Modification of the brain-derived neurotrophic factor gene: A portal to transform mesenchymal stem cells into advantageous engineering cells for neuroregeneration and neuroprotection

Experimental Neurology

Volumn 190, Issue 2, 2004, Pages 396-406

  Zhao, Lian Xu ^a   Zhang, Jie ^b   Cao, Feng ^b   Meng, Ling ^b   Wang, Dong Mei ^b   Li, Yan Hua ^b   Nan, Xue ^b   Jiao, Wen Cang ^b   Zheng, Min ^b   Xu, Xiao Hu ^a   Pei, Xue Tao ^b  

^a SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^b BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

Author keywords

Brain derived neurotrophic factor; Gene therapy; Mesenchymal stem cells; Retroviral vector; Stem cells

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; GLIAL FIBRILLARY ACIDIC PROTEIN; NESTIN; RETINOIC ACID;

ADULT; ARTICLE; CALCIUM CURRENT; CELL DIFFERENTIATION; CELL LOSS; CENTRAL NERVOUS SYSTEM; CHROMOSOME ABERRATION; CONTROLLED STUDY; DNA MODIFICATION; FEMALE; GENE EXPRESSION; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MALE; MESENCHYME CELL; NERVE CELL; NERVE REGENERATION; NEUROPROTECTION; NORMAL HUMAN; OLIGODENDROGLIA; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE; STEM CELL;

ADULT; BONE MARROW CELLS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL DIFFERENTIATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MESENCHYMAL STEM CELLS; MIDDLE AGED; MULTIPOTENT STEM CELLS; NERVE REGENERATION; NEURONS; NEUROPROTECTIVE AGENTS; OLIGODENDROGLIA; PATCH-CLAMP TECHNIQUES; TISSUE ENGINEERING; TRANSDUCTION, GENETIC; TRETINOIN;

EID: 8644265331     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.expneurol.2004.06.025     Document Type: Article

References (50)

1. A. Benraiss, E. Chmielnicki, K. Lerner, D. Roh, and S.A. Goldman Adenoviral brain-derived neurotrophic factor induces both neostriatal and olfactory neuronal recruitment from endogenous progenitor cell in the adult forebrain J. Neurosci. 21 2001 6718 6731
2. T.R. Brazelton, F.M. Rossi, G.I. Keshet, and H.M. Blau From marrow to brain: expression of neuronal phenotypes in adult mice Science 290 2000 1775 1779
3. Z. Cai, Y. Pang, F. Xiao, and P.G. Rhodes Chronic ischemia preferentially causes white matter injury in the neonatal rat brain Brain Res. 898 2001 126 135
4. A.I. Caplan, and S.P. Bruder Mesenchymal stem cells: building block for molecular medicine in the 21 century Trends Mol. Med. 7 2001 259 263
5. X. Chen, M. Katakowski, Y. Li, D. Lu, L. Wang, L. Zhang, J. Chen, Y. Xu, S. Gautam, A. Mahmood, and M. Chopp Human bone marrow stromal cell cultures conditioned by traumatic brain tissue extracts: growth factor production J. Neurosci. Res. 69 2002 687 691
6. X. Chen, Y. Li, L. Wang, M. Katakowski, L. Zhang, J. Chen, Y. Xu, S.C. Gautam, and M. Chopp Ischemic rat brain extracts induce human marrow stromal cell growth factor production Neuropathology 22 2002 275 279
7. Y. Cui, M. Yu, H.Q. Zhang, Y.Z. Zhao, Y.L. Ma, H. Wang, L. Shen, and L.S. Li Mesenchyma-like stem cells from multiple tissues bear a resemblance in both appearance and character Stem Cell Cell. Ther. 1 2003 26 31
8. R. Dalal, and D. Djakiew Molecular characterization of neurotrophin expression and the corresponding tropomyosin receptor kinases (Trks) in epithelial and stromal cells of the human prostate Mol. Cell. Endocrinol. 134 1997 15 22
9. R.J. Deans, and A.B. Moseley Mesenchymal stem cells: biology and potential clinical uses Exp. Hematol. 28 2000 875 884
10. S.M. Devine, C. Cobbs, M. Jennings, A. Bartholomew, and R. Hoffman Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates Blood 101 2003 2999 3001
11. S.P. Dormady, O. Bashayan, R. Dougherty, X.M. Zhang, and R.S.D. Basch Immortalized multipotential mesenchymal cells and the hematopoietic microenvironment J. Hematother. Stem Cell Res. 10 2001 125 140
12. M.U. Fareed, and F.L. Moolten Suicide gene transduction sensitizes murine embryonic and human mesenchymal stem cells to ablation on demand a fail safe protection against cellular misbehavior Gene Ther. 9 2002 955 962
13. F.H. Gage Mammalian neural stem cells Science 287 2000 1433 1438
14. Z. Guo, J. Yang, X. Liu, X. Li, C. Hou, P.H. Tang, and N. Mao Biological features of mesenchymal stem cells from human bone marrow Chin. Med. J. (England) 114 2001 950 953
15. O.P. Hamill, A. Marty, E. Neher, B. Sakmann, and F.J. Sigworth Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches Pfluegers Arch. 391 1981 85 100
16. L. Hou, H. Cao, D. Wang, G. Wei, C. Bai, Y. Zhang, and X. Pei Induction of umbilical cord blood mesenchymal stem cells into neuron-like cells in vitro Int. J. Hematol. 78 2003 256 261
17. S.C. Hung, H. Cheng, C.Y. Pan, M.J. Tsai, L.S. Kao, and H.L. Ma In vitro differentiation of size-sieved stem cells into electrically active neural cells Stem Cells 20 2002 22 259
18. R. Huss, C. Lange, E.M. Weissinger, H.J. Kolb, and K. Thalmeier Evidence of peripheral lood-derived, plastic-adherent CD34/low hematopoietic stem cell clones with mesenchymal stem cell characteristics Stem Cells 18 2000 252 260
19. H.K. Jin, and E.H. Schuchman Ex vivo gene therapy using bone marrow-derived cells: combined effects of intracerebral and intravenous transplantation in a mouse model of Niemann-Pick disease Molec. Ther. 8 2003 876 885
20. S.K. Kang, D.H. Lee, Y.C. Bae, H.K. Kim, S.Y. Baik, and J.S. Jung Improvement of neurological deficits by intracerebral transplantation of human adipose tissue-derived stromal cells after cerebral ischemia in rats Exp. Neurol. 183 2003 355 366
21. G.C. Kopen, D.J. Prockop, and D.G. Phinney Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains Proc. Natl. Acad. Sci. 96 1999 10711 10716
22. G.M. Kruger, J.T. Mosher, S. Bixby, N. Joseph, T. Iwashita, and S.J. Morrison Neural crest stem cells persist in the adult gut but undergo changes in self-renewal, neuronal subtype potential, and factor responsiveness Neuron 35 2002 657 669
23. K. Kurozumi, K. Nakamura, T. Tamiya, Y. Kawano, M. Kobune, S. Hirai, H. Uchida, K. Sasaki, Y. Ito, K. Kato, O. Honmou, K. Houkin, I. Date, and H. Hamada BDNF gene-modified mesenchymal stem cells promote functional recovery and reduce infarct size in the rat middle cerebral artery occlusion model Molec. Ther. 9 2004 189 197
24. M.A. Laurenzi, T. Beccari, L. Stenke, M. Sjolinder, S. Stinchi, and J.A. Lindgren Expression of mRNA encoding neurotrophins and neurotrophin receptors in human granulocytes and bone marrow cells-Enhanced neurotrophin-4 expression induced by LTB4 J. Leukocyte Biol. 64 1998 228 234
25. J. Lee, S. Kuroda, H. Shichinohe, J. Ikeda, T. Seki, K. Hida, M. Tada, K. Sawada, and Y. Iwasaki Migration and differentiation of nuclear fluorescence-labeled bone marrow stromal cells after transplantation into cerebral infarct and spinal cord injury in mice Neuropathology 23 2003 169 180
26. C. Lo-Bianco, J.L. Ridet, B.L. Schneider, N. Deglon, and P. Aebischer Alpha-synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease Proc. Natl. Acad. Sci. U. S. A. 99 2002 10813 10818
27. S.A. Lyness, C. Zarow, and H.C. Chui Neuron loss in key cholinergic and aminergic nuclei in Alzheimer disease: a meta-analysis Neurobiol. Aging 24 2003 1 23
28. A. Mahmood, D. Lu, L. Wang, Y. Li, M. Lu, and M. Chopp Treatment of traumatic brain injury in female rats with intravenous administration of bone marrow stromal cells Neurosurgery 49 2001 1196 1203
29. S. Makino, K. Fukuda, S. Miyoshi, F. Konishi, H. Kodama, J. Pan, M. Sano, T. Takahashi, S. Hori, H. Abe, J. Hata, A. Umezawa, and S. Ogawa Cardiomyocytes can be generated from marrow stromal cells in vitro J. Clin. Invest. 103 1999 697 705
30. Y. Manabe, I. Nagano, M.S. Gazi, T. Murakami, M. Shiote, M. Shoji, H. Kitagawa, and K. Abe Glial cell line-derived neurotrophic factor protein prevents motor neuron loss of transgenic model mice for amyotrophic lateral sclerosis Neurol. Res. 25 2003 195 200
31. A.K. McAllister, D.C. Lo, and L.C. Katz Neurotrophins regulate dendritic growth in developing visual cortex Neuron 15 1995 791 803
32. J.A. Medin, and D.H. Fowler Post-transduction events in retrovirus-mediated gene therapy involving hematopoietic stem cells: beyond efficiency issues J. Cell. Biochem., Suppl. 38 2002 46 54
33. M.G. Murer, Q. Yan, and R. Raisman-Vozari Brain-derived neurotrophic factor in the control human, and in Alzheimer's disease and Parkinson's disease Prog. Neurobiol. 63 2001 71 124
34. J. Ourednik, V. Ourednik, W.P. Lynch, M. Schachner, and E.Y. Snyder Neural stem cells display an inherent mechanism for rescuing dysfunctional neurons Nat. Biotechnol. 20 2002 1103 1110
35. M.F. Pittenger, A.M. Mackay, S.C. Beck, R.K. Jaiswal, R. Douglas, J.D. Mosca, M.A. Moorman, D.W. Simonetti, S. Craig, and D.R. Marshak Multilineage potential of adult human mesenchymal stem cells Science 284 1999 143 147
36. B.A. Reynolds, and S. Weiss Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system Science 225 1992 1707 1710
37. N. Rismanchi, C.L. Floyd, R.F. Berman, and B.G. Lyeth Cell death and long-term maintenance of neuron-like state after differentiation of rat bone marrow stromal cells: a comparison of protocols Brain Res. 991 2003 46 55
38. F. Rubio, Z. Kokaia, A. Arco, M. Garcia-Simon, E. Snyder, O. Lindvall, J. Satrustegui, and A. Martinez-Serrano BDNF gene transfer to the mammalian brain using CNS-derived neural precursors Gene Ther. 6 1999 1851 1866
39. J. Sanchez-Ramos, S. Song, F. Cardozo-Pelaez, C. Hazzi, T. Stedeford, A. Willing, T.B. Freeman, S. Saporta, W. Janssen, N. Patel, D.R. Cooper, and P.R. Sanberg Adult bone marrow stromal cells differentiate into neural cells in vitro Exp. Neurol. 164 2000 247 256
40. E.J. Schwarz, G.M. Alexander, D.J. Prockop, and S.A. Azizi Multipotential marrow stromal cells transduced to produce l-dopa: engraftment in a rat model of Parkinson disease Hum. Gene Ther. 10 1999 2539 2549
41. E.J. Schwarz, R.L. Reger, G.M. Alexander, R. Class, S.A. Azizi, and D.J. Prockop Rat marrow stromal cells rapidly transduced with a self-inactivating retrovirus synthesize l-dopa in vitro Gene Ther. 8 2001 1214 1223
42. F.W. Sorensen, J.O. Larsen, R. Eide, and J.D. Schionning Neuron loss in cerebellar cortex of rats exposed to mercury vapor: a stereological study Acta Neuropathol. (Berlin) 100 2000 95 100
43. T.P. Sutula, and A. Pitkanen More evidence for seizure-induced neuron loss: is hippocampal sclerosis both cause and effect of epilepsy? Neurology 57 2001 169 170
44. M. Tagaya, H.P. Haring, I. Stuiver, S. Wagner, T. Abumiya, J. Lucero, P. Lee, B.R. Copeland, D. Seiffert, and G.J. del-Zoppo Rapid loss of microvascular integrin expression during focal brain ischemia reflects neuron injury J. Cereb. Blood Flow Metab. 21 2001 835 846
45. C. Toma, M.F. Pittenger, K.S. Cahill, B.J. Byrne, and P.D. Kessler Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart Circulation 105 2002 93 98
46. M. Tomita, Y. Adachi, H. Yamada, K. Takahashi, K. Kiuchi, H. Oyaizu, K. Ikebukuro, H. Kaneda, M. Matsumura, and S. Ikehara Bone marrow-derived stem cells can differentiate into retinal cells in injured rat retina Stem Cells 20 2002 279 283
47. L.R. Zhao, W.M. Duan, M. Reyes, C.D. Keene, C.M. Verfaillie, and W.C. Low Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats Exp. Neurol. 174 2002 11 20
48. H. Zhao, M.A. Yenari, D. Cheng, R.M. Sapolsky, and G.K. Steinberg Bcl-2 overexpression protects against neuron loss within the ischemic margin following experimental stroke and inhibits cytochrome c translocation and caspase-3 activity J. Neurochem. 85 2003 1026 1036
49. L.X. Zhao, J. Zhang, X.H. Xu, and X.T. Pei Stem cell and gene therapy: theory, technology and the prospect of application Stem Cell Cell. Ther. 1 2 2003 10 17
50. D. Woodbury, E.J. Schwarz, D.J. Prockop, and I.B. Black Adult rat and human bone marrow stromal cells differentiate into neurons J. Neurosci. Res. 61 2000 364 370