Retinoic acid-elicited RARα/RXRα signaling attenuates aβ production by directly inhibiting γ-secretase-mediated cleavage of amyloid precursor protein

ACS Chemical Neuroscience

Volumn 4, Issue 7, 2013, Pages 1093-1100

  Kapoor, Arun ^a,c   Wang, Bo Jeng ^a,e   Hsu, Wen Ming ^d   Chang, Ming Yun ^a   Liang, Shu Mei ^b   Liao, Yung Feng ^a,c  

^a INSTITUTE OF CELLULAR AND ORGANISMIC BIOLOGY   (Taiwan)

^b AGRICULTURAL BIOTECHNOLOGY RESEARCH CENTER   (Taiwan)

^c NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^e NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

secretase; Alzheimer's disease; amyloid precursor protein; amyloid ; APP C99; ERK; retinoic acid

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; DIMETHYL SULFOXIDE; GAMMA SECRETASE; MITOGEN ACTIVATED PROTEIN KINASE 1; RETINOIC ACID; RETINOIC ACID RECEPTOR ALPHA; RETINOID X RECEPTOR ALPHA;

ARTICLE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; CELLS, CULTURED; HUMANS; MAP KINASE SIGNALING SYSTEM; RETINOID X RECEPTOR ALPHA; SIGNAL TRANSDUCTION; TRETINOIN;

EID: 84880381926     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn400039s     Document Type: Article

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