Loss of DOK2 induces carboplatin resistance in ovarian cancer via suppression of apoptosis

Gynecologic Oncology

Volumn 130, Issue 2, 2013, Pages 369-376

  Lum, Elena ^a   Vigliotti, Michele ^a   Banerjee, Nilanjana ^b   Cutter, Noelle ^a   Wrzeszczynski, Kazimierz O ^a   Khan, Sohail ^c   Kamalakaran, Sitharthan ^b   Levine, Douglas A ^d   Dimitrova, Nevenka ^b   Lucito, Robert ^e  

^a Cold Spring Harbor ^*  (United States)

^b PHILIPS RESEARCH LABORATORIES   (Germany)

^c STONY BROOK UNIVERSITY   (United States)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^e DONALD AND BARBARA ZUCKER SCHOOL OF MEDICINE AT HOFSTRA NORTHWELL   (United States)

Author keywords

Epigenetics Platinum resistance Genomics Ovarian Cancer Apoptosis

Indexed keywords

CARBOPLATIN; DOCKING PROTEIN; DOCKING PROTEIN 2; PLATINUM; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ANOIKIS; APOPTOSIS; ARTICLE; CANCER RESISTANCE; CELL CULTURE; CLINICAL ARTICLE; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; METHYLATION; OVARY CANCER; PHENOTYPE; PRIORITY JOURNAL; TISSUE CULTURE;

APOPTOSIS; EPIGENETICS; GENOMICS; OVARIAN CANCER; PLATINUM RESISTANCE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANOIKIS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARBOPLATIN; CELL LINE, TUMOR; DNA METHYLATION; DRUG RESISTANCE, NEOPLASM; EPIGENESIS, GENETIC; FEMALE; HUMANS; OVARIAN NEOPLASMS; PHOSPHOPROTEINS;

EID: 84880310916     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2013.05.002     Document Type: Article

References (44)

1. Cancer Genome Atlas Research Network Integrated genomic analyses of ovarian carcinoma Nature 474 7353 2011 609 615
2. Z.C. Wang Profiles of genomic instability in high-grade serous ovarian cancer predict treatment outcome Clin Cancer Res 18 20 2012 5806 5815
3. R.C. Bast Jr., B. Hennessy, and G.B. Mills The biology of ovarian cancer: new opportunities for translation Nat Rev Cancer 9 6 2009 415 428
4. S.W. Tsao Characterization of human ovarian surface epithelial cells immortalized by human papilloma viral oncogenes (HPV-E6E7 ORFs) Exp Cell Res 218 2 1995 499 507
5. R. Lucito Representational oligonucleotide microarray analysis: a high-resolution method to detect genome copy number variation Genome Res 13 10 2003 2291 2305
6. B. Naume, X. Zhao, M. Synnestvedt, E. Borgen, H.G. Russnes, and O.C. Lingjærde Presence of bone marrow micrometastasis is associated with different recurrence risk within molecular subtypes of breast cancer Mol Oncol 1 2 2007 160 171
7. S. Kamalakaran Methylation detection oligonucleotide microarray analysis: a high-resolution method for detection of CpG island methylation Nucleic Acids Res 37 12 2009 e89
8. M.K. Siu Stem cell transcription factor NANOG controls cell migration and invasion via dysregulation of E-cadherin and FoxJ1 and contributes to adverse clinical outcome in ovarian cancers Oncogene 2012 [in press]
9. X. Liao Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation Carcinogenesis 30 1 2009 131 140
10. D.W. Chan Loss of MKP3 mediated by oxidative stress enhances tumorigenicity and chemoresistance of ovarian cancer cells Carcinogenesis 29 9 2008 1742 1750
11. A.H. Berger Identification of DOK genes as lung tumor suppressors Nat Genet 42 3 2010 216 223
12. M. Niki Role of Dok-1 and Dok-2 in leukemia suppression J Exp Med 200 12 2004 1689 1695
13. T. Yasuda Role of Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia J Exp Med 200 12 2004 1681 1687
14. C.H. An Mutational and expressional analysis of a haploinsufficient tumor suppressor gene DOK2 in gastric and colorectal cancers APMIS 119 8 2011 562 564
15. R. Mashima Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma Lab Invest 90 9 2010 1357 1364
16. T. Fojo Cancer, DNA repair mechanisms, and resistance to chemotherapy J Natl Cancer Inst 93 19 2001 1434 1436
17. R. Morrison Targeting the mechanisms of resistance to chemotherapy and radiotherapy with the cancer stem cell hypothesis J Oncol 2011 2011 941876
18. M.M. Gottesman Mechanisms of cancer drug resistance Annu Rev Med 53 2002 615 627
19. C. Balch Role of epigenomics in ovarian and endometrial cancers Epigenomics 2 3 2010 419 447
20. S.M. Frisch, and R.A. Screaton Anoikis mechanisms Curr Opin Cell Biol 13 5 2001 555 562
21. M. Zhan, H. Zhao, and Z.C. Han Signalling mechanisms of anoikis Histol Histopathol 19 3 2004 973 983
22. Y.N. Kim Anoikis resistance: an essential prerequisite for tumor metastasis Int J Cell Biol 2012 2012 306879
23. M.A. Cifone, and I.J. Fidler Correlation of patterns of anchorage-independent growth with in vivo behavior of cells from a murine fibrosarcoma Proc Natl Acad Sci U S A 77 2 1980 1039 1043
24. I. Macpherson, and L. Montagnier Agar suspension culture for the selective assay of cells transformed by polyoma virus Virology 23 1964 291 294
25. A. Daponte Prognostic significance of hypoxia-inducible factor 1 alpha(HIF-1 alpha) expression in serous ovarian cancer: an immunohistochemical study BMC Cancer 8 2008 335
26. B. Bachtiary Overexpression of hypoxia-inducible factor 1alpha indicates diminished response to radiotherapy and unfavorable prognosis in patients receiving radical radiotherapy for cervical cancer Clin Cancer Res 9 6 2003 2234 2240
27. S. Enatsu Expression of hypoxia-inducible factor-1 alpha and its prognostic significance in small-sized adenocarcinomas of the lung Eur J Cardiothorac Surg 29 6 2006 891 895
28. H.C. Sun Expression of hypoxia-inducible factor-1 alpha and associated proteins in pancreatic ductal adenocarcinoma and their impact on prognosis Int J Oncol 30 6 2007 1359 1367
29. J.H. Wu Identification of DNA methylation of SOX9 in cervical cancer using methylated-CpG island recovery assay Oncol Rep 29 1 2012 Jan 125 132
30. M. Sun SOX9 expression and its methylation status in gastric cancer Virchows Arch 460 3 2012 271 279
31. L. Gan ZIC1 is downregulated through promoter hypermethylation, and functions as a tumor suppressor gene in colorectal cancer PLoS One 6 2 2011 e16916
32. T. Ezponda The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer Oncogene 2012 [in press]
33. G. Xue Akt/PKB-mediated phosphorylation of Twist1 promotes tumor metastasis via mediating cross-talk between PI3K/Akt and TGF-beta signaling axes Cancer Discov 2 3 2012 248 259
34. A. Giordano Epithelial-mesenchymal transition and stem cell markers in patients with HER2-positive metastatic breast cancer Mol Cancer Ther 11 11 2012 Nov 2526 2534
35. I. Gomez TWIST1 is expressed in colorectal carcinomas and predicts patient survival PLoS One 6 3 2011 e18023
36. M. Katoh Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades Cancer Biol Ther 5 9 2006 1059 1064
37. C.C. Malbon Frizzleds: new members of the superfamily of G-protein-coupled receptors Front Biosci 9 2004 1048 1058
38. J. Li Human ovarian cancer and cisplatin resistance: possible role of inhibitor of apoptosis proteins Endocrinology 142 1 2001 370 380
39. M.K. Tang c-Met overexpression contributes to the acquired apoptotic resistance of nonadherent ovarian cancer cells through a cross talk mediated by phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2 Neoplasia 12 2 2010 128 138
40. C.D. Simpson, K. Anyiwe, and A.D. Schimmer Anoikis resistance and tumor metastasis Cancer Lett 272 2 2008 177 185
41. M.C. Guadamillas, A. Cerezo, and M.A. Del Pozo Overcoming anoikis - pathways to anchorage-independent growth in cancer J Cell Sci 124 Pt 19 2011 3189 3197
42. B.M. Bolstad A comparison of normalization methods for high density oligonucleotide array data based on variance and bias Bioinformatics 19 2 2003 185 193
43. Y. Benjamini, and Y. Hochberg Controlling the false discovery rate: a practical and powerful approach to multiple testing J R Stat Soc Ser B 57 1995 289 300
44. K. Pollard, S. Dudoit, and M.J. van der Laan Multiple testing procedures: R multtest package and applications to genomics Berkeley Division of Biostatistics Working Paper Series 164 2004 [U.C.]