicidin LL37/hCAP18 in the tammar wallaby (Macropus eugenii). Tissue and Cell 40, 459-466. doi:10.1016/j.tice.2008.05.002
40. Cheng, Y., and Belov, K. (2012). Evolution of the Major Histocompatibility Complex: Insights from characterisation of marsupial genes. eLS doi:10. 1002/9780470015902.a0023982
41. Cheng, Y., Siddle, H. V., Beck, S., Eldridge, M. D., and Belov, K. (2009). High levels of genetic variation at MHC class II DBB loci in the tammar wallaby (Macropus eugenii). Immunogenetics 61, 111-118. doi:10.1007/s00251-008- 0347-6
42. Cheng, Y., Stuart, A., Morris, K., Taylor, R., Siddle, H., Deakin, J., Jones, M., Amemiya, C. T., and Belov, K. (2012a). Antigen-presenting genes and genomic copy number variations in the Tasmanian devil MHC. BMC Genomics 13, 87. doi:10.1186/1471-2164-13-87
43. Cheng, Y. Y., Sanderson, C., Jones, M., and Belov, K. (2012b Low MHC Class II diversity in the Tasmanian devil (Sarcophilus harrisii). Immunogenetics 64, 525-533. doi:10.1007/s00251-012-06.14-4
44. Chiarini-Garcia, H., and Pereira, F. M. (1999).Acomparative study of lymph node mast cell populations in five marsupial species. Tissue & Cell 31, 318-326. doi:10.1054/tice.1999.0049
45. Chiarini-Garcia, H, Santos, A, and Machado, C (2000). Mast cell types and cell-to-cell interactions in lymph nodes of the opossum Didelphis albiventris. Anatomy and Embryology 201, 197-206. doi:10.1007/s004.290050018
46. Cisternas, P. A., and Armati, P. J. (1999). Development of the thymus, spleen, lymph nodes and liver in the marsupial, Isoodon macrourus (northern brown bandicoot, Peramelidae). Anatomy and Embryology 200, 433-443. doi:10.1007/s004290050293
47. Cisternas, P. A., and Armati, P. J. (2000). Immune system cell markers in the northern brown bandicoot, Isoodon macrourus. Developmental and Comparative Immunology 24, 771-782. doi:10.1016/S0145-305X(00) 00030-6
48. Cooke, M. M., and Alley, M. R. (2002). Development of the lung of the brushtail possum, Trichosurus vulpecula. Journal of Anatomy 200, 113-121. doi:10.1046/j.0021-8782.2001.00019.x
49. Cooper, D. W., and Larsen, E. (2006). Immunocontraception of mammalian wildlife: Ecological and immunogenetic issues. Reproduction 132, 821-828. doi:10.1530/REP-06-0037
50. Coutinho, H. B., Sewell, H. F., Tighe, P., King, G., Nogueira, J. C., Robalinho, T. I., Coutinho, H., King, G., Sewell, H., Tighe, P., Coutinho, V., Robalinho, T., and Carvalho, A. (1993). Immunocytochemical study of Peyer's patches follicular-associated epithelium in the marsupial, Didelphis albiventris. Developmental and Comparative Immunology 17, 537-548. doi:10.1016/S0145-305X(05)80009-6
51. Coutinho, H. B., Nogueira, J. C., King, G., Coutinho, V. B., Robalinho, T. I., Amorim, A. M., Cavalcanti, V. M., Robins, R. A., and Sewell, H. F. (1994). Immunocytochemical study of the ontogeny of Peyer's patches in the Brazilian marsupial Didelphis albiventris. Journal of Anatomy 185, 347-354.
52. Coutinho, H. B., Sewell, H. F., Tighe, P., King, G., Nogueira, J. C., Robalinho, T. I., Coutinho, V. B., and Cavalcanti, V. M. (1995). Immunocytochemical study of the ontogeny of the marsupial Didelphis albiventris immune system. Journal of Anatomy 187, 37-46.
53. Croix, D. A., Samples, N. K., Vandeberg, J. L., and Stone, W. H. (1989). Immune response of a marsupial (Monodelphis domestica) to sheep red blood cells. Developmental and Comparative Immunology 13, 73-78. doi:10.1016/0145-305X(89) 90019-0
54. Cui, S. L., and Selwood, L. (2000). cDNA cloning, characterization, expression and recombinant protein production of leukemia inhibitory factor (LIF) from the marsupial, the brushtail possum (Trichosurus vulpecula). Gene 243, 167-178. doi:10.1016/S0378-1119(99)00513-2
55. Cui, S., Hope, R. M., Rathjen, J., Voyle, R. B., and Rathjen, P. D. (2001). Structure, sequence and function of a marsupial LIF gene: Conservation of IL-6 family cytokines. Cytogenetics and Cell Genetics 92, 271-278. doi:10.1159/000056915
56. Cutts, H., and Krause, W. J. (1982). Postnatal development of the spleen in Didelphis virginiana Journal of Anatomy 135, 601-613.
57. Daly, K. A., Digby, M., Lefevre, C., Mailer, S., Thomson,P., Nicholas, K., and Williamson, P. (2007). Analysis of the expression of immunoglobulins throughout lactation suggests two periods of immune transfer in the tammar wallaby (Macropus eugenii). Veterinary Immunology and Immunopathology 120, 187-200. doi:10.1016/j.vetimm.2007.07.008
58. Deakin, J. E., Belov, K., Curach, N. C., Green, P., and Cooper, D. W. (2005). Variation in level of immune response raises questions about the feasibility of using immunological methods to manage New Zealand brushtail possums. Wildlife Research 32, 1-6. doi:10.1071/WR03107
59. Deakin, J. E., Siddle, H. V., Cross, J. G., Belov, K., and Graves, J. A. (2007). Class I genes have split from theMHCin the tammar wallaby. Cytogenetic and Genome Research 116, 205-211. doi:10.1159/000098188
60. Deane, E. M., and Cooper, D. W. (1984). Immunology of pouch young marsupials. I. Levels of immunoglobulin transferrin and albumin in the blood and milk of euros and wallaroos (hill kangaroos: Macropus robustus, marsupialia). Developmental and Comparative Immunology 8, 863-876. doi:10.1016/0145-305X(84) 90069-7
61. Duckworth, J., Wilson, K., Cui, X., Molinia, F., and Cowan, P. (2007). Immunogenicity and contraceptive potential of three infertility-relevant zona pellucida 2 epitopes in the marsupial brushtail possum (Trichosurus vulpecula). Reproduction 133, 177-186. doi:10.1530/REP-06-0088
62. Duignan, P. J. (2004). Health assessment of wallabies from Kawau Island. Surveillance 31, 16-18.
63. Duncan, L., Webster, K., Gupta, V., Nair, S., and Deane, E. (2010). Molecular characterisation of the CD79a and CD79b subunits of the B cell receptor complex in the gray short-tailed opossum (Monodelphis domestica) and tammar wallaby (Macropus eugenii): Delayed B cell immunocompetence in marsupial neonates. Veterinary Immunology and Immunopathology 136, 235-247. doi:10.1016/j.vetimm.2010.03.013
64. Duncan, L. G., Nair, S. V., and Deane, E. M. (2012). Immunohistochemical localization of T-lymphocyte subsets in the developing lymphoid tissues of the tammar wallaby (Macropus eugenii). Developmental and Comparative Immunology 38, 475-486. doi:10.1016/j.dci.2012.06.015
65. Edwards, M. J., Hinds, L. A., Deane, E. M., and Deakin, J. E. (2012).Areview of complementary mechanisms which protect the developing marsupial pouch young. Developmental and Comparative Immunology 37, 213-220. doi:10.1016/j.dci.2012.03.013
66. Fox, D. H., Rowlands, D. T. J., and Wilson, D. B. (1976). Proliferative reactivity of opossum peripheral blood leukocytes to allogenic cells, mitogens and specific antigens. Transplantation 21, 164-167. doi:10.10.97/00007890- 197602000-00015
67. Fraser, E. A., and Hill, J. P. (1916). The development of the thymus, epithelial bodies and thyroid in the Marsupialia. Part I. Trichosurus vulpecula. Philosophical Transactions of the Royal Society B 207, 1-85. doi:10.10.98/rstb.1916.0001
68. Gouin, N., Deakin, J. E., Miska, K. B., Miller, R. D., Kammerer, C. M., Graves, J. A., VandeBerg, J. L., and Samollow, P. B. (2006). Linkage mapping and physical localization of the major histocompatibility complex region of the marsupial Monodelphis domestica. Cytogenetic and Genome Research 112, doi:10.1159/000089882
69. Hanger, J. J., and Heath, T. J. (1994). The arrangements of gut-associated lymphoid tissue and lymph pathways in the koala, Phascolarctos cinereus. Journal of Anatomy 185, 129-134.
70. Harrison, G. A., and Deane, E.M. (1999).cDNAsequence of the lymphotoxin beta chain from a marsupial, Macropus eugenii (Tammar wallaby). Journal of Interferon & Cytokine Research 19, 1099-1102. doi:10.1089/107999099313028
71. Harrison, G. A., and Deane, E. M. (2000). cDNA cloning of lymphotoxin alpha (LT-alpha) from a marsupial, Macropus eugenii. DNA Sequence 10, 399-403.
72. Harrison, G. A., and Wedlock, D. N. (2000). Marsupial cytokines. Structure, function and evolution. Developmental and Comparative Immunology 24, 473-484. doi:10.1016/S0145-305X(00)00010-0
73. Harrison, G. A., Broughton, M. J., Young, L. J., Cooper, D. W., and Deane, E. M. (1999). Conservation of 3 'untranslated region elements in tammar wallaby (Macropus eugenii) TNF-alpha mRNA. Immunogenetics 49, 464-467. doi:10.1007/s002510050521
74. Harrison, G. A., Young, L. J., Watson, C. M., Miska, K. B., Miller, R. D., and Deane, E. M. (2003).Asurvey of Type I interferons from a marsupial and monotreme: Implications for the evolution of the Type I interferon gene family in mammals. Cytokine 21, 105-119. doi:10.1016/S1043-4666(03) 00029-2
75. Harrison, G. A., McNicol, K. A., and Deane, E. M. (2004). Interferon alpha/beta genes from a marsupial, Macropus eugenii. Developmental and Comparative Immunology 28, 927-940. doi:10.1016/j.dci.2004.02.002
76. Hawken, R. J., Maccarone, P., Toder, R., Marshall Graves, J. A., and Maddox, J. F. (1999). Isolation and characterization of marsupial IL5 genes. Immunogenetics 49, 942-948. doi:10.1007/s002510050577
77. Hayday, A. C. (2000). Gamma delta cells: A right time and a right place for a conserved third way of protection Annual Review of Immunology 18, 975-1026. doi:10.1146/annurev.immunol.18.1.975
78. Hayes, T. G. (1968). Studies of a primitive mammalian spleen, the opossum (Didelphis virginiana). Journal of Morphology 124, 445-450. doi:10.1002/jmor.1051240404
79. Haynes, J. I. (1991). Cervical lymph nodes and mast cells in the marsupial Sminthopsis crassicaudata. The Anatomical Record 231, 7-13. doi:10.1002/ar.1092310103
80. Haynes, J. I. (2001). The marsupial and monotreme thymus, revisited. Journal of Zoology 253, 167-173. doi:10.1017/S0952836901000152
81. Hemsley, S. W., Canfield, P. J., and Husband, A. J. (1995). Immunohistological staining of lymphoid tissue in four Australian marsupial species using species cross-reactive antibodies. Immunology and Cell Biology 73, 321-325. doi:10.1038/icb.1995.49
82. Hemsley, S. W., Canfield, P. J., and Husband, A. J. (1996). Histological and immunohistological investigation of alimentary tract lymphoid tissue in the koala (Phascolarctos cinereus), brushtail possum (Trichosurus vulpecula) and ringtail possum (Pseudocheirus peregrinus). Journal of Anatomy 188, 279-288.
83. Holland, O. J., Cowan, P. E., Gleeson, D. M., and Chamley, L. W. (2008a). Identification of novel major histocompatibility complex Class I sequences in a marsupial, the brushtail possum (Trichosurus vulpecula). Immunogenetics 60, 609-619. doi:10.1007/s00251-008-0316-0
84. Holland, O. J., Cowan, P. E., Gleeson, D. M., and Chamley, L. W. (2008b Novel alleles in classical major histocompatibility complex Class II loci of the brushtail possum (Trichosurus vulpecula). Immunogenetics 60, 449-460. doi:10.1007/s00251-008-0300-8
85. Holland, O. J., Cowan, P. E., Gleeson, D. M., Duckworth, J. A., and Chamley, L. W. (2009). MHC haplotypes and response to immunocontraceptive vaccines in the brushtail possum. Journal of Reproductive Immunology 82, 57-65. doi:10.1016/j.jri.2009.04.008
86. Holland, O. J., Cowan, P. E., Gleeson, D. M., Duckworth, J. A., and Chamley, L. W. (2010). Immunocontraceptive vaccines and major histocompatibility complex variation in the brushtail possum. Journal of Reproductive Immunology 86, 1-74. doi:10.1016/j.jri.2010.06.067
87. Hubbard, G., Saphire, D., Hackleman, S., Silva, M., Vandeberg, J., and Stone, W. (1991). Ontogeny of the thymus gland of a marsupial (Monodelphis domestica). Laboratory Animal Science 41, 227-232.
88. Infante, A. J., Samples, N. K., Croix, D. A., Redding, T. S., VandeBerg, J. L., and Stone, W. H. (1991). Cellular immune response of a marsupial, Monodelphis domestica. Developmental and Comparative Immunology 15, 189-199. doi:10.1016/0145-305X(91)90010-V
89. Johnstone, J. (1898). The thymus in marsupials. Zoological Journal of the Linnean Society 26, 537-557. doi:10.1111/j.1096-3642.1898.tb00410.x
90. Johnstone, J. (1901). Cervical glands of marsupials. Proceeds and Transactions of the Liverpool Biological Society, Liverpool 15, 354-362.
91. Jones, M., Cordell, J., Beyers, A., Tse, A., and Mason, D. (1993). Detection of T and B cells in many animal species using cross-reactive anti-peptide antibodies. Journal of Immunology 150, 5429-5435.
92. Jones, K. E., Patel, N. G., Levy, M. A., Storeygard, A., Balk, D., and Gittleman, J. L. (2008). Global trends in emerging infectious diseases Nature 451, 990-993. doi:10.1038/nature06536
93. Jurd, R. D. (1994). "Not proper mammals": Immunity in monotremes and marsupials. Comparative Immunology, Microbiology and Infectious Diseases 17, 41-52. doi:10.1016/0147-9571(94)90005-1
94. Kalmutz, S. (1962). Antibody production in the opossum embryo. Nature 193, 851-853. doi:10.1038/193851a0
95. Kelley, J., Walter, L., and Trowsdale, J. (2005). Comparative genomics of natural killer cell receptor gene clusters. PLOS Genetics 1(2), e27. doi:10.1371/journal.pgen.0010027
96. Kreiss, A., Cheng, Y., Kimble, F., Wells, B., Donovan, S., Belov, K., and Woods, G. M. (2011). Allorecognition in the Tasmanian devil (Sarcophilus harrisii), an endangered marsupial species with limited genetic diversity. PLoS ONE 6(7), e22402. doi:10.1371/journal.pone.0022402
97. Kristensen, F., Kristensen, B., and Lazary, S. (1982). The Lymphocyte Stimulation Test in veterinary immunology. Veterinary Immunology and Immunopathology 3, 203-277. doi:10.1016/0165-2427(82)90036-8
98. La Via, M., Rowlands, D. Jr, and Block, M. (1963). Antibody formation in embryos. Science 140, 1219-1220. doi:10.1126/science.140.3572.1219
99. Lam, M. K-P., Hickson, R. E., Cowan, P. E., and Cooper, D. W. (2000). A major histocompatibility (MHC) microsatellite locus in brushtail possums (Trichosurus vulpecula). Online Journal of Veterinary Research 4, 139-141.
100. Lam, M. K., Belov, K., Harrison, G. A., and Cooper, D. W. (2001a). Cloning of theMHCClass II DRB cDNA from the brushtail possum (Trichosurus vulpecula). Immunology Letters 76, 31-36. doi:10.1016/S0165-2478(00) 00314-X
101. Lam, M. K., Belov, K., Harrison,G. A., and Cooper, D. W. (2001b). AnMHC Class I gene in the Australian brushtail possum (Trichosurus vulpecula). Immunogenetics 53, 430-433. doi:10.1007/s002510100336
102. Liebler-Tenorio, E. M., and Pabst, R. (2006).MALTstructure and function in farm animals. Veterinary Research 37, 257-280. doi:10.1051/vetres: 2006001
103. Lucero, J. E., Rosenberg, G. H., and Miller, R. D. (1998). Marsupial light chains: Complexity and conservation of lambda in the opossum Monodelphis domestica. Journal of Immunology 161, 6724-6732.
104. Marx, J. J., Burrell, R., and Fisher, S. Q. (1971). Study of afferent and efferent limbs of immune response in opossums. Journal of Immunology 106, 1043-1049.
105. McKenzie, L. M., and Cooper, D. W. (1994). Low MHC Class II variability in a marsupial. Reproduction, Fertility and Development 6, 721-726. doi:10.1071/RD9940721
106. Meyer-Lucht, Y, Otten, C, Puttker, T, and Sommer, S (2008). Selection, diversity and evolutionary patterns of the MHC class II DAB in freeranging Neotropical marsupials. BMC Genetics 9, 39. doi:10.1186/1471-2156-9-39
107. Mier, J. W., and Gallo, R. C. (1980). Purification and some characteristics of human T-cell growth factor from phytohemagglutinin-stimulated lymphocyte-conditioned media. Proceedings of the National Academy of Sciences of the United States of America 77, 6134-6138. doi:10.1073/pnas.77.10.6134
108. Mikkelsen, T. S., Wakefield, M. J., Aken, B., Amemiya, C. T., Chang, J. L. et al. (2007). Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences. Nature 447, 167-177. doi:10.1038/nature05805
109. Miller, J. F. A. P., Block, M., Rowlands, D. T., and Kind, P. (1965). Effect of thymectomy on haematopoietic organs of the opossum "embryo". Proceedings of the Society for Experimental Biology and Medical Science 118, 916-921.
110. Miller, R. D., Grabe, H., and Rosenberg, G. H. (1998). V(H) repertoire of a marsupial (Monodelphis domestica). Journal of Immunology 160, 259-265.
111. Miller, R. D., Bergemann, E. R., and Rosenberg, G. H. (1999). Marsupial light chains: IGK with fourVfamilies in the opossum Monodelphis domestica. Immunogenetics 50, 329-335. doi:10.1007/s002510050609
112. Miska, K. B., and Miller, R. D. (1999). Marsupial MHC Class I: Classical sequences from the opossum, Monodelphis domestica. Immunogenetics 50, 89-93. doi:10.1007/s002510050692
113. Miska, K. B., Wright, A. M., Lundgren, R., Sasaki-McClees, R., Osterman, A., Gale, J. M., and Miller, R. D. (2004). Analysis of a marsupial MHC region containing two recently duplicated Class I loci. Mammalian Genome 15, 851-864. doi:10.1007/s00335-004-2224-4
114. Montali, R. J., Bush, M., Cromie, R., Holland, S. M., Maslow, J. N., Worley, M., Witebsky, F. G., and Phillips, T. M. (1998). Primary Mycobacterium avium complex infections correlate with lowered cellular immune reactivity in Matschie's tree kangaroos (Dendrolagus matschiei). The Journal of Infectious Diseases 178, 1719-1725. doi:10.1086/314517
115. Moriarty, K. (1973). A possible deficiency of cell-mediated immunity in the opossum, Trichosurus vulpecula, in relation to tuberculosis. New Zealand Veterinary Journal 21, 167-169. doi:10.1080/00480169.1973. 34098
116. Moriarty, K. M., and Thomas,M.J. (1986). Absence of lymphokine-enhanced macrophage migration in vitro in the Australian brush-tailed opossum, Trichosurus vulpecula Veterinary Immunology and Immunopathology 13, 365-370. doi:10.1016/0165-2427(86)90029-2
117. Morris, K., Austin, J. J., and Belov, K. (2013). Low MHC diversity in the Tasmanian devil pre-dates European settlement and may explain susceptibility to disease epidemics. Biology Letters 9, 1-5. doi:10.1098/rsbl.2012.0900
118. Murchison, E. P., Tovar, C., Hsu, A., Bender, H. S., and Kheradpour, P. et al. (2010). The Tasmanian devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer. Science 327, 84-87. doi:10.1126/science. 1180616
119. Murchison, E. P., Schulz-Trieglaff, O. B., Ning, Z. M., Alexandrov, L. B., Bauer, M. J. et al. (2012). Genome sequencing and analysis of the Tasmanian devil and its transmissible cancer. Cell 148, 780-791. doi:10.1016/j.cell.2011. 11.065
120. Nishikawa, K., and Takagi, T. (1988). Comparative immunobiology of the palatine tonsil Acta Oto-Laryngologica 105, 43-47. doi:10.3109/00016488809125003
121. O'hUigin, C, Sultmann, H, Tichy, H, and Murray, B.W. (1998). Isolation of MHC Class II DMA and DMB cDNA sequences in a marsupial: The gray short-tailed opossum (Monodelphis domestica). Journal of Molecular Evolution 47, 578-585. doi:10.1007/PL00006414
122. Old, J. M., and Deane, E. M. (2000). Development of the immune system and immunological protection in marsupial pouch young. Developmental and Comparative Immunology 24, 445-454. doi:10.1016/S0145-305X (00)00008-2
123. Old, J. M., and Deane, E. M. (2001). Histology and immunohistochemistry of the gut-associated lymphoid tissue of the eastern grey kangaroo, Macropus giganteus. Journal of Anatomy 199, 657-662. doi:10.1017/S002187820100872X
124. Old, J. M., and Deane, E. M. (2002a). The gut-associated lymphoid tissues of the northern brown bandicoot (Isoodon macrourus). Developmental and Comparative Immunology 26, 841-848. doi:10.1016/S0145-305X (02)00031-9
125. Old, J. M., and Deane, E. M. (2002b). Immunohistochemistry of the lymphoid tissues of the tammar wallaby, Macropus eugenii. Journal of Anatomy 201, 257-266. doi:10.1046/j.1469-7580.2002.00090.x
126. Old, J. M., and Deane, E. M. (2003). The detection of mature T- and B-cells during development of the lymphoid tissues of the tammar wallaby (Macropus eugenii). Journal of Anatomy 203, 123-131. doi:10.1046/j.14.69-7580. 2003.00207.x
127. Old, J. M., Deane, E. M., and Harrison, G. A. (2001). Molecular characterisation of the tammar wallaby (Macropus eugenii) CD3 epsilon chain cDNA. Molecular Immunology 38, 359-364. doi:10.1016/S0161-5890(01)00072-4
128. Old, J. M., Selwood, L, and Deane, E.M.(2003a).Ahistological investigation of the lymphoid and immunohaematopoietic tissues of the adult stripefaced dunnart (Sminthopsis macroura). Cells, Tissues, Organs 173, 115-121. doi:10.1159/000068946
129. Old, J. M., Selwood, L, and Deane, E. M. (2003b). Development of the lymphoid tissues of the stripe-faced dunnart (Sminthopsis macroura Cells, Tissues, Organs 175, 192-201. doi:10.1159/000074941
130. Old, J. M., Selwood, L., and Deane, E. M. (2004a). The appearance and distribution of mature T and B cells in the developing immune tissues of the stripe-faced dunnart (Sminthopsis macroura). Journal of Anatomy 205, 25-33. doi:10.1111/j.0021-8782.2004.00310.x
131. Old, J. M., Selwood, L., and Deane, E. M. (2004b). A developmental investigation of the liver, bone marrow and spleen of the stripe-faced dunnart (Sminthopsis macroura). Developmental and Comparative Immunology 28, 347-355. doi:10.1016/j.dci.2003.08.004
132. Old, J. M., Carman, R. L., Fry, G., and Deane, E. M. (2006). The immune tissues of the endangered red-tailed phascogale (Phascogale calura
133. Journal of Anatomy 208, 381-387. doi:10.1111/j.1469-7580.2006.00.530.x
134. Paddle, R. (2012). The thylacine's last straw: Epidemic disease in a recent mammalian extinction Australian Zoologist, In press. doi:10.7882/AZ. 2012.008
135. Papadimitriou, J. M., and Ashman, R. B. (1972). A poxvirus in a marsupial papilloma. Journal of General Virology 16, 87-89. doi:10.1099/0022-1317-16-1-87
136. Parra, Z. E., Baker, M. L., Schwarz, R. S., Deakin, J. E., Lindblad-Toh, K., and Miller, R. D. (2007). Discovery of a new T cell receptor in marsupials. Proceedings of the National Academy of Sciences USA 104, 9776-9781.
137. Parra, Z. E., Baker, M. L., Hathaway, J., Lopez, A. M., Trujillo, J., Sharp, A., and Miller, R. D. (2008). Comparative genomic analysis and evolution of the T cell receptor loci in the opossum Monodelphis domestica BMC Genomics 9, 111. doi:10.1186/1471-2164-9-111
138. Parra, Z. E., Baker, M. L., Lopez, A. M., Trujillo, J., Volpe, J. M., and Miller, R. D. (2009). TCRmu recombination and transcription relative to the conventional TCR during postnatal development in opossums. Journal of Immunology 182, 154-163.
139. Parra, Z.E., Ohta, Y., Criscitiello, M.F., Flajnik, M.F., and Miller, R. D. (2010). The dynamic TCRd: TCRd chains in the amphibian Xenopus tropicalis utilize antibody-like V genes. European Journal of Immunology 40, 2319-2329. doi:10.1002/eji.201040515
140. Parra, Z. E., Lillie, M., and Miller, R. D. (2012a).Amodel for the evolution of the mammalian T cell receptor a/d and m loci based on evidence from the duckbill platypus. Molecular Biology and Evolution 29, 3205-3214. doi:10.1093/molbev/mss128
141. Parra, Z. E., Mitchell, K., Dalloul, R. A., and Miller, R. D. (2012b). A second TCRd locus in Galliformes uses antibody-like V domains: Insight into the evolution of TCRd and TCRm genes in tetrapods. Journal of Immunology 188, 3912-3919. doi:10.4049/jimmunol.1103521
142. Paulesu, L., Jantra, S., Ietta, F., Brizzi, R., and Bigliardi, E. (2008). Interleukin-1 in reproductive strategies. Evolution & Development 10, 778-788. doi:10.1111/j.1525-142X.2008.00292.x
143. Poskitt, D. C., Barnett, J., Duffey, K., Kimpton, W. G., and Muller, H. K. (1984a). Involution of the thymus in marsupial mice. Developmental and Comparative Immunology 8, 483-488.doi:10.1016/0145-305X(84) 90056-9
144. Poskitt, D. C., Barnett, J., Duffey, K., Lee, A. K., Kimpton,W. G., and Muller, H. K. (1984b). Stress-related involution of lymphoid tissues in Australian marsupial mice. Immunobiology 166, 286-295. doi:10.1016/S0171- 2985(84)80046-7
145. Poskitt, D. C., Duffey, K., Barnett, J., Kimpton, W. G., and Muller, H. K. (1984c). The gut-associated lymphoid system of two species of Australian marsupial mice, Antechinus swainsonii and Antechinus stuartii. Distribution, frequency and structure of Peyer's patches and lymphoid follicles in the small and large intestine. The Australian Journal of Experimental Biology and Medical Science 62, 81-88. doi:10.1038/icb.1984.8
146. Renfree, M. B., Papenfuss, A. T., Deakin, J. E., Lindsay, J., Heider, T. et al. (2011). Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development. Genome Biology 12, 1-25. doi:10.1186/gb-2011-12-12-414
147. Schuurman, H., Kuper, C. F., and Kendall, M. D. (1997). Thymic microenvironment at the light microscopic level. Microscopy Research and Technique 38, 216-226. doi:10.1002/(SICI)1097-0029(19970801) 38:3<216::AID-JEMT3>3.0.CO;2-K
148. Selwood, L., and Coulson, G. (2006). Marsupials as models for research. Australian Journal of Zoology 54, 137-138. doi:10.1071/ZOv54 n3-IN
149. Siddle, H. V., Deakin, J. E., Baker, M. L., Miller, R. D., and Belov, K. (2006). Isolation of major histocompatibility complex Class I genes from the tammar wallaby (Macropus eugenii). Immunogenetics 58, 487-493. doi:10.1007/s00251-006-0107-4
150. Siddle, H. V., Kreiss, A., Eldridge, M. D., Noonan, E., Clarke, C. J., Pyecroft, S., Woods, G. M., and Belov, K. (2007a). Transmission of a fatal clonal tumor by biting occurs due to depleted MHC diversity in a threatened carnivorous marsupial. Proceedings of the National Academy of Sciences USA 104, 16221-16226.
151. Siddle, H. V., Sanderson, C., and Belov, K. (2007b). Characterization of major histocompatibility complex Class I and Class II genes from the Tasmanian devil (Sarcophilus harrisii). Immunogenetics 59, 753-760. doi:10.1007/s00251- 007-0238-2
152. Siddle, H. V., Deakin, J. E., Coggill, P., Hart, E., Cheng, Y., Wong, E. S., Harrow, J., Beck, S., and Belov, K. (2009). MHC-linked and un-linked Class I genes in the wallaby.BMCGenomics 10(310), 1-15. doi:10.1186/1471-2164-10-310
153. Siddle, H. V., Deakin, J. E., Coggill, P., Whilming, L., Harrow, J., Kaufman, J., Beck, S., and Belov, K. (2011). The tammar wallaby major histocompatibility complex shows evidence of past genomic instability. BMC Genomics 12(421), 1-15. doi:10.1186/1471-2164-12-421
154. Sitnikova, T., and Su, C. (1998). Coevolution of immunoglobulin heavy- and light-chain variable-region gene families. Molecular Biology and Evolution 15, 617-625. doi:10.1093/oxfordjournals.molbev.a025.965
155. Slade, R. W., Hale, P. T., Francis, D. I., Graves, J. A., and Sturm, R. A. (1994). The marsupial MHC: The tammar wallaby, Macropus eugenii, contains an expressed DNA-like gene on chromosome 1. Journal of Molecular Evolution 38, 496-505. doi:10.1007/BF00178850
156. Stanley, N. F., Yadav, M., Waring, H., and Eadie, M. (1972). The effect of thymectomy on response to various antigens of a marsupial Setonix brachyurus (Quokka). The Australian Journal of Experimental Biology and Medical Science 50, 689-702. doi:10.1038/icb.1972.62
157. Stewart, N. J., Bettiol, S. S., Kreiss, A., Fox, N., and Woods, G. M. (2008). Mitogen-induced responses in lymphocytes from platypus, the Tasmanian devil and the eastern barred bandicoot. Australian Veterinary Journal 86, 408-413. doi:10.1111/j.1751-0813.2008.00349.x
158. Stone, W. H., Bruun, D. A., and Manis, G. S. (1996). The immunobiology of the marsupial Monodelphis domestica. In 'Modulators of Immune Responses, the Evolutionary Trail. Vol. 11'. (Eds J. S. Stolen, T. C. Fletcher and J. C. Bayne.) pp. 149-165. (SOS Publications: Fairhaven, NJ.)
159. Stone,W.H., Bruun, D. A., Fuqua, C., Glass, L. C., Reeves, A., Holste, S., and Figueroa, F. (1999). Identification and sequence analysis of an MHC Class II B gene in a marsupial (Monodelphis domestica). Immunogenetics 49, 461-463. doi:10.1007/s002510050520
160. Symington, J (1898). The thymus gland in the marsupialia. Journal of Anatomy 32, 278-291.
161. Turner, K. J., Alpers, M. P., and Wight, M. (1972). Delayed hypersensitivity in the marsupial Setonix brachyurus (quokka). Journal of Immunology 108, 1675-1680.
162. Tyndale-Biscoe, C. H., and Renfree, M. (1987). 'Reproductive Physiology of Marsupials.' (Cambridge University Press: Cambridge.)
163. van der Kraan, L. E., Wong, E. S., Lo, N., Ujvari, B., and Belov, K. (2013). Identification of natural killer cell receptor genes in the genome of the marsupial Tasmanian devil (Sarcophilus harrisii). Immunogenetics 65, 25-35. doi:10.1007/s00251-012-0643-z
164. Wang, X., and Miller, R. D. (2012). Recombination, transcription and diversity of a partially germ-line joinedVHin a mammal.Immunogenetics 64, 713-717. doi:10.1007/s00251-012-0627-z
165. Wang, X., Olp, J.J., and Miller, R. D. (2009). On the genomics of immunoglobulins in the gray, short-tailed opossum Monodelphis domestica. Immunogenetics 61, 581-596. doi:10.1007/s00251-009-0385-8
166. Wang, J. H., Wong, E. S. W., Whitley, J. C., Li, J., Stringer, J. M., Short, K. R., Renfree, M. B., Belov, K., and Cocks, B. G. (2011a). Ancient antimicrobial peptides kill antibiotic-resistant pathogens: Australian mammals provide new options. PLoS ONE 6(8), e24030. doi:10.1371/journal.pone.0024030
167. Wang, X., Parra, Z.E., and Miller, R. D. (2011b). Platypus TCRm provides insight into the origins and evolution of a uniquely mammalian TCR locus Journal of Immunology 187, 5246-5254. doi:10.4049/jimmunol.1101113
168. Wang, X., Parra, Z.E., and Miller, R. D. (2012a).AVpreB3 homologue from a marsupial, the gray short-tailed opossum, Monodelphis domestica. Immunogenetics 64, 647-652. doi:10.1007/s00251-012-0626-0
169. Wang, X., Sharp, A. R., and Miller, R. D. (2012b). Early postnatal B cell ontogeny and antibody repertoire maturation in the opossum, Monodelphis domestica PLoS ONE 7(9), 1-10. doi:10.1371/journal. pone.0045931
170. Wedlock, D. N., Aldwell, F. E., and Buddle, B. M. (1996). Molecular cloning and characterization of tumor necrosis factor alpha (TNFalpha) from the Australian common brushtail possum, Trichosurus vulpecula. Immunology and Cell Biology 74, 151-158. doi:10.1038/icb.1996.20
171. Wedlock, D. N., Aldwell, F. E., and Buddle, B. M. (1998). Nucleotide sequence of a marsupial interleukin-10 cDNA from the Australian brushtail possum (Trichosurus vulpecula). DNA Sequence 9, 239-244.
172. Wedlock, D. N., Goh, L. P., McCarthy,A. R., Midwinter,R. G., Parlane, N. A., and Buddle, B. M. (1999a). Physiological effects and adjuvanticity of recombinant brushtail possum TNF-alpha. Immunology and Cell Biology 77, 28-33. doi:10.1046/j.1440-1711.1999.00793.x
173. Wedlock, D. N., Goh, L. P., Parlane, N. A., and Buddle, B. M. (1999b Molecular cloning and physiological effects of brushtail possum interleukin-1 beta. Veterinary Immunology and Immunopathology 67, 359-372. doi:10.1016/S0165-2427(99)00004-5
174. Wilkinson, R., Kotlarski, I., and Barton, M. (1992a). Koala lymphoid cells: Analysis of antigen-specific responses. Veterinary Immunology and Immunopathology 33, 237-247. doi:10.1016/0165-2427(92)90184-R
175. Wilkinson, R., Kotlarski, I., Barton, M., and Phillips, P. (1992b). Isolation of koala lymphoid cells and their in vitro responses to mitogens. Veterinary Immunology and Immunopathology 31, 21-33. doi:10.1016/0165-2427(92) 90084-4
176. Wong, E., Young, L. J., Papenfuss, A. T., and Belov, K. (2006). In silico identification of opossum cytokine genes suggests the complexity of the marsupial immune system rivals that of eutherian mammals. Immunome Research 2(4),
177. Wong, E., Papenfuss, A. T., Heger, A., Hsu, A., Ponting, C. P., Miller, R. D., Fenelon, J., Renfree, M. B., Gibbs, R. A., and Belov, K. (2011a doi:10.1186/1471-2164-12-420 Transcriptomic analysis supports similar functional roles for the two thymuses of the Tammar wallaby. BMC Genomics 12(420), 1-12. doi:10.1186/1471-2164-12-420
178. Wong, E. S. W., Papenfuss, A. T., and Belov, K. (2011b). Immunome database for marsupials and monotremes. BMC Immunology 12, 48. doi:10.1186/1471-2172-12-48
179. Yadav, M. (1973). The presence of the cervical and thoracic thymus lobes in marsupials. Australian Journal of Zoology 21, 285-301. doi:10.1071/ZO9730285
180. Yadav, M, and Papadimitriou, J. M. (1969). III. Ultrastructure of the neonatal thymus of a marsupial, Setonix brachyurus. Australian Journal of Experimental Biology and Medical Science 47, 653-668. doi:10.1038/icb.1969.163
181. Yadav, M., Stanley, N. F., and Waring, H. (1972a). The thymus glands of a marsupial, Setonix brachyurus (quokka), and their role in immune responses. Effect of thymectomy on somatic growth and blood leucocytes. The Australian Journal of Experimental Biology and Medical Science 50, 357-364. doi:10.1038/icb.1972.29
182. Yadav, M., Stanley, N. F., and Waring, H. (1972b). The thymus glands of a marsupial, Setonix brachyurus (quokka), and their role in immune responses. Structure and growth of the thymus glands. The Australian Journal of Experimental Biology and Medical Science 50, 347-356. doi:10.1038/icb.1972.28
183. Yadav, M., Waring, H., and Stanley, N. (1974). Effect of thymectomy on skin allograft survival in a macropod marsupial Setonix brachyurus. Transplantation 17, 30-36. doi:10.1097/00007890-197401000-00006
184. Young, L. (2011). Expressed sequence identification and characterisation of the cDNA for Interleukin-4 from the mitogen-stimulated tissue of a marsupial, Macropus eugenii. Veterinary Immunology and Immunopathology 140, 335-340. doi:10.1016/j.vetimm.2010.12.006
185. Young, L. J. (2012). Phenotyping of leukocytes in the lungs of potoroid marsupials. Comparative Clinical Pathology 21, 9-14. doi:10.1007/s00580-010- 1056-8
186. Young, L. J., and Deane, E. M. (2007). Culture and stimulation of tammar wallaby lymphocytes. Veterinary Research Communications 31, 685-701. doi:10.1007/s11259-007-0057-9
187. Young, L. J., and Harrison, G. A. (2010). Molecular characterisation of Interleukin-1 Beta in the Tammar wallaby (Macropus eugenii). The Journal of Veterinary Medical Science 72, 1521-1526. doi:10.1292/jvms.10-0100
188. Young, L. J., McFarlane, R., Slender, A. L., and Deane, E. M. (2003). Histological and immunohistological investigation of the lymphoid tissue in normal and mycobacteria-affected specimens of the rufous harewallaby (Lagorchestes hirsutus) Journal of Anatomy 202, 315-325. doi:10.1046/j.1469- 7580.2003.00165.x
189. Young, L. J., Cross, M. L., Duckworth, J. A., Flenady, S., and Belov, K. (2012). Molecular identification of Interleukin-2 in the lymphoid tissues of the common brushtail possum, Trichosurus vulpecula Developmental and Comparative Immunology 36, 236-240. doi:10.1016/j.dci.2011.05.010
190. Zelus, D., Robinson-Rechavi, M., Delacre, M., Auriault, C., and Laudet, V. (2000). Fast evolution of Interleukin-2 in mammals and positive selection in ruminants. Journal of Molecular Evolution 51, 234-244.
191. Zhu, J., and Paul,W. E. (2008).CD4Tcells: Fates, functions, and faults. Blood 112, 1557-1569. doi:10.1182/blood-2008-05-078154
192. Zhu, J., Yamane, H., and Paul,W.E. (2010). Differentiation of EffectorCD4T cell populations. Annual Review of Immunology 28, 445-489. doi:10.11.46/annurev-immunol-030409-101212