Myocardin-related transcription factor-A is a key regulator in retinoic acid-induced neural-like differentiation of adult bone marrow-derived mesenchymal stem cells

Gene

Volumn 523, Issue 2, 2013, Pages 178-186

  Wang, Nan ^a   Xu, Yao ^a   Qin, Tao ^a   Wang, Feng Po ^a   Ma, Lin Lin ^a   Luo, Xue Gang ^a   Zhang, Tong Cun ^a,b  

^a TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b WUHAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Cellular differentiation; Mesenchymal stem cells; Myocardin related transcription factor A; Neural cells; Neurofilament H; Retinoic acid

Indexed keywords

BETA TUBULIN; MESSENGER RNA; MICROTUBULE ASSOCIATED PROTEIN 2; MYOCARDIN; MYOCARDIN RELATED TRANSCRIPTION FACTOR A; RETINOIC ACID; SERUM RESPONSE FACTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; MYOCARDIN RELATED TRANSCRIPTION FACTOR A, RAT; MYOCARDIN-RELATED TRANSCRIPTION FACTOR-A, RAT; NEUROFILAMENT PROTEIN; NEUROFILAMENT PROTEIN H;

ADULT; ANIMAL CELL; ARTICLE; BONE MARROW DERIVED MESENCHYMAL STEM CELL; CELL DIFFERENTIATION; CELLULAR DISTRIBUTION; CHANNEL GATING; CONTROLLED STUDY; DNA FRAGMENTATION; DOWN REGULATION; EMBRYO; IN VITRO STUDY; IN VIVO STUDY; MALE; MEMBRANE STEADY POTENTIAL; MESENCHYMAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RAT; UPREGULATION; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; MEMBRANE POTENTIAL; MESENCHYMAL STROMA CELL; METABOLISM; NERVE CELL; PHYSIOLOGY; TIME;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; GENE EXPRESSION REGULATION; MALE; MEMBRANE POTENTIALS; MESENCHYMAL STROMAL CELLS; NEUROFILAMENT PROTEINS; NEURONS; RATS; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRETINOIN;

MLCS; MLOWN;

EID: 84880423692     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2013.03.043     Document Type: Article

References (36)

1. Anghileri E., et al. Neuronal differentiation potential of human adipose-derived mesenchymal stem cells. Stem Cells Dev. 2008, 17:909-916.
2. Bain G., Kitchens D., Yao M., Huettner J.E., Gottlieb D.I. Embryonic stem cells express neuronal properties in vitro. Dev. Biol. 1995, 168:342-357.
3. Bi Y., et al. Pre-activation of retinoid signaling facilitates neuronal differentiation of mesenchymal stem cells. Dev. Growth Differ. 2010, 52:419-431.
4. Bianco P., Robey P.G. Stem cells in tissue engineering. Nature 2001, 414:118-121.
5. Cao X.L., Hu X.M., Hu J.Q., Zheng W.X. Myocardin-related transcription factor-A promoting neuronal survival against apoptosis induced by hypoxia/ischemia. Brain Res. 2011, 1385:263-274.
6. Cen B., et al. Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes. Mol. Cell. Biol. 2003, 23:6597-6608.
7. Ebert A.D., Yu J., Rose F.F., Lorson C.L., Thomson J.A., Svendsen C.N. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 2009, 457:277-280.
8. Erceg S., et al. Transplanted oligodendrocytes and motoneuron progenitors generated from human embryonic stem cells promote locomotor recovery after spinal cord transection. Stem Cells 2010, 28:1541-1549.
9. Fraichard A., Chassande O., Bilbaut G., Dehay C., Savatier P., Samarut J. In vitro differentiation of embryonic stem cells into glial cells and functional neurons. J. Cell Sci. 1995, 108:3181-3188.
10. Gavrieli Y., Sherman Y., Ben-Sasson S.A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 1992, 119:493-501.
11. Hellmann M.A., Panet H., Barhum Y., Melamed E., Offen D. Increased survival and migration of engrafted mesenchymal bone marrow stem cells in 6-hydroxydopamine-lesioned rodents. Neurosci. Lett. 2006, 395:124-128.
12. Ishikawa M., et al. Involvement of the serum response factor coactivator megakaryoblastic leukemia (MKL) in the activin-regulated dendritic complexity of rat cortical neurons. J. Biol. Chem. 2010, 285:32734-32743.
13. Jang Y.K., et al. Retinoic acid-mediated induction of neurons and glial cells from human umbilical cord-derived hematopoietic stem cells. J. Neurosci. Res. 2004, 75:573-584.
14. Jeon E.S., Park W.S., Lee M.J., Kim Y.M., Han J., Kim J.H. A Rho kinase/myocardin-related transcription factor-A-dependent mechanism underlies the sphingosylphosphorylcholine-induced differentiation of mesenchymal stem cells into contractile smooth muscle cells. Circ. Res. 2008, 103:635-642.
15. Kalita K., Kuzniewska B., Kaczmarek L. MKLs: co-factors of serum response factor (SRF) in neuronal responses. Int. J. Biochem. Cell Biol. 2012, 44:1444-1447.
16. Knoll B., et al. Serum response factor controls neuronal circuit assembly in the hippocampus. Nat. Neurosci. 2006, 9:195-204.
17. Li X., Li H., Bi J., Chen Y., Jain S., Zhao Y. Human cord blood-derived multipotent stem cells (CB-SCs) treated with all-trans-retinoic acid (ATRA) give rise to dopamine neurons. Biochem. Biophys. Res. Commun. 2012, 419:110-116.
18. Loew L.M. A Laboratory Handbook 1998, 375-379. Academic Press, San Diego.
19. Maden M. Retinoic acid in the development, regeneration and maintenance of the nervous system. Nat. Rev. Neurosci. 2007, 8:755-765.
20. Mao C., Kisaalita W.S. Determination of resting membrane potential of individual neuroblastoma cells (IMR-32) using a potentiometric dye (TMRM) and confocal microscopy. J. Fluoresc. 2004, 14:739-743.
21. Medjkane S., Perez-Sanchez C., Gaggioli C., Sahai E., Treisman R. Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis. Nat. Cell Biol. 2009, 11:257-268.
22. Miralles F., Posern G., Zaromytidou A.I., Treisman R. Actin dynamics control SRF activity by regulation of its coactivator MAL. Cell 2003, 11:329-342.
23. Mokalled M.H., Johnson A., Kim Y., Oh J., Olson E.N. Myocardin-related transcription factors regulate the Cdk5/Pctaire1 kinase cascade to control neurite outgrowth, neuronal migration and brain development. Development 2010, 137:2365-2374.
24. Montiel-Eulefi E., Nery A.A., Rodrigues L.C., Sánchez R., Romero F., Ulrich H. Neural differentiation of rat aorta pericyte cells. Cytometry A 2012, 81:65-71.
25. O'Sullivan N.C., Pickering M., Di Giacomo D., Loscher J.S., Murphy K.J. Mkl transcription cofactors regulate structural plasticity in hippocampal neurons. Cereb. Cortex 2010, 20:1915-1925.
26. Pittenger M.F., et al. Multilineage potential of adult human mesenchymal stem cell. Science 1999, 284:143-147.
27. Prockop D.J. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 1997, 276:71-74.
28. Rasmussen M.A., Hall V.J., Carter T.F., Hyttel P. Directed differentiation of porcine epiblast-derived neural progenitor cells into neurons and glia. Stem Cell Res. 2011, 7:124-136.
29. Shiota J., Ishikawa M., Sakagami H., Tsuda M., Baraban J.M., Tabuchi A. Developmental expression of the SRF co-activator MAL in brain: role in regulating dendritic morphology. J. Neurochem. 2006, 98:1778-1788.
30. Tio M., Tan K.H., Lee W., Wang T.T., Udolph G. Roles of db-cAMP, IBMX and RA in aspects of neural differentiation of cord blood derived mesenchymal-like stem cells. PLoS One 2010, 24:e9398.
31. Trzaska K.A., et al. Brain-derived neurotrophic factor facilitates maturation of mesenchymal stem cell-derived dopamine progenitors to functional neurons. J. Neurochem. 2009, 110:1058-1069.
32. Wang N., et al. Cooperation of phosphatidylcholine-specific phospholipase C and basic fibroblast growth factor in the neural differentiation of mesenchymal stem cells in vitro. Int. J. Biochem. Cell Biol. 2008, 40:294-306.
33. Wang N., et al. Cooperation of myocardin and Smad2 in inducing differentiation of mesenchymal stem cells into smooth muscle cells. IUBMB Life 2012, 64:331-339.
34. Wickramasinghe S.R., Alvania R.S., Ramanan N., Wood J.N., Mandai K., Ginty D.D. Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons. Neuron 2008, 58:532-545.
35. Wislet-Gendebien S., Hans G., Leprince P., Rigo J.M., Moonen G.B. Rogister, plasticity of cultured mesenchymal stem cells: switch from nestin-positive to excitable neuron-like phenotype. Stem Cells 2005, 23:392-402.
36. Zhao L.X., et al. Modification of the brain-derived neurotrophic factor gene: a portal to transform mesenchymal stem cells into advantageous engineering cells for neuroregeneration and neuroprotection. Exp. Neurol. 2004, 190:396-406.