ZIC1 is downregulated through promoter hypermethylation, and functions as a tumor suppressor gene in colorectal cancer

PLoS ONE

Volumn 6, Issue 2, 2011, Pages

  Gan, Lihong ^a   Chen, Shujie ^b   Zhong, Jing ^a   Wang, Xian ^c   Lam, Emily K Y ^d   Liu, Xin ^d   Zhang, Jianbin ^d   Zhou, Tianhua ^e   Yu, Jun ^d   Si, Jianmin ^b   Wang, Liangjing ^a   Jin, Hongchuan ^c  

^a THE SECOND AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c ZHEJIANG UNIVERSITY   (China)

^d CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^e ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; CASPASE 3; COMPLEMENTARY DNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAD; PROTEIN BCL XL; PROTEIN KINASE B; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; ZINC FINGER OF THE CEREBELLUM 1; TRANSCRIPTION FACTOR; TRANSCRIPTOME; ZIC1 PROTEIN, HUMAN;

ADULT; APOPTOSIS; ARTICLE; CANCER INHIBITION; COLON CARCINOGENESIS; COLORECTAL CANCER; CONTROLLED STUDY; DEMETHYLATION; DNA MICROARRAY; DOWN REGULATION; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE INACTIVATION; GENE SILENCING; GENETIC ASSOCIATION; GENETIC IDENTIFICATION; GENETIC SELECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; NUCLEOTIDE SEQUENCE; PRIMARY TUMOR; PROMOTER REGION; PROTEIN METHYLATION; PROTEIN TARGETING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE; UPREGULATION; CELL PROLIFERATION; COLORECTAL TUMOR; DNA METHYLATION; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY; TUMOR CELL LINE;

VERTEBRATA;

APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; COLORECTAL NEOPLASMS; DNA METHYLATION; DOWN-REGULATION; FEMALE; GENE SILENCING; GENES, TUMOR SUPPRESSOR; HUMANS; MALE; MIDDLE AGED; PROMOTER REGIONS, GENETIC; TRANSCRIPTION FACTORS; TRANSCRIPTOME;

EID: 79951922993     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0016916     Document Type: Article

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