Recombination, transcription, and diversity of a partially germline-joined VH in a mammal

Immunogenetics

Volumn 64, Issue 9, 2012, Pages 713-717

  Wang, Xinxin ^a   Miller, Robert D ^a  

^a UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

Antibody repertoire; Evolution; Germline joined VH; Marsupial

Indexed keywords

PROTEIN; UNCLASSIFIED DRUG; VH PROTEIN;

ARTICLE; B LYMPHOCYTE; GENETIC RECOMBINATION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GERM LINE; MONODELPHIS DOMESTICA; NONHUMAN; OPOSSUM; PRIORITY JOURNAL; WEANING;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODY DIVERSITY; BASE SEQUENCE; COMPLEMENTARITY DETERMINING REGIONS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; GERM CELLS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR SEQUENCE DATA; MONODELPHIS; RECOMBINATION, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, AMINO ACID; SPLEEN; TIME FACTORS; TRANSCRIPTION, GENETIC; V(D)J RECOMBINATION;

DIDELPHIDAE; MAMMALIA; METATHERIA; MONODELPHIS DOMESTICA; VERTEBRATA;

EID: 84866735595     PISSN: 00937711     EISSN: 14321211     Source Type: Journal    
DOI: 10.1007/s00251-012-0627-z     Document Type: Article

References (22)

1. Alt FW, Yancopoulos GD, Blackwell TK, Wood C, Thomas E, Boss M, Coffman R, Rosenberg N, Tonegawa S, Baltimore D (1984) Ordered rearrangement of immunoglobulin heavy chain variable region segments. EMBO J 3:1209-1219
2. Aveskogh M, Pilstrom L, Hellman L (1999) Cloning and structural analysis of IgM (μ chain) and the heavy chain V region repertoire in the marsupial Monodelphis domestica. Dev Comp Immunol 23:597-606
3. Baker ML, Belov K, Miller RD (2005) Unusually similar patterns of antibody V segment diversity in distantly related marsupials. J Immunol 174:5665-5671
4. Berens SJ, Wylie DE, Lopez OJ (1997) Use of a single VH family and long CDR3s in the variable region of cattle Ig heavy chains. Int Immunol 9:189-199
5. Hardy RR, Carmack CE, Shinton SA, Kemp JD, Hayakawa K (1991) Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J Exp Med 173:1213-1225
6. Johansson J, Aveskogh M, Munday B, Hellman L (2002) Heavy chain V region diversity in the duck-billed platypus (Ornithorynchus anatinus): long and highly variable complementarity-determining region 3 compensates for limited germline diversity. J Immunol 168:5155-5162
7. Kokubu F, Litman R, Shamblott MJ, Hinds K, Litman GW (1988) Diverse organization of immunoglobulin VH gene loci in a primitive vertebrate. EMBO J 7:3413-3422
8. Lee SS, Fitch D, Flajnik MF, Hsu E (2000) Rearrangement of immunoglobulin genes in shark germ cells. J Exp Med 191:1637-1648
9. Lewis SM, Wu GE (2000) The old and the restless. J Exp Med 191:1631-1636
10. Malecek K, Lee V, Feng W, Huang JL, Flajnik MF, Ohta Y, Hsu E (2008) Immunoglobulin heavy chain exclusion in the shark. PLoS Biol 6:e157
11. Miller RD, Grabe H, Rosenberg GH (1998) VH repertoire of a marsupial (Monodelphis domestica). J Immunol 160:259-265
12. Old JM, Deane EM (2000) Development of the immune system and immunological protection in marsupial pouch young. Dev Comp Immunol 24:445-454
13. Parra ZE, Baker ML, Schwarz R, Deakin JE, Lindblad-Toh K, Miller RD (2007) Discovery of a new T cell receptor in marsupials. Proc Natl Acad Sci USA 104:9776-9781
14. Reynaud CA, Dahan A, Anquez V, Weill JC (1989) Somatic hyperconversion diversifies the single VH gene of the chicken with a high incidence in the D region. Cell 59:171
15. Rumfelt LL, Avila D, Diaz M, Bartl S, McKinney EC, Flajnik MF (2001) A shark antibody heavy chain encoded by a nonsomatically rearranged VDJ is preferentially expressed in early development and is convergent with mammalian IgG. Proc Natl Acad Sci USA 98:1775-1780
16. Saini SS, Allore B, Jacobs RM, Kaushik A (1999) Exceptionally long CDR3H region with multiple cysteine residues in functional bovine IgM antibodies. Eur J Immunol 29:2420
17. H+Vλ pairings. Int Immunol 15:845-853
18. Samollow PB (2006) Status and applications of genomic resources for the gray, short-tailed opossum, Monodelphis domestica, an American marsupial model for comparative biology. Aus J Zool 54:173-196
19. Tonegawa S (1983) Somatic generation of antibody diversity. Nature 302:575-581
20. Ventura-Holman T, Lobb CJ (2002) Structural organization of the immunoglobulin heavy chain locus in the channel catfish: the IgH locus represents a composite of two gene clusters. Mol Immunol 38:557-564
21. Wang X, Olp JJ, Miller RD (2009) On the genomics of immunoglobulins in the gray, short-tailed opossum Monodelphis domestica. Immunogenetics 61:581-596
22. Volpe JM, Cowell LG, Kepler TB (2006) SoDA: implementation of a 3D alignment algorithm for inference of antigen receptor recombinations. Bioinformatics 22:438-444