microRNA Regulation and Its Consequences in Cancer

Current Pathobiology Reports

Volumn 1, Issue 1, 2013, Pages 71-79

  Parpart, Sonya ^a,b   Wang, Xin Wei ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

Author keywords

Cancer; Epigenetic; microRNA; miRNA; Pathobiology; Post transcriptional; Regulation; RNA structure; Single nucleotide polymorphisms; SNPs; Transcriptional

Indexed keywords

EID: 84880362470     PISSN: None     EISSN: 2167485X     Source Type: Journal    
DOI: 10.1007/s40139-012-0002-7     Document Type: Review

References (85)

1. Lee RC, Feinbaum RL, Ambros V (1993) The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75:843–854
2. Baek D, Villen J, Shin C et al (2008) The impact of microRNAs on protein output. Nature 455:64–71
3. Lu J, Getz G, Miska EA et al (2005) MicroRNA expression profiles classify human cancers. Nature 435:834–838
4. Volinia S, Calin GA, Liu CG et al (2006) A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA 103:2257–2261
5. Lee Y, Jeon K, Lee JT et al (2002) MicroRNA maturation: stepwise processing and subcellular localization. EMBO J 21:4663–4670
6. Lee Y, Kim M, Han J et al (2004) MicroRNA genes are transcribed by RNA polymerase II. EMBO J 23:4051–4060
7. Zhou X, Wong ST (2008) Computational systems bioinformatics and bioimaging for pathway analysis and drug screening. Proc IEEE Inst Electr Electron Eng 96:1310–1331
8. Borchert GM, Lanier W, Davidson BL (2006) RNA polymerase III transcribes human microRNAs. Nat Struct Mol Biol 13:1097–1101
9. Schanen BC, Li X (2011) Transcriptional regulation of mammalian miRNA genes. Genomics 97:1–6
10. vis-Dusenbery BN, Hata A (2010) MicroRNA in cancer: the involvement of aberrant microRNA biogenesis regulatory pathways. Genes Cancer 1:1100–1114
11. Rodriguez A, Griffiths-Jones S, Ashurst JL, Bradley A (2004) Identification of mammalian microRNA host genes and transcription units. Genome Res 14:1902–1910
12. Saini HK, Griffiths-Jones S, Enright AJ (2007) Genomic analysis of human microRNA transcripts. Proc Natl Acad Sci USA 104:17719–17724
13. Calin GA, Sevignani C, Dumitru CD et al (2004) Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA 101:2999–3004
14. Marson A, Levine SS, Cole MF et al (2008) Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell 134:521–533
15. Fujita S, Ito T, Mizutani T et al (2008) miR-21 Gene expression triggered by AP-1 is sustained through a double-negative feedback mechanism. J Mol Biol 378:492–504
16. Seike M, Goto A, Okano T et al (2009) MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers. Proc Natl Acad Sci USA 106:12085–12090
17. Talotta F, Cimmino A, Matarazzo MR et al (2009) An autoregulatory loop mediated by miR-21 and PDCD4 controls the AP-1 activity in RAS transformation. Oncogene 28:73–84
18. Huang GL, Zhang XH, Guo GL et al (2008) Expression of microRNA-21 in invasive ductal carcinoma of the breast and its association with phosphatase and tensin homolog deleted from chromosome expression and clinicopathologic features. Zhonghua Yi Xue Za Zhi 88:2833–2837
19. Velu CS, Baktula AM, Grimes HL (2009) Gfi1 regulates miR-21 and miR-196b to control myelopoiesis. Blood 113:4720–4728
20. Ribas J, Ni X, Haffner M et al (2009) miR-21: an androgen receptor-regulated microRNA that promotes hormone-dependent and hormone-independent prostate cancer growth. Cancer Res 69:7165–7169
21. Shi XB, Xue L, Yang J et al (2007) An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells. Proc Natl Acad Sci USA 104(50):19983–19988
22. Ambs S, Prueitt RL, Yi M et al (2008) Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer. Cancer Res 68:6162–6170
23. Ferraro L, Ravo M, Nassa G et al (2012) Effects of oestrogen on microRNA expression in hormone-responsive breast cancer cells. Horm Cancer 3:65–78
24. • Paris O, Ferraro L, Grober OM et al (2012) Direct regulation of microRNA biogenesis and expression by estrogen receptor beta in hormone-responsive breast cancer. Oncogene 31:4196–4206
25. O’donnell KA, Wentzel EA, Zeller KI et al (2005) c-Myc-regulated microRNAs modulate E2F1 expression. Nature 435:839–843
26. Chang TC, Yu D, Lee YS et al (2008) Widespread microRNA repression by Myc contributes to tumorigenesis. Nat Genet 40:43–50
27. • Bui TV, Mendell JT (2010) Myc: maestro of MicroRNAs. Genes Cancer 1:568–575
28. Xi Y, Shalgi R, Fodstad O et al (2006) Differentially regulated micro-RNAs and actively translated messenger RNA transcripts by tumor suppressor p53 in colon cancer. Clin Cancer Res 12:2014–2024
29. Raver-Shapira N, Marciano E, Meiri E et al (2007) Transcriptional activation of miR-34a contributes to p53-mediated apoptosis. Mol Cell 26:731–743
30. He L, He X, Lowe SW, Hannon GJ (2007) microRNAs join the p53 network: another piece in the tumour-suppression puzzle. Nat Rev Cancer 7:819–822
31. Fukao T, Fukuda Y, Kiga K et al (2007) An evolutionarily conserved mechanism for microRNA-223 expression revealed by microRNA gene profiling. Cell 129:617–631
32. Ji J, Yamashita T, Wang XW (2011) Wnt/beta-catenin signaling activates microRNA-181 expression in hepatocellular carcinoma. Cell Biosci 1:4
33. Coller HA, Forman JJ, Legesse-Miller A (2007) “Myc’ed messages”: myc induces transcription of E2F1 while inhibiting its translation via a microRNA polycistron. PLoS Genet 3:e146
34. • Hatziapostolou M, Polytarchou C, Aggelidou E et al (2011) An HNF4alpha-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis. Cell 147:1233–1247
35. Zhu Q, Wang Z, Hu Y et al (2012) miR-21 promotes migration and invasion by the miR-21-PDCD4-AP-1 feedback loop in human hepatocellular carcinoma. Oncol Rep 27:1660–1668
36. Godlewski J, Nowicki MO, Bronisz A et al (2010) MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells. Mol Cell 37:620–632
37. Bartel B (2005) MicroRNAs directing siRNA biogenesis. Nat Struct Mol Biol 12:569–571
38. Kim VN (2005) MicroRNA biogenesis: coordinated cropping and dicing. Nat Rev Mol Cell Biol 6:376–385
39. Thomson JM, Newman M, Parker JS et al (2006) Extensive post-transcriptional regulation of microRNAs and its implications for cancer. Genes Dev 20:2202–2207
40. Merritt WM, Lin YG, Han LY et al (2008) Dicer, Drosha, and outcomes in patients with ovarian cancer. N Engl J Med 359:2641–2650
41. Kumar MS, Lu J, Mercer KL et al (2007) Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat Genet 39:673–677
42. Kumar MS, Pester RE, Chen CY et al (2009) Dicer1 functions as a haploinsufficient tumor suppressor. Genes Dev 23:2700–2704
43. • Lambertz I, Nittner D, Mestdagh P et al (2010) Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo. Cell Death Differ 17:633–641
44. Chiosea S, Jelezcova E, Chandran U et al (2006) Up-regulation of dicer, a component of the MicroRNA machinery, in prostate adenocarcinoma. Am J Pathol 169:1812–1820
45. Kaul D, Sikand K (2004) Defective RNA-mediated c-myc gene silencing pathway in Burkitt’s lymphoma. Biochem Biophys Res Commun 313:552–554
46. Davis BN, Hata A (2009) Regulation of microRNA biogenesis: a miRiad of mechanisms. Cell Commun Signal 7:18
47. Gregory RI, Yan KP, Amuthan G et al (2004) The Microprocessor complex mediates the genesis of microRNAs. Nature 432:235–240
48. Fukuda T, Yamagata K, Fujiyama S et al (2007) DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs. Nat Cell Biol 9:604–611
49. Chendrimada TP, Gregory RI, Kumaraswamy E et al (2005) TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature 436:740–744
50. Haase AD, Jaskiewicz L, Zhang H et al (2005) TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing. EMBO Rep 6:961–967
51. Michael MZ, O’Connor SM, Holst Pellekaan NG et al (2003) Reduced accumulation of specific microRNAs in colorectal neoplasia. Mol Cancer Res 1:882–891
52. Obernosterer G, Leuschner PJ, Alenius M, Martinez J (2006) Post-transcriptional regulation of microRNA expression. RNA 12:1161–1167
53. Lehrbach NJ, Armisen J, Lightfoot HL et al (2009) LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans. Nat Struct Mol Biol 16:1016–1020
54. Wulczyn FG, Smirnova L, Rybak A et al (2007) Post-transcriptional regulation of the let-7 microRNA during neural cell specification. FASEB J 21:415–426
55. Heo I, Joo C, Kim YK et al (2009) TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. Cell 138:696–708
56. Hagan JP, Piskounova E, Gregory RI (2009) Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells. Nat Struct Mol Biol 16:1021–1025
57. • Michlewski G, Caceres JF (2010) Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis. Nat Struct Mol Biol 17:1011–1018
58. Diederichs S, Haber DA (2007) Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression. Cell 131:1097–1108
59. Rybak A, Fuchs H, Hadian K et al (2009) The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2. Nat Cell Biol 11:1411–1420
60. Jha A, Mehra M, Shankar R (2011) The regulatory epicenter of miRNAs. J Biosci 36:621–638
61. Guil S, Gattoni R, Carrascal M et al (2003) Roles of hnRNP A1, SR proteins, and p68 helicase in c-H-ras alternative splicing regulation. Mol Cell Biol 23:2927–2941
62. Davis BN, Hilyard AC, Lagna G, Hata A (2008) SMAD proteins control DROSHA-mediated microRNA maturation. Nature 454:56–61
63. Adams BD, Claffey KP, White BA (2009) Argonaute-2 expression is regulated by epidermal growth factor receptor and mitogen-activated protein kinase signaling and correlates with a transformed phenotype in breast cancer cells. Endocrinology 150:14–23
64. Suzuki HI, Yamagata K, Sugimoto K et al (2009) Modulation of microRNA processing by p53. Nature 460:529–533
65. Weinmann L, Hock J, Ivacevic T et al (2009) Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. Cell 136:496–507
66. • Kedde M, van Kouwenhove M, Zwart W et al (2010) A Pumilio-induced RNA structure switch in p27–3′ UTR controls miR-221 and miR-222 accessibility. Nat Cell Biol 12:1014–1020
67. Larrea MD, Wander SA, Slingerland JM (2009) p27 as Jekyll and Hyde: regulation of cell cycle and cell motility. Cell Cycle 8:3455–3461
68. • Ryan BM, Robles AI, Harris CC (2010) Genetic variation in microRNA networks: the implications for cancer research. Nat Rev Cancer 10:389–402
69. Landi D, Gemignani F, Naccarati A et al (2008) Polymorphisms within micro-RNA-binding sites and risk of sporadic colorectal cancer. Carcinogenesis 29:579–584
70. Yu Z, Li Z, Jolicoeur N et al (2007) Aberrant allele frequencies of the SNPs located in microRNA target sites are potentially associated with human cancers. Nucleic Acids Res 35:4535–4541
71. • Gong J, Tong Y, Zhang HM et al (2012) Genome-wide identification of SNPs in microRNA genes and the SNP effects on microRNA target binding and biogenesis. Hum Mutat 33:254–263
72. Zeng Y, Cullen BR (2005) Efficient processing of primary microRNA hairpins by Drosha requires flanking nonstructured RNA sequences. J Biol Chem 280:27595–27603
73. Newman MA, Thomson JM, Hammond SM (2008) Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing. RNA 14:1539–1549
74. Yang J, Zhou F, Xu T et al (2008) Analysis of sequence variations in 59 microRNAs in hepatocellular carcinomas. Mutat Res 638:205–209
75. • Wan Y, Kertesz M, Spitale RC et al (2011) Understanding the transcriptome through RNA structure. Nat Rev Genet 12:641–655
76. Barski A, Jothi R, Cuddapah S et al (2009) Chromatin poises miRNA- and protein-coding genes for expression. Genome Res 19:1742–1751
77. Roman-Gomez J, Agirre X, Jimenez-Velasco A et al (2009) Epigenetic regulation of microRNAs in acute lymphoblastic leukemia. J Clin Oncol 27:1316–1322
78. • Suh SO, Chen Y, Zaman MS et al (2011) MicroRNA-145 is regulated by DNA methylation and p53 gene mutation in prostate cancer. Carcinogenesis 32:772–778
79. Weber B, Stresemann C, Brueckner B, Lyko F (2007) Methylation of human microRNA genes in normal and neoplastic cells. Cell Cycle 6:1001–1005
80. • Wiklund ED, Kjems J, Clark SJ (2010) Epigenetic architecture and miRNA: reciprocal regulators. Epigenomics 2:823–840
81. Saito Y, Liang G, Egger G et al (2006) Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell 9:435–443
82. Lujambio A, Ropero S, Ballestar E et al (2007) Genetic Unmasking of an Epigenetically Silenced microRNA in Human Cancer Cells. Cancer Res 67:1424–1429
83. Brueckner B, Stresemann C, Kuner R et al (2007) The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function. Cancer Res 67:1419–1423
84. Fazi F, Racanicchi S, Zardo G et al (2007) Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein. Cancer Cell 12:457–466
85. Wang XW, Heegaard NH, Orum H (2012) MicroRNAs in liver disease. Gastroenterology 142:1431–1443