A quinazoline-2,4-diamino analog suppresses vibrio cholerae flagellar motility by interacting with motor protein pomb and induces envelope stress

Antimicrobial Agents and Chemotherapy

Volumn 57, Issue 8, 2013, Pages 3950-3959

  Wang, Hongxia ^a,b   Zhang, Li ^b,c   Silv, Anisia J ^a,b   Benitez, Jorge A ^a  

^a SOUTHERN RESEARCH INSTITUTE   (United States)

^b MOREHOUSE SCHOOL OF MEDICINE   (United States)

^c CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLERA TOXIN; MOLECULAR MOTOR; OMPU PROTEIN; OUTER MEMBRANE PROTEIN; POMB PROTEIN; PORIN; QUINAZOLINE 2,4 DIAMINO DERIVATIVE; QUINAZOLINE DERIVATIVE; RNA POLYMERASE; SIGMA FACTOR; SODIUM; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL MEMBRANE; BIOTYPE; CONTROLLED STUDY; DRUG PROTEIN BINDING; FLAGELLUM; HIGH THROUGHPUT SCREENING; MICROBIAL ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN FOLDING; PROTEIN SECRETION; STRESS; VIBRIO CHOLERAE;

ADHESINS, BACTERIAL; AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; CELL MEMBRANE; CHOLERA TOXIN; DNA-DIRECTED RNA POLYMERASES; FLAGELLA; GENES, BACTERIAL; PROTEIN FOLDING; PROTEIN INTERACTION MAPPING; QUINAZOLINES; SODIUM CHANNELS; STRESS, PHYSIOLOGICAL; TRANSCRIPTION, GENETIC; VIBRIO CHOLERAE;

EID: 84880305166     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00473-13     Document Type: Article

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