Androgens and estrogens stimulate ribosome biogenesis in prostate and breast cancer cells in receptor dependent manner

Gene

Volumn 526, Issue 1, 2013, Pages 46-53

  Ray, Swagat ^a,b   Johnston, Rebecca ^a   Campbell, David C ^a   Nugent, Shannen ^a   McDade, Simon S ^a   Waugh, David ^a   Panov, Konstantin I ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

Androgen receptor; Cancer; Estrogen receptor; Ribosomal RNA; Ribosome biogenesis; RNA polymerase I

Indexed keywords

ANDROGEN RECEPTOR; DNA DIRECTED RNA POLYMERASE; ESTRADIOL; ESTROGEN RECEPTOR; METRIBOLONE; RIBOSOME RNA;

ANDROGEN THERAPY; ARTICLE; BIOGENESIS; BREAST CANCER; CANCER CELL; CANCER GROWTH; CONTROLLED STUDY; ESTROGEN THERAPY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROSTATE CANCER; RIBOSOME; RNA SYNTHESIS; SIGNAL TRANSDUCTION; STIMULUS; TRANSCRIPTION INITIATION;

ANDROGEN RECEPTOR; AR; BCA; BREAST CANCER; CANCER; CHIP; CHROMATIN IMMUNOPRECIPITATION ASSAY; ER; ESTROGEN RECEPTOR; PCA; PIC; POL; POLYMERASE; PREINITIATION COMPLEX; PROSTATE CANCER; RB; RIBOSOMAL RNA; RIBOSOME BIOGENESIS; RNA POLYMERASE I; RRNA;

ANDROGEN ANTAGONISTS; ANDROGENS; ANILIDES; BREAST NEOPLASMS; CELL LINE, TUMOR; ESTRADIOL; ESTROGEN RECEPTOR MODULATORS; ESTROGENS; FEMALE; HUMANS; MALE; MCF-7 CELLS; NEOPLASMS, HORMONE-DEPENDENT; NITRILES; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; RECEPTORS, ESTROGEN; RIBOSOMES; RNA, NEOPLASM; RNA, RIBOSOMAL; SIGNAL TRANSDUCTION; TOSYL COMPOUNDS; TRANSCRIPTION, GENETIC;

EID: 84880330152     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2013.04.018     Document Type: Article

References (28)

1. Bennett N.C., Gardiner R.A., Hooper J.D., Johnson D.W., Gobe G.C. Molecular cell biology of androgen receptor signalling. Int. J. Biochem. Cell Biol. 2010, 42:813-827.
2. Bywater M.J., Poortinga G., Sanij E., Hein N., Peck A., Cullinane C., Wall M., Cluse L., Drygin D., Anderes K., Huser N., Proffitt C., Bliesath J., Haddach M., Schwaebe M.K., Ryckman D.M., Rice W.G., Schmitt C., Lowe S.W., Johnstone R.W., Pearson R.B., McArthur G.A., Hannan R.D. Inhibition of RNA polymerase I as a therapeutic strategy to Promote cancer-specific activation of p53. Cancer Cell 2012, 22:51-65.
3. Dai M.S., Lu H. Crosstalk between c-Myc and ribosome in ribosomal biogenesis and cancer. J. Cell. Biochem. 2008, 105:670-677.
4. Drygin D., Siddiqui-Jain A., O'Brien S., Schwaebe M., Lin A., Bliesath J., Ho C.B., Proffitt C., Trent K., Whitten J.P., Lim J.K., Von Hoff D., Anderes K., Rice W.G. Anticancer activity of CX-3543: a direct inhibitor of rRNA biogenesis. Cancer Res. 2009, 69:7653-7661.
5. Drygin D., Rice W.G., Grummt I. The RNA polymerase I transcription machinery: an emerging target for the treatment of cancer. Annu. Rev. Pharmacol. Toxicol. 2010, 50:131-156.
6. Drygin D., Lin A., Bliesath J., Ho C.B., O'Brien S.E., Proffitt C., Omori M., Haddach M., Schwaebe M.K., Siddiqui-Jain A., Streiner N., Quin J.E., Sanij E., Bywater M.J., Hannan R.D., Ryckman D., Anderes K., Rice W.G. Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth. Cancer Res. 2011, 71:1418-1430.
7. Grummt I. Life on a planet of its own: regulation of RNA polymerase I transcription in the nucleolus. Genes Dev. 2003, 17:1691-1702.
8. Hurtado A., Holmes K.A., Ross-Innes C.S., Schmidt D., Carroll J.S. FOXA1 is a key determinant of estrogen receptor function and endocrine response. Nat. Genet. 2011, 43:27-33.
9. IACR http://globocan.iarc.fr/factsheets/populations/factsheet.asp?uno=900.
10. James M.J., Zomerdijk J.C. Phosphatidylinositol-3 kinase and mTOR signaling pathways regulate RNA polymerase I transcription in response to IGF-1 and nutrients. J. Biol. Chem. 2003.
11. Jemal A., Bray F., Center M.M., Ferlay J., Ward E., Forman D. Global cancer statistics. CA Cancer J. Clin. 2011, 61:69-90.
12. Kopp K., Gasiorowski J.Z., Chen D., Gilmore R., Norton J.T., Wang C., Leary D.J., Chan E.K., Dean D.A., Huang S. Pol I transcription and pre-rRNA processing are coordinated in a transcription-dependent manner in mammalian cells. Mol. Biol. Cell 2007, 18:394-403.
13. Kos M., Tollervey D. Yeast pre-rRNA processing and modification occur cotranscriptionally. Mol. Cell 2010, 37:809-820.
14. Lempiainen H., Shore D. Growth control and ribosome biogenesis. Curr. Opin. Cell Biol. 2009, 21:855-863.
15. Li H., Handsaker B., Wysoker A., Fennell T., Ruan J., Homer N., Marth G., Abecasis G., Durbin R. The Sequence Alignment/Map format and SAMtools. Bioinformatics 2009, 25:2078-2079.
16. Mangelsdorf D.J., Thummel C., Beato M., Herrlich P., Schutz G., Umesono K., Blumberg B., Kastner P., Mark M., Chambon P., Evans R.M. The nuclear receptor superfamily: the second decade. Cell 1995, 83:835-839.
17. Moss T., Langlois F., Gagnon-Kugler T., Stefanovsky V. A housekeeper with power of attorney: the rRNA genes in ribosome biogenesis. Cell. Mol. Life Sci. 2007, 64:29-49.
18. Panov K.I., Friedrich J.K., Zomerdijk J.C. A step subsequent to preinitiation complex assembly at the ribosomal RNA gene promoter is rate limiting for human RNA polymerase I-dependent transcription. Mol. Cell. Biol. 2001, 21:2641-2649.
19. Paule M.R., White R.J. Survey and summary: transcription by RNA polymerases I and III. Nucleic Acids Res. 2000, 28:1283-1298.
20. Ruggero D., Pandolfi P.P. Does the ribosome translate cancer?. Nat. Rev. Cancer 2003, 3:179-192.
21. Russell J., Zomerdijk J.C. RNA-polymerase-I-directed rDNA transcription, life and works. Trends Biochem. Sci. 2005, 30:87-96.
22. Stefanovsky V., Langlois F., Gagnon-Kugler T., Rothblum L.I., Moss T. Growth factor signaling regulates elongation of RNA polymerase I transcription in mammals via UBF phosphorylation and r-chromatin remodeling. Mol. Cell 2006, 21:629-639.
23. Stefanovsky V.Y., Langlois F., Bazett-Jones D., Pelletier G., Moss T. ERK modulates DNA bending and enhancesome structure by phosphorylating HMG1-boxes 1 and 2 of the RNA polymerase I transcription factor UBF. Biochemistry 2006, 45:3626-3634.
24. Tenbaum S., Baniahmad A. Nuclear receptors: structure, function and involvement in disease. Int. J. Biochem. Cell Biol. 1997, 29:1325-1341.
25. Thomas C., Gustafsson J.A. The different roles of ER subtypes in cancer biology and therapy. Nat. Rev. Cancer 2011, 11:597-608.
26. Warner J.R. The economics of ribosome biosynthesis in yeast. Trends Biochem. Sci. 1999, 24:437-440.
27. Welsh A.W., Lannin D.R., Young G.S., Sherman M.E., Figueroa J.D., Henry N.L., Ryden L., Kim C., Love R.R., Schiff R., Rimm D.L. Cytoplasmic estrogen receptor in breast cancer. Clin. Cancer Res. 2012, 18:118-126.
28. Zentner G.E., Saiakhova A., Manaenkov P., Adams M.D., Scacheri P.C. Integrative genomic analysis of human ribosomal DNA. Nucleic Acids Res. 2011, 39:4949-4960.