The protective role of alpha lipoic acid against pesticides induced testicular toxicity- histopathological and histochemical studies

Journal of Aquaculture Research and Development

Volumn 1, Issue 1, 2010, Pages

  Gawish, Azza M ^a  

^a CAIRO UNIVERSITY   (Egypt)

Author keywords

Antioxi dants; Apoptosis; Fibrosis; Pesticides; Reproduction

Indexed keywords

EID: 84880342139     PISSN: None     EISSN: 21559546     Source Type: Journal    
DOI: 10.4172/2155-9546.1000101     Document Type: Article

References (70)

1. Nuckols JR, Gunier RB, Riggs P (2007) Linkage of California pesticide use reporting data-base spatial land use for exposure assessment. Environ Health Perspec 115: 684-689.
2. Roy TS, Seidler FJ, Slotkin TA (2004) Morphologic effects of subtoxic neonatal chlorpyrifos exposure in developing rat brain: Regionally selective alterations in neurons and glia. Brain Res Dev Brain Res 148: 197-206.
3. Tamura H, Maness SC, Reishman K, Dorman DC, Gray LE, et al. (2001) Androgen Receptor antagonism by the organophosphate insecticide fenitrothion. Toxicol Sci 60: 56-62.
4. Pajoumand A, Jalali N, Abdollahi N, Shadnia S (2002) Survival following severe aluminium phosphide poisoning. J Pharm Pract Res 32: 297-299.
5. Hileman B (1994) Environmental estrogens linked to reproductive abnormalities and cancer. Chem Eng New 31: 19-23.
6. Okamura A, Kamijima M, Shibata E (2005) A comprehensive evaluation of the testicular toxicity of dichlorvos in Wistar rayts. Toxicology 213: 129-37.
7. Presibella KM, Kita DH, Carneiro CB, Andrade AJM, Dalsenter PR, et al. (2005) Reproductive evaluation of two pesticides combined (deltamethrine and endosulfan) in female rats. Reproduc Toxicol 20: 95-101.
8. Afi Fi NA, Ramadan A, El-Aziz MI, Saki EE (1991) Infl uence of dimethoate on testicular and epidymal organs, testosterone plasma level and their tissue residues in rats. Dtsch Tierarztl Wochenschr 98: 419-423.
9. Chitra KC, Latchoumycandane C, Mathur PP (1999) Chronic effect of endosulfan on the testicular functions of rat. Asian J Andrology 1: 203-206.
10. Gangadharan B, Murugan MA, Mathur PP (2001) Effect of methoxychlor on antioxidant system of goat epididymal sperm in vitro. Asian J Androl 3: 285-288.
11. Ibrahim SF, Khairul O, Srijit D, Abas MO, Norzaiti A, et al. (2008) A Study of the Antioxidant Effect of Alpha Lipoic Acids on Sperm Quality Clinics. 63: 545-550.
12. Tuzmen N, Candan N, Kays E, Demiryas N (2008) Biochemical effects of chlorpyrifos and deltamethrin on altered antioxidative defense mechanisms and lipid peroxidation in rat liver. Cell Biochem Funct 26: 119-124.
13. Suskind A, Hayner-Buchan A, Feustel PJ (2007) Analysis of human undescended testes. B J U International 101: 1441 - 1445.
14. Bartke A (1995) Apoptosis of male germ cells, a generalized or a cell type-specifi c phenomenon? Endocrinology 136: 3-4.
15. Billig H, Furuta I, Rivier C, Tapanainen J, Parvinen M, et al. (1995) Apoptosis in testis germ cells: developmental changes in gonadotropin dependence and localization to selective tubule stages. Endocrinology 136: 5-12.
16. Henriksen K, Hakovirta H, Parvinen M (1995) Testosterone inhibits and induces apoptosis in rat seminiferous tubules in a stage-specifi c manner: in situ quantifi cation in squash preparations after administration of ethane dimethane sulfonate. Endocrinology 136: 3285-3289.
17. Hikim APS, Wang C, Leung A, Swerdloff RS (1995) Involvement of apoptosis in adult rats after gonadotropin-releasing hormone antagonist treatment. Endocrinology 136: 2770-2775.
18. Gotz ME, Dirr A, Burger R, Janetzky B, Weinmuller M, et al. (1994) Effect of lipoic acid on redox state of coenzyme Q in mice treated with 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine and diethyldithiocarbamate. Eur J Pharmacol 266: 291-300.
19. Han D, Handelman G, Marcocci L, Sen CK, Roy S, et al. (1997) Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization. Biofactors 6: 321-338.
20. Henriksen EJ (2006) Exercise training and the antioxidant alpha-lipoic acid in the treatment of insulin resistance and type 2 diabetes. Free Radic Biol Med 40: 3-12.
21. Selvakumar P, Lakshmikuttyamma A, Kanthan R, Kanthan SC, Dimmock JR, et al. (2004) High expression of methionine aminopeptidase 2 in human colorectal adeno carcinomas. Clin Cancer Res 10: 2771-2775
22. Ohkawa H, Ohishi N, Yagi K (1979) Assayof lipid peroxidases in animal tissues by thiobarbituric acid reaction. Anal Biochem 95: 351-8.
23. Tremblay RR (2001) Practical consequences of the validation of a mathematical model in assessment of partial androgen defi ciency in the aging male using bioavailable testosterone. The Aging Male 4: 23-9.
24. Bancrot JD, Stevens (2002) Theory and Practice of Histological Techniques. (Fourth Edition), Queen's Medical Center, Notingham, University Hospital NHS Trust.
25. Gavrieli Y, Sherman Y, Ben-Sasson SA (1992) Identifi cation of programmed cell death in situ via specifi c labeling of nuclear DNA fragmentation. J Cell Biol Nov 119: 493-501.
26. Sarkar R, Mohanakumar KP, Chowdhury M (2000) Effects of an organophosphate pesticide, quinalphos, on the hypothalamo-pituitary-gonadal axis in adult male rats. J Reprod Fertil 118: 29-38.
27. Serin M, Gülbaş H, Gürses I, Erkal HS, Yücel N (2007) The histopathological evaluation of the effectiveness of melatonin as a protectant against acute lung injury induced by radiation therapy in a rat model. Int J Radiat Biol 83: 187-93.
28. Cakir S, Sarikaya R (2005) Genotoxicity testing of some organophosphate insecticides in the Drosophila wing spot test. Food Chem Toxicol 43: 443-450.
29. Prashanthi N, Narayana K, Nayanatara A, Chandra KH, Bairy KL, et al. (2006) The reproductive toxicity of the organophosphate pesticide 0, 0-dimethyl 0-4-nitrophenyl phosphorothioate (methyl parathion) in the male rat. Folia Morphol 65: 309-321.
30. Sultatos LG (1994) Mammalian toxicology of organophosphorous pesticides. J Toxicol Environ Health 43: 271-289.
31. Kackar R, Srivastava MK, Raizada RB (1997) Induction of gonadal toxicity to male rats after chronic exposure to mancozeb. Ind Health 35: 104-111.
32. Sugár J, Tóth K, Csuka O, Gáti E, Somfai-Relle S (1979) Role of pesticides in hepatocarcinogenesis. J Toxicol Environ Health 5: 183-91.
33. Linder RE, Klinefelter GR, Strader LF, Suarez JD, Roberts NL (1997) Spermatotoxicity of dichloroacetic acid. Reprod Toxicol 11: 681-8.
34. Ibrahim NA, El-Gamal BA (2003) Effect of diazinon, an organophosphate insecticide, on plasma lipid constituents in experimental animals. J Biochem Mol Biol 36: 499-504.
35. Parasmthi K, Muralithara J, Rajini P (2005) Fenvalerate induced oxidative damage inrat tissue and its attenuation by dietary sesame oil. Food Chem Toxicol 43: 299- 306.
36. Qu JH, Hong X, Chem JF, Wang Y, Sun H (2008) Fenvalerate inhibits progesterone production through cAMP- dependent signal pathway. Toxicol Lett 176: 31-39.
37. Banerjee BD, Seth V, Battacharya A, Pasha ST, Chakrabory AK (1999) Biochemical effects of some pesticides on lipid peroxidation and free radical scavengers. Toxicol Lett 107: 33-47.
38. Etemadi-Aleagha A, khgari M, Abdollahi M (2002) A brief review on oxidative stress and cardiac diseases. Mid East Pharmac 10: 8-9.
39. Biewenga GP, Haenen GR, Bast A ((1997) The pharmacology of the antioxidant lipoic acid. Gen Pharmacol 29: 315-331.
40. Packer L, Witt EH, Tritschler HJ (1995) Alpha-Lipoic acid as a biological antioxidant. Free Radic Biol Med 19: 227-250.
41. Packer L, Witt EH, Tritschler HJ (1995) Alpha-lipoic acid as a biological antioxidant. Free Radic Biol Med 19: 227-250.
42. Packer L, Kraemer K, Rimbach G (2001) Molecular aspects of lipoic and in the prevention of diabetes complications. Nutrition 17: 888-95.
43. Cronan JE, Zhao X, Jiang Y (2005) Function, attachment and synthesis of lipoic acid in Escherichia coli. Adv Microb Physiol 50: 103-46.
44. Reed LJ (2001) A Trail of Research from Lipoic Acid to alpha-Keto Acid dehydrogenase Complexes. J Biol Chem 276: 38329-36.
45. Aliev G, Liu J, Shenk J C, Fischbach K, Pacheco GJ, et al. (2008) Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats. J Cell Mol Med 13: 320-333.
46. Ames BN, Liu J (2004) Delaying the Mitochondrial Decay of Aging with Acetylcarnitine. Ann N Y Acad Sci 1033: 108-116.
47. Astroff AB, FreshWater KJ, Eigenberg DA (1998) Comparative organophosphate-induced effects observed in adult and neonatal Sprague Dawley rats during the conduct of multigeneration toxicity studies. Reprod Toxicol 2: 619-645.
48. Bast A, Haenen GR (1988) Interplay between lipoic acid and glutathione in the protection against microsomal lipid peroxidation. Biochim Biophys Acta 963: 558-561.
49. Crammer JS, Avery DL, Grady RR, Kitay JI (1978) Postnatal endocrine dysfunction resulting from prenatal exposure to carbofuran, diazinon or chlordane. J Environ Pathol Toxicol 2: 357-369.
50. Elangovan S, Chidambaram P, Yenjerla M, Palaninathan V (2004) Protective effect of DL-α-lipoic acid in cyclophosphamide induced oxidative injury in rat testis. Reprod Toxicol 19: 163-167.
51. Haenen GRMM, Bast A (1991) Scavenging of hypochlorous acid by lipoic acid. Biochem Pharmacol 2: 2244-2246.
52. Haugaard N (1968) Cellular mechanisms of oxygen toxicity. Physiol Rev 48: 311- 373.
53. Jadaramkunti UC, Kaliwal BB (2002) Dicofol formulation induced toxicity on tests and accessory reproductive organs in albino rats. Bull Environ Contam Toxicol 69: 741-748.
54. Kackar R, Srivastara MK, Raizada RB (1997) Induction of gonadal toxicity to male rats after chronic exposure to mancozob. Ind Health 35: 104-11.
55. Khan SM (2006) Protective effect of black tea extract on the levels of lipid peroxidation and antioxidant enzymes in liver of mice with pesticide - induced liver injury. Cell biochem Funct 24: 327-332.
56. Kozlov AV, Gille L, Staniek K, Nohl H (1999) Dihydrolipoic maintains ubiquinone in the antioxidant active form by two-electron reduction of ubiquinone and one-electron reduction of ubisemiquinone. Arch Biochem Biophys 363:148-154.
57. Leistra M, Zweers AJ, Warinton JS, Crum SCH, Hand LH, et al. (2003) Fate of the insecticide lambda-cyhalothrin in ditch enclosures differing in vegetation density. Pest Manage Sci 60: 75-84.
58. Mathew G, Vijayalaxmi KK, Rahiman MA (1992) Methyl parathion induced sperm shape abnormalities in mouse. Mutat Res 280: 169-173.
59. Patrick L (2002) Mercury toxicity and antioxidants: Part 1: role of glutathione and alpha-lipoic acid in the treatment of mercury toxicity. Altern Med Rev 7: 456-71.
60. Pesch S, Bergmann M, Bostedt H (2006) Determination of some enzymes and Macro-and microelements in stallion seminal plasma and their correlations to semen quality. Theriogenology 66: 307-313.
61. Pryor WA, Houk KN, Foote CS, Fukuto JM, Ignarro LJ, Squadrito GL, et al. (2006) Free radical biology and medicine: it's a gas, man! Am J Physiol Regul Integr Comp Physiol 291: R491-R511.
62. Reuber MD (1985) Carcinogenicity and toxicity of malathion and malaxon. Environ Res 37: 119-153.
63. Rooney J (2007) The role of thiols, dithiols, nutritional factors and interacting ligands in the toxicology of mercury. Toxicology 234: 145-156.
64. Rull RP, Ritz B, Shaw GM (2006). Neural tube defects and maternal residential proximity to agricultural pesticide applications. Am J Epidemiol 163: 743-753.
65. Scholich H, Murphy ME, Sies H (1989). Antioxidant activity of dihydrolipoate against microsomal lipid peroxidation and its dependence on alpha-tocopherol. Biochim Biophys Acta 1001: 256-261.
66. Suresh CJ (2007) Testicular toxicity of chlorpyrifos (an organophosphate pesticide) in albino rat. Toxicol Ind Health 23: 439-444.
67. Soderlund DM, Clark JM, Sheets L P, Mullin LS, Piccirillo VJ, et al. (2002) Mechanism of pyrethroid neurotoxicity: implication for cumulative risk assessment. Toxicology 171: 3-59.
68. Tinoco R, Halperine D (1998) Poverty production and health: inhibition of erythrocyte cholinesterase via occupational exposure to organophosphate insecticides in Chipas, Mexico. Arch Environ Health 53: 29-35.
69. Verma RS (2001) Chlorpyrifos-induced alterations in levels of thiobarbituric acid reactive substances and glutathione in rat brain. Indian J Exp Biol 39: 174-77.
70. Vidyasagar J, Karunakar N, Reddy MS, Rajnarayana K, Surender T, et al. (2004) Oxidative stress and antioxidant status in acute organophosphorus insecticide poisoning. Indian J Pharmacol.