CUL3 and protein kinases: Insights from PLK1/KLHL22 interaction

Cell Cycle

Volumn 12, Issue 14, 2013, Pages 2291-2296

  Metzger, Thibaud ^a   Kleiss, Charlotte ^a   Sumara, Izabela ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

BTB proteins; CUL3; Kinases; KLHL22; PLK1; Ubiquitin

Indexed keywords

CULLIN; CULLIN 3; POLO LIKE KINASE 1; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ARTICLE; ENZYME ACTIVITY; GENE INTERACTION; HUMAN; IN VITRO STUDY; PROTEIN TARGETING; UBIQUITINATION;

EID: 84880418571     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.25369     Document Type: Article

References (36)

1. Beck J, Maerki S, Posch M, Metzger T, Persaud A, Scheel H, et al. Ubiquitylation-dependent localization of PLK1 in mitosis. Nat Cell Biol 2013; 15:430-9; PMID:23455478; http://dx.doi.org/10.1038/ncb2695
2. Nigg EA. Mitotic kinases as regulators of cell division and its checkpoints. Nat Rev Mol Cell Biol 2001; 2:21-32; PMID:11413462; http://dx.doi.org/10.1038/35048096 (Pubitemid 33676958)
3. Komander D, Rape M. The ubiquitin code. Annu Rev Biochem 2012; 81:203-29; PMID:22524316; http://dx.doi.org/10.1146/annurev-biochem-060310-170328
4. Willems AR, Schwab M, Tyers M. A hitchhiker's guide to the cullin ubiquitin ligases: SCF and its kin. Biochim Biophys Acta 2004; 1695:133-70; PMID:15571813; http://dx.doi.org/10.1016/j.bbamcr.2004.09.027 (Pubitemid 39574971)
5. Stogios PJ, Privé GG. The BACK domain in BTBkelch proteins. Trends Biochem Sci 2004; 29:634-7; PMID:15544948; http://dx.doi.org/10.1016/j.tibs. 2004.10.003
6. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, et al. Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell 2011; 44:325-40; PMID:21906983; http://dx.doi.org/10.1016/j.molcel.2011.08. 025
7. Peters JM. The anaphase promoting complex/cyclosome: a machine designed to destroy. Nat Rev Mol Cell Biol 2006; 7:644-56; PMID:16896351; http://dx.doi.org/10.1038/nrm1988
8. Kraft C, Herzog F, Gieffers C, Mechtler K, Hagting A, Pines J, et al. Mitotic regulation of the human anaphase- promoting complex by phosphorylation. EMBO J 2003; 22:6598-609; PMID:14657031; http://dx.doi.org/10.1093/emboj/cdg627 (Pubitemid 38009606)
9. Sumara I, Maerki S, Peter M. E3 ubiquitin ligases and mitosis: embracing the complexity. Trends Cell Biol 2008; 18:84-94; PMID:18215523; http://dx.doi.org/10.1016/j.tcb.2007.12.001
10. Petroski MD, Deshaies RJ. Function and regulation of cullin-RING ubiquitin ligases. Nat Rev Mol Cell Biol 2005; 6:9-20; PMID:15688063; http://dx.doi.org/10.1038/nrm1547 (Pubitemid 40064895)
11. Lindon C, Pines J. Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells. J Cell Biol 2004; 164:233-41; PMID:14734534; http://dx.doi.org/10.1083/jcb.200309035 (Pubitemid 38133943)
12. Li W, Ye Y. Polyubiquitin chains: functions, structures, and mechanisms. Cell Mol Life Sci 2008; 65:2397-406; PMID:18438605; http://dx.doi.org/10.1007/ s00018-008-8090-6
13. Zhang DD, Hannink M. Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress. Mol Cell Biol 2003; 23:8137-51; PMID:14585973; http://dx.doi.org/10.1128/MCB.23.22.8137-8151.2003 (Pubitemid 37377505)
14. Wakabayashi N, Dinkova-Kostova AT, Holtzclaw WD, Kang MI, Kobayashi A, Yamamoto M, et al. Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers. Proc Natl Acad Sci USA 2004; 101:2040-5; PMID:14764894; http://dx.doi.org/10.1073/pnas.0307301101 (Pubitemid 38229011)
15. Lénárt P, Petronczki M, Steegmaier M, Di Fiore B, Lipp JJ, Hoffmann M, et al. The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1. Curr Biol 2007; 17:304-15; PMID:17291761; http://dx.doi.org/10.1016/j.cub.2006.12.046
16. Elowe S, Hümmer S, Uldschmid A, Li X, Nigg EA. Tension-sensitive Plk1 phosphorylation on BubR1 regulates the stability of kinetochore microtubule interactions. Genes Dev 2007; 21:2205-19; PMID:17785528; http://dx.doi.org/10. 1101/gad.436007 (Pubitemid 47360842)
17. Lo SC, Li X, Henzl MT, Beamer LJ, Hannink M. Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling. EMBO J 2006; 25:3605-17; PMID:16888629; http://dx.doi.org/10.1038/sj.emboj.7601243 (Pubitemid 44264871)
18. Zhuang M, Calabrese MF, Liu J, Waddell MB, Nourse A, Hammel M, et al. Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol Cell 2009; 36:39-50; PMID:19818708; http://dx.doi.org/10.1016/j.molcel.2009.09.022
19. Lee DF, Kuo HP, Liu M, Chou CK, Xia W, Du Y, et al. KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta. Mol Cell 2009; 36:131-40; PMID:19818716; http://dx.doi.org/10.1016/j.molcel.2009.07. 025
20. Bunce MW, Boronenkov IV, Anderson RA. Coordinated activation of the nuclear ubiquitin ligase Cul3-SPOP by the generation of phosphatidylinositol 5-phosphate. J Biol Chem 2008; 283:8678-86; PMID:18218622; http://dx.doi.org/10. 1074/jbc. M710222200
21. Lee YR, Yuan WC, Ho HC, Chen CH, Shih HM, Chen RH. The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses. EMBO J 2010; 29:1748-61; PMID:20389280; http://dx.doi.org/10.1038/emboj.2010.62
22. Moghe S, Jiang F, Miura Y, Cerny RL, Tsai MY, Furukawa M. The CUL3-KLHL18 ligase regulates mitotic entry and ubiquitylates Aurora-A. Biol Open 2012; 1:82-91; PMID:23213400; http://dx.doi.org/10.1242/bio.2011018
23. Zhang DD, Lo SC, Cross JV, Templeton DJ, Hannink M. Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol Cell Biol 2004; 24:10941-53; PMID:15572695; http://dx.doi.org/10. 1128/MCB.24.24.10941-10953.2004 (Pubitemid 39603148)
24. Maerki S, Olma MH, Staubli T, Steigemann P, Gerlich DW, Quadroni M, et al. The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis. J Cell Biol 2009; 187:791-800; PMID:19995937; http://dx.doi.org/10.1083/jcb.200906117
25. Maerki S, Beck J, Sumara I, Peter M. Finding the midzone: the role of ubiquitination for CPC localization during anaphase. Cell Cycle 2010; 9:2921-2; PMID:20714224; http://dx.doi.org/10.4161/cc.9.15.12740
26. Canning P, Cooper CD, Krojer T, Murray JW, Pike AC, Chaikuad A, et al. Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases. J Biol Chem 2013; 288:7803-14; PMID:23349464; http://dx.doi.org/10.1074/jbc. M112.437996
27. Kobayashi A, Kang MI, Okawa H, Ohtsuji M, Zenke Y, Chiba T, et al. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol 2004; 24:7130-9; PMID:15282312; http://dx.doi.org/10.1128/MCB.24.16.7130-7139.2004 (Pubitemid 39014439)
28. Elia AE, Rellos P, Haire LF, Chao JW, Ivins FJ, Hoepker K, et al. The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polobox domain. Cell 2003; 115:83-95; PMID:14532005; http://dx.doi.org/ 10.1016/S0092-8674(03)00725-6 (Pubitemid 37255320)
29. Cheng KY, Lowe ED, Sinclair J, Nigg EA, Johnson LN. The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex. EMBO J 2003; 22:5757-68; PMID:14592974; http://dx.doi.org/10.1093/ emboj/cdg558 (Pubitemid 37408815)
30. Hanisch A, Wehner A, Nigg EA, Silljé HH. Different Plk1 functions show distinct dependencies on Polo- Box domain-mediated targeting. Mol Biol Cell 2006; 17:448-59; PMID:16267267; http://dx.doi.org/10.1091/mbc.E05-08-0801 (Pubitemid 43049496)
31. Lee KS, Park JE, Kang YH, Zimmerman W, Soung NK, Seong YS, et al. Mechanisms of mammalian pololike kinase 1 (Plk1) localization: self- versus non-selfpriming. Cell Cycle 2008; 7:141-5; PMID:18216497; http://dx.doi.org/10. 4161/cc.7.2.5272 (Pubitemid 351366510)
32. Park JE, Soung NK, Johmura Y, Kang YH, Liao C, Lee KH, et al. Polo-box domain: a versatile mediator of polo-like kinase function. Cell Mol Life Sci 2010; 67:1957-70; PMID:20148280; http://dx.doi.org/10.1007/s00018-010-0279-9
33. Ohta A, Schumacher FR, Mehellou Y, Johnson C, Knebel A, Macartney TJ, et al. The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction. Biochem J 2013; 451:111-22; PMID:23387299; http://dx.doi.org/10.1042/BJ20121903
34. Kim JE, You DJ, Lee C, Ahn C, Seong JY, Hwang JI. Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation. Cell Signal 2010; 22:1645-54; PMID:20600852; http://dx.doi.org/10.1016/j.cellsig.2010.06.004
35. Sumara I, Quadroni M, Frei C, Olma MH, Sumara G, Ricci R, et al. A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells. Dev Cell 2007; 12:887-900; PMID:17543862; http://dx.doi.org/10.1016/j.devcel.2007.03.019 (Pubitemid 46805917)
36. Wakabayashi M, Mori T, Isobe K, Sohara E, Susa K, Araki Y, et al. Impaired KLHL3-Mediated Ubiquitination of WNK4 Causes Human Hypertension. Cell Rep 2013.