The art of blocking ADP-ribosyltransferases (ARTs): Nanobodies as experimental and therapeutic tools to block mammalian and toxin ARTs

FEBS Journal

Volumn 280, Issue 15, 2013, Pages 3543-3550

  Menzel, Stephan ^a   Rissiek, Björn ^a   Haag, Friedrich ^a   Goldbaum, Fernando A ^b   Koch Nolte, Friedrich ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b FUNDACIÓN INSTITUTO LELOIR   (Argentina)

Author keywords

ADP ribosyltransferase; enzyme inhibitor; nanobody; recombinant antibody; single domain antibody; toxin

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSE; CHOLERA TOXIN; DIPHTHERIA ANTIBODY; DIPHTHERIA TOXIN; DIPHTHERIA TOXOID; NANOBODY; NEUTRALIZING ANTIBODY; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 2; RECOMBINANT ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; TOXIN ANTIBODY;

ABSENCE OF SIDE EFFECTS; ADENOSINE DIPHOSPHATE RIBOSYLATION; ANTIGEN ANTIBODY REACTION; ANTIGEN SPECIFICITY; ARTIODACTYLA; BACTERIAL VIRULENCE; COMPLEMENTARITY DETERMINING REGION; CORYNEBACTERIUM DIPHTHERIAE; CYTOSOL; DRUG MECHANISM; DRUG TARGETING; ENZYME INHIBITION; ENZYME SPECIFICITY; HUMAN; IMMUNOTHERAPY; MAMMAL; MEMBRANE BINDING; NONHUMAN; PRIORITY JOURNAL; REVIEW; SALMONELLA ENTERICA;

ADP-RIBOSYLTRANSFERASE; ENZYME INHIBITOR; NANOBODY; RECOMBINANT ANTIBODY; SINGLE-DOMAIN ANTIBODY; TOXIN;

ADP RIBOSE TRANSFERASES; AMINO ACID SEQUENCE; ANIMALS; BACTERIAL INFECTIONS; BACTERIAL TOXINS; CAMELIDS, NEW WORLD; DRUG DELIVERY SYSTEMS; HUMANS; MOLECULAR SEQUENCE DATA; SINGLE-DOMAIN ANTIBODIES; VIRULENCE FACTORS;

CAMELIDAE; CORYNEBACTERIUM DIPHTHERIAE; EQUIDAE; LAMA GLAMA; MAMMALIA; SALMONELLA; SALMONELLA ENTERICA;

EID: 84880324634     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12313     Document Type: Review

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