Synthesis and characterization of a high-affinity NOTA-conjugated bombesin antagonist for GRPR-targeted tumor imaging

Bioconjugate Chemistry

Volumn 24, Issue 7, 2013, Pages 1144-1153

  Varasteh, Zohreh ^a   Velikyan, Irina ^a,c,d   Lindeberg, Gunnar ^b   Sörensen, Jens ^c,d   Larhed, Mats ^b   Sandström, Mattias ^d   Selvaraju, Ram Kumar ^a   Malmberg, Jennie ^a   Tolmachev, Vladimir ^b   Orlova, Anna ^a  

^a University Platform for Preclinical PET   (Sweden)

^b Department of Medicinal Chemistry   (Sweden)

^c UPPSALA UNIVERSITY   (Sweden)

^d UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; DISEASES; DISSOCIATION; GLYCOLS; MAMMALS; TUMORS;

HIGH AFFINITY; HYDROPHILICS; IMAGING AGENT; MOLECULAR TARGETS; PEPTIDE RECEPTOR; PROSTATE CANCERS; SYNTHESIS AND CHARACTERIZATIONS; SYNTHESISED; TRIAZACYCLONONANE; TUMOR IMAGING;

PEPTIDES;

BOMBESIN ANTAGONIST; GALLIUM 68; GASTRIN RELEASING PEPTIDE RECEPTOR; INDIUM 111;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG ANTAGONISM; DRUG CONJUGATION; DRUG SYNTHESIS; HYDROPHILICITY; IC 50; INTERNALIZATION; ISOTOPE LABELING; KIDNEY CLEARANCE; MALE; MOLECULARLY TARGETED THERAPY; MOUSE; NONHUMAN; PLASMA CLEARANCE; POSITRON EMISSION TOMOGRAPHY; RADIOCHEMISTRY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TUMOR XENOGRAFT;

EID: 84880383358     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc300659k     Document Type: Article

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